Effects of rocky desertification on soil bacterial community in alpine grasslands of the Qinghai-Tibet Plateau by Shan Li, Shan Li, Huakun Zhou, Wenying Wang, Haze Ade, Haze Ade, Zhonghua Zhang, Li Ma, Zhen Wang, Qiang Zhang, Jingjing Wei, Jingjing Wei, Hongye Su, Hongye Su, Ruimin Qin, Ruimin Qin, Zhengchen Shi, Zhengchen Shi, Xue Hu, Xue Hu, Faliang Wu

“…However, little is known about the effects of rocky desertification on soil microbial communities of soil. Here, we investigated five different layers of rocky desertification grassland in the Qinghai-Tibet Plateau, including nil rock desertification (NRD); potential rocky desertification (PRD); light rocky desertification (LRD); moderate rocky desertification (MRD); and severe rocky desertification (SRD), we compared soil bacterial community with soil physiochemical properties in different rocky desertification conditions. …”
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Une inscription méconnue de Cos/Cosa dans la cité des Cadurques by Sabine Armani

“…Therefore, what is presented here is a new mention of a citizen of the civitas of the Cadurci, of which only two representatives were known until now –making it all the more difficult to ascertain the identity of the person in question. …”
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Expression Analysis of Fibronectin Type III Domain-Containing (FNDC) Genes in Inflammatory Bowel Disease and Colorectal Cancer by Tilo Wuensch, Jonas Wizenty, Janina Quint, Wolfgang Spitz, Madeleen Bosma, Olaf Becker, Andreas Adler, Wilfried Veltzke-Schlieker, Martin Stockmann, Sascha Weiss, Matthias Biebl, Johann Pratschke, Felix Aigner

“…The G-protein-coupled receptor 116 (GPR116) was found as a putative FNDC4 receptor. We here aim to comprehensively analyze the mRNA expression of FNDC1, FNDC3A, FNDC3B, FNDC4, FNDC5, and GPR116 in nonaffected and affected mucosal samples of patients with IBD or colorectal cancer (CRC). …”
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Balancing selection at a wing pattern locus is associated with major shifts in genome-wide patterns of diversity and gene flow by Rodríguez de Cara, María Ángeles, Jay, Paul, Rougemont, Quentin, Chouteau, Mathieu, Whibley, Annabel, Huber, Barbara, Piron-Prunier, Florence, Ramos, Renato Rogner, Freitas, André V. L., Salazar, Camilo, Silva-Brandão, Karina Lucas, Torres, Tatiana Teixeira, Joron, Mathieu

“…Selection shapes genetic diversity around target mutations, yet little is known about how selection on specific loci affects the genetic trajectories of populations, including their genome-wide patterns of diversity and demographic responses. Here we study the patterns of genetic variation and geographic structure in a neotropical butterfly, Heliconius numata, and its closely related allies in the so-called melpomene-silvaniform clade. …”
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Integrating pharmacogenomics and cheminformatics with diverse disease phenotypes for cell type-guided drug discovery by Arda Halu, Sarvesh Chelvanambi, Julius L. Decano, Joan T. Matamalas, Mary Whelan, Takaharu Asano, Namitra Kalicharran, Sasha A. Singh, Joseph Loscalzo, Masanori Aikawa

“…However, despite their widespread use, CMap-based methods have thus far been agnostic to the biological activity of drugs as well as to the genomic effects of drugs in multiple disease contexts. Here, we present a network-based statistical approach, Pathopticon, that uses CMap to build cell type-specific gene-drug perturbation networks and integrates these networks with cheminformatic data and diverse disease phenotypes to prioritize drugs in a cell type-dependent manner. …”
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Non-thermal atmospheric pressure plasma-irradiated cysteine protects cardiac ischemia/reperfusion injury by preserving supersulfides by Akiyuki Nishimura, Tomohiro Tanaka, Kakeru Shimoda, Tomoaki Ida, Shota Sasaki, Keitaro Umezawa, Hiromi Imamura, Yasuteru Urano, Fumito Ichinose, Toshiro Kaneko, Takaaki Akaike, Motohiro Nishida

