Effect of straw retention and mineral fertilization on P speciation and P-transformation microorganisms in water- extractable colloids of a Vertisol by S. Bai, S. Bai, Y. Ge, D. Yao, Y. Wang, J. Tan, J. Tan, S. Zhang, Y. Peng, X. Jiang

“…Yet, the underlying information regarding soil P species and P-transformation microorganisms at the microparticle scale under long-term straw retention and mineral fertilization is barely known. Here, a fixed field experiment (<span class="inline-formula">∼</span> 13 years) in a Vertisol was performed to explore the impacts of straw retention and mineral fertilization on inorganic P, organic P, and P-transformation microorganisms in bulk soils and WECs through a sequential extraction procedure, P K-edge X-ray absorption near-edge structure (XANES), <span class="inline-formula">³¹</span>P nuclear magnetic resonance (NMR), and metagenomics analysis. …”
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Adaptive Autophagy Offers Cardiorenal Protection in Rats with Acute Myocardial Infarction by Zhendong Feng, Han Xue Jiang, Huiyang Chen, Yu Ning Liu, Yahui Wang, Rui Bing Yang, Xueting Han, Chen Hui Xia, Ze Bing Zhu, Hongcai Shang, Aiming Wu, Wei Jing Liu

“…Understanding the multifactorial changes involved in the kidney and heart after acute myocardial infarction (AMI) is prerequisite for further mechanisms and early intervention, especially autophagy changes. Here, we discussed the role of adaptive autophagy in the heart and kidney of rats with AMI. …”
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The Genetic Landscape of Human Glioblastoma and Matched Primary Cancer Stem Cells Reveals Intratumour Similarity and Intertumour Heterogeneity by Chiara Pesenti, Stefania Elena Navone, Laura Guarnaccia, Andrea Terrasi, Jole Costanza, Rosamaria Silipigni, Silvana Guarneri, Nicola Fusco, Laura Fontana, Marco Locatelli, Paolo Rampini, Rolando Campanella, Silvia Tabano, Monica Miozzo, Giovanni Marfia

“…The morbidity and mortality of this disease strongly encourage exploring genetic characteristics of GSCs. Here, using array-CGH platform, we investigated genetic and genomic aberration profiles of GBM parent tumour (n=10) and their primarily derived GSCs. …”
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Development and Validation of Multiplex-PCR Assay for <i>β-Carotene hydroxylase</i> and <i>γ-Tocopherol methyl transferase</i> Genes Governing Enhanced Multivitamins in Maize for I... by Munegowda Manoj Gowda, Vignesh Muthusamy, Rashmi Chhabra, Hriipulou Duo, Saikat Pal, Nisrita Gain, Ashvinkumar Katral, Ravindra K. Kasana, Rajkumar U. Zunjare, Firoz Hossain

“…Additionally, multiple PCR assays for various genes increase the required costs and resources. Here, we aimed to develop a multiplex-PCR assay to simultaneously identify different allelic forms of <i>crtRB1</i> and <i>vte4</i> genes and validate them in a backcross-based segregating population. …”
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Forest edge landscape context affects mosquito community composition and risk of pathogen emergence by Adam Hendy, Nelson Ferreira Fé, Igor Pedrosa, André Girão, Taly Nayandra Figueira dos Santos, Claudia Reis Mendonça, José Tenaçol Andes Júnior, Flamarion Prado Assunção, Edson Rodrigues Costa, Vincent Sluydts, Marcelo Gordo, Vera Margarete Scarpassa, Michaela Buenemann, Marcus Vinícius Guimarães de Lacerda, Maria Paula Gomes Mourão, Nikos Vasilakis, Kathryn A. Hanley

“…Although often treated as uniform interfaces, the landscape context of edge habitats can greatly impact ecological interactions. Here, we investigated how the landscape context of forest edges shapes mosquito community structure in an Amazon rainforest reserve near the city of Manaus, Brazil, using hand-nets to sample mosquitoes at three distinct forest edge types. …”
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Validating a clinically based MS-MLPA threshold through comparison with Sanger sequencing in glioblastoma patients by Halka Lhotska, Karolina Janeckova, Hana Cechova, Jaromir Macoun, Tatiana Aghova, Libuse Lizcova, Karla Svobodova, Lucie Hodanova, Dora Konecna, Jiri Soukup, Filip Kramar, David Netuka, Zuzana Zemanova

“…Conclusions Our results show that the threshold for methylation detection with the MS-MLPA method determined here is useful from a diagnostic perspective because it allows the stratification of patients who will benefit from specific treatment protocols, including temozolomide. …”
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Characterization and functional analysis of conserved non-coding sequences among poaceae: insights into gene regulation and phenotypic variation in maize by Yi Luo, Hang Zhai, Xiu Zhong, Bo Yang, Yang Xu, Tianhong Liu, Qi Wang, Yang Zhou, Yan Mao, Yaxi Liu, Qi Tang, Yanli Lu, Yao Wang, Jie Xu

