Genetic Analysis of Undiagnosed Juvenile GM1-Gangliosidosis by Microarray and Exome Sequencing by Ahmed Bouhouche, Houyam Tibar, Yamna Kriouale, Mohammed Jiddane, Imane Smaili, Naima Bouslam, Ali Benomar, Mohamed Yahyaoui, Elmostafa El Fahime

“…Recently, whole exome sequencing (WES) has become increasingly used when a strong hypothesis cannot be formulated based on the clinical phenotype. Here, we present three patients belonging to a consanguineous Moroccan family with a GM1-gangliosidosis with unusual clinical onset and atypical radiological presentation that had eluded diagnosis for over a decade. …”
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Dynamics of spatial phase coherence in a dissipative Bose–Hubbard atomic system by Vatré, Rémy, Bouganne, Raphaël, Bosch Aguilera, Manel, Ghermaoui, Alexis, Beugnon, Jérôme, Lopes, Raphael, Gerbier, Fabrice

“…Equivalently, the spatial correlation function (the Fourier-conjugate quantity of the momentum distribution) progressively narrows down as more photons are scattered. Here we measure the correlation function of the matter field for fixed distances corresponding to nearest-neighbor (n-n) and next-nearest-neighbor (n-n-n) sites of the optical lattice as a function of time, hereafter called n-n and n-n-n correlators. …”
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VOWEL FORMANT VARIABILITY IN THE SPEECH OF PATIENTS WITH DEMENTIA: A PRELIMINARY ANALYSIS by Gloria Gagliardi, Chiara Meluzzi

“…For this reason, we present here a preliminary investigation on 2 Italian-speaking patients diagnosed with dementia compared with control speakers balanced for all sociolinguistic parameters. …”
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Comparative evaluation of cell-based assay technologies for scoring drug-induced condensation of SARS-CoV-2 nucleocapsid protein by Rui Tong Quek, Cyna R. Shirazinejad, Christina L. Young, Kierra S. Hardy, Samuel Lim, Phillip J. Elms, David T. McSwiggen, Timothy J. Mitchison, Pamela A. Silver

“…These approaches lack information on protein dynamics, are limited by microscope resolution, and are insensitive to subtle condensation phenotypes missed by overfit analysis pipelines. Here, we evaluate two alternative cell-based assays: high-throughput single molecule tracking (htSMT) and proximity-based condensate biosensors using NanoBIT (split luciferase) and NanoBRET (bioluminescence resonance energy transfer) technologies. …”
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Identification of fatty acid anabolism patterns to predict prognosis and immunotherapy response in gastric cancer by Weijie Sun, Yanhong Xia, Feifan Jin, Jinghao Cao, Gaoping Wu, Keyi Li, Yanhua Yu, Yunyi Wu, Gaoqi Ye, Ke Xu, Dengpan Liu, Weidong Jin

“…However, the correlation between fatty acid metabolism and the development and progression of GC remains largely unknown. Here, we profiled the genetic alterations of fatty acid anabolism-related genes (FARGs) in gastric cancer samples from the TCGA cohort and GEO database to evaluate the possible relationships and their internal regulatory mechanism. …”
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Non-invasive 4D transcranial functional ultrasound and ultrasound localization microscopy for multimodal imaging of neurovascular response by Rebecca M. Jones, Ryan M. DeRuiter, Hanjoo R. Lee, Saachi Munot, Hatim Belgharbi, Francisco Santibanez, Oleg V. Favorov, Paul A. Dayton, Gianmarco F. Pinton

“…These two methods have complementary spatio-temporal characteristics, making them ideally suited for multimodal imaging, but both suffer from limitations associated with transcranial ultrasound imaging. Here, these two methods are combined on the same data acquisition, completely non-invasively, using contrast-enhancements, which solves the dual challenges of sensitivity during transcranial imaging and the ability to implement super-resolution. …”
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Differential transport pathways of saturated and unsaturated fatty acid esters in male mouse hepatocytes by Fengwu Chen, Aizhen Yang, Yue Lu, Yuxin Zhang, Jingyu Zhang, Jianan Bu, Runlin Guo, Yue Han, Depei Wu, Yi Wu

“…Whether SFA and UFA are differentially transported in liver remains elusive. Here, we find the secretion of UFA but not SFA esters is retarded in a male mouse hepatic endoplasmic reticulum (ER) stress model. …”
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Green tea silver nanoparticles improve physiological motor and cognitive function in BALB/c mice during inflammation by Herbert Izo, Ninsiima, Ejike, Daniel Eze, Kenneth, Ssekatawa, Halima, Nalugo, Caroline, Asekenye, David, Onanyang, Edson Ireeta, Munanura, Moses, Ariong, Kevin, Matama, Gerald, Zirintunda, Ngala Elvis, Mbiydzenyuy, Fred, Ssempijja, Adam Moyosore, Afodun, Ibe Michael, Usman, Oscar Hilary, Asiimwe, Julius, Tibyangye, Keneth Iceland, Kasozi

