Three-dimensional electrical structure in the northwestern sector of the Sichuan-Yunnan diamond block by Yunyun Zhang, Yunyun Zhang, Yunyun Zhang, Xiaobin Chen, Xiaobin Chen, Peijie Wang, Juntao Cai, Juntao Cai, Zhongyin Liu, Zhongyin Liu, Jiong Zhang, Jiong Zhang, Xingxing Huang, Xingxing Huang

“…Thus, our study suggests that the northwest boundary of the Sichuan-Yunnan diamond block, contrary to previous studies that considered it a transitional boundary, is located at the Dedeng-Batang-Riyu fault. Here, the boundary is a high-resistivity barrier, electrically isolating the Qiangtang block in the southwest from the Sichuan-Yunnan block in the northeast. …”
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Function over form: The benefits of aspen as surrogate brood‐rearing habitat for greater sage‐grouse by Michel T. Kohl, Charles P. Sandford, Paul C. Rogers, Renee Chi, Terry A. Messmer, David K. Dahlgren

“…In doing so, practitioners may overlook alternative vegetation communities that could maintain wildlife populations under alternative conditions (e.g., climate change). Here, we term these areas surrogate habitat, defined as vegetation communities or resource sites that provide similar critical resources as conventional sites, and assess their potential for conservation using a case study of greater sage‐grouse (Centrocercus urophasianus) on Parker Mountain, Utah (1998–2009). …”
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Direct observation of chiral edge current at zero magnetic field in a magnetic topological insulator by Jinjiang Zhu, Yang Feng, Xiaodong Zhou, Yongchao Wang, Hongxu Yao, Zichen Lian, Weiyan Lin, Qiushi He, Yishi Lin, Youfang Wang, Yongqian Wang, Shuai Yang, