Solvent-dripping modulated 3D/2D heterostructures for high-performance perovskite solar cells by Xiaoming Chang, Randi Azmi, Tinghuan Yang, Nan Wu, Sang Young Jeong, Herui Xi, Drajad Satrio Utomo, Badri Vishal, Furkan H. Isikgor, Hendrik Faber, Zhaoheng Ling, Mingjie He, Marco Marengo, Pia Dally, Adi Prasetio, Yu-Ying Yang, Chuanxiao Xiao, Han Young Woo, Kui Zhao, Martin Heeney, Stefaan De Wolf, Leonidas Tsetseris, Thomas D. Anthopoulos

“…Unfortunately, the random orientation of the spontaneously formed 2D phase atop the pre-deposited 3D perovskite film can deteriorate charge extraction owing to energetic disorder, limiting the maximum attainable efficiency and long-term stability of the PSCs. Here, we introduce a meta-amidinopyridine ligand and the solvent post-dripping step to generate a highly ordered 2D perovskite phase on the surface of a 3D perovskite film. …”
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Multifractal characteristics of pore structure in the terrestrial shale reservoirs of the Lianggaoshan formation in northeast sichuan basin and its geological significance by Jiping Wang, Jiping Wang, Hongmei Shao, Hongmei Shao, Yuanhao Zhang, Yuanhao Zhang, Zhenxue Jiang, Zhenxue Jiang, Bo Gao, Bo Gao, Lingling Li, Lingling Li, Huifang Pan, Huifang Pan, Haonan Wang, Haonan Wang, Xi Lu, Xi Lu, Hengyuan Qiu, Hengyuan Qiu, Xiaobiao He, Xiaobiao He, Chengju Zhang, Chengju Zhang

“…Furthermore, the methodologies and insights presented here are broadly applicable to unconventional resource exploration and development in similar geological settings globally, providing new ideas for researchers studying shale reservoir pore systems.…”
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Speciation of Potentially Carcinogenic Trace Nickel(II) Ion Levels in Human Saliva: A Sequential Metabolomics-Facilitated High-Field ¹H NMR Investigation by Kayleigh Hunwin, Georgina Page, Mark Edgar, Mohammed Bhogadia, Martin Grootveld

“…<b>Introduction/Objectives:</b> Since the biological activities and toxicities of ‘foreign’ and/or excess levels of metal ions are predominantly determined by their precise molecular nature, here we have employed high-resolution ¹H NMR analysis to explore the ‘speciation’ of paramagnetic Ni(II) ions in human saliva, a potentially rich source of biomolecular Ni(II)-complexants/chelators. …”
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Strength Training Session Induces Important Changes on Physiological, Immunological, and Inflammatory Biomarkers by Ayla Karine Fortunato, Washington Martins Pontes, Débora Maria Soares De Souza, Jéssica Santos Ferreira Prazeres, Lucas Soares Marcucci-Barbosa, Júlia Miranda Mól Santos, Érica Leandro Marciano Veira, Eduardo Bearzoti, Kelerson Mauro De Castro Pinto, André Talvani, Albená Nunes Da Silva

“…The hypertrophy is dependent on the eccentric muscle actions and on the inflammatory response. Here, we evaluate the physiological, immunological, and inflammatory responses induced by a session of strength training with a focus on predominance of the eccentric muscle actions. …”
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Dynamics and regulatory roles of RNA m6A methylation in unbalanced genomes by Shuai Zhang, Ruixue Wang, Kun Luo, Shipeng Gu, Xinyu Liu, Junhan Wang, Ludan Zhang, Lin Sun

“…The dosage-related effects under the condition of genomic imbalance (i.e. aneuploidy) are related to various epigenetic regulatory mechanisms. Here, we investigated the roles of RNA m6A modification in unbalanced genomes using aneuploid Drosophila. …”
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Adoptive cell transfer of piezo-activated macrophage rescues immunosuppressed rodents from life-threating bacterial infections by Xiaoyi Liu, Wenxiu Xu, Junkun Feng, Ying Wang, Kai Li, Yi Chen, Wenjun Wang, Weiwei Zhao, Shaohua Ge, Jianhua Li

“…However, the interaction between innate immune cells and these catalytic nanoparticles remains poorly understood. Here, by using rodent models of bacterial infection, we test the antimicrobial properties of ultrasound-responsive piezo-catalytic nanoparticles (piezoNP). …”
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Reduction in <i>Aedes aegypti</i> Population After a Year-Long Application of Targeted Sterile Insect Releases in the West Valley Region of Southern California by Solomon Kibret Birhanie, Jacob Hans, Jennifer Thieme Castellon, Ale Macias, Rubi Casas, Huy Hoang, Deanna Mormile, Kecia Pitts-Love, Michelle Q. Brown

