The Impact of Online Interactive Platform Services on Oral Health Behaviors in Older Adults With Mild Cognitive Impairment: Protocol for a Randomized Controlled Trial by Yin Q, Chai Z, Tao B, Liu P, Luo Y, Zhao Q, Yang B

“…To address this, we designed an intervention to improve oral health behaviors specifically for elderly individuals with MCI. Here we describe the protocol for a study with the following aims: to enhance oral health behaviors through online education tailored to the cognitive load of older adults and to maintain or delay cognitive decline.Patients and Methods: This randomized, parallel, single-blind controlled trial will evaluate the effectiveness of an oral health behavior intervention based on an online interactive platform (e-COM[OH]) in older adults with MCI. …”
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Characterization of mammary glands and milk fat globule transcripts in lactating buffalo and goats by Hancai Jiang, Xiaoxian Xu, Shuwan Wang, Xinhui Song, Ling Li, Qingyou Liu, Kuiqing Cui, Deshun Shi, Jian Wang, Hui Li, Jieping Huang, Zhipeng Li

“…Milk fat globules may be a non-invasive way to obtain mammary transcripts. Here, we aimed to reveal the universal rule of the transcript profiles of the milk fat globules and mammary glands from buffaloes and goats by RNA-sequencing analysis. …”
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Mind the blind spot: lessons from fungal community sequencing in a plant–soil feedback experiment by Mengshuai Liu, Jose G. Maciá-Vicente, Jasper van Ruijven, Wopke van der Werf, Zhenling Cui, Fusuo Zhang, Chunxu Song, Liesje Mommer

“…Few attempts have yet been made to identify the pathogen species involved in negative PSF. Here, we hypothesize that the strength of negative PSF experienced by a crop species is determined by the relative abundance of host-specific soil-borne pathogenic fungi, that is in turn driven by the crop’s relative abundance (in time). …”
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Design of anti-poisoning catalysts for hydrogen oxidation reaction in next-generation anion exchange membrane fuel cells by Jiho Min, Yunjin Kim, Seunghyun Lee, Keonwoo Ko, Sourabh S. Chougule, Abhishek A. Chavan, Khikmatulla Davletbaev, Beomjun Pak, Hyelim Park, Sung-Dae Yim, Namgee Jung

“…Over the past years, the development of benzene-tolerant catalysts has mainly focused on metal alloy nanoparticles such as PtRu, without pursuing the design of breakthrough catalyst structures that can more effectively reduce benzene poisoning. Here, we introduce an anti-poisoning catalyst structure promoted by the synergistic effect of carbon shell encapsulation and metal alloying. …”
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Neuroinflammation mediates the progression of neonate hypoxia-ischemia brain damage to Alzheimer’s disease: a bioinformatics and experimental study by Shengjie Zhang, Ruqiu Zhang, Zhaoqin Chen, Zihan Shao, An Li, Fan Li, Fang Huang

“…However, the shared pathogenesis of patients affected with both neurological disorders has not been fully elucidated.PurposeWe here aim to identify the shared molecular signatures between nHIBD and AD. …”
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Nanoscale polarization transient gratings by Laura Foglia, Björn Wehinger, Giovanni Perosa, Riccardo Mincigrucci, Enrico Allaria, Francesco Armillotta, Alexander Brynes, Matthew Copus, Riccardo Cucini, Dario De Angelis, Giovanni De Ninno, W. Dieter Engel, Danny Fainozzi, Luca Giannessi, Ezio Iacocca, Nupur N. Khatu, Simone Laterza, Ettore Paltanin, Jacopo Stefano Pelli-Cresi, Giuseppe Penco, Denny Puntel, Primož Rebernik Ribič, Filippo Sottocorona, Mauro Trovò, Clemens von Korff Schmising, Kelvin Yao, Claudio Masciovecchio, Stefano Bonetti, Filippo Bencivenga

“…In particular, in the extreme ultraviolet regime these manipulation capabilities are hampered by the lack of efficient optics, especially for polarization control. Here, we present a method to create periodic, polarization modulations at the nanoscale using a tailored configuration of the FERMI free electron laser and demonstrate its capabilities by comparing the dynamics induced by this polarization transient grating with those driven by a conventional intensity grating on a thin ferrimagnetic alloy. …”
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Drosophila ubiquitin-specific peptidase 14 stabilizes the PERIOD protein by regulating a ubiquitin ligase SLIMB by So Who Kang, Jung-Eun Park, Soonhyuck Ok, Minhui Um, Hyeonjeong Son, Seunghee Byun, Nayoung Park, Su Jin Lee, Thị Xuân Thùy Trần, Gyeongmin Kim, Jeonghun Yeom, Kyunggon Kim, Eun Young Kim, Min-Ji Kang

