Cytosolic phospholipase A2 in infiltrating monocyte derived macrophages does not impair recovery after spinal cord injury in female mice by Ethan P. Glaser, Timothy J. Kopper, William M. Bailey, Hassan K. Kashif, Reena Kumari, Andrew N. Stewart, John C. Gensel

“…We hypothesize that cPLA2 activation in MDMs after SCI contributes to secondary injury. Here, we report that cPLA2 plays an important role in the myelin-induced inflammatory macrophage phenotype in vitro using macrophages derived from cPLA2 knockout bone marrow. …”
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Soil microbiome interventions for carbon sequestration and climate mitigation by Gwyn A. Beattie, Anna Edlund, Nwadiuto Esiobu, Jack Gilbert, Mette Haubjerg Nicolaisen, Janet K. Jansson, Paul Jensen, Marco Keiluweit, Jay T. Lennon, Jennifer Martiny, Vanessa R. Minnis, Dianne Newman, Raquel Peixoto, Christopher Schadt, Jan Roelof van der Meer

“…ABSTRACT Mitigating climate change in soil ecosystems involves complex plant and microbial processes regulating carbon pools and flows. Here, we advocate for the use of soil microbiome interventions to help increase soil carbon stocks and curb greenhouse gas emissions from managed soils. …”
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Forecasting contrail climate forcing for flight planning and air traffic management applications: the CocipGrid model in pycontrails 0.51.0 by Z. Engberg, R. Teoh, T. Abbott, T. Dean, M. E. J. Stettler, M. L. Shapiro

“…As only 2 %–3 % of all flights are likely responsible for 80 % of the global annual contrail energy forcing (EF<span class="inline-formula">_contrail</span>), re-routing these flights could reduce the occurrence of strongly warming contrails. Here, we develop a contrail forecasting tool that produces global maps of persistent contrail formation and their EF<span class="inline-formula">_contrail</span> formatted to align with standard weather and turbulence forecasts for integration into existing flight planning and air traffic management workflows. …”
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Circular RNA RHOT1 Regulates miR-142-5p/CCND1 to Participate in Chondrocyte Autophagy and Proliferation in Osteoarthritis by Gu Man, Haiwen Yang, Kai Shen, Donghong Zhang, Julin Zhang, Hao Wu, Hongyu Zhang, Jinhuan Wang

“…Nevertheless, the function of circRHOT1 in the modulation of OA progression is still obscure. Here, we explored the effect of circRHOT1 on autophagy and extracellular matrix (ECM) in OA. …”
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Oridonin ameliorates renal fibrosis in diabetic nephropathy by inhibiting the Wnt/β-catenin signaling pathway by Jushuang Li, Lan Shu, Qianqian Jiang, Baohong Feng, Zhimin Bi, Geli Zhu, Yanxia Zhang, Xiangyou Li, Jun Wu

“…However, whether Ori can alleviate renal fibrosis in DN remains unknown. Here, we investigated the mechanism through which Ori affects the Wnt/β-catenin signaling pathway in diabetic rats and human proximal tubular epithelial cells (HK-2) exposed to high glucose (HG) levels. …”
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Eminescu – poezia naşterii şi a stingerii (elemente de antropogonie eminesciană) by Carmina Cojocaru

“…The poet reached the highest degree of understanding life, the essence drawn out of a long line of other existing essences which, in our opinion, makes the most complex, shattering confession whose deep meaning is represented by human essence and becomes part of the Eminescu antropogonic foundation: comprehending life as „part of the whole” that would immediately lead to the complet understanding of death, and from here to the staggering elevation of the most stirring verse: “Nu credeam să-nvăţ a muri vreodată”. …”
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Selective light olefin synthesis with high ethylene abundance via CO2 hydrogenation over (Ga-In)2O3/SSZ-13 catalysts by Yasemen Kuddusi, Laura Piveteau, Mounir Mensi, Daniel C. Cano-Blanco, Andreas Züttel

“…The findings presented here provide a strategy to tune CO2 hydrogenation product distributions toward specific target products.…”
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Multi-ancestry genome-wide meta-analysis with 472,819 individuals identifies 32 novel risk loci for psoriasis by Min Zhang, Wenting Su, Jiahui Deng, Bin Zhai, Gaizhi Zhu, Ran Gao, Qi Zeng, Jinming Qiu, Ziqing Bian, He Xiao, Guoming Luan, Renxi Wang