“…Growing evidence has suggested that supersulfides, formed by catenation of sulfur atoms, contribute to various biological processes involving electron transfer in cells. Here, we report that non-thermal plasma-irradiated cysteine (Cys∗) protects mouse hearts against ischemia/reperfusion (I/R) injury by preventing supersulfide catabolism. …”
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Divergent paths of mammary gland involution: unveiling the cellular dynamics in abruptly and gradually involuted mouse models by Sarmila Majumder, Sanjay Mishra, Neelam Shinde, Maria C. Cuitino, Morgan Bauer, Dinesh Ahirwar, Mustafa M. Basree, Vijaya Bharti, Kate Ormiston, Resham Mawalkar, Sara Alsammerai, Gautam Sarathy, Anna E. Vilgelm, Xiaoli Zhang, Ramesh K. Ganju, Bhuvaneswari Ramaswamy

“…Our previous study utilizing a murine model demonstrated precancerous changes, specifically hyperplasia, a non-obligate precursor of breast cancer in the mammary glands of AI mice. Here we investigated mechanisms during early events of AI that prompts precancerous changes in mouse mammary glands. …”
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Principles, barriers and enablers to agroecological animal production systems: a qualitative approach based on five case studies by B. Dumont, C. Barlagne, P. Cassart, J.E. Duval, A. Fanchone, J-L. Gourdine, O. Huguenin-Elie, Y. Kazakova, J. Klötzli, A. Lüscher, E. Oteros-Rozas, D. Pomies, M.G. Rivera Ferre, W.A.H. Rossing, V. Stefanova, A. Swartebroeckx, C. Zagaria

“…So far, most of the research on agroecological animal production systems was conducted at farm scale, and the potential of agroecological principles addressing social dimensions and food system−level approaches has been underexplored. Here, we analyse how the whole set of agroecological principles was mobilised in five case studies on grassland-based, silvopastoral or integrated crop-livestock systems in Switzerland, Guadeloupe, French uplands, Bulgaria and Andalucía. …”
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A catalogue of land-based adaptation and mitigation solutions to tackle climate change by Maria Vincenza Chiriacò, Claudia Dămătîrcă, Sara Abd Alla, Sara Barilari, Rebeca Biancardi Aleu, Tommaso Brazzini, Tiago Capela Lourenço, Carlotta Annamaria de Carolis Villars, Suzie Durand, Giulio Di Lallo, Ricardo Encarnação Coelho, Océane Espin, Noelia Ferreras-Alonso, Giulia Galluccio, Daniel Ganszky, Sofie Hellsten, Gema Hernández-Moral, Jane Ihrfors, Iphigenia Keramitsoglou, Chris T. Kiranoudis, Attila Nemethy, Robert Oakes, Jesús Ortuño Castillo, Amandine Valérie Pastor, Patricia Pérez-Ramirez, Iván Ramos-Diez, Panagiotis Sismanidis, Chiara Trozzo, Chiara De Notaris

“…One requisite to support actors in the land sector is to provide them publicly available, reliable and ready-to-use information related to the implementation of Land-based Adaptation and Mitigation Solutions (LAMS). Here we introduce a LAMS catalogue, a collection of meaningful quantitative and qualitative information on 60 solutions characterised according to a set of specifications (e.g., mitigation and adaptation potential, cost of implementation, suitability factors, synergies and trade-offs, drivers and barriers to the implementation). …”
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ESAT-6 protein suppresses allograft rejection by inducing CD4+Foxp3+ regulatory T cells through IκBα/cRel pathway by Xiaofei Huang, Xiaofei Huang, Yuqun Zeng, Jingru Lin, Huazhen Liu, Huazhen Liu, Chun-Ling Liang, Chun-Ling Liang, Yuchao Chen, Yuchao Chen, Feifei Qiu, Feifei Qiu, Jonathan S. Bromberg, Zhenhua Dai, Zhenhua Dai

“…Finally, CD4+CD25- conventional T cells were cultured to induce Tregs and their proliferation.ResultsHere we found that ESAT-6 significantly extended murine skin and heart allograft survival, alleviated CD3+ T cell infiltration and increased Foxp3+ Tregs in an allograft. …”
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Targeting estrogen-regulated system xc − promotes ferroptosis and endocrine sensitivity of ER+ breast cancer by Jiawei Cao, Tong Zhou, Tao Wu, Rixu Lin, Ju Huang, Dejin Shi, Jiawei Yu, Yinrui Ren, Changrui Qian, Licai He, Guang Wu, Zhixiong Dong, Shaofei Yuan, Haihua Gu