“…Abstract The circadian clock orchestrates behavior and physiology through the oscillation of key clock proteins like PERIOD (PER). Here, we investigate the role of ubiquitin-specific peptidase 14 (USP14) in modulating PER stability and circadian rhythms in Drosophila. …”
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Assimilating ESA CCI land surface temperature into the ORCHIDEE land surface model: insights from a multi-site study across Europe by L.-E. Olivera-Guerra, C. Ottlé, N. Raoult, P. Peylin

“…We use the land data assimilation system for the ORCHIDEE model (ORCHIDAS) to conduct a series of synthetic twin data assimilation experiments accounting for actual data availability and uncertainty from ESA CCI-LST to find an optimal strategy for assimilating LST. Here, we test different strategies of assimilation, notably investigating (i) two optimization methods (a random search technique and a gradient-based technique) and (ii) different ways to assimilate LST using the only raw data and/or different characteristics of the LST diurnal cycle (e.g. mean daily, daily amplitude, maximum and minimum temperatures, and morning and afternoon gradients). …”
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Oligodendrocyte precursor cells facilitate neuronal lysosome release by Li-Pao Fang, Ching-Hsin Lin, Yasser Medlej, Renping Zhao, Hsin-Fang Chang, Qilin Guo, Zhonghao Wu, Yixun Su, Na Zhao, Davide Gobbo, Amanda Wyatt, Vanessa Wahl, Frederic Fiore, Szu-Min Tu, Ulrich Boehm, Wenhui Huang, Shan Bian, Amit Agarwal, Marcel A. Lauterbach, Chenju Yi, Jianqin Niu, Anja Scheller, Frank Kirchhoff, Xianshu Bai

“…Abstract Oligodendrocyte precursor cells (OPCs) shape brain function through many non-canonical regulatory mechanisms beyond myelination. Here we show that OPCs form contacts with their processes on neuronal somata in a neuronal activity-dependent manner. …”
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Identification of a distal enhancer of Ucp1 essential for thermogenesis and mitochondrial function in brown fat by Duo Su, Tingting Jiang, Yulong Song, Die Li, Siyuan Zhan, Tao Zhong, Jiazhong Guo, Li Li, Hongping Zhang, Linjie Wang

“…However, the molecular mechanisms by which enhancer–promoter chromatin interactions control Ucp1 transcriptional regulation in brown adipose tissue (BAT) are unclear. Here, we employed circularized chromosome conformation capture coupled with next-generation sequencing (4C-seq) to generate high-resolution chromatin interaction profiles of Ucp1 in interscapular brown adipose tissue (iBAT) and epididymal white adipose tissue (eWAT) and revealed marked changes in Ucp1 chromatin interaction between iBAT and eWAT. …”
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Altered functional network topology properties to detect anxiety and depression caused by Crohn’s disease and disease severity by Jiaxing Yang, Kechen Yue, Jingwen Sun, Changjie Pan, Xintong Wu, Yongjun Cheng, Xiaomeng Wu, Haifeng Shi

“…Objective: Here we investigated changes in topological properties of functional brain networks among individuals with Crohn’s disease (CD) and to determine whether these changes are related to CD severity, as well as CD-associated anxiety and depression, which are regulated by the brain–gut axis mechanism. …”
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Association Between Diurnal Temperature Range and Risk of Cardiomyopathy-Induced Hospitalisation in Henan, China: A Time-Series Study by Zhang Z, Wang Y, Zhou Y, Pei J, Zhao G, Dong P, Yang K, Liu H, Xie N, Li X, Zang X, Lin F, Chen Z

“…Additionally, while a robust association has been reported between temperature and cardiomyopathy (CM), evidence of the impact of DTR is relatively limited. Here, we determined whether an association exists between DTR and CM hospitalisations in vulnerable populations.Methods: CM admission data (2016– 2021) were collected from seven tertiary hospitals in Henan.We used a GAM combined with a distributed lag non-linear model (DLNM) to investigate the delayed effects of DTR on daily hospitalisations for CM.Stratified analysis was performed in subgroups according to sex, age, and season. …”
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DDX18 coordinates nucleolus phase separation and nuclear organization to control the pluripotency of human embryonic stem cells by Xianle Shi, Yanjing Li, Hongwei Zhou, Xiukun Hou, Jihong Yang, Vikas Malik, Francesco Faiola, Junjun Ding, Xichen Bao, Miha Modic, Weiyu Zhang, Lingyi Chen, Syed Raza Mahmood, Effie Apostolou, Feng-Chun Yang, Mingjiang Xu, Wei Xie, Xin Huang, Yong Chen, Jianlong Wang