“…However, deeper insight into the genetic susceptibility of psoriasis is still unclear. Methods Here we performed the largest multi-ancestry meta-analysis of genome-wide association study including 28,869 psoriasis cases and 443,950 healthy controls. …”
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A multicenter micro-costing analysis of flexible cystoscopic procedures in Korea by Uiemo Je, Woong Kyu Han, Hee-Kyo Jeong, Hankil Lee, Kwang Suk Lee, Sung Ku Kang, Byeong-Ju Kwon, Sung-Uk Kuh

“…Conclusions: The significant discrepancy between HIRA (Health Insurance Review & Assessment Service)’s estimated costs and those identified here suggests that current fees for cystoscopic procedures may be underestimated and require reassessment. …”
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Non-lytic spread of poliovirus requires the nonstructural protein 3CD by David Aponte-Diaz, Jayden M. Harris, Tongjia Ella Kang, Victoria Korboukh, Mohamad S. Sotoudegan, Jennifer L. Gray, Neela H. Yennawar, Ibrahim M. Moustafa, Andrew Macadam, Craig E. Cameron

“…The studies of PV 3CD protein reported here will hopefully provoke a more deliberate look at the presence and function of LIR motifs in viral proteins of viruses known to use autophagy as the basis for non-lytic spread.IMPORTANCEPoliovirus (PV) and other enteroviruses hijack the cellular secretory autophagy pathway for non-lytic virus transmission. …”
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Controllable synthesis of nonlayered high-κ Mn3O4 single-crystal thin films for 2D electronics by Jiashuai Yuan, Chuanyong Jian, Zhihui Shang, Yu Yao, Bicheng Wang, Yixiang Li, Rutao Wang, Zhipeng Fu, Meng Li, Wenting Hong, Xu He, Qian Cai, Wei Liu

“…However, high dielectric constant (κ) materials, which can be integrated with 2D semiconductors, are still rare. Here, we report a hydrate-assisted thinning chemical vapor deposition (CVD) technique to grow manganese oxide (Mn3O4) single crystal nanosheets, enabled by a strategy to minimize the substrate lattice mismatch and control the growth kinetics. …”
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Liver sinusoidal endothelial cells regulate the balance between hepatic immunosuppression and immunosurveillance by Kimberly N. Kremer, Hadeel A. Khammash, Anjelica M. Miranda, Lauren N. Rutt, Shannon M. Twardy, Paige E. Anton, Margaret L. Campbell, Christian Garza-Ortiz, David J. Orlicky, Roberta Pelanda, Rebecca L. McCullough, Raul M. Torres

“…Repair of liver injury is initiated by interactions between injured hepatocytes and liver sinusoidal endothelial cells (LSEC), however, chronic injury can lead to fibrosis. Here, using a diethylnitrosamine/carbon tetrachloride (DEN/CCl4) mouse model of early HCC development, we demonstrate that chronic liver injury and fibrosis are sufficient to induce a CD8 T cell exhaustion signature with a corresponding increase in expression of immunosuppressive molecules on LSEC. …”
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Mouse ZGRF1 helicase facilitates DNA repair and maintains efficient fertility by Ernest Wee Kiat Lim, Smaragda Kompocholi, André Brannvoll, K. Stine V. Bagge, Jennifer R. Gruhn, Javier Martin-Gonzalez, Eliene Albers, Ian D. Hickson, Andrés López-Contreras, Michael Lisby

“…These attributes point to ZGRF1 as a potential anti-cancer drug target. Here, we investigated the role of ZGRF1 in tumorigenesis using the mouse model. …”
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Comprehensive Evaluation and Error-Component Analysis of Four Satellite-Based Precipitation Estimates against Gauged Rainfall over Mainland China by Guanghua Wei, Haishen Lü, Wade T. Crow, Yonghua Zhu, Jianbin Su, Li Ren

