Characterization and functional analysis of conserved non-coding sequences among poaceae: insights into gene regulation and phenotypic variation in maize by Yi Luo, Hang Zhai, Xiu Zhong, Bo Yang, Yang Xu, Tianhong Liu, Qi Wang, Yang Zhou, Yan Mao, Yaxi Liu, Qi Tang, Yanli Lu, Yao Wang, Jie Xu

“…To explore the regulatory characteristics of the CNS identified, the flanking regions of CNS were compared with the peaks called using both transposase-accessible chromatin with high-throughput sequencing (ATAC-seq) and chromatin immunoprecipitation with high-throughput sequencing (ChIP-Seq) data of histone modifications. …”
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Blood proteomics and multimodal risk profiling of human volunteers after incision injury: A translational study for advancing personalized pain management after surgery by Daniel Segelcke, Julia R. Sondermann, Christin Kappert, Bruno Pradier, Dennis Görlich, Manfred Fobker, Jan Vollert, Peter K. Zahn, Manuela Schmidt, Esther M. Pogatzki-Zahn

“…Thus, prognostic prediction models that include bio-psycho-social and physiological factors in line with the complex nature of chronic pain would be urgently required. …”
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Identification of ALEKSIN as a novel multi-IRF inhibitor of IRF- and STAT-mediated transcription in vascular inflammation and atherosclerosis by Aleksandra Antonczyk, Katarzyna Kluzek, Natalia Herbich, Mahdi Eskandarian Boroujeni, Bart Krist, Dorota Wronka, Anna Karlik, Lukasz Przybyl, Adam Plewinski, Joanna Wesoly, Hans A. R. Bluyssen

“…Finally, we identified a novel signature of 46 ALEKSIN and STATTIC commonly inhibited pro-atherogenic target genes, which was upregulated in atherosclerotic plaques in the aortas of high-fat diet-fed ApoEKO mice and associated with inflammation, proliferation, adhesion, chemotaxis, and response to lipids. …”
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Sulforaphane ameliorates non-alcoholic steatohepatitis by KLF4-mediated macrophage M2 polarization by Xianghui Huang, Jia Xu, Ye Xu, Bingxin Huangfu, Feng Zhang, Yanzhou Hu, Ruxin Gao, Xinxin Ren, Boyang Zhang, Kunlun Huang, Xiaoyun He

“…In this study, we confirmed the protective effects of SFN on excessive lipid accumulation and inflammatory injury in a high-fat, high-fructose diet-induced non-alcoholic steatohepatitis (NASH) mouse model. …”
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Are we serologically prepared against an avian influenza pandemic and could seasonal flu vaccines help us? by Iván Sanz-Muñoz, Javier Sánchez-Martínez, Carla Rodríguez-Crespo, Corina S. Concha-Santos, Marta Hernández, Silvia Rojo-Rello, Marta Domínguez-Gil, Ahmed Mostafa, Luis Martinez-Sobrido, Jose M. Eiros, Aitor Nogales

“…Together with HPAI H5N1, avian influenza viruses H7N9 (high and low pathogenic) stand out due to their high mortality rates in humans. …”
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Oral medications for the treatment of postural orthostatic tachycardia syndrome; a systematic review of studies before and during the COVID-19 pandemic by Benjamin C. Pierson, Kyle Apilado, Kyle Apilado, M. Alaric Franzos, M. Alaric Franzos, Rhonda Allard, James D. Mancuso, David Tribble, David Tribble, David Saunders, Tracey Perez Koehlmoos, Tracey Perez Koehlmoos

“…Most included studies were judged to be of moderate to high quality, with largely low risk of bias. The most frequently studied medications were beta-blockers, ivabradine, and midodrine. …”
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Immunotherapy combined with chemotherapy without locoregional radiotherapy in de novo metastatic nasopharyngeal carcinoma: two case reports and a literature review by Yingna Gao, Xiaoqiong Shi, Jianqiao He, Hui Yao, Guoning Yu, Lin Zhao, Yi Ma, Yi Ma, Hongliang Zheng, Minhui Zhu, Caiyun Zhang

