A dynamic peripheral immune landscape during human pregnancy by Xiuxing Liu, Lei Zhu, Zhaohao Huang, Zhaohuai Li, Runping Duan, He Li, Lihui Xie, Xiaozhen Chen, Wen Ding, Binyao Chen, Yuehan Gao, Juan Su, Xianggui Wang, Wenru Su

“…However, these changes can increase the risk of disease in the mother. Here, we conducted single-cell RNA sequencing on peripheral blood mononuclear cells from pregnant women at different stages of pregnancy to elucidate the dynamic transcriptional changes in the maternal immune system. …”
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Tumor CEMIP drives immune evasion of colorectal cancer via MHC-I internalization and degradation by Ying Zhu, Jiao Li, Tao Zhang, Lei Zhao, Min Jin, Jinghua Ren, Jing Tang, Haihong Wang, Zhenyu Lin, Qing Liang, Ruiqi Li, Biying Zhang, Qingling Hua, Guojie Xu, Jiayuan Chen, Lanqing Wang, Dejun Zhang, Dandan Yu

“…Overexpression of CEMIP in tumor tissues is associated with a poor prognosis in colorectal cancer. Here, in this research, we aim to address the role of CEMIP in mediating MHC-I expression in tumor cells and investigate the underlying regulatory mechanisms.Method Protein levels were analyzed by western blotting. …”
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Parallel single-cell metabolic analysis and extracellular vesicle profiling reveal vulnerabilities with prognostic significance in acute myeloid leukemia by Dorian Forte, Roberto Maria Pellegrino, Paolo Falvo, Paulina Garcia-Gonzalez, Husam B. R. Alabed, Filippo Maltoni, Davide Lombardi, Samantha Bruno, Martina Barone, Federico Pasini, Francesco Fabbri, Ivan Vannini, Benedetta Donati, Gianluca Cristiano, Chiara Sartor, Simona Ronzoni, Alessia Ciarrocchi, Sandra Buratta, Lorena Urbanelli, Carla Emiliani, Simona Soverini, Lucia Catani, Francesco Bertolini, Rafael José Argüello, Michele Cavo, Antonio Curti

“…Notably, extracellular vesicles from adverse-risk patients enhance leukemia cell engraftment in vivo. Here, we show a potential noninvasive approach based on liquid ‘cell-extracellular vesicle’ biopsy toward a redefined metabolic stratification in AML.…”
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Sequential use of low-load-blood-flow-restricted vs. high-load resistance training on neuromuscular activation, hypertrophy and neuromuscular performance by Romina Ledergerber, Paul Ritsche, Eric Lichtenstein, Martin Keller

“…Linear mixed models were used to analyze group differences over time, with Cohen’s d effect sizes. Here, we report the preliminary data of 20 participants. …”
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The Inventory of the Estate farm Senkoniai by Stasys Pamerneckis, Roberta Sakalauskaitė

“…One of them (No 13) is being presented here as an example. The inventory is written in Polish and is called "land measuring" (mierczy), i.e., the quantity of the land and its quality (whether it is a humus, a humus with loam, a sandy loam), its purpose (whether it is arable, used as a hayfield, a pasture, grown with bushes, a forest, or it is barren land) is indicated in it. …”
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Soil Inversion with Subsoiling Increases Cotton Yield Through Improving Soil Properties and Root Growth by Pengcheng Li, Shulin Wang, Weina Feng, Helin Dong, Cangsong Zheng, Miao Sun, Jingjing Shao, Zhenggui Zhang, Zhanlei Pan, Jian Wang, Guilan Sun, Junhong Li, Yaopeng Zhang, Wenqi Zhao, Menghua Zhai, Zhanbiao Wang

“…It remains unclear whether soil inversion with subsoiling could halt the deterioration. Here, a field experiment was set from 2015 to 2017 with three treatments: CK, 15 cm rotary tillage; T1, replace the top 20 cm soil layer with the 20–40 cm soil layer and loosen the 40–55 cm soil layer; T2, replace the top 20 cm soil layer with the 20–40 cm soil layer and loosen the 40–70 cm soil layer. …”
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CHI-KAT8i5 suppresses ESCC tumor growth by inhibiting KAT8-mediated c-Myc stability by Dandan Zhang, Ming Jiang, Pan Li, Kyle Vaughn Laster, Dengyun Zhao, Yafei Zhi, Huifang Wei, Wenna Nie, Yunfeng Gao, Qiong Wu, Pu Xiang, Xinyu He, Kangdong Liu, Zigang Dong

