Opposing roles of p38α-mediated phosphorylation and PRMT1-mediated arginine methylation in driving TDP-43 proteinopathy by Mari Aikio, Hana M. Odeh, Heike J. Wobst, Bo Lim Lee, Úna Chan, Jocelyn C. Mauna, Korrie L. Mack, Bradley Class, Thomas A. Ollerhead, Alice F. Ford, Edward M. Barbieri, Ryan R. Cupo, Lauren E. Drake, Joshua L. Smalley, Yuan-Ta Lin, Stephanie Lam, Reuben Thomas, Nicholas Castello, Ashmita Baral, Jenna N. Beyer, Mohd A. Najar, John Dunlop, Aaron D. Gitler, Ashkan Javaherian, Julia A. Kaye, George M. Burslem, Dean G. Brown, Christopher J. Donnelly, Steven Finkbeiner, Stephen J. Moss, Nicholas J. Brandon, James Shorter

“…However, it is unclear how p38 MAPK affects TDP-43 proteinopathy. Here, we show that p38α MAPK inhibition reduces pathological TDP-43 phosphorylation, aggregation, cytoplasmic mislocalization, and neurotoxicity. …”
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Comparative Ethics of Modern Payment Models by Jacob Riegler

“…From a theoretical perspective, the issue here is clear – there are minimal incentives in pure capitation to provide more care. …”
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Catalysing change in health and medical research policy: an Australian case study of deliberative democracy to reform sex and gender policy recommendations by Sue Haupt, Cheryl Carcel, Lily Halliday, Saraid Billiards, Lyn Carson, Kyle Redman, Scott Lappan-Newton, Karin R. Aubrey, Xander Bickendorf, Jane E. Bourke, Michael Buchert, Jessica Da Gama Duarte, Ayan Dasvarma, Thomas F. E. Drake-Brockman, Thomas F. E. Drake-Brockman, Thomas F. E. Drake-Brockman, Thomas F. E. Drake-Brockman, Kerryn Drysdale, Stephen C. C. Dymock, Laura N. Eadie, Laura N. Eadie, Melanie Eckersley-Maslin, Melanie Eckersley-Maslin, Melanie Eckersley-Maslin, Moritz Falk Eissmann, James Fazio, Bridget G. Haire, Melinda Holder, Nicole Kleppe, Ken Knight, Jonathan Mauclair, Celine Northcott, Brian G. G. O. Oliver, Tracy A. O'Mara, Ken Pang, Steven Philpot, Tertia D. Purves-Tyson, Jacob Stewart-Olsen, Lauren Ursich, Natalia Vukelic, Marina H. Yakou, Bronwyn Graham, Bronwyn Graham, Severine Lamon, Rachel Huxley, Kelly Thompson, Kelly Thompson, Keziah Bennett-Brook, Christine Jenkins, Christine Jenkins, Zoe Wainer, Zoe Wainer, Mark Woodward, Mark Woodward, Louise Chappell, Robyn Norton, Robyn Norton

“…To ensure that Australian health and medical research is fit-for-purpose, we realised that potent initiatives would be necessary to expedite strategic reframing of thought and behaviour. Here we report on our innovative engagement of end-users for democratic self-determined policy reform to guide health and medical research, based on robust data. …”
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Analysis of some error-causing factors in two-dimensional geoelectrical studies and providing a solution to minimize them by Hosein Moghaddasi, Mohsen Moghaddasi, Ahmad Neyamadpour

“…It can be understood based on Figure 3 what will happen when the ‘n’ factor jumps from 6 to 12 to 18. Here, the dipole length is kept constant at 1 meter. …”
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Call for Papers: How attractive are political parties and trade unions to young people? by IF and FRFG