“…Identification of CNS provides valuable information about potentially functional genomic elements, regulatory regions, and helps to gain insights into the genetic basis of crop agronomic traits. Results Here, we comprehensively analyze CNS in maize, by comparing the genomes of maize inbred line B73 (Zea mays ssp. mays), its close wild relative Zea mays spp. mexicana, and other grasses in Poaceae, including sorghum (Sorghum bicolor), foxtail millet (Setaria italica) and two adlay (Coix lacryma) cultivars. …”
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Comprehensive FR1(C) and FR3 Lower and Upper Mid-Band Propagation and Material Penetration Loss Measurements and Channel Models in Indoor Environment for 5G and 6G by Dipankar Shakya, Mingjun Ying, Theodore S. Rappaport, Hitesh Poddar, Peijie Ma, Yanbo Wang, Idris Al-Wazani

“…Allocations in the lower and upper mid-band aim to balance coverage and capacity, but there is limited knowledge about the radio propagation characteristics in the 4&#x2013;24 GHz frequency bands. Here we present the world&#x2019;s first comprehensive indoor propagation measurement and channel modeling study at 6.75 GHz and 16.95 GHz in mid-band spectrum conducted at the NYU WIRELESS Research Center spanning distances from 11&#x2013;97 m using 31 dBm EIRP transmit power with 15 and 20 dBi gain rotatable horn antennas at 6.75 GHz and 16.95 GHz, respectively. …”
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Cryo-EM structure of an activated GPR4–Gs signaling complex by Yitong Ma, Yijie Wang, Mengyuan Tang, Yuan Weng, Ying Chen, Yueming Xu, Shuxiao An, Yiran Wu, Suwen Zhao, Huanhuan Xu, Dali Li, Mingyao Liu, Weiqiang Lu, Heng Ru, Gaojie Song

“…However, the 3D structure remains unknown, and the roles of other conserved residues within psGPCRs are not well understood. Here we report cryo-electron microscopy (cryo-EM) structures of active zebrafish GPR4 at both pH 6.5 and 8.5, each highlighting a distribution of histidine and acidic residues at the extracellular region. …”
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Skeletal progenitor LRP1 deficiency causes severe and persistent skeletal defects with Wnt pathway dysregulation by Mohammad Alhashmi, Abdulrahman M. E. Gremida, Santosh K. Maharana, Marco Antonaci, Amy Kerr, Shijian Fu, Sharna Lunn, David A. Turner, Noor A. Al-Maslamani, Ke Liu, Maria M. Meschis, Hazel Sutherland, Peter Wilson, Peter Clegg, Grant N. Wheeler, Robert J. van ‘t Hof, George Bou-Gharios, Kazuhiro Yamamoto

“…Our work addresses the critical question of how these skeletal pathologies emerge. Here, we show the abundant expression of LRP1 in skeletal progenitor cells at mouse embryonic stage E10.5 and onwards, especially in the perichondrium, the stem cell layer surrounding developing limbs essential for bone formation. …”
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Rancang Bangun Purwarupa Pemilah Sampah Pintar Berbasis Deep Learning by Kahlil Muchtar, Nyak Twoman Anshari, Chairuman Chairuman, Khalid Alhabibie, Khairul Munadi

“…Deep Learning method applied here is using Convolutional Neural Network (CNN). …”
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ALKBH5, an m6A demethylase, attenuates tumor growth and inhibits metastasis in papillary thyroid carcinoma by Yong Zhuang, Qingyan Cai, Xin Hu, Huibin Huang

“…However, it remains unclear whether ALKBH5 regulates the growth and metastasis of papillary thyroid carcinoma (PTC). Here, we compared cancer tissues and paracancerous tissues from PTC patients, along with cultured cells expressing ALKBH5 (overexpression, silent gene expression, normal stable expression). …”
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Addressing inter individual variability in CSF levels of brain derived proteins across neurodegenerative diseases by Sára Mravinacová, Sofia Bergström, Jennie Olofsson, Nerea Gómez de San José, Sarah Anderl-Straub, Janine Diehl-Schmid, Klaus Fassbender, Klaus Fliessbach, Holger Jahn, Johannes Kornhuber, G. Bernhard Landwehrmeyer, Martin Lauer, Johannes Levin, Albert C. Ludolph, Johannes Prudlo, Anja Schneider, Matthias L. Schroeter, Jens Wiltfang, Petra Steinacker, FTLD Consortium, Markus Otto, Peter Nilsson, Anna Månberg

“…Cerebrospinal fluid (CSF) proteins are promising candidates for reflecting brain pathology; however, their diagnostic utility may be compromised by natural variability between individuals, weakening their association with disease. Here, we measured the levels of 69 pre-selected proteins in cerebrospinal fluid using antibody-based suspension bead array technology in a multi-disease cohort of 499 individuals with neurodegenerative disorders including Alzheimer’s disease (AD), behavioral variant frontotemporal dementia, primary progressive aphasias, amyotrophic lateral sclerosis (ALS), corticobasal syndrome, primary supranuclear palsy, along with healthy controls. …”
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Therapeutic effects of cyclophosphamide, dsDNA preparations and combinations thereof against Krebs-2 ascites cancer cells and various cancer transplants by E. A. Potter, E. V. Dolgova, A. M. Minkevich, Ya. R. Efremov, O. S. Taranov, V. V. Omigov, V. P. Nikolin, N. A. Popova, A. S. Proskurina, E. I. Vereschagin, A. V. Kozel, V. A. Rogachev, D. B. Petrov, A. A. Ostanin, E. R. Chernykh, N. A. Kolchanov, S. S. Bogachev