“…Hypersensitivity was measured through the temperature sensation experiment and a non-linear regression analysis was done. Here, synthesized green tea AgNPs registered anabsorbance band at 460 nm, phytochemicals due to presence of organic functional groups of O––C––O of oxycarbons, of C––C of a conjugate alkene, C––O of a stretching bond of a secondary alcohol. …”
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Le fromage en Gaule à l’âge du Fer et à l’époque romaine : état des lieux pour sa production et analyse de sa place dans le monde antique by Alain Ferdière, Jean-Marc Séguier

“…However, the study of this production is difficult to document using only the material data provided by archaeology: this is why the subject remains largely unstudied. The aim here is therefore to study, in as much detail as possible, the subject of cheese for the whole of pre-Roman and Roman Gaul –beyond the territory of present-day France– taking into account the various geographical areas for which almost only archaeological documentation is available. …”
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Le réseau hydraulique à Pompéi (Italie) de l’époque des Samnites à Auguste (fin ive-fin ier s. av. J.-C.) by Federico Giletti

“…This study pursues this line of research, re-examining its phases and proposals through a wide-ranging analysis of the issues tackled, but above all by proposing a new and systematic approach to the subject, from which it has been possible to take stock of some elements and to verify or arrive at new conclusions on others.While the bibliography concerning certain aspects of Pompeii’s water management is rich, dedicated and in some cases quite comprehensive, regarding which this research has demonstrated the limits of a generic approach absent excavation work, on other topics by contrast the study presented here provided an opportunity for the first time to deepen our knowledge of issues and artefacts and the possibility of bringing together the various topics.With regard to the water supply to the Archaic and Hellenistic city, therefore, it was possible to identify an integrated system of supply to the entire urban space, consisting of catchment wells and cisterns for recovering rainwater from the roofs. …”
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Presenting the model of social entrepreneurship in the development of rural tourism in the target villages of Gilan province by Fatemeh Doozandeh Ziabari, hamed fallah tafti, Mir Mohammad Asadi, Mahdi Basouli

“…Social entrepreneurship in tourism, referred to here as tourism social entrepreneurship, is positioned as a market-oriented approach to address various social problems through tourism entrepreneurship.Extended Abstract                                           IntroductionTourism entrepreneurship is a popular research topic due to its ability to combine different topics such as technological innovation, economic geography, and cultural change. …”
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Single cell RNA sequencing reveals human tooth type identity and guides in vitro hiPSC derived odontoblast differentiation (iOB) by Sesha Hanson-Drury, Sesha Hanson-Drury, Sesha Hanson-Drury, Anjali P. Patni, Anjali P. Patni, Anjali P. Patni, Anjali P. Patni, Deborah L. Lee, Deborah L. Lee, Deborah L. Lee, Ammar Alghadeer, Ammar Alghadeer, Ammar Alghadeer, Ammar Alghadeer, Yan Ting Zhao, Yan Ting Zhao, Yan Ting Zhao, Devon Duron Ehnes, Devon Duron Ehnes, Devon Duron Ehnes, Vivian N. Vo, Vivian N. Vo, Vivian N. Vo, Sydney Y. Kim, Sydney Y. Kim, Druthi Jithendra, Druthi Jithendra, Ashish Phal, Ashish Phal, Ashish Phal, Natasha I. Edman, Natasha I. Edman, Natasha I. Edman, Natasha I. Edman, Thomas Schlichthaerle, Thomas Schlichthaerle, David Baker, David Baker, David Baker, Jessica E. Young, Jessica E. Young, Julie Mathieu, Julie Mathieu, Hannele Ruohola-Baker, Hannele Ruohola-Baker, Hannele Ruohola-Baker, Hannele Ruohola-Baker, Hannele Ruohola-Baker

“…To bioengineer missing dentin, increased understanding of human tooth development is required. Here we interrogate at the single cell level the signaling interactions that guide human odontoblast and ameloblast development and which determine incisor or molar tooth germ type identity. …”
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A mechanistic-statistical approach to infer dispersal and demography from invasion dynamics, applied to a plant pathogen by Saubin, Méline, Coville, Jérome, Xhaard, Constance, Frey, Pascal, Soubeyrand, Samuel, Halkett, Fabien, Fabre, Frédéric

“…However, accurately inferring LDD is challenging as it requires both large-scale data and a methodology that encompasses the redistribution of individuals in time and space. Here, we propose a mechanistic-statistical framework to estimate dispersal from one-dimensional invasions. …”
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Repeated positron emission tomography tracing neutrophil elastase in a porcine intensive-care sepsis model by Frida Wilske, Olof Eriksson, Rose-Marie Amini, Sergio Estrada, Helena Janols, Amina Khalil, Anders Larsson, Miklós Lipcsey, Sara Mangsbo, Jonathan Sigfridsson, Jan Sjölin, Paul Skorup, Anders Wall, Viola Wilson, Markus Castegren, Gunnar Antoni

