An Investigation of Manifold-Based Direct Control for a Brain-to-Body Neural Bypass by E. Losanno, M. Badi, E. Roussinova, A. Bogaard, M. Delacombaz, S. Shokur, S. Micera

“…The BBI module decoding motor commands from brain signals should provide the user with intuitive, accurate, and stable control. Here, we present a preliminary investigation in a monkey of a brain decoding strategy based on the direct coupling between the activity of intrinsic neural ensembles and output variables, aiming at achieving ease of learning and long-term robustness. …”
Get full text

Integrated metabolomics and proteomics revealed astragaloside IV inhibiting Pdxk-mediated vitamin B6 metabolism based on liquid chromatography-tandem mass spectrometry combined wit... by Shi Qiu, Sifan Guo, Zhibo Wang, Ying Cai, Dandan Xie, Wanying Sun, Aihua Zhang

“…Astragaloside IV (ASIV) is a representative component of traditional herbs Astragalus membranaceus which belongs to medicinal food homology, but the molecular targets regulating cellular amino acid (AA) metabolism of the therapeutic effect are still unclear. Here, we integrated metabolomics and proteomics approach with pattern recognition to exploring potential targets and AA metabolic characteristics of ASIV on diabetic db/db mouse and Min6 cell lines. …”
Get full text

IDH-mutant gliomas in children and adolescents - from biology to clinical trials by Louise Evans, Sarah Trinder, Sarah Trinder, Andrew Dodgshun, Andrew Dodgshun, David D. Eisenstat, David D. Eisenstat, David D. Eisenstat, James R. Whittle, James R. Whittle, James R. Whittle, Jordan R. Hansford, Jordan R. Hansford, Jordan R. Hansford, Santosh Valvi, Santosh Valvi, Santosh Valvi

“…Those with primary mismatch-repair deficient mIDH astrocytomas (PMMRDIA) have a particularly poor prognosis. Here, we describe the biology of mIDH gliomas and review the literature regarding the emergence of mIDH inhibitors, including clinical trials in adults. …”
Get full text

Pharmacist-led DE-eSCALation of opioids post-surgical dischargE (DESCALE) – A multi-centre, non-randomised, feasibility study protocol [version 2; peer review: 1 approved, 2 approv... by Ellie Santer, Julie H Hedayioglu, Vanessa J Short, Sabina Hulbert, Emma L Veale, Melanie Rees-Roberts, Johanna Theron

“…A declining General Practitioner (GP) workforce and increased patient numbers, however, means gaps in healthcare during transfer of care. Here we report a mixed-methods protocol to understand the feasibility, and acceptability of a clinical pharmacist (CP)-led early opioid deprescribing intervention for discharged surgical patients. …”
Get full text

Generation Victoria (GenV): protocol for a longitudinal birth cohort of Victorian children and their parents by Elizabeth K. Hughes, William Siero, Alisha Gülenç, Susan A. Clifford, Tony Frugier, Simon M. Hall, Jatender Mohal, Kathryn North, Natasha Zaritski, Sharon Goldfeld, Richard Saffery, Melissa Wake

“…and intervention research (what actually works, how much and for whom?). Here, we describe the key features of its protocol. …”
Get full text

The giant genome of lily provides insights into the hybridization of cultivated lilies by Yuwei Liang, Qiang Gao, Fan Li, Yunpeng Du, Jian Wu, Wenqiang Pan, Shaokun Wang, Xiuhai Zhang, Mingfang Zhang, Xiaoming Song, Linlin Zhong, Fan Zhang, Yan Li, Zhiwei Wang, Danqing Li, Qing Duan, Shenchong Li, Chunlian Jin, Peihua Zhang, Yang Gu, Zhong-Hua Chen, Klaus F. X. Mayer, Xiaofan Zhou, Jihua Wang, Liangsheng Zhang

“…The absence of their genomic information has impeded evolutionary studies and genome-based breeding efforts. Here, we present reference genomes for Lilium sargentiae (lily, 35.66 Gb) and Gloriosa superba (flame lily, 5.09 Gb). …”
Get full text

NORDIC denoising on VASO data by Lasse Knudsen, Lasse Knudsen, Luca Vizioli, Federico De Martino, Lonike K. Faes, Daniel A. Handwerker, Steen Moeller, Peter A. Bandettini, Peter A. Bandettini, Laurentius Huber

“…For the data presented here, with a proper set of parameters, NORDIC reduced thermal noise with minimal bias on the underlying signal and preserved spatial resolution. …”
Get full text

Detection of CRISPR‒Cas and type I R–M systems in Klebsiella pneumoniae of human and animal origins and their relationship to antibiotic resistance and virulence by Xue Li, Ling Wang, Jinghuan Lin, Yingjuan Gu, Zhihua Liu, Jing Hu