“…Over 99.6% eggs collected from female mosquitoes mated with irradiated males did not hatch, indicating a high level of sterility of the irradiated males utilized for our SIT application. Here, we demonstrated the potential of SIT when combined with IVM strategies such as In2Care^® Mosquito Stations, offering a holistic approach to reducing the public health risks associated with <i>Aedes</i>-borne diseases.…”
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The spatially informed mFISHseq assay resolves biomarker discordance and predicts treatment response in breast cancer by Evan D. Paul, Barbora Huraiová, Natália Valková, Natalia Matyasovska, Daniela Gábrišová, Soňa Gubová, Helena Ignačáková, Tomáš Ondris, Michal Gala, Liliane Barroso, Silvia Bendíková, Jarmila Bíla, Katarína Buranovská, Diana Drobná, Zuzana Krchňáková, Maryna Kryvokhyzha, Daniel Lovíšek, Viktoriia Mamoilyk, Veronika Mancikova, Nina Vojtaššáková, Michaela Ristová, Iñaki Comino-Méndez, Igor Andrašina, Pavel Morozov, Thomas Tuschl, Fresia Pareja, Jakob N. Kather, Pavol Čekan

“…This technique ensures tumor purity, unbiased whole transcriptome profiling, and explicitly quantifies intratumoral heterogeneity. Here we show mFISHseq has 93% accuracy compared to immunohistochemistry. …”
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The SIRT5-JIP4 interaction promotes osteoclastogenesis by modulating RANKL-induced signaling transduction by Kecheng Zhu, Chunxiang Sheng, Linlin Zhang, Yuying Yang, Xiaojing Chen, Tao Jiang, Jiaxi Song, Deng Zhang, Xiao Wang, Hongyan Zhao, Lihao Sun, Libin Zhou, Bei Tao, Jianmin Liu

“…However, the precise molecular steps that regulate RANKL signaling remain largely unknown. Here, we revealed the indispensable role of a class III histone deacetylase (SIRT5) in the processes of RANKL-induced osteoclast differentiation and activation. …”
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Incremental cost of treating antimicrobial-resistant infections among hospitalised patients in India: a cohort study by Sanjay M Mehendale, Kamini Walia, Pallab Ray, Nusrat Shafiq, Shankar Prinja, Sagar Khadanga, Susmita Chatterjee, Raman Gangakhedkar, Samiran Panda, Sanjay Bhattacharya, Megha Mamulwar, Abhijit Kadam, Gayatri Bhambure, Shilpa Bembalkar, Shraddha Bapat, Arati Mane, Shobha Rajure, Jayanthi Mathaiyan, Yamunadevi Ramanathan, Vijayshri Suresh Deotale, Gourangie Gogoi, Ruchita Attal, Jharna Mandal, Venkateswaran Ramanathan

“…Background Accurate estimates of incremental cost (IC) attributable to antimicrobial resistance (AMR) provide information of immense public health importance to the policy makers. Here, we present the IC from patient perspective for treating antimicrobial-resistant pathogens in India.Methods This cohort study was conducted in eight hospitals including government (GH), private (PH) and trust hospitals (TH), considering their ownership, geographical location and categories of cities. …”
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Monitoring M-Protein, Therapeutic Antibodies, and Polyclonal Antibodies in a Multiparametric Mass Spectrometry Assay Provides Insight into Therapy Response Kinetics in Patients wit... by Charissa Wijnands, Peter G. A. Karel, Jolein Gloerich, Gad Armony, Anastasia Tzasta, Corrie M. de Kat Angelino, Luciano Di Stefano, Vincent Bonifay, Theo M. Luider, Martijn M. VanDuijn, Sandra J. Croockewit, Elizabeth A. de Kort, Daan A. R. Castelijn, Claudia A. M. Stege, Hans J. C. T. Wessels, Alain J. van Gool, Niels W. C. J. van de Donk, Joannes F. M. Jacobs

“…However, t-Abs can significantly decrease the total polyclonal immunoglobulin (Ig) levels which require supplemental IgG infusion. Here, we demonstrate the simultaneous monitoring of M-proteins, t-Abs, and polyclonal Ig-titers using an untargeted mass spectrometry assay, offering a comprehensive view of therapy response. …”
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CISD2-mediated mitochondrial dysfunction and iron redistribution contributes to ferroptosis in arsenic-induced nonalcoholic steatohepatitis by Jingyuan Zhang, Lu Wang, Yang Lu, Fei Zheng, Xiaoqian Ding, Xiaofeng Yao, Jie Bai, Ningning Wang, Guang Yang, Tianming Qiu, Xiance Sun

“…Our prior research established the involvement of ferroptosis in arsenic-induced NASH, but the precise underlying mechanisms remain elusive. Here, we found that exposure to NaAsO2 had a suppressive effect on the expression of CDGSH iron-sulfur domain-containing protein 2 (CISD2) at the protein and gene levels, and overexpression of CISD2 inhibited NaAsO2-induced ferroptosis and NASH. …”
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Global biogeography of N₂-fixing microbes: <i>nifH</i> amplicon database and analytics workflow by M. Morando, J. D. Magasin, S. Cheung, S. Cheung, M. M. Mills, J. P. Zehr, K. A. Turk-Kubo