“…Abstract Pluripotent stem cells possess a unique nuclear architecture characterized by a larger nucleus and more open chromatin, which underpins their ability to self-renew and differentiate. Here, we show that the nucleolus-specific RNA helicase DDX18 is essential for maintaining the pluripotency of human embryonic stem cells. …”
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Variation in a single allele drives divergent yield responses to elevated CO2 between rice subspecies by Yunlong Liu, Siyu Zhang, Haoyu Qian, Chengbo Shen, Shuijin Hu, Weijian Zhang, Yong Wang, Shan Huang, Songhan Wang, Zhenghui Liu, Ganghua Li, Xiangdong Fu, Yanfeng Ding, Shan Li, Kees Jan van Groenigen, Yu Jiang

“…The molecular mechanisms driving this difference remain unclear, limiting the potential of future rice yield increases through breeding efforts. Here, we show that between-species variation in the DNR1 (DULL NITROGEN RESPONSE1) allele, a regulator of nitrate-use efficiency in rice plants, explains the divergent response to elevated atmospheric CO2 (eCO2) conditions. eCO2 increased rice yield by 22.8–32.3% in plants carrying or mimicking the indica DNR1 allele, but only by 3.6–11.1% in plants carrying the japonica DNR1 allele. …”
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Importin subunit beta‐1 mediates ERK5 nuclear translocation, and its inhibition synergizes with ERK5 kinase inhibitors in reducing cancer cell proliferation by Zoe Lombardi, Lucia Gardini, Anatolii V. Kashchuk, Alessio Menconi, Matteo Lulli, Ignazia Tusa, Alessandro Tubita, Luisa Maresca, Barbara Stecca, Marco Capitanio, Elisabetta Rovida

“…Despite many processes regulating ERK5 nuclear translocation having been determined, the nuclear transporters involved have not yet been identified. Here, we investigated the role of importin subunit alpha (α importin) and importin subunit beta‐1 (importin β1) in ERK5 nuclear shuttling to identify additional targets for cancer treatment. …”
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Getting the best of carbon bang for mangrove restoration buck by Jingfan Zhang, Zhe Lu, Jinge Zhou, Guoming Qin, Yicheng Bai, Christian J. Sanders, Peter I. Macreadie, Jiacan Yuan, Xingyun Huang, Faming Wang

“…To effectively allocate climate finance for mangrove restoration, a thorough assessment of restoration potential is necessary. Here we show a net loss of ecosystem service value (ESV) of 29.2 billion USD ($) due to land changes in mangroves from 1996 to 2019. …”
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Stimulus-activated ribonuclease targeting chimeras for tumor microenvironment activated cancer therapy by Yuqi Zhang, Jinfeng Zhu, Ling Qiu, Zhengzhong Lv, Zhongsheng Zhao, Xingxiang Ren, Yirui Guo, Yan Chen, Miao Li, Yurong Fan, Zhixin Han, Yiming Feng, Haibin Shi

“…However, potential off-target degradation is a serious issue. Here, a RiboTAC is designed for tumor microenvironment triggered activation. …”
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Development and Validation of a Novel Classification System and Prognostic Model for Open Traumatic Brain Injury: A Multicenter Retrospective Study by Yuhui Chen, Li Chen, Liang Xian, Haibing Liu, Jiaxing Wang, Shaohuai Xia, Liangfeng Wei, Xuewei Xia, Shousen Wang

“…Conclusions The implementation of our proposed OTBI classification system and its use alongside the other prognostic factors identified here may improve the prediction of patient prognosis and aid in the selection of the most suitable treatment strategies.…”
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Development of <i>Aspergillus oryzae</i> BCC7051 as a Robust Cell Factory Towards the Transcriptional Regulation of Protease-Encoding Genes for Industrial Applications by Sarocha Panchanawaporn, Chanikul Chutrakul, Sukanya Jeennor, Jutamas Anantayanon, Kobkul Laoteng

“…Enzyme-mediated protein degradation is a major concern in industrial fungal strain improvement, making low-proteolytic strains preferable for enhanced protein production. Here, we improved food-grade <i>Aspergillus oryzae</i> BCC7051 by manipulating the transcriptional regulation of protease-encoding genes. …”
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Vinblastine resets tumor-associated macrophages toward M1 phenotype and promotes antitumor immune response by Jing Wang, Jin Wang, Yi-Na Wang, Yuan-Yuan Wang, Wen-Juan Bai, Nai-Jun Miao

“…RNA-seq of TAM of treated and untreated with VBL was performed to explore the changes in pathway activities. siRNA mediated knockdown experiments were performed to verify the target pathway that was affected by VBL treatment.Results Here, we showed that VBL, an antineoplastic agent that destabilizes microtubule, drove macrophage polarization into the M1-like phenotype both in vitro and in tumor models. …”
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