“…Nevertheless, ER+ breast cancer is relatively resistant to ferroptosis inducers. Here, we uncovered that ERα suppressed ferroptosis in ER+ breast cancer. …”
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Redefining NSP12 activity in SARS-CoV-2 and its regulation by NSP8 and NSP7 by Deepa Singh, Tushar Kushwaha, Rajkumar Kulandaisamy, Vikas Kumar, Kamal Baswal, Saras H. Tiwari, Arkadyuti Ghorai, Manoj Kumar, Saroj Kumar, Soumya De, Aparoy Polamarasetty, Deepak Sehgal, Madhumohan R. Katika, Suresh Gadde, Marceline Côté, Sarala R. Kayampeta, Mohan Babu Appaiahgari, Krishna K. Inampudi

“…While coronavirus RNA replication is sufficiently understood, the interplay among these NSPs and its influence on RNA binding and nascent strand synthesis remains poorly understood. Here, we reconstituted a functional RdRp holoenzyme using recombinant SARS-CoV-2 NSP12, NSP7, and NSP8 in vitro. …”
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Cool topoclimates promote cold-adapted plant diversity in temperate mountain forests by Borderieux, Jeremy, De Lombaerde, Emiel, De Pauw, Karen, Sanczuk, Pieter, Vangansbeke, Pieter, Vanneste, Thomas, De Frenne, Pieter, Gégout, Jean-Claude, Serra-Diaz, Josep

“…Understanding how topography and canopies interactively affect understory temperature is key to identifying stable refugia that could shelter cold-adapted forest specialist plants under climate change. Here we report on growing season understory temperatures using 48 loggers in contrasting topographic features and canopy of a mid-range mountain valley spanning from 475 m a.s.l. to 1203 m a.s.l. in the Vosges Mountains (NE France). …”
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Novel Drug Delivery Particles Can Provide Dual Effects on Cancer “Theranostics” in Boron Neutron Capture Therapy by Abdul Basith Fithroni, Haruki Inoue, Shengli Zhou, Taufik Fatwa Nur Hakim, Takashi Tada, Minoru Suzuki, Yoshinori Sakurai, Manabu Ishimoto, Naoyuki Yamada, Rani Sauriasari, Wolfgang A. G. Sauerwein, Kazunori Watanabe, Takashi Ohtsuki, Eiji Matsuura

“…We have previously reported on self-forming nanoparticles for drug delivery consisting of a biodegradable polymer, namely, “AB-type” Lactosome^® nanoparticles (AB-Lac particles)- highly loaded with hydrophobic B compounds, namely <i>o</i>-Carborane (Carb) or 1,2-dihexyl-<i>o</i>-Carborane (diC6-Carb), and the latter (diC6-Carb) especially showed the “molecular glue” effect. Here we present in vivo and ex vivo studies with human pancreatic cancer (AsPC-1) cells to find therapeutically optimal formulas and the appropriate treatment conditions for these particles. …”
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Continuous photo-oxidation of methane to methanol at an atomically tailored reticular gas-solid interface by Yuchen Hao, Liwei Chen, Haodong Liu, Wenfeng Nie, Xiangjie Ge, Jiani Li, Hui-Zi Huang, Chao Sun, Cuncai Lv, Shangbo Ning, Linjie Gao, Yaguang Li, Shufang Wang, An-Xiang Yin, Bo Wang, Jinhua Ye

“…However, in commonly used aqueous-phase systems, photocatalysis efficiency is severely limited due to the ultralow availability of CH4 gas and H2O2 intermediate at the flooded interface. Here, we report an atomically modified metal-organic framework (MOF) membrane nanoreactor that promotes direct CH4 photo-oxidation to methanol at the gas-solid interface in a reticular open framework. …”
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Detection of fusion events by RNA sequencing in FFPE versus freshly frozen colorectal cancer tissue samples by Maxim Sorokin, Maxim Sorokin, Maxim Sorokin, Maxim Sorokin, Vladimir Lyadov, Vladimir Lyadov, Vladimir Lyadov, Maria Suntsova, Marat Garipov, Anna Semenova, Natalia Popova, Egor Guguchkin, Rustam Heydarov, Marianna Zolotovskaia, Xiaowen Zhao, Qing Yan, Ye Wang, Evgeny Karpulevich, Anton Buzdin, Anton Buzdin, Anton Buzdin, Anton Buzdin

