Analytical performance of OncoPrism-HNSCC, an RNA-based assay to inform immune checkpoint inhibitor treatment decisions for recurrent/metastatic head and neck squamous cell carcino... by Jeffrey Hiken, Jon Earls, Kevin C. Flanagan, Rachel L. Wellinghoff, Michelle Ponder, David N. Messina, Jarret I. Glasscock, Eric J. Duncavage

“…The clinical performance of OncoPrism-HNSCC has been validated. Here, we report its analytical performance in the presence of potentially confounding sources of variation. …”
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Hepatobiliary organoid research: the progress and applications by Rui-Qi Zou, Rui-Qi Zou, Yu-Shi Dai, Yu-Shi Dai, Fei Liu, Fei Liu, Si-Qi Yang, Si-Qi Yang, Hai-Jie Hu, Hai-Jie Hu, Fu-Yu Li, Fu-Yu Li

“…Consequently, it is widely used in basic and clinical studies, becoming important preclinical models for studying diseases and developing therapies. Here, we introduced the definition and advantages of organoids and described the development and advances in hepatobiliary organoids research. …”
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Five decades of Abramov glacier dynamics reconstructed with multi-sensor optical remote sensing by E. Mattea, E. Berthier, A. Dehecq, T. Bolch, T. Bolch, A. Bhattacharya, A. Bhattacharya, S. Ghuffar, M. Barandun, M. Hoelzle

“…This hampers interpretation of the driving factors of glacier change, their interaction with mass balance, and regional representativity of single glaciers. Here, we reconstruct ice dynamics at the reference Abramov glacier using satellite-based optical remote sensing. …”
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High‐Throughput Single‐Nucleus RNA Profiling of Minimal Puncture FFPE Samples Reveals Spatiotemporal Heterogeneity of Cancer by Weiqin Jiang, Xiang Zhang, Ziye Xu, Qing Cheng, Xiaohan Li, Yuyi Zhu, Fangru Lu, Ling Dong, Linghui Zeng, Weixiang Zhong, Yongcheng Wang, Longjiang Fan, Hongyu Chen

“…Diverse single‐nucleus RNA sequencing (snRNA‐seq) techniques have been developed for FFPE samples, however, how to perform high‐throughput snRNA‐seq on small FFPE puncture samples is still a challenge. Here, the previously developed snRNA‐seq technique (snRandom‐seq) is optimized by implementing a pre‐indexing procedure for the minimal puncture FFPE samples. …”
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Observed upper-ocean structure and seasonal production in the southern Kerguelen Plateau region, 1994-2021 by Man Liang, Annie Foppert, Annie Foppert, Karen J. Westwood, Karen J. Westwood, Sophie Bestley, Sophie Bestley

“…In the Indian sector of the Southern Ocean, 80°E marks an important transition in ocean circulation between the greater Prydz Bay gyre to the west and the Australian Antarctic gyre to the east. Here, the submarine Kerguelen Plateau impedes the eastward flow of the Antarctic Circumpolar Current (ACC), topographically steering the flow. …”
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Estimation of radiation doses of population residing nearby area of uranium ore mining and processing in Kazakhstan by tooth enamel EPR spectroscopy by Kassym Zhumadilov, Alexander Ivannikov, Murat Kassymzhanov, Assel Bagramova, Issa Zhantore, Sarsenova Samal, Valeriy Stepanenko, Artem Khailov, Masaharu Hoshi

“…Accumulated radiation EPR doses in enamel were assessed for 96 teeth samples.From the measured values of EPR doses and the age of tooth enamel since its formation, the individual annual EPR dose rates (DR) were determined with average value of 1.75 ± 0.46 mGy/year corresponding to the hourly DR of 0.20 ± 0.05 µGy/hour (here and below after ± sign the error of the mean is shown). …”
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The international multi-system OSEs/OSSEs by the UN Ocean Decade Project SynObs and its early results by Yosuke Fujii, Yosuke Fujii, Elisabeth Remy, Magdalena Alonso Balmaseda, Shoichiro Kido, Jennifer Waters, K. Andrew Peterson, Gregory C. Smith, Ichiro Ishikawa, Kamel Chikhar