“…Could the underrepresentation of younger members be viewed as a problem here as well? • How great is the reluctance of young people to engage in and for political parties and trade unions from an internationally comparative perspective, for instance OECD-wide? …”
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E4F1 coordinates pyruvate metabolism and the activity of the elongator complex to ensure translation fidelity during brain development by Michela Di Michele, Aurore Attina, Pierre-François Roux, Imène Tabet, Sophie Laguesse, Javier Florido, Morane Houdeville, Armelle Choquet, Betty Encislai, Giuseppe Arena, Carlo De Blasio, Olivia Wendling, François-Xavier Frenois, Laura Papon, Lucille Stuani, Maryse Fuentes, Céline Jahannault Talignani, Mélanie Rousseau, Justine Guégan, Yoan Buscail, Pierrick Dupré, Henri-Alexandre Michaud, Geneviève Rodier, Floriant Bellvert, Hanna Kulyk, Carole Ferraro Peyret, Hugo Mathieu, Pierre Close, Francesca Rapino, Cédric Chaveroux, Nelly Pirot, Lucie Rubio, Adeline Torro, Tania Sorg, Fabrice Ango, Christophe Hirtz, Vincent Compan, Elise Lebigot, Andrea Legati, Daniele Ghezzi, Laurent Nguyen, Alexandre David, Claude Sardet, Matthieu Lacroix, Laurent Le Cam

“…Abstract Pyruvate metabolism defects lead to severe neuropathies such as the Leigh syndrome (LS) but the molecular mechanisms underlying neuronal cell death remain poorly understood. Here, we unravel a connection between pyruvate metabolism and the regulation of the epitranscriptome that plays an essential role during brain development. …”
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Connecting climate science and society: reflections from early and mid-career researchers at the World Climate Research Programme Open Science Conference 2023 by Leandro B. Díaz, Leandro B. Díaz, Leandro B. Díaz, Carla Gulizia, Carla Gulizia, Carla Gulizia, Shipra Jain, Shipra Jain, Gaby S. Langendijk, Hindumathi Palanisamy, Valentina Rabanal, Valentina Rabanal, Candice S. Charlton, Alima Dajuma, Felix K. Donkor, Temitope S. Egbebiyi, Temitope S. Egbebiyi, Ghafi Kondi Akara, Ghafi Kondi Akara, Amna Jrrar, Md Rezwan Siddiqui, Yassine Ait Brahim, Yassine Ait Brahim, Bapentire D. Angnuureng, Anna-Adriana Anschütz, Founi M. Awo, Founi M. Awo, Alejandro Builes-Jaramillo, Alison Cobb, Mohamadou A. Diallo, Mohamadou A. Diallo, Houda Er-Retby, Houda Er-Retby, Houda Er-Retby, Thierry C. Fotso-Nguemo, Benjamin Gwinneth, Masilin Gudoshava, Franck E. Kemgang Ghomsi, Franck E. Kemgang Ghomsi, Franck E. Kemgang Ghomsi, Inés M. Leyba, Inés M. Leyba, Redouane Lguensat, Redouane Lguensat, Roché Mahon, Shailendra K. Mandal, Lucia Mumo, Meshel Muzuva, Meshel Muzuva, Rodric M. Nonki, Juan A. Rivera, Juan A. Rivera, Alcade C. Segnon, Alcade C. Segnon, Laouali I. Tanimoune, Erlich-Honest E. I. Zauisomue, Gilbert Siame

“…These discussions focused on three key priority challenges: how to produce robust, usable, and used climate information at the local scale; how to address key climate research and knowledge gaps in the Global South; and how EMCRs could support policy-making with climate information. We present here our perspective on these major challenges, possible ways to address them, and what could be the contribution of EMCRs. …”
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Multimodal data-based longitudinal prognostic model for predicting atrial fibrillation recurrence after catheter ablation in patients with patent foramen ovale and paroxysmal atria... by Shoupeng Duan, Xujun Li, Jun Wang, Yuhong Wang, Tianyou Xu, Fuding Guo, Yijun Wang, Lingpeng Song, Zeyan Li, Xiaomeng Yang, Xiaoyu Shi, Hengyang Liu, Liping Zhou, Yueyi Wang, Hong Jiang, Lilei Yu