“…However, patients with a high tumor burden do not benefit from additional LRRT, which inevitably results in toxicity. …”
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No Galaxy-scale [C ii] Fast Outflow in the z = 6.72 Red Quasar HSC J1205–0000 by Mahoshi Sawamura, Takuma Izumi, Kouichiro Nakanishi, Takeshi Okuda, Michael A. Strauss, Masatoshi Imanishi, Yoshiki Matsuoka, Yoshiki Toba, Hideki Umehata, Takuya Hashimoto, Shunsuke Baba, Tomotsugu Goto, Toshihiro Kawaguchi, Kotaro Kohno, Dragan Salak, Taiki Kawamuro, Kazushi Iwasawa, Masafusa Onoue, Chien-Hsiu Lee, Kianhong Lee

“…We present an improved analysis of Atacama Large Millimeter/submillimeter Array data of the [C  ii ] 158 μ m line and the underlying rest-frame far-infrared (FIR) continuum emission, previously reported in T. …”
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Research on Meshing Simulation Analysis Method for Complex Flanks Based on Surface Synthesis Method by Li Jiaqi, Guo Yuliang, Wei Bingyang, Cao Xuemei

“…Based on analysis of the Ease-off surface, the complete contact morphological characteristics of tooth surface are obtained: the contact line-off, contact path, transmission error, etc., which are highly consistent with the actual contact pattern of the tooth surface. …”
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Research on polymorphic network application technology oriented intelligent manufacturing by Tao ZOU, Huifeng ZHANG, Wanxin GAO, Qi XU, Congqi SHEN, Jun ZHU, Zhongxia PAN, Xingchang GUO

“…The rise of intelligent manufacturing has induced many new demands on network technology.The polymorphic network separates the network technology from the support environment, supporting the coexistence as well as flexible loading and operation of various network technologies in the same network support environment, and can provide diversified, customizable, and highly reliable network service capabilities.The network environment requirements of intelligent manufacturing were studied, and smart factories were taken as an example to design efficient technical solutions based on the polymorphic network for various application scenarios.Different network technologies were efficiently adapted to application scenarios such as collaborative research and development design, production line control, machine vision quality inspection, unmanned intelligent inspection, accident emergency response, etc.The study verified the technical advantages of applying polymorphic networks to intelligent manufacturing, which could provide strong support for promoting the transformation and upgrading of the manufacturing industry.…”
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Existence and Uniqueness of Mild Solution for Fractional-Order Controlled Fuzzy Evolution Equation by Naveed Iqbal, Azmat Ullah Khan Niazi, Ramsha Shafqat, Shamsullah Zaland

“…In this article, we investigated the existence and uniqueness of mild solutions for fractional-order controlled fuzzy evolution equations with Caputo derivatives of the controlled fuzzy nonlinear evolution equation of the form  0cDIγxI=αxI+PI,xI+AIWI,I∈0,T,xI0=x0, in which γ∈0,1, E1 is the fuzzy metric space and I=0,T is a real line interval. With the help of few conditions on functions P:I×E1×E1⟶E1, WI is control and it belongs to E1, A∈FI,LE1, and α stands for the highly continuous fuzzy differential equation generator. …”
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Isolation and molecular detection of Peste des petits ruminants virus in an outbreak investigation in Benishangul Gumuz, Ethiopia by Mengesha Abebe, Yimer Lama, Aliy Abdi, Shegu Dereje, Abdeta Debela, Waktole Hika, Hirpa Tola Eyob

“…Peste des petits ruminants (PPR) is a severe and highly communicable disease. It is viral disease that particularly affects shoats. …”
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Promise and Peril: Stellar Contamination and Strict Limits on the Atmosphere Composition of TRAPPIST-1 c from JWST NIRISS Transmission Spectra by Michael Radica, Caroline Piaulet-Ghorayeb, Jake Taylor, Louis-Philippe Coulombe, Björn Benneke, Loic Albert, Étienne Artigau, Nicolas B. Cowan, René Doyon, David Lafrenière, Alexandrine L’Heureux, Olivia Lim

