Progesterone induces meiosis through two obligate co-receptors with PLA2 activity by Nancy Nader, Lama Assaf, Lubna Zarif, Anna Halama, Sharan Yadav, Maya Dib, Nabeel Attarwala, Qiuying Chen, Karsten Suhre, Steven Gross, Khaled Machaca

“…Despite the established physiological importance of P4 nongenomic signaling, the details of its signal transduction cascade remain elusive. Here, using Xenopus oocyte maturation as a well-established physiological readout of nongenomic P4 signaling, we identify the lipid hydrolase ABHD2 (α/β hydrolase domain-containing protein 2) as an essential mPRβ co-receptor to trigger meiosis. …”
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No Need to Know: Toward Astrophysics-free Gravitational-wave Cosmology by Amanda M. Farah, Thomas A. Callister, Jose María Ezquiaga, Michael Zevin, Daniel E. Holz

“…Furthermore, it is commonly presumed that the form of the mass distribution must be known a priori to obtain unbiased measurements of cosmological parameters in this fashion. Here, we demonstrate that spectral sirens can accurately infer cosmological parameters without such prior assumptions. …”
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Micro Immune Response On-chip (MIRO) models the tumour-stroma interface for immunotherapy testing by Alice Perucca, Andrea Gómez Llonín, Oriol Mañé Benach, Clement Hallopeau, Elisa I. Rivas, Jenniffer Linares, Marta Garrido, Anna Sallent-Aragay, Tom Golde, Julien Colombelli, Eleni Dalaka, Judith Linacero, Marina Cazorla, Teresa Galan, Jordi Pastor Viel, Xavier Badenas, Alba Recort-Bascuas, Laura Comerma, Patricia Fernandez-Nogueira, Ana Rovira, Pere Roca-Cusachs, Joan Albanell, Xavier Trepat, Alexandre Calon, Anna Labernadie

“…In vitro modelling of the complex interactions between cancer cells and their microenvironment could provide a path to understanding immune therapy sensitivity and resistance. Here we develop MIRO, a fully humanised in vitro platform to model the spatial organisation of the tumour/stroma interface and its interaction with immune cells. …”
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Convergent origin and accelerated evolution of vesicle-associated RhoGAP proteins in two unrelated parasitoid wasps by Colinet, Dominique, Cavigliasso, Fanny, Leobold, Matthieu, Pichon, Apolline, Urbach, Serge, Cazes, Dominique, Poullet, Marine, Belghazi, Maya, Volkoff, Anne-Nathalie, Drezen, Jean-Michel, Gatti, Jean-Luc, Poirié, Marylène

“…This evolutionary model has been less described in parasitoid wasps, which use maternal fluids, including venom, to protect their eggs from encapsulation by the host immune system. Here, we evidence the convergent recruitment and accelerated evolution of two multigene families of RhoGAPs presumably involved in virulence in two unrelated parasitoid wasp species, Leptopilina boulardi (Figitidae) and Venturia canescens (Icheumonidae). …”
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Maternal neonicotinoid pesticide exposure impairs glucose metabolism by deteriorating brown fat thermogenesis by Wenwen Zhu, Jiali Fang, Chenbo Ji, Hong Zhong, Tianying Zhong, Xianwei Cui

“…Increasing evidence has suggested that NEOs may affect glucose homeostasis, but little research has linked NEOs exposure to gestational diabetes mellitus (GDM), which is the most common disease in pregnancy. We here aimed to investigate the association between NEOs exposure and GDM occurrence. …”
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Spatial Distribution Characteristics of Micronutrients and Their Deficiency Effect on the Root Morphology and Architecture in Citrus Rootstock by Gaofeng Zhou, Yiping Fu, Mei Yang, Yanhong Li, Jing Zhang

“…., Ptr) and red tangerine (<i>Citrus reticulata</i> Blanco, Cre), were employed here. The analysis of the mineral nutrient distribution characteristics in different root parts showed that, except for the P concentrations in Ptr, the last two LR levels (second and third LRs) had the highest macronutrient concentrations. …”
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Sun-simulated-driven production of high-purity methanol from carbon dioxide by Jiqing Jiao, Yanbin Ma, Xiaoqian Han, Awu Ergu, Chao Zhang, Pingping Chen, Wei Liu, Qiquan Luo, Zhaolin Shi, Han Xu, Chen Chen, Yaguang Li, Tongbu Lu