“…Abstract Background Clinical studies on atrial fibrillation (AF) recurrence after catheter ablation in patients diagnosed with patent foramen ovale (PFO) and paroxysmal AF (PAF) are scarce. Here, we aimed to develop a nomogram model utilizing multimodal data for the risk stratification of AF recurrence following catheter ablation in individuals diagnosed with PFO and new-onset PAF. …”
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Uptake and 4-week outcomes of an ‘opt-out’ smoking cessation referral strategy in a London-based lung cancer screening setting by Anthony Edey, Neal Navani, Kitty Chan, Graham Robinson, Janine Zylstra, Paul Robinson, Laura Green, Anand Devaraj, Jane Rowlands, Allan Hackshaw, Carolyn Horst, Arjun Nair, Sam M Janes, Kate Davies, Jeannie Eng, Mamta Ruparel, Samantha L Quaife, Jennifer L Dickson, Magali Taylor, Angshu Bhowmik, Hasti Robbie, Joseph Jacob, Laura Farrelly, Sophie Tisi, Tanya Patrick, Andrew Creamer, Helen Hall, Samanjit Hare, Jon Teague, Samuel M Janes, Esther Arthur-Darkwa, Thea Buchan, Stephen Ellis, Thomas Callender, Rachael Sarpong, John McCabe, Zaheer Mangera, Ethaar El-Emir, Terry O'Shaughnessy, Geoff Bellingan, Nick Screaton, Priyam Verghese, William M Ricketts, Vicky Bowyer, Kylie Gyertson, Fanta Bojang, Claire Levermore, Tania Anastasiadis, Ruth Prendecki, Amyn Bhamani, Malavika Suresh, Judy Airebamen, Alice Cotton, Kaylene Phua, Elodie Murali, Simranjit Mehta, Karen Parry-Billings, Columbus Ife, April Neville, Zahra Hanif, Helen Kiconco, Ricardo McEwen, Dominique Arancon, Nicholas Beech, Derya Ovayolu, Christine Hosein, Sylvia Patricia Enes, Qin April Neville, Aashna Samson, Urja Patel, Fahmida Hoque, Hina Pervez, Sofia Nnorom, Moksud Miah, Julian McKee, Mark Clark, Anant Patel, Sara Lock, Rajesh Banka, Ugo Ekeowa, Charlotte Cash, Tunku Aziz, Alberto Villanueva, Elena Stefan, Charlie Sayer, Navinah Nundlall, Andrew Crossingham, Tanita Limani, Kate Gowers, Andrew Perugia, James Rusius, Anne-Marie Hacker, Monica L Mullin, Evangelos Katsampouris, Chuen R Khaw, Chuen Khaw, Sheetal Karavadra, Alan Shaw, Chris Valerio, Ali Mohammed, Lynsey Gallagher, Mehran Azimbagirad, Burcu Ozaltin, Maureen Browne, Eleanor Hellier, Catherine Nestor