“…However, tumor biosamples are usually formalin-fixed paraffin-embedded (FFPE) tissue blocks where RNA is heavily degraded, which in theory may result in decreased efficiency of fusion detection. Here, for the first time, we compared the efficacy of gene fusion detection by RNAseq for matched pairs of freshly frozen in RNA stabilizing solution (FF) and FFPE tumor tissue samples obtained from 29 human colorectal cancer patients. …”
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Application of various canopy resistance calculation methods in vineyard evapotranspiration simulation at daily scale in Northwest China by Jingying Zhang, Dianyu Chen, Xiaotao Hu, Lucheng Qiu, Shujian Wang, Xuanrong Zhu, La Zhuo, Dongyan Zhang, Linzhe Wu, Linlin Zhang

“…The suitability of methods of calculation of rc largely affects the simulation performance of ET. Here, the Jarvis (JA) model, the coupled surface resistance (CO) model, the Farias (FA) model, the Kelliher-Leuning (KL) model, the Katerji-Perrier (KP) model and the new coupling (N) model which considering interaction among different factors were used for rc calculation in a vineyard in Northwest China. …”
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Recent centennial drought on the Tibetan Plateau is outstanding within the past 3500 years by Yu Liu, Huiming Song, Zhisheng An, Qiang Li, Steven W. Leavitt, Ulf Büntgen, Qiufang Cai, Ruoshi Liu, Congxi Fang, Changfeng Sun, Kerstin Treydte, Meng Ren, Lidong Mo, Yi Song, Wenju Cai, Quan Zhang, Weijian Zhou, Achim Bräuning, Jussi Grießinger, Deliang Chen, Hans W. Linderholm, Ashish Sinha, Hai Cheng, Lu Wang, Ying Lei, Junyan Sun, Wei Gong, Xuxiang Li, Linlin Cui, Liang Ning, Lingfeng Wan, Thomas W. Crowther, Constantin M. Zohner

“…Yet, understanding historical and recent hydroclimate fluctuations and their wide-ranging ecological and societal consequences remains challenging due to short instrumental observations and partly ambiguous proxy reconstructions. Here, we present a precisely-dated 3476-year precipitation reconstruction derived from tree-ring δ18O data on the Tibetan Plateau, representing one of the few multi-millennia-long annually-resolved terrestrial δ18O records to date. …”
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Protocol for a multisite randomised controlled trial assessing the effect of the Telehealth for Early Developmental Intervention in babies born very preterm (TEDI-Prem) programme o... by Alicia J Spittle, Peter J Anderson, Angela T Morgan, Rachel Schembri, Li Huang, Kim Dalziel, Rod W Hunt, Katherine Lee, Anne E Holland, Karli Treyvaud, Abbey L Eeles, Stacey Dusing, Shaaron Brown, Susan M Fehring, Gillian Henty, Elizabeth Kozaris

“…TEDI-Prem aims to improve neurodevelopmental outcomes and parental well-being in children born VPT. Here we present the protocol outlining a multicentre, pragmatic, parallel-group, randomised controlled trial to determine the efficacy of TEDI-Prem plus usual care, compared with usual care alone.Methods and analysis We will recruit 466 VPT infants from the neonatal units of five hospitals in Victoria, Australia. …”
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Sox6 and ALDH1A1 Truncation by Asparagine Endopeptidase Defines Selective Neuronal Vulnerability in Parkinson's Disease by Shuke Nie, Bowei Li, Mengmeng Wang, Zijun Chen, Jiayan Ren, Zixuan Li, Xinli Xu, Zhengjiang Qian, Zhongyun Xie, Jianxin Han, Zhentao Zhang, Zhaohui Zhang, Yingjie Zhu, Zuxin Chen, Xifei Yang, Keqiang Ye

“…However, the molecular mechanism for this distinct vulnerability remains unclear. Here, it is shown that Legumain, also known as asparagine endopeptidase (AEP), is activated in a subgroup of SRY‐box transcription factor 6 /Aldehyde dehydrogenase 1 family member A1, (Sox6+/ALDH1A1+) neurons in the ventral tier of the SNpc and cleaves Sox6 and ALDH1A1, leading to repression of Special AT‐rich sequence binding protein 1 (Satb1) that is a dimeric/tetrameric transcription factor specifically binding to AT‐rich DNA sequences, and toxic dopamine metabolite accumulation. …”
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