“…The synergistic and opposed effects of the two systems on virulence and antibiotic-resistance genes need further study.IMPORTANCEK. pneumoniae is an important opportunistic pathogen responsible for both human and animal infections, and the emergence of hypervirulent and multidrug-resistant K. pneumoniae has made it difficult to control this pathogen worldwide. Here, we find that CRISPR‒Cas and restriction–modification systems, which function as adaptive and innate immune systems in bacteria, have synergistic and opposed effects on virulence and antibiotic resistance genes in K. pneumoniae. …”
Get full text

Genomic characterization and radiation tolerance of Naganishia kalamii sp. nov. and Cystobasidium onofrii sp. nov. from Mars 2020 mission assembly facilities by Patrick Leo, Marcus de Melo Texeira, Atul M. Chander, Nitin K. Singh, Anna C. Simpson, Andrey Yurkov, Fathi Karouia, Jason E. Stajich, Christopher E. Mason, Kasthuri Venkateswaran

“…Another yeast strain FKI-L6-BK-PAB1T, isolated from the Kennedy Space Center Payload Hazardous and Servicing Facility, was placed in the genus Cystobasidium (Cystobasidiales, Cystobasidiomycetes) and is distantly related to C. benthicum. Here we propose two novel species with the type strains, Naganishia kalamii sp. nov. …”
Get full text

Targets of influenza human T-cell response are mostly conserved in H5N1 by John Sidney, A-Reum Kim, Rory D. de Vries, Bjoern Peters, Philip S. Meade, Florian Krammer, Alba Grifoni, Alessandro Sette

“…ABSTRACT Frequent recent spillovers of subtype H5N1 clade 2.3.4.4b highly pathogenic avian influenza (HPAI) virus into poultry and mammals, especially dairy cattle, including several human cases, increased concerns over a possible future pandemic. Here, we performed an analysis of epitope data curated in the Immune Epitope Database (IEDB). …”
Get full text

WAC Facilitates Mitophagy‐mediated MSC Osteogenesis and New Bone Formation via Protecting PINK1 from Ubiquitination‐Dependent Degradation by Shuai Fan, Jinteng Li, Guan Zheng, Ziyue Ma, Xiaoshuai Peng, Zhongyu Xie, Wenjie Liu, Wenhui Yu, Jiajie Lin, Zepeng Su, Peitao Xu, Peng Wang, Yanfeng Wu, Huiyong Shen, Guiwen Ye

“…While the WW domain‐containing coiled‐coil adaptor (WAC) protein is primarily associated with transcriptional regulation and autophagy, its involvement in MSC osteogenesis remains unclear. Here, the data reveal that the levels of WAC are diminished in both osteoporosis patients and osteoporosis mouse models. …”
Get full text

Direct calibration using atmospheric particles and performance evaluation of Particle Size Magnifier (PSM) 2.0 for sub-10 nm particle measurements by Y. Liu, Y. Liu, A. Yli-Kujala, F. Schmidt-Ott, S. Holm, L. Ahonen, T. Chan, J. Enroth, J. Vanhanen, R. Cai, T. Petäjä, M. Kulmala, Y. Chen, J. Kangasluoma

“…<p>The Particle Size Magnifier is widely used for measuring nano-sized particles. Here we calibrated the newly developed Particle Size Magnifier version 2.0 (PSM 2.0). …”
Get full text

Biparatopic binding of ISB 1442 to CD38 in trans enables increased cell antibody density and increased avidity by Jeremy Loyau, Thierry Monney, Marco Montefiori, Fedir Bokhovchuk, Jeremy Streuli, Matthew Blackburn, Arnaud Goepfert, Lydia N. Caro, Samitabh Chakraborti, Stefania De Angelis, Camille Grandclément, Stanislas Blein, M. Lamine Mbow, Ankita Srivastava, Mario Perro, Stefano Sammicheli, Eugene A. Zhukovsky, Michael Dyson, Cyrille Dreyfus

“…We previously reported the pharmacology of ISB 1442, designed to reestablish synthetic immunity in CD38+ hematological malignancies. Here, we describe the discovery, optimization and characterization of the ISB 1442 antigen binding fragment (Fab) arms, their assembly to 2 + 1 format, and present the high-resolution co-crystal structures of the two anti-CD38 Fabs, in complex with CD38. …”
Get full text

Attenuation of Myocardial Injury by HMGB1 Blockade during Ischemia/Reperfusion Is Toll-Like Receptor 2-Dependent by Jan Mersmann, Franziska Iskandar, Kathrina Latsch, Katharina Habeck, Vera Sprunck, René Zimmermann, Ralf R. Schumann, Kai Zacharowski, Alexander Koch