“…Introduction Lung cancer screening (LCS) enables the delivery of smoking cessation interventions to a population experiencing long-term tobacco dependence, but the optimal delivery method remains unclear. Here, we report uptake and short-term outcomes of an ‘opt-out’ smoking cessation referral strategy in an LCS cohort.Methods Individuals currently smoking tobacco who attended a face-to-face lung health check in the SUMMIT study (NCT03934866) were offered very brief advice on smoking cessation and where possible, an ‘opt-out’ referral to their local stop smoking service (SSS). …”
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The MAJORANA DEMONSTRATOR Neutrinoless Double-Beta Decay Experiment by N. Abgrall, E. Aguayo, F. T. Avignone, A. S. Barabash, F. E. Bertrand, M. Boswell, V. Brudanin, M. Busch, A. S. Caldwell, Y.-D. Chan, C. D. Christofferson, D. C. Combs, J. A. Detwiler, P. J. Doe, Yu. Efremenko, V. Egorov, H. Ejiri, S. R. Elliott, J. Esterline, J. E. Fast, P. Finnerty, F. M. Fraenkle, A. Galindo-Uribarri, G. K. Giovanetti, J. Goett, M. P. Green, J. Gruszko, V. E. Guiseppe, K. Gusev, A. L. Hallin, R. Hazama, A. Hegai, R. Henning, E. W. Hoppe, S. Howard, M. A. Howe, K. J. Keeter, M. F. Kidd, A. Knecht, O. Kochetov, S. I. Konovalov, R. T. Kouzes, B. D. LaFerriere, J. Leon, L. E. Leviner, J. C. Loach, P. N. Luke, S. MacMullin, R. D. Martin, S. Mertens, L. Mizouni, M. Nomachi, J. L. Orrell, C. O'Shaughnessy, N. R. Overman, David Phillips, A. W. P. Poon, K. Pushkin, D. C. Radford, K. Rielage, R. G. H. Robertson, M. C. Ronquest, A. G. Schubert, B. Shanks, T. Shima, M. Shirchenko, K. J. Snavely, N. Snyder, D. Steele, J. Strain, A. M. Suriano, J. Thompson, V. Timkin, W. Tornow, R. L. Varner, S. Vasilyev, K. Vetter, K. Vorren, B. R. White, J. F. Wilkerson, T. Williams, W. Xu, E. Yakushev, A. R. Young, C.-H. Yu, V. Yumatov

“…The array will be situated in a low-background environment and surrounded by passive and active shielding. Here we describe the science goals of the Demonstrator and the details of its design.…”
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The 2023 dengue outbreak in Lombardy, Italy: A one-health perspective by Francesca Rovida, Marino Faccini, Carla Molina Granè, Irene Cassaniti, Sabrina Senatore, Eva Rossetti, Giuditta Scardina, Manuela Piazza, Giulia Campanini, Daniele Lilleri, Stefania Paolucci, Guglielmo Ferrari, Antonio Piralla, Francesco Defilippo, Davide Lelli, Ana Moreno, Luigi Vezzosi, Federica Attanasi, Marzia Soresini, Manuela Barozzi, Lorenzo Cerutti, Stefano Paglia, Angelo Regazzetti, Maurilia Marcacci, Guido Di Donato, Marco Farioli, Mattia Manica, Piero Poletti, Antonio Lavazza, Maira Bonini, Stefano Merler, Fausto Baldanti, Danilo Cereda, Antonella Sarasini, Milena Furione, Dalila Mele, Federica Bergami, Josè Camilla Sammartino, Alessandro Ferrari, Greta Romano, Antonino Maria Guglielmo Pitrolo, Maya Carrera, Rita Brugnoli, Nunzia Laini, Francesca Bonalda, Sara Arfani, Giuditta Zamboni, Fanny Delfanti, Piergiuseppe Ferrari, Anxhela Dafa, Antonella Negri, Filippa Parisi, Marcello Tirani, Michela Viscardi, Gabriele Del Castillo, Federica Morani, Francesco Scovenna, Sheila Sansebastian, Manuel Maffeo, Mario Chiari, Enrico Tallarita

“…Introduction: Here we reported the virological, entomological and epidemiological characteristics of the large autochthonous outbreak of dengue (DENV) occurred in a small village of the Lombardy region (Northern Italy) during summer 2023. …”
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Providing a model of purchase intention and customer experience on customer behavior in virtual networks by Kazem Tolooee, Hossein budaghi Khajeh Noubar, Hossein Gharehbiglo, Mojtaba Ramazani

“…Despite the many advantages of online stores that have been mentioned, the problem here is that when a customer visits and intends to buy from an online store, he is not faced with a real seller and a real store, but with an online website and virtual store that presents information about his product and invites the customer to buy these products (Rasuli et al, 2018). …”
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Modeling the construction of an efficient customer club for the quantitative and qualitative development of increasing customers in the banking system by Ali Taher khani kojariha, Younos Vakil Alroaia