“…SynObs plans to use the results of the flagship OSEs to contribute to the reports on the ocean observing network design made by international organizations and projects. Here, we introduce this initiative, and we report on some initial results. …”
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Homo erectus adapted to steppe-desert climate extremes one million years ago by Julio Mercader, Pamela Akuku, Nicole Boivin, Alfredo Camacho, Tristan Carter, Siobhán Clarke, Arturo Cueva Temprana, Julien Favreau, Jennifer Galloway, Raquel Hernando, Haiping Huang, Stephen Hubbard, Jed O. Kaplan, Steve Larter, Stephen Magohe, Abdallah Mohamed, Aloyce Mwambwiga, Ayoola Oladele, Michael Petraglia, Patrick Roberts, Palmira Saladié, Abel Shikoni, Renzo Silva, María Soto, Dominica Stricklin, Degsew Z. Mekonnen, Wenran Zhao, Paul Durkin

“…Abstract Questions about when early members of the genus Homo adapted to extreme environments like deserts and rainforests have traditionally focused on Homo sapiens. Here, we present multidisciplinary evidence from Engaji Nanyori in Tanzania’s Oldupai Gorge, revealing that Homo erectus thrived in hyperarid landscapes one million years ago. …”
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Uptake kinetics and distribution of flupyrimin by rice (Oryza sativa L.): Effects of subcellular fractionation and soil factors by Xugen Shi, Min Wang, Zhenyu Jiang, Ruqiang Cui, Baotong Li, Xianpeng Zhang, Lianhu Zhang, Duantao Cao

“…Elucidating the absorption and distribution properties of flupyrimin in rice will help assess the potential risks of human exposure to flupyrimin via the food chain. Here, we studied the uptake kinetics and transport mechanisms of flupyrimin in rice plants grown under hydroponic and soil conditions. …”
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Liposomal Formulation of Hydroxychloroquine Can Inhibit Autophagy In Vivo by Wieslawa H. Dragowska, Jagbir Singh, Mohamed Wehbe, Malathi Anantha, Katarina Edwards, Sharon M. Gorski, Marcel B. Bally, Ada W. Y. Leung

“…Previously, we found that free HCQ in combination with gefitinib (Iressa^®, ZD1839) significantly reduced tumor volume in immunocompromised mice bearing gefitinib-resistant JIMT-1 breast cancer xenografts. Here, we sought to evaluate whether a liposomal formulation of HCQ could effectively modulate autophagy in vivo and augment treatment outcomes in the same tumor model. …”
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TEAD1‐Mediated Trans‐Differentiation of Vascular Smooth Muscle Cells into Fibroblast‐Like Cells Contributes to the Stabilization and Repair of Disrupted Atherosclerotic Plaques... by Ming Zhai, Zhijun Lei, Yefei Shi, Jiayun Shi, Yanxi Zeng, Shiyu Gong, Weixia Jian, Jianhui Zhuang, Qing Yu, Mark W. Feinberg, Wenhui Peng

“…Central to this process is the modulation of vascular smooth muscle cells (VSMCs) phenotypes, emphasizing their pivotal role in atherosclerotic plaque stability and healing post‐disruption. Here, an expansion of FSP1+ cells in a tandem stenosis (TS) model of atherosclerotic mice is unveiled, predominantly originating from VSMCs through single‐cell RNA sequencing (scRNA‐seq) analyses and VSMC lineage tracing studies. …”
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Pyrrocidines A and B demonstrate synergistic inhibition of Fusarium verticillioides growth by Lily W. Lofton, Lily W. Lofton, Quentin D. Read, Hailey L. Hamilton, Anthony E. Glenn, Jaci A. Hawkins, Trevor R. Mitchell, Scott E. Gold

“…Deletion of FvZBD1 resulted in dramatic increases in fumonisin production (FB1 >30-fold). Here, using pyrrocidine dose-response assays, we discovered a potent synergy between pyrrocidines A and B, where they functioned powerfully together to inhibit F. verticillioides growth. …”
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Bi-targeting of thioredoxin 1 and telomerase by thiotert promotes cell death of myelodysplastic syndromes and lymphoma by Qiangan Jing, Yunyi Wu, Yanchun Li, Chaoting Zhou, Junyu Zhang, Jun Xia, Keyi Li, Yuhuan Shen, Hongfeng Yao, Xiangmin Tong, Jing Du, Lushan Yu, Ying Wang