“…Both electro- and thermo-catalytic CO2 reduction to CH3OH can only produce CH3OH in low concentration (typically mixed with water), requiring energy-intensive purification processes. Here we design a sun-simulated-driven tandem catalytic system comprising CO2 electroreduction to syngas, and further photothermal conversion into high-purity CH3OH (volume fraction > 97%). …”
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Reciprocal regulation between DNMT3A/3B and microRNAs miRs-299-3p/-30e is a causal factor for the downregulation of microRNAs targeting androgen receptor in prostate cancer by Kavya Ganapathy, Christian F. Harrs, Samuel Harris, Stephen J. Staklinski, Ayman Khatib, Jong Y. Park, Ratna Chakrabarti

“…We previously reported that microRNAs (miRNA)-299-3p and −30e target androgen receptor (AR) and are downregulated in advanced prostate cancer (PCa). Here we report that miR-34c, an AR targeting miRNA and miR-299-3p, both are differentially downregulated in PCa cells from African American (AA) and Caucasian American (CA) patients due to disparate promoter hypermethylation in these miRNA genes. …”
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A feedback loop between Paxillin and Yorkie sustains Drosophila intestinal homeostasis and regeneration by Dan Jiang, Pengyue Li, Yi Lu, Jiaxin Tao, Xue Hao, Xiaodong Wang, Wei Wu, Jinjin Xu, Haoen Zhang, Xiaoyu Li, Yixing Chen, Yunyun Jin, Lei Zhang

“…Abstract Balanced self-renewal and differentiation of stem cells are crucial for maintaining tissue homeostasis, but the underlying mechanisms of this process remain poorly understood. Here, from an RNA interference (RNAi) screen in adult Drosophila intestinal stem cells (ISCs), we identify a factor, Pax, which is orthologous to mammalian PXN, coordinates the proliferation and differentiation of ISCs during both normal homeostasis and injury-induced midgut regeneration in Drosophila. …”
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Gut Dysbiosis and Abnormal Bile Acid Metabolism in Colitis-Associated Cancer by Li Liu, Min Yang, Wenxiao Dong, Tianyu Liu, Xueli Song, Yu Gu, Sinan Wang, Yi Liu, Zaripa Abla, Xiaoming Qiao, Wentian Liu, Kui Jiang, Bangmao Wang, Jie Zhang, Hailong Cao

“…Studies have shown the association between gut dysbiosis, abnormal bile acid metabolism, and inflammation process. Here, we aimed to investigate these two factors in the CAC model. …”
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Delay of innate immune responses following influenza B virus infection affects the development of a robust antibody response in ferrets by Thomas Rowe, Ashley Fletcher, Melissa Lange, Yasuko Hatta, Gabriela Jasso, David E. Wentworth, Ted M. Ross

“…Inoculation of ferrets, with over 1,500 human clinical influenza isolates (1998–2019) resulted in lower antibody responses (HI <1:160) to 86% (387 out of 448) influenza B viruses (IBVs) compared to 2.7% (30 out of 1,094) influenza A viruses (IAVs). Here, we show that the immune responses in ferrets inoculated with IBV were delayed and reduced compared to IAV. …”
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Interleukin 15‐Presenting Nanovesicles with Doxorubicin‐Loaded Ferritin Cores for Cancer Immunochemotherapy by Yihui Zhai, Wen Zhang, Jinming Wang, Ying Kong, Rong Rong, Tianqun Lang, Chao Zheng, Yanke Wang, Yang Yu, Helen He Zhu, Ying Cai, Pengcheng Zhang, Yaping Li

“…The IL15‐displaying nanovesicle introduced here holds promise as a potential platform for immunochemotherapy in the treatment of cancer.…”
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TAB2 Promotes the Stemness and Biological Functions of Cervical Squamous Cell Carcinoma Cells by Yijia Zhou, Yuandong Liao, Chunyu Zhang, Junxiu Liu, Wei Wang, Jiaming Huang, Qiqiao Du, Tianyu Liu, Qiaojian Zou, Hua Huang, Pan Liu, Shiyin Ooi, Run Chen, Meng Xia, Hongye Jiang, Manman Xu, Yuwen Pan, Shuzhong Yao

“…However, the specific mechanisms involved in regulating cell functions remain largely unknown. Here, we analyzed published data from public databases and our global transcriptome data, thus identifying cancer-related signaling pathways and molecules. …”
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Low-dose radiation ameliorates PM2.5-induced lung injury through non-canonical TLR1/TLR2-like receptor pathways modulated by Akkermansia muciniphila by Li Wang, Zhipeng Li, Huan He, Lijing Qin, Weiqiang Xu, Hongyuan Tian, Rongrong Liu, Xinru Lian, Wen Li, Yali Qi, Zhicheng Wang