“…The types of customer clubs include two main models: 1- The easy to join open club, as the name suggests, it is open to everyone, because it has no cost and conditions. Here is the company that needs members. Most of the members use the facilities of the club. …”
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Tacedinaline (CI-994), a class I HDAC inhibitor, targets intrinsic tumor growth and leptomeningeal dissemination in MYC-driven medulloblastoma while making them susceptible to anti... by Arndt Borkhardt, Nan Qin, Stephen T Keir, Darell D Bigner, Allison Cole, Matthias Wölfl, Viktoria Marquardt, Johanna Theruvath, David Pauck, Daniel Picard, Lena Blümel, Mara Maue, Jasmin Bartl, Ulvi Ahmadov, Maike Langini, Frauke-Dorothee Meyer, Joselyn Cruz-Cruz, Claus M Graef, Till Milde, Olaf Witt, Anat Erdreich-Epstein, Gabriel Leprivier, Ulf Kahlert, Anja Stefanski, Kai Stühler, Julia Hauer, Thomas Beez, Christiane B Knobbe-Thomsen, Ute Fischer, Jörg Felsberg, Finn K Hansen, Rajeev Vibhakar, Sujatha Venkatraman, Samuel H Cheshier, Guido Reifenberger, Thomas Kurz, Marc Remke, Siddhartha Mitra

“…Therefore, targeting epigenetic modifiers for cancer treatment has gained increasing interest, and inhibitors for various epigenetic modulators have been intensively studied in clinical trials. Here, we report a cross-entity, epigenetic drug screen to evaluate therapeutic vulnerabilities in MYC amplified MB, which sensitizes them to macrophage-mediated phagocytosis by targeting the CD47-signal regulatory protein α (SIRPα) innate checkpoint pathway.Methods We performed a primary screen including 78 epigenetic inhibitors and a secondary screen including 20 histone deacetylase inhibitors (HDACi) to compare response profiles in atypical teratoid/rhabdoid tumor (AT/RT, n=11), MB (n=14), and glioblastoma (n=14). …”
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Is it Time to Recognize Political Anxiety as a Social Determinant of Health? by Brandon Ambrosino

“…In the past month alone, there have been countless reported variations on a single theme: “Early polling shows the presidential race to be neck and neck, but here’s an alternative data point that might make you feel very strong.” …”
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Application of Fuzzy Hierarchy Analysis method to identify factors on the professional development of newly graduated teachers from Farhangian University by Nader Habibzadeh, Ebrahim Salehiomran, Saeed Ghiyasinoshan

“…What is very important here is the professional growth and development of the teacher as a result of the activity in the study groups and the effort to rebuild and improve. …”
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CAR-CIK vs. CAR-T: benchmarking novel cytokine-induced killer cells as solid tumor immunotherapy in ErbB2+ rhabdomyosarcoma by Laura M. Moser, Laura M. Moser, Laura M. Moser, Laura M. Moser, Laura M. Moser, Catrin Heim, Sebastian E. Koschade, Sebastian E. Koschade, Sebastian E. Koschade, Sebastian E. Koschade, Sebastian E. Koschade, Philipp Wendel, Philipp Wendel, Philipp Wendel, Philipp Wendel, Süleyman Bozkurt, Sabine Harenkamp, Hermann Kreyenberg, Hermann Kreyenberg, Michael Merker, Michael Merker, Christian Münch, Christian Münch, Christian Münch, Elise Gradhand, Meike Vogler, Meike Vogler, Meike Vogler, Evelyn Ullrich, Evelyn Ullrich, Evelyn Ullrich, Evelyn Ullrich, Evelyn Ullrich, Halvard Bönig, Halvard Bönig, Jan-Henning Klusmann, Jan-Henning Klusmann, Jan-Henning Klusmann, Jan-Henning Klusmann, Peter Bader, Peter Bader, Peter Bader, Peter Bader, Peter Bader, Winfried S. Wels, Winfried S. Wels, Winfried S. Wels, Eva Rettinger, Eva Rettinger, Eva Rettinger, Eva Rettinger, Eva Rettinger