“…Conclusion The neutrophil elastase PET-tracer [11C]NES is a novel and unique instrument to study the acute innate neutrophil immune response in sepsis and associated vital organ failure. We here present images and quantitative data of the neutrophil elastase distribution the first hours of acute experimental sepsis. …”
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Deterrent Effects of Clary Sage Oil and Two Major Constituents against <em>Drosophila suzukii</em> (Diptera: Drosophilidae) by Yu Wang, Fengyi Wen, Xiangyi Zhou, Guoxing Chen, Chunxia Tian, Jiali Qian, Huiming Wu, Mengli Chen

“…Clary sage oil repels a variety of agricultural and household pests; however, whether it has a repellent effect against <i>D. suzukii</i> remains unknown. Here, we found that clary sage oil exhibited dose-dependent repellency against <i>D. suzukii</i> adults in a T-maze assay, a two-choice assay and a two-choice attraction assay. …”
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Identification of Potential Vectors and Detection of Rift Valley Fever Virus in Mosquitoes Collected Before and During the 2022 Outbreak in Rwanda by Isidore Nsengimana, Emmanuel Hakizimana, Jackie Mupfasoni, Jean Nepomuscene Hakizimana, Augustino A. Chengula, Christopher J. Kasanga, Gillian Eastwood

“…Information on vector species with a role in RVFV eco-epidemiology in Rwanda is scarce. Here we sought to identify potential mosquito vectors of RVFV in Rwanda, their distribution and abundance, as well as their infection status. …”
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Two rice cultivars recruit different rhizospheric bacteria to promote aboveground regrowth after mechanical defoliation by Changjin Jiang, Fei Wang, Jinling Tian, Wanyuan Zhang, Kabin Xie

“…However, it is unclear whether and how defoliated plants exploit beneficial microbiota from the soil to promote aboveground regrowth. Here, we compared the defoliation-triggered changes in the root exudation and bacterial microbiome of two rice cultivars (Oryza sativa L ssp.), indica/xian cultivar Minghui63 and japonica/geng cultivar Nipponbare. …”
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Neuroprotection by chronic administration of Fluoroethylnormemantine (FENM) in mouse models of Alzheimer's disease by Allison Carles, Aline Freyssin, Sarra Guehairia, Thomas Reguero, Michel Vignes, Hélène Hirbec, Gilles Rubinstenn, Tangui Maurice

“…Abstract Background Fluoroethylnormemantine (FENM), a new Memantine (MEM) derivative, prevented amyloid-β[25–35] peptide (Aβ25–35)-induced neurotoxicity in mice, a pharmacological model of Alzheimer's disease (AD) with high predictive value for drug discovery. Here, as drug infusion is likely to better reflect drug bioavailability due to the interspecies pharmacokinetics variation, we analyzed the efficacy of FENM after chronic subcutaneous (SC) infusion, in comparison with IP injections in two AD mouse models, Aβ25–35-injected mice and the transgenic APPswe/PSEN1∂E9 (APP/PS1) line. …”
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Molecular detection of parasites and host preference in wild-caught Culicoides biting midges (Diptera: Ceratopogonidae) in Chiang Mai and Nakhon Si Thammarat Provinces, Thailand by Kyi Soe Baby, Kaewmee Saowalak, Mano Chonlada, Pattanawong Urassaya, Tipparawong Nopporn, Siriyasatien Padet, Gatherer Derek, Urbaniak Michael D., Bates Paul A., Jariyapan Narissara

“…Information about host-vector-parasite specificity is required to confirm their status. Here, molecular detection of haemosporidians, Leishmania, trypanosomatids, and filarial nematodes in biting midges was conducted to understand their potential role as vectors, and their host preference was determined. …”
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Indoor and Ambient Air Pollution in Chennai, India during COVID-19 Lockdown: An Affordable Sensors Study by Naveen Puttaswamy, V. Sreekanth, Ajay Pillarisetti, Adithi R. Upadhya, Sudhakar Saidam, Balachandar Veerappan, Krishnendu Mukhopadhyay, Sankar Sambandam, Ronak Sutaria, Kalpana Balakrishnan

“…Due to COVID-19 related lockdowns, some TAPHE-2 activities were delayed; however, continuous indoor and outdoor air quality data were collected in and around Chennai, India. We report here the impact of graded COVID-19 lockdown on indoor particulate matter (PM2.5 and PM10) levels based on calibrated data from affordable real-time PM sensors called atmos™ and ambient PM levels from publicly available regulatory monitors. …”
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