“…To this end, the final run gauge-calibrated IMERG V06 (V06C) and uncalibrated IMERG V06 (V06UC) products are comprehensively evaluated here against 2088 precipitation gauges acquired between March 2014 and June 2018 over China. …”
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3D‐Printed Talus‐Calcaneus Prosthesis in Treating Ewing's Sarcoma: A Case Report by Weiyi Wang, Jingjing An, Minxun Lu, Xuanhong He, Zhuangzhuang Li, Yitian Wang, Taojun Gong, Yong Zhou, Li Min, Yi Luo, Chongqi Tu

“…However, the intricate anatomical structure and unique location of the talus and calcaneus present significant challenges for prosthetic reconstruction. Case Presentation Here, we present the case of an 11‐year‐old adolescent patient diagnosed with Ewing's sarcoma of the talus, accompanied by suspected involvement of the calcaneus. …”
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Dual regulation of the levels and function of Start transcriptional repressors drives G1 arrest in response to cell wall stress by Mihai Spiridon-Bodi, Cristina Ros-Carrero, J. Carlos Igual, Mercè Gomar-Alba

“…Finally, we found that Whi7 protein instability further increased during cell wall stress and that Whi7 degradation triggered advanced cell cycle re-entry. Conclusions Here, we show that cell wall stress signaling specifically enhances Whi7 function as a Start transcriptional repressor. …”
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Systemic delivery of AAV5, AAV8, and AAV9 packaging a C5-12-microdystrophin-FLAG expression cassette in non-human primates by Mengping Liu, Erica Cook, Yanshan Dai, Erich Ehlert, Francois du Plessis, Jacek Lubelski, Bogdan G. Sleczka, Petia Shipkova, Zhuyin Li, Joshua Gamse, David Gordon, Leonard P. Adam, Paul C. Levesque, Glen B. Banks

“…Non-human primates (NHPs) provide a more accurate assessment of the feasibility of achieving an effective and safe dose than rodents. Here, we compared a single systemic administration of AAV5, AAV8, or AAV9 in NHPs, each packaging the C5-12-microdystrophin-FLAG expression cassette. …”
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Long-term nitrogen fertilization alters the partitioning of amino acids between citrus leaves and fruits by Yuanlai Zhao, Huaye Xiong, Yayin Luo, Bin Hu, Jie Wang, Xiaodong Tang, Yuehong Wang, Xiaojun Shi, Xiaojun Shi, Yueqiang Zhang, Yueqiang Zhang, Heinz Rennenberg, Heinz Rennenberg

“…However, information on free amino acid contents in leaves of fruiting and non-fruiting branches during long-term N fertilizer application remains scarce.MethodsHere, a four-year field experiment (2018-2021) in a citrus orchard revealed consistently lower total N and amino acid contents in leaves of fruiting compared to non-fruiting branches.Results and discussionAppropriate N fertilizer application increased free amino acid and total N contents in leaves of both types of branches and fruits, but excessive amounts led to decreases. …”
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TYRO3 blockade enhances anti-PD-1 therapy response by modulating expression of CCN1 in tumor microenvironment by Miso Park, Da-Sol Kuen, Keon Wook Kang, Yeonseok Chung, Jaewoo Park, Munkyung Choi, Yeonji Kim, Eun Chae Roh, Yong June Choi, Yoon Gyoon Kim, Sung Yun Cho

“…Whereas AXL and MERTK have been extensively studied, the role of TYRO3, in the TME, is still undetermined.Methods Here, we screened the TYRO3-focused chemical library consisting of 208 compounds and presented a potent and highly selective TYRO3 inhibitor, KRCT87. …”
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Exosome-mediated delivery of miR-9 induces cancer-associated fibroblast-like properties in human breast fibroblasts by Sara Baroni, S Romero-Cordoba, I Plantamura, M Dugo, E D’Ippolito, A Cataldo, G Cosentino, V Angeloni, A Rossini, M G Daidone, M V Iorio

“…Most microRNA (miRNA) studies focused on tumor cell, but there is increasing evidence of their involvement in reprogramming NFs into CAFs. Here we show that miR-9, upregulated in various breast cancer cell lines and identified as pro-metastatic miRNA, affects the properties of human breast fibroblasts, enhancing the switch to CAF phenotype, thus contributing to tumor growth. …”
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