“…CIK cells are a heterogenous population of predominantly T cells with a mixed natural killer (NK) phenotype and combine non-MHC-restricted cytotoxicity with potent anti-tumor capacity of the adaptive immune system. Here, we characterize and compare efficacy, phenotypic subpopulations and modes of action of CAR-CIK cells and conventional CAR-T cells from same-donor samples in ErbB2+ rhabdomyosarcoma (RMS).MethodsTo benchmark CAR-CIK against conventional CAR-T cells, effector cells were generated from same-donor samples and lentivirally transduced with a second generation CD28-CD3ζ CAR. …”
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Ensemble estimates of global wetland methane emissions over 2000–2020 by Z. Zhang, B. Poulter, J. R. Melton, W. J. Riley, G. H. Allen, D. J. Beerling, P. Bousquet, J. G. Canadell, E. Fluet-Chouinard, P. Ciais, N. Gedney, P. O. Hopcroft, A. Ito, R. B. Jackson, A. K. Jain, K. Jensen, F. Joos, T. Kleinen, S. H. Knox, S. H. Knox, T. Li, X. Li, X. Liu, K. McDonald, G. McNicol, P. A. Miller, J. Müller, P. K. Patra, P. K. Patra, C. Peng, S. Peng, Z. Qin, R. M. Riggs, M. Saunois, Q. Sun, H. Tian, X. Xu, Y. Yao, Y. Xi, W. Zhang, W. Zhang, Q. Zhu, Q. Zhu, Q. Zhuang

“…However, despite reports of rising emission trends, a comprehensive evaluation and attribution of recent changes remains limited. Here we assessed global wetland CH<span class="inline-formula">₄</span> emissions from 2000–2020 based on an ensemble of 16 process-based wetland models. …”
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Magnitude and dynamics of the T-cell response to SARS-CoV-2 infection at both individual and population levels by Thomas M. Snyder, Rachel M. Gittelman, Mark Klinger, Damon H. May, Edward J. Osborne, Ruth Taniguchi, H. Jabran Zahid, Ian M. Kaplan, Jennifer N. Dines, Matthew T. Noakes, Ravi Pandya, Xiaoyu Chen, Summer Elasady, Emily Svejnoha, Peter Ebert, Mitchell W. Pesesky, Patricia De Almeida, Hope O’Donnell, Quinn DeGottardi, Gladys Keitany, Jennifer Lu, Allen Vong, Rebecca Elyanow, Paul Fields, Hussein Al-Asadi, Julia Greissl, Lance Baldo, Simona Semprini, Claudio Cerchione, Fabio Nicolini, Massimiliano Mazza, Ottavia M. Delmonte, Kerry Dobbs, Rocio Laguna-Goya, Gonzalo Carreño-Tarragona, Santiago Barrio, Luisa Imberti, Alessandra Sottini, Eugenia Quiros-Roldan, Camillo Rossi, Andrea Biondi, Laura Rachele Bettini, Mariella D’Angio, Paolo Bonfanti, Miranda F. Tompkins, Camille Alba, Clifton Dalgard, Vittorio Sambri, Giovanni Martinelli, Jason D. Goldman, Jason D. Goldman, James R. Heath, Helen C. Su, Luigi D. Notarangelo, Estela Paz-Artal, Joaquin Martinez-Lopez, Bryan Howie, Jonathan M. Carlson, Harlan S. Robins

“…This central role for T cells makes them a desirable target for assessing the immune response to SARS-CoV-2 infection.MethodsHere, we combined two high-throughput immune profiling methods to create a quantitative picture of the T-cell response to SARS-CoV-2. …”
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Le camp légionnaire romain de Mayence/Mogontiacum (Allemagne) : nouveaux résultats sur l’enceinte et la chronologie by Daniel Burger-Völlmecke

“…De facto, it is only now that we can assume that the two legions XIV Gemina and XVI Gallica were permanently stationed here. During the occupation period, with its flexibly operating units, there is no historical evidence for a double legionary fortress, nor is one to be expected. …”
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