“…These nondetections of spectral features are in line with predictions that even heavier, CO _2 -rich atmospheres would be efficiently lost on TRAPPIST-1 c given the cumulative high-energy irradiation experienced by the planet. …”
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Novel and potent MICA/B antibody is therapeutically effective in KRAS LKB1 mutant lung cancer models by Shohei Koyama, Yujiro Naito, John D Minna, David E Gerber, Ryan R Kowash, Manoj Sabnani, Laura T Gray, Qing Deng, Nusrat U A Saleh, Luc Girard, Kentaro Masahiro, Zhiqian Lucy Liu, Hemanta Baruah, Esra A Akbay

“…AHA-1031 binds to the α3 domain of MICA/B, preventing shedding and targeting tumor cells to ADCC. AHA-1031 exhibits high affinity and specificity to MICA/B, preventing MICA/B shedding in tumor lines and inducing ADCC in vitro. …”
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Model-Based Variation-Aware Optimization for Offset Calibration and Pre-Sensing in DRAM Sense Amplifiers by Dongyeong Kim, Geon Kim, Suyeon Kim, Jewon Park, Sinwook Kim, Hyeona Seo, Chaehyuk Lim, Sowon Kim, Juwon Lee, Jeonghyeon Yun, Hyerin Lee, Jinseok Park, Yongbok Lee, Seungchan Lee, Myoungjin Lee

“…This article proposes a new mathematical model that accurately predicts statistical margin characteristics of bit-line sense amplifiers (BLSAs) with offset calibration (OC) and pre-sensing (PS), while providing techniques to improve sensing margins. …”
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Assessment of prognosis and responsiveness to immunotherapy in colorectal cancer patients based on the level of immune cell infiltration by Kaili Liao, Minqi Zhu, Lei Guo, Zijun Gao, Jinting Cheng, Bing Sun, Yihui Qian, Bingying Lin, Jingyan Zhang, Tingyi Qian, Yixin Jiang, Yanmei Xu, Qionghui Zhong, Xiaozhong Wang

“…The prognostic potential of the models was quantitatively assessed using Cox regression analysis and the development of column line plots. Immunotherapy sensitivity analysis was performed using CIBERSORT and TIMER algorithms. …”
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Dynamics of endothelial function in patients with arterial hypertension with different cardiovascular risk against the background of antihypertensive therapy by N.O. Pertseva, T.S. Turlyun, N.A. Sanina

“…The second group consisted of 54 patients with hypertension and a high risk of cardiovascular events, namely type 2 diabetes. …”
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La nécropole de Vannes/Darioritum : données inédites sur les pratiques funéraires armoricaines dans un secteur occupé du ier au ive s. apr. J.-C. by Annaïg Le Martret, Marie Grall, Vanessa Brunet

“…In contrast with other regions of ancient Gaul, but in line with what is usually found in the west, secondary cremation deposits mostly take the form of an isolated ossuary vessel, containing a partial and random sample of the deceased’s cremated remains. …”
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Performance Evaluation of Dual-Drive Mach-Zehnder Modulator and Optomechanical Crystal Cavity Comb Generation for All-Optical Band Conversion in 5G-Advanced Cellular Systems by Vicente Fito, Raul Ortiz, Maria Morant, Laura Mercade, Alejandro Martinez, Roberto Llorente

“…Optical frequency combs, featuring a spectrum of discrete, equally spaced coherent frequency lines, are crucial for high-precision metrology, spectroscopy, and telecommunications. …”
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Studying a collection of common-wheat varieties for leaf rust resistance, crop yield and grain quality in the environmental conditions of Novosibirsk region by L. P. Sochalova, V. A. Aparina, N. I. Boyko, E. V. Zuev, E. V. Morozova, E. V. Musinov, N. A. Vinichenko, I. N. Leonova, V. V. Piskarev

“…The relationship between a variety’s genotype, environmental conditions and phytopathogenic load are the key factors contributing to high yields that should be taken into account in selecting donors for resistance and high manifestation of valuable traits. …”
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