“…Additionally, gut microbiota and inflammation are crucial in lung injury and the health benefits of LDR through gut microbiota need further exploration. Here, we aim to investigate the impact of LDR on PM2.5-induced lung injury in vivo and in vitro, and elucidated the potential mechanisms of anti-inflammation activated by gut microbiota. …”
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Melt inclusion bubbles provide new insights into crystallisation depths and CO2 systematics at Soufrière Hills Volcano, Montserrat by TiVonne A. Howe, Thomas E. Christopher, Thomas E. Christopher, Séverine Moune, Séverine Moune, Hugh Tuffen, Federica Schiavi

“…Total CO2 concentrations in SHV magma are therefore underestimated, together with volatile-derived entrapment pressures and inferred magma storage depths. Here, we present a new dataset of volatile (H2O and total CO2) and major element concentrations in plagioclase- and orthopyroxene-hosted SHV MI, that span almost all of the eruptive activity (Phases 1, 2, 4, and 5), and include the first measurement of bubble-hosted CO2 for SHV and indeed the Lesser Antilles Arc. …”
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The simulation of ELM control by the advanced divertor configuration in EAST by Y.L. Li, T.Y. Xia, Z.P. Luo, Q.Z. Yu, S.F. Mao, B. Gui, X.X. He, H.M. Qi, P.C. Xie, M.Y. Ye, the EAST team

“…Using the EFIT code, a series of plasma equilibria with different 2nd X-points and nearly fixed last closed flux surfaces (LCFSs) are generated to analyze the effects of the different magnetic configurations on ELMs. Here we mainly discuss the standard single-null (SN), snowflake plus (SF+), and snowflake minus (SF-) divertors. …”
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Selective arm-usage of pre-miR-1307 dysregulates angiogenesis and affects breast cancer aggressiveness by Oyku Ece Sumer, Korbinian Schelzig, Janine Jung, Xiaoya Li, Janina Moros, Luisa Schwarzmüller, Ezgi Sen, Sabine Karolus, Angelika Wörner, Verônica Rodrigues de Melo Costa, Nishanth Belugali Nataraj, Efstathios-Iason Vlachavas, Clarissa Gerhäuser, Karin Müller-Decker, Dominic Helm, Yosef Yarden, Birgitta Elisabeth Michels, Cindy Körner

“…However, the impact of global deregulation of pre-miR-1307 and its individual mature miRNAs in breast cancer has not been investigated in breast cancer, yet. Results Here, we found significant upregulation of three mature miRNA species derived from pre-miR-1307 in human breast cancer tissue. …”
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Controlling the Crystallinity and Morphology of Bismuth Selenide via Electrochemical Exfoliation for Tailored Reverse Saturable Absorption and Optical Limiting by Hao Yan, Bingxue Li, Junjie Pan, Xuan Fang, Yongji Yu, Dengkui Wang, Dan Fang, Yanyan Zhan, Xiaohua Wang, Jinhua Li, Xiaohui Ma, Guangyong Jin

“…As an emerging two-dimensional (2D) Group-VA material, bismuth selenide (Bi₂Se₃) exhibits favorable electrical and optical properties. Here, three distinct morphologies of Bi₂Se₃ were obtained from bulk Bi₂Se₃ through electrochemical intercalation exfoliation. …”
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Electrochemotherapy with bleomycin, oxaliplatin, or cisplatin in mouse tumor models, from tumor ablation to in situ vaccination by Katja Uršič Valentinuzzi, Katja Uršič Valentinuzzi, Urška Kamenšek, Urška Kamenšek, Simona Kranjc Brezar, Chloe Heranney, Chloe Heranney, Tilen Komel, Tilen Komel, Simon Buček, Simon Buček, Maja Čemažar, Maja Čemažar, Gregor Serša, Gregor Serša

“…IntroductionIn addition to its direct cytotoxic effects, ablative therapies as electrochemotherapy (ECT) can elicit indirect antitumor effects by triggering immune system responses. Here, we comprehensively analyzed this dual effectiveness of intratumoral ECT with chemotherapeutic drugs bleomycin (BLM), oxaliplatin (OXA), and cisplatin (CDDP). …”
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Microbial community structure and functional traits involved in the adaptation of culturable bacteria within the gut of amphipods from the deepest ocean by Yukun Cui, Yu Xiao, Zhuo Wang, Paiyao Ji, Changhao Zhang, Yongqi Li, Jiasong Fang, Xi Yu

“…However, research on the gut microbiota of amphipods related to ecological functions and environmental adaptation is still limited. Here, we used 16S rRNA sequencing technology and a culture-dependent method to analyze the composition of the gut microbiota in Amphipoda living in the Mariana Trench. …”
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