“…Summary: The integrated analysis of histone modifier enzymes in solid tumors, especially in esophageal squamous cell carcinoma (ESCC), is still inadequate. Here, we investigate the expression levels of histone modifier enzymes in ESCC tissues. …”
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Investigating intra‐tumoural heterogeneity and microenvironment diversity in primary cardiac angiosarcoma through single‐cell RNA sequencing by Jingyuan Huo, Zhen Wang, Wenting Zhao, Miao Chen, Haoyang Li, Fengpu He, Xiao Tian, Yaqi Ma, Firyuza Husanova, Liang Ma, Yiming Ni, Hongda Ding, Weidong Li, Hongfei Xu

“…Understanding cellular heterogeneity and tumour microenvironment (TME) is crucial for the development of effective therapies. Here, we investigated the intratumoural heterogeneity and TME diversity of PCAS using single‐cell RNA sequencing (scRNA‐seq). …”
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Last-millennium volcanic forcing and climate response using SO₂ emissions by L. R. Marshall, L. R. Marshall, L. R. Marshall, A. Schmidt, A. Schmidt, A. Schmidt, A. P. Schurer, N. L. Abraham, N. L. Abraham, L. J. Lücke, R. Wilson, K. J. Anchukaitis, G. C. Hegerl, B. Johnson, B. L. Otto-Bliesner, E. C. Brady, M. Khodri, K. Yoshida

“…The representation of volcanic forcing in the latest generation of climate models has improved significantly, but most models prescribe the aerosol optical properties rather than using <span class="inline-formula">SO₂</span> emissions directly and including interactions between the aerosol, chemistry, and dynamics. Here, we use the UK Earth System Model (UKESM) to simulate the climate of the last millennium (1250–1850 CE) using volcanic <span class="inline-formula">SO₂</span> emissions. …”
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Age-Related Water Use Pattern of the Introduced Species Atriplex canescens Was Influenced by Root Distribution in Desert by Hai Zhou, Xiangyan Feng, Zhibin He, Bing Liu, Fang Li, Heng Ren, Qiyue Yang, Jianjun Kang, Shuai Wang, Wenzhi Zhao

“…However, little is known about the dynamics of root water uptake and age-related water sources for the shrubs, which restricts the efficacy of vegetation restoration. Here, we examined the distribution of roots and isotopic values of δ18O and δD in soil water at depths ranging from 0 to 300 cm, groundwater, precipitation, and shrub xylem at different stages of shrub maturity to determine water use patterns in shrub plantations. …”
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The transcriptional repressor HEY2 regulates mitochondrial oxidative respiration to maintain cardiac homeostasis by Peilu She, Bangjun Gao, Dongliang Li, Chen Wu, Xuejiao Zhu, Yuan He, Fei Mo, Yao Qi, Daqing Jin, Yewei Chen, Xin Zhao, Jinzhong Lin, Hairong Hu, Jia Li, Bing Zhang, Peng Xie, Chengqi Lin, Vincent M. Christoffels, Yueheng Wu, Ping Zhu, Tao P. Zhong

“…Abstract Energy deprivation and metabolic rewiring of cardiomyocytes are widely recognized hallmarks of heart failure. Here, we report that HEY2 (a Hairy/Enhancer-of-split-related transcriptional repressor) is upregulated in hearts of patients with dilated cardiomyopathy. …”
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Exploring the mechanisms of Devonian oceanic anoxia: impact of ocean dynamics, palaeogeography, and orbital forcing by J. Gérard, L. Sablon, J. J. C. Huygh, A.-C. Da Silva, A. Pohl, C. Vérard, M. Crucifix

“…While growing geological evidence has demonstrated a temporal correlation between astronomical forcing and anoxia during this period, underlying physical mechanisms remain unknown, hence questioning causality. Here, we perform multiple sensitivity experiments, using an Earth system model of intermediate complexity (cGENIE), to isolate the influences of specific Devonian climate and palaeogeography components on ocean oxygen levels, contributing to the better understanding of the intricate interplay of factors preconditioning the ocean to anoxia. …”
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Genome-wide association study identifies candidate genes affecting body conformation traits of Zhongwei goat by Mingxuan Han, Xinbo Wang, Haidong Du, Yanlong Cao, Zhanqiang Zhao, Shuran Niu, Xuxu Bao, Youjun Rong, Xiaofang Ao, Furong Guo, Qincheng Xia, Fangzheng Shang, Ruijun Wang, Yanjun Zhang

“…In this study, we used the MGISEQ-T7 platform to re-sequence 240 Zhongwei goats (133 male; 107 female) belonging to 5 metrics of growth traits at different growth stages (40 days and 6 months, here in after referred to as 40d and 6 m), namely, Body Weight (BW), Body Height (BH), Body Length (BL), Chest Circumference (CC), Tube Circumference (TC) were examined. …”
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Treatment of pancreatic cancer with irreversible electroporation and intratumoral CD40 antibody stimulates systemic immune responses that inhibit liver metastasis in an orthotopic... by Partha Ray, Tomoko Hayashi, Karen Messer, Stephen Schoenberger, Aaron Miller, Dennis Carson, Sara McArdle, Zbigniew Mikulski, Jayanth S Shankara Narayanan, Suna Erdem, Herve Tiriac, Minya Pu, Rebekah R White