“…Abstract Thioredoxin1 (TRX1) and telomerase are both attractive oncology targets that are tightly implicated in tumor initiation and development. Here, we reported that the 6-dithio-2-deoxyguanosine analog thiotert exhibits an effective cytotoxic effect on myelodysplastic syndromes (MDS) cell SKM-1 and lymphoma cell U-937. …”
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Evaluation of a biomarker for amyotrophic lateral sclerosis derived from a hypomethylated DNA signature of human motor neurons by Calum Harvey, Alicja Nowak, Sai Zhang, Tobias Moll, Annika K Weimer, Aina Mogas Barcons, Cleide Dos Santos Souza, Laura Ferraiuolo, Kevin Kenna, Noah Zaitlen, Christa Caggiano, Pamela J Shaw, Michael P Snyder, Jonathan Mill, Eilis Hannon, Johnathan Cooper-Knock

“…As others have highlighted, this offers an opportunity to develop a sensitive and specific biomarker based on detection of DNA released from dying MN within accessible biofluids. Here we have performed whole genome bisulfite sequencing (WGBS) of iPSC-derived MN from neurologically normal individuals. …”
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Transcriptome and DNA methylation profiling during the NSN to SN transition in mouse oocytes by Hannah Demond, Soumen Khan, Juan Castillo-Fernandez, Courtney W. Hanna, Gavin Kelsey

“…Although the NSN-SN transition is known to be essential for developmental competence of the oocyte, less is known about the accompanying molecular changes. Here we examine the changes in the transcriptome and DNA methylation during the NSN to SN transition in mouse oocytes. …”
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Biological and psychosocial factors associated with the persistence of pruritus symptoms: protocol for a prospective, exploratory observational study in Germany (individual project... by Sonja Ständer, Stefan W Schneider, Gudrun Schneider, Stefan Kahnert, Manuel Pedro Pereira, Christian Mess, Volker Huck, Konstantin Agelopoulos, Gina Frank

“…It probably involves interactions between biological and psychosocial factors and pruritus-specific risk factors as well as mechanisms shared with other persistent somatic symptoms addressed in other projects of the SOMACROSS Research Unit (RU). Here we aim to identify psychosocial and biological factors and their interactions which might be associated with the persistence of CP with and without immunologic/inflammatory origin, that is, atopic dermatitis and pruritus on non-inflamed skin. …”
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Measurement error in remotely sensed fractional snow cover datasets: implications for ecological research by Rowan Jacques-Hamilton, Mihai Valcu, Eunbi Kwon, Tom S L Versluijs, Bart Kempenaers

“…However, researchers should be aware of the possible error and bias in such datasets. Here, we quantify measurement error in commonly used data on snow cover, and demonstrate how biases have the potential to alter conclusions of ecological studies. …”
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P-block element modulated 1 T phase MoS2 with Ru lattice grafting for high-performance Li | |O2 batteries by Peng Wang, Danyang Zhao, Peng Zhang, Xiaobin Hui, Zhiwei Zhang, Rutao Wang, Chengxiang Wang, Xiaoli Ge, Xiaojing Liu, Yuguang C. Li, Longwei Yin

“…To circumvent these issues, here we propose a p-block element (In-O) doping strategy to stabilize the 1 T phase MoS2 by moderating the surface orbital steric effect and strengthening the internal chemical bonding, and thus for the epitaxial Ru nanocatalyst graft on the stabilized 1T-MoS2 for Li | |O2 batteries. …”
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A Chinese drug-compatibility-based approach to purslane hydrogels for acute eczema therapy by Ling Wang, Yuzhong Zhang, Shenglin Geng, Lan Ma, Yiran Wang, Dongxu Han, Guojuan Fan, Weifen Zhang, Weifen Zhang, Weifen Zhang, Yanna Lv, Jinlong Ma, Jinlong Ma, Jinlong Ma

“…However, most of the clinical applications of purslane are freshly prepared decoction, not as easy to apply as cream, because the decoction is easy to breed bacteria and easy to oxidize. Here, based on the theory of Chinese medicines compatibility, we made a purslane-tannic acid hydrogel (PL-HATA) by simple methods under mild conditions to solve the drawbacks of easy oxidation and inconvenience of use of Purslane. …”
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The chromatin remodeling factor OsINO80 promotes H3K27me3 and H3K9me2 deposition and maintains TE silencing in rice by Kangxi Du, Jiabing Wu, Jiachen Wang, Wenhao Xie, Liufan Yin, Xiang Li, Chao Li, Aiwu Dong

“…Moreover, whether INO80 helps regulate heterochromatin remains unknown. Here, we characterize the regulatory effects of OsINO80 on protein-coding genes and transposable elements (TEs) in rice. …”
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