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13401
Intranigral Administration of β-Sitosterol-β-D-Glucoside Elicits Neurotoxic A1 Astrocyte Reactivity and Chronic Neuroinflammation in the Rat Substantia Nigra
Published 2020-01-01“…Chronic consumption of β-sitosterol-β-D-glucoside (BSSG), a neurotoxin contained in cycad seeds, leads to Parkinson’s disease in humans and rodents. Here, we explored whether a single intranigral administration of BSSG triggers neuroinflammation and neurotoxic A1 reactive astrocytes besides dopaminergic neurodegeneration. …”
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13402
Bioinspired hierarchical porous tough adhesive to promote sealing of high-pressure bleeding
Published 2025-03-01“…The currently widely used hemostatic bioadhesives are ineffective for hemorrhage from major arteries and the heart due to the absence of biologically compatible flexible structures capable of simultaneously ensuring conformal tough adhesion and biomechanical support. Here, inspired by the principle of chromatin assembly, we present a tissue-conformable tough matrix for robust sealing of severe bleeding. …”
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13403
TNF inhibitors target a mevalonate metabolite/TRPM2/calcium signaling axis in neutrophils to dampen vasculitis in Behçet’s disease
Published 2024-10-01“…Abstract TNF inhibitors have been used to treat autoimmune and autoinflammatory diseases. Here we report an unexpected mechanism underlying the therapeutic effects of TNF inhibitors in Behçet’s disease (BD), an autoimmune inflammatory disorder. …”
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13404
Expression‐based machine learning models for predicting plant tissue identity
Published 2025-01-01“…The competing frameworks to select an agricultural‐ or ecological‐based model species were rejected, in favor of building knowledge in a species that would facilitate genome‐enabled research. Methods Here, we examine the ability of models based on Arabidopsis gene expression data to predict tissue identity in other flowering plants. …”
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13405
Pollen metabarcoding reveals a broad diversity of plant sources available to farmland flower visitors near tropical montane forest
Published 2025-01-01“…Despite the widely recognized role of pollinators in ecosystem services, we currently have a poor understanding of the contribution of Natural Protected Areas neighboring agricultural landscapes to crop pollinator diversity and plant-pollinator interactions. Here, we conducted monthly surveys over a period of one year to study the diversity of insect visitors in dominant fruit crops—avocado, plum, apple, and blackberry—and used pollen DNA metabarcoding to characterize the community of plant sources in and around low-intensive farmland bordered by protected montane forest in Costa Rica. …”
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13406
Life satisfaction around the world: Measurement invariance of the Satisfaction With Life Scale (SWLS) across 65 nations, 40 languages, gender identities, and age groups.
Published 2025-01-01“…The Satisfaction With Life Scale (SWLS) is a widely used self-report measure of subjective well-being, but studies of its measurement invariance across a large number of nations remain limited. Here, we utilised the Body Image in Nature (BINS) dataset-with data collected between 2020 and 2022 -to assess measurement invariance of the SWLS across 65 nations, 40 languages, gender identities, and age groups (N = 56,968). …”
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13407
Land-use and land-cover changes and emerging non-tuberculous and tuberculous infectious diseases in humans and animals: a mixed-methods review of research findings from global and...
Published 2025-01-01“…These depend on diverse LULC changes, different types of infectious disease systems, and spatio-temporal scales of studies. Here, using both a bibliometric and scoping review method, we summarize the reliability and availability of published relevant studies on LULC effects on mycobacteria, an important group of infectious bacteria that affect humans and both wild and domestic animals. …”
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13408
Atacama Large Aperture Submillimeter Telescope (AtLAST) science: Our Galaxy [version 2; peer review: 2 approved]
Published 2025-02-01“…Understanding the evolution of these belts requires deep imaging capable of studying belts around young stellar objects to Kuiper belt analogues around the nearest stars. Here we present a plan for observing the Galactic Plane and circumstellar environments to quantify the physical structure, the magnetic fields, the dynamics, chemistry, star formation, and planetary system evolution of the galaxy in which we live with AtLAST; a concept for a new, 50m single-dish sub-mm telescope with a large field of view which is the only type of facility that will allow us to observe our Galaxy deeply and widely enough to make a leap forward in our understanding of our local ecology.…”
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13409
The phosphorus negotiation game (P-Game): first evaluation of a serious game to support science-policy decision making played in more than 20 countries worldwide
Published 2025-01-01“…We strongly believe that the underlying methodology described here could also be used for other topics.…”
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13410
Atg5 deficiency in basophils improves metabolism in lupus mice by regulating gut microbiota dysbiosis