“…We have previously shown that IRE alone is capable of generating protective, neoantigen-specific immunity. Here, we aim to generate meaningful therapeutic immune effects by combining IRE with local (intratumoral) delivery of a CD40 agonistic antibody (CD40Ab).Methods KPC46 organoids were generated from a tumor-bearing male KrasLSL-G12D-p53LSL-R172H-Pdx-1-Cre (KPC) mouse. …”
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Hsa_circ_0001304 promotes vascular neointimal hyperplasia accompanied by autophagy activation by Shi-Qing Mu, Jia-Jie Lin, Yu Wang, Li-Yun Yang, Sen Wang, Zhao-Yi Wang, An-Qi Zhao, Wen-Jun Luo, Zi-Qi Dong, Yu-Guang Cao, Ze-An Jiang, Si-Fan Wang, Shan-Hu Cao, Li Meng, Yang Li, Shu-Yan Yang, Shao-Guang Sun

“…Platelet-derived growth factor-BB (PDGF-BB)-induced vascular remodeling is accompanied by autophagy activation, however, the involvement of circular RNAs (circRNAs) remains unclear. Here, we show the role of PDGF-BB-regulated hsa_circ_0001304 (circ-1304) in neointimal hyperplasia and its potential involvement in VSMC autophagy, while also elucidating the potential mechanisms. …”
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Unraveling the protein kinase C/NDRG1 signaling network in breast cancer by C. Saponaro, M. Damato, E. Stanca, S. Aboulouard, F. A. Zito, S. De Summa, D. Traversa, L. Schirosi, S. Bravaccini, F. Pirini, E. Fonzi, M. Tebaldi, M. Puccetti, A. Gaballo, L. Pantalone, M. Ronci, L. Magnani, D. Sergi, A. Tinelli, S. Tacconi, L. Siculella, A. M. Giudetti, I. Fournier, M. Salzet, M. Trerotola, D. Vergara

“…The overexpression of NDRG1 is an indicator of poor prognosis in various types of cancer. Here, we found that NDRG1 is an independent prognostic marker of poor outcome in breast cancer (BC). …”
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Beta 3 adrenoreceptors protect from hypertrophic remodelling through AMP‐activated protein kinase and autophagy by Emilie Dubois‐Deruy, Roselle Gelinas, Christophe Beauloye, Hrag Esfahani, Lauriane Y.M. Michel, Chantal Dessy, Luc Bertrand, Jean‐Luc Balligand

“…We previously showed that cardiac‐specific expression of β3‐AR inhibits the hypertrophic response to neurohormonal stimulation. Here, we further analysed signalling pathways involved in the anti‐hypertrophic effect of β3‐AR. …”
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Sharing of cmeRABC alleles between C. coli and C. jejuni associated with extensive drug resistance in Campylobacter isolates from infants and poultry in the Peruvian Amazon by Kerry K. Cooper, Evangelos Mourkas, Francesca Schiaffino, Craig T. Parker, Tackeshy N. Pinedo Vasquez, Paul F. Garcia Bardales, Pablo Peñataro Yori, Maribel Paredes Olortegui, Katia Manzanares Villanueva, Lucero Romaina Cachique, Hermann Silva Delgado, Matthew D. Hitchings, Steven Huynh, Samuel K. Sheppard, Ben Pascoe, Margaret N. Kosek

“…Resistance to fluoroquinolones and macrolides is particularly concerning as this compromises the two most effective oral antibiotic agents currently available for human campylobacteriosis. Here, we report on the prevalence and worldwide distribution of the operon cmeRABC, which encodes an efflux pump conferring high levels of combined resistance to fluoroquinolones and macrolides in Campylobacter strains isolated from poultry (n = 75) and children (n = 177). …”
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Female Adolescent Soccer Players Utilize Different Neuromuscular Strategies Between Limbs During the Propulsion Phase of a Lateral Vertical Jump by Matthew D DeLang, Joseph P Hannon, Shiho Goto, James M Bothwell, J Craig Garrison

“… # Levels of Evidence 3B # Clinical Relevance Symmetrical findings on functional tasks have underlying internal asymmetries observed here in female adolescent soccer players. The lateral vertical jump may highlight these internal asymmetries (hip- versus knee-dominant movement strategies) due to the high coordinative demand to perform the task. …”
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A comprehensive, population level evaluation of previously reported drug triggers of pemphigus highlights immunomodulatory capacity as a common characteristic by Justin Baroukhian, Kristina Seiffert-Sinha, Animesh A. Sinha

“…The significant associations reported here provide empirical support for the hypothesis that certain drugs act as triggers for PV. …”
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