“…For each sample, the database includes physical and chemical metadata obtained from the Simons Collaborative Marine Atlas Project (CMAP). Here we demonstrate the utility of this database for revealing global biogeographical patterns of prominent diazotroph groups and highlight the influence of sea surface temperature. …”
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Injectable Hierarchical Bioactive Hydrogels with Fibroblast Growth Factor 21/Edaravone/Caffeic Acid Asynchronous Delivery for Treating Parkinson's Disease by Junpeng Xu, Peng Dai, Chen Zhang, Na Dong, Caiyan Li, Chonghui Tang, Zhihao Jin, Shih‐Ho Lin, Luyang Ye, Tianmiao Sun, Yukai Jin, Fenzan Wu, Lihua Luo, Ping Wu, Shengcun Li, Xiaokun Li, Shan‐hui Hsu, Dawei Jiang, Zhouguang Wang

“…The combination of clinical drugs targeting different symptoms with smart hydrogels to achieve asynchronous releases is highly translational and challenging. Here, a hierarchical bioactive hydrogel (OACDP) is designed with asynchronous release based on PD pathology. …”
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Association between PNPLA2 Gene Polymorphisms and the Risk of Diabetic Kidney Disease in a Chinese Han Population with Type 2 Diabetes by Hailing Zhao, Haojun Zhang, Yan Wang, Tingting Zhao, Meihua Yan, Xi Dong, Qian Wang, Jialin Li, Liang Ma, Ping Li

“…Diabetic kidney disease (DKD) is one of the most common complications of diabetes and the leading cause of end-stage renal disease. Here, we investigated the association of PNPLA2 gene variations with DKD susceptibility in a Chinese Han population. …”
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Effects of dietary curcumin supplementation on the liver health of juvenile channel catfish (Ictalurus punctatus) fed high-starch diet by Qisheng Lu, Yutong Zheng, Yu Wang, Yulong Liu, Jingyue Cao, Haokun Liu, Junyan Jin, Zhimin Zhang, Yunxia Yang, Xiaoming Zhu, Shouqi Xie, Dong Han

“…However, whether curcumin helps to ameliorate HCD-induced liver damage in fish remains unknown. Here, we formulated four diets: normal-carbohydrate diet (CON), high-starch diets (HSD), 0.02 % and 0.04 % curcumin added to HSD (HSC0.02 % and HSC0.04 %) to investigate the effects of curcumin on the liver health of channel catfish (Ictalurus punctatus). …”
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LRP1 involvement in FHIT-regulated HER2 signaling in non-small cell lung cancer by Théophile Ponchel, Emma Loeffler, Julien Ancel, Audrey Brisebarre, Nathalie Lalun, Véronique Dalstein, Anne Durlach, Gaëtan Deslée, Stéphane Dedieu, Myriam Polette, Béatrice Nawrocki-Raby

“…We previously showed that a down-regulation of FHIT causes an up-regulation of the activity of HER2 associated to an epithelial-mesenchymal transition (EMT) and that lung tumor cells harboring a FHITlow/pHER2high phenotype are sensitive to anti-HER2 drugs. Here, we sought to decipher the FHIT-regulated HER2 signaling pathway in NSCLC. …”
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Substrate transport and drug interaction of human thiamine transporters SLC19A2/A3 by Peipei Li, Zhini Zhu, Yong Wang, Xuyuan Zhang, Chuanhui Yang, Yalan Zhu, Zixuan Zhou, Yulin Chao, Yonghui Long, Yina Gao, Songqing Liu, Liguo Zhang, Pu Gao, Qianhui Qu

“…Despite their physiological and pharmacological significance, the molecular underpinnings of substrate and drug recognition remain unknown. Here we present ten cryo-EM structures of human thiamine transporters SLC19A3 and SLC19A2 in outward- and inward-facing conformations, complexed with thiamine, pyridoxine, metformin, fedratinib, and amprolium. …”
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Concentration-dependent effects of immunomodulatory cocktails on the generation of leukemia-derived dendritic cells, DCleu mediated T-cell activation and on-target/off-tumor toxici... by Hazal Aslan Rejeski, Hazal Aslan Rejeski, Anne Hartz, Anne Hartz, Elias Rackl, Elias Rackl, Lin Li, Lin Li, Christoph Schwepcke, Christoph Schwepcke, Kai Rejeski, Kai Rejeski, Christoph Schmid, Christoph Schmid, Andreas Rank, Andreas Rank, Jörg Schmohl, Doris Kraemer, Peter Bojko, Helga Maria Schmetzer, Helga Maria Schmetzer

“…To guide potential clinical application of these response modifiers, we analyzed three different DC-generating protocols that combine a constant GM-CSF dose with varying concentrations of PGE1 (Kit-M), OK-432 (Kit-I), and PGE2 (Kit-K). Here, we specifically aimed to assess how different response modifier concentrations impact DC/DCleu generation, immune cell activation and leukemic blast lysis. …”
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Lattes/Lattara (Hérault), comptoir étrusque du littoral languedocien by Éric Gailledrat, Ariane Vacheret

“…A step further was taken in the 2000s, when the excavations reached the foundation levels in the southern part of the site (sector 27). Here a building was uncovered, the plan and construction techniques of which are based on Mediterranean, and more particularly Etruscan, examples. …”
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