“…Plasma levels of HMGB1 were increased MI/R in TLR2−/−-mice after CABG surgery in patients carrying a TLR2 polymorphism (Arg753Gln). We here provide evidence that absence of TLR2 signalling abrogates infarct-sparing effects of HMGB1 blockade.…”
Get full text

FBXO31-mediated ubiquitination of OGT maintains O-GlcNAcylation homeostasis to restrain endometrial malignancy by Na Zhang, Yang Meng, Song Mao, Huiling Ni, Canhua Huang, Licong Shen, Kun Fu, Lu Lv, Chunhong Yu, Piyanat Meekrathok, Chunmei Kuang, Fang Chen, Yu Zhang, Kai Yuan

“…However, clinical characterization of dysregulated O-GlcNAcylation homeostasis in EC and interrogating its molecular mechanism remain incomplete. Here we report that O-GlcNAcylation level is positively correlated with EC histologic grade in a Chinese cohort containing 219 tumors, validated in The Cancer Genome Atlas dataset. …”
Get full text

Observation of ultraviolet photothermoelectric bipolar impulse in gallium-based heterostructure nanowires by Jinjie Zhu, Qing Cai, Pengfei Shao, Shengjie Zhang, Haifan You, Hui Guo, Jin Wang, Junjun Xue, Bin Liu, Hai Lu, Youdou Zheng, Rong Zhang, Dunjun Chen

“…Abstract The incorporation of thermal dynamics alongside conventional optoelectronic principles holds immense promise for advancing technology. Here, we introduce a GaON/GaN heterostructure-nanowire ultraviolet electrochemical cell of observing a photothermoelectric bipolar impulse characteristic. …”
Get full text

An Unusually Short Latent Period of Therapy-Related Myeloid Neoplasm Harboring a Rare MLL-EP300 Rearrangement: Case Report and Literature Review by Reina Takeda, Kazuaki Yokoyama, Seiichiro Kobayashi, Toyotaka Kawamata, Sousuke Nakamura, Tomofusa Fukuyama, Mika Ito, Nozomi Yusa, Eigo Shimizu, Nobuhiro Ohno, Rui Yamaguchi, Seiya Imoto, Satoru Miyano, Kaoru Uchimaru, Arinobu Tojo

“…However, the occurrence of t-MN in adult T-cell leukemia/lymphoma (ATL) patients is rarely reported, possibly due to the dismal prognosis of ATL per se. Here, we report a 62-year-old female who developed t-MN only three months after the completion of conventional chemotherapy and anti-CCR4 antibody for ATL acute type. …”
Get full text

Melatonin induces drought stress tolerance by regulating the physiological mechanisms, antioxidant enzymes, and leaf structural modifications in Rosa centifolia L by Muhammad Ahsan, Adnan Younis, Aftab Jamal, Mohammed O. Alshaharni, Uthman Balgith Algopishi, Abeer Al-Andal, Mateen Sajid, Muhammad Naeem, Jawad Ahmad Khan, Emanuele Radicetti, Mohammad Valipour, Gulzar Akhtar

“…However, its potential mechanisms against drought stress in fragrant roses are not well understood. Here, we aim to investigate the role of melatonin on Rosa centifolia plants cultivated under drought stress (40 % field capacity) and normal irrigation (80 % field capacity). …”
Get full text

Les Jeunes Tunisiens, une contre-expérience de la minoration ? Politisation des langues dans la presse francophone en Tunisie coloniale (1907-1912) by Sarra Zaïed

“…The stakes of bilingualism are captured here through the press. The press in colonial Tunisia developed at the beginning of the 20th century, and periodicals, in Arabic or French, were an essential part of political life. …”
Get full text

Exploring the prognostic significance of lactate-mitochondria-related genes in prostate cancer by Yuan Wang, Ronghui Chen, Feng-Le Jiang, Feng-Le Jiang, Xin Jiang, Xin Jiang, Yuehong Zhou, Yingying Zhou, Xinyi Hong, Chaoying Lin, Wei-Jia Wang, Wei-Jia Wang, Sufang Qiu

“…To identify novel prognostic markers of PCa based on lactate-mitochondria-related genes (LMRGs), RNA sequencing data and clinical information of PCa from The Cancer Genome Atlas (TCGA) and the cBioPortal database were used to construct a lactate-mitochondria-related risk signature. Here, we established a novel nine-LMRG risk signature for PCa, and Kaplan-Meier curves confirmed a worse prognosis for high-risk subgroups in the TCGA dataset. …”
Get full text