“…The present work is the first report in the series of papers from our group where we describe the development of anticancer therapy based on the selective targeting of TISCs. Here were characterize a cytoreductive activity of cyclophosphamide (CP), double-stranded DNA (dsDNA) and combinations thereof against the TISC population present in mouse Krebs-2 ascites. …”
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Enhanced myofibroblast differentiation of eMSCs in intrauterine adhesions by Jun Song, Meiqi Li, Yuan Tao, Yumeng Li, Canrong Mai, Jingting Zhang, Lan Yao, Shaoquan Shi, Jianyong Xu

“…Conclusions In conclusion, we have demonstrated here that the scar tissues in IUA biopsy are characterized with enhanced differentiation of pro-fibrotic fibroblast and myofibroblast. …”
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Altered zygotic gene expression caused by sperm with Tdrd6 variants disrupts early embryonic development by Zhijie Hu, Yuqi Zhang, Renfei Cai, Qiuju Chen, Haiyan Guo, Danjun Li, Weidong Lin, Hongxi He, Haibo Wu, Yali Liu, Bin Li, Qianwen Xi, Hongyuan Gao, Jian Zhang, Qifeng Lyu, Yanping Kuang, Xuefeng Lu

“…Abstract The precise mechanisms behind early embryonic arrest due to sperm‐related factors and the most effective strategies are not yet fully understood. Here, we present two cases of male infertility linked to novel TDRD6 variants, associated with oligoasthenoteratozoospermia (OAT) and early embryonic arrest. …”
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Distribution and environmental drivers of macrofaunal nematode communities across gradients of methane seepage at cold seeps on Hikurangi Margin (New Zealand) and potential implica... by Daniel Leduc, Ashley A. Rowden, Ashley A. Rowden, Sarah Seabrook, David A. Bowden, Andrew R. Thurber, Andrew R. Thurber, Jane Halliday, Cliff S. Law, Cliff S. Law, Olivia S. Pereira, Bethany G. Whitten, Andrew Marriner

“…To date, research conducted on New Zealand’s Hikurangi Margin seep communities has focused on communities at 650-1200 m water depth. Here, we characterize the macrofaunal nematode communities of New Zealand cold seeps for the first time, and at deeper (&gt; 1200 m) seep locations (Maungaroa, Glendhu and Urutī South). …”
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Compaction of Hyaloclastite from the Active Geothermal System at Krafla Volcano, Iceland by Guðjón H. Eggertsson, Jackie E. Kendrick, Joshua Weaver, Paul A. Wallace, James E. P. Utley, John D. Bedford, Michael J. Allen, Sigurður H. Markússon, Richard H. Worden, Daniel R. Faulkner, Yan Lavallée

“…Hyaloclastites commonly form high-quality reservoir rocks in volcanic geothermal provinces. Here, we investigated the effects of confinement due to burial following prolonged accumulation of eruptive products on the physical and mechanical evolution of surficial and subsurface (depths of 70 m, 556 m, and 732 m) hyaloclastites from Krafla volcano, Iceland. …”
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Evaluation of the recombinant protein Sh-TSP-2 for the serological diagnosis of imported urogenital schistosomiasis and comparison with commercially available tests by María Pilar Luzón-García, Laura Navarro, Esther Rodríguez, Manuel Jesús Soriano-Pérez, José Vázquez-Villegas, María Isabel Cabeza-Barrera, Alex Loukas, Nerea Castillo-Fernández, María Jesús Perteguer, Javier Sotillo, Joaquín Salas-Coronas

“…However, there is still a lack of evidence regarding the most appropriate methods for this purpose. Here we assessed the diagnostic efficacy of a newly developed serological technique that utilizes the recombinant protein Sh-TSP-2, applied to the urine and serum of migrants suspected of having urogenital schistosomiasis. …”
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Mitochondrial targeting of Candida albicans SPFH proteins and requirement of stomatins for SDS-induced stress tolerance by Hyunjeong Kim, Marienela Y. Heredia, Xiao Chen, Maisha Ahmed, Mohammad Qasim, Tracy L. Callender, Aaron D. Hernday, Jason M. Rauceo

“…In the yeast Candida albicans, stomatin-like protein 3 (Slp3) forms punctate foci at the plasma membrane, and SLP3 overexpression causes cell death following exposure to the surfactant, SDS, and the oxidative stressor, H2O2. Here, we sought to determine the cellular localization and functionally characterize stomatin-like protein 2 (Slp2), prohibitin-1 (Phb1), prohibitin-2 (Phb2), and prohibitin-12 (Phb12) in C. albicans. …”
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