Published 2025-01-01“…Emerging evidence shows that basophil activation plays a critical role in the pathogenesis of SLE; however, the underlying mechanisms remain largely unknown. Here, we investigated the effects of autophagic inhibition on the pathogenesis of basophils in SLE using Autophagy-related gene 5 (Atg5) knockout (Atg5 −/−) as an autophagic inhibitor. …”
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13411
Hameaux et villages paysans de la période romaine en plaine d’Alsace
Published 2020-12-01“…The examples of rural settlements presented here are almost all located west of Strasbourg, in the area of the lower Bruche valley and in the Kochersberg area. …”
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13412
Leaf Water Potential in a Mixed Mediterranean Forest from Machine Learning and Unmanned Aerial Vehicle (UAV)-Based Hyperspectral Imaging
Published 2024-12-01“…While remote sensing has emerged as a useful tool for estimating vegetation water status, <inline-formula><math xmlns="http://www.w3.org/1998/Math/MathML" display="inline"><semantics><mrow><mi>ψ</mi></mrow></semantics></math></inline-formula><sub>leaf</sub> remains unexplored, particularly in mixed forests. Here, we use spectral indices derived from unmanned aerial vehicle-based hyperspectral imaging and machine learning algorithms to assess <inline-formula><math xmlns="http://www.w3.org/1998/Math/MathML" display="inline"><semantics><mrow><mi>ψ</mi></mrow></semantics></math></inline-formula><sub>leaf</sub> in a mixed, multi-species Mediterranean forest comprised of five key woody species: <i>Pinus halepensis</i>, <i>Quercus calliprinos</i>, <i>Cupressus sempervirens</i>, <i>Ceratonia siliqua</i>, and <i>Pistacia lentiscus</i>. …”
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13413
Controlled lattice deformation for high-mobility two-dimensional MoTe2 growth
Published 2025-03-01“…However, the target product 2H-MoTe2 from Mo precursor suffers from long growth time and suboptimal crystal quality, and MoOx precursor confronts the dilemma of unclear growth mechanism and inconsistent growth products. Here, we developed magnetron-sputtered MoO3 film for fast and high-mobility 2H-MoTe2 growth. …”
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13414
Increased spindle-related brain activation in right middle temporal gyrus during N2 than N3 among healthy sleepers: Initial discovery and independent sample replication
Published 2025-01-01“…N3 sleep, the underlying neural mechanism is not clearly illustrated. Here, we tested the discrepancy in spindle-related brain activation between N2 and N3 within healthy college students (dataset 1: n = 27, 59 % females, median age 23 years), using simultaneous electroencephalography-functional magnetic resonance imaging (EEG-fMRI). …”
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13415
Interleukin‐37 promotes DMBA/TPA skin cancer through SIGIRR‐mediated inhibition of glycolysis in CD103+DC cells
Published 2023-04-01“…However, the specific molecular mechanism and role of IL‐37 in skin cancer remain unclear. Here, we report that IL‐37b‐transgenic mice (IL‐37tg) treated with the carcinogenic 7,12‐dimethylbenzoanthracene (DMBA)/12‐o‐tetradecylphorbol‐13‐acetate (TPA) exhibited enhanced skin cancer and increased tumor burden in the skin by inhibiting the function of CD103+ dendritic cells (DCs). …”
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13416
Dermal fibroblast-derived extracellular matrix (ECM) synergizes with keratinocytes in promoting re-epithelization and scarless healing of skin wounds: Towards optimized skin tissue...
Published 2025-05-01“…Dermal fibroblasts are the primary cell type responsible for remodeling the extracellular matrix (ECM) in wound healing. Here, we investigated whether ECM derived from exogenous fibroblasts, in combination with keratinocytes, promoted scarless cutaneous wound healing. …”
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13417
IGJR issue 1/2018
Published 2017-06-01“…Topic abstract In recent years, there has been a rising interest in measuring and comparing intergenerational justice in the expenditure schemes of welfare states. Here, the focus is on analysing the allocation of social expenditures for the elderly (i.e., citizens 65 years of age and older) relative to the share allocated for young people. …”
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13418
Impaired inflammatory resolution with severe SARS-CoV-2 infection in leptin knock out obese hamster
Published 2025-02-01“…However, the mechanisms underlying severe illnesses in individuals with obesity are poorly understood. Here, we used gene-edited leptin knock out (Leptin−/−) obese hamsters to establish a severe infection model. …”
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13419
Mucosal SARS-CoV-2 S1 adenovirus-based vaccine elicits robust systemic and mucosal immunity and protects against disease in animals
Published 2025-01-01“…While approved SARS-CoV-2 vaccines have been instrumental in saving lives and reducing healthcare and economic burdens, the induction of mucosal immunity remains an unmet need. Here, we engineered and evaluated a non-replicating adenovirus 5 (rAd5)-based vaccine expressing the SARS-CoV-2 S1 subunit (rAd5-SARS2-S1). …”
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13420
Molecular mechanisms of libido influencing semen quality in geese through the hypothalamic-pituitary-testicular-external genitalia axis
Published 2025-02-01“…Gene Ontology (GO) analysis indicated that the term ''male gonad development'' was significantly enriched in the hypothalamus. Here, the expression of LHX9 was positively correlated with ANM, and negatively correlated with SC and SQF (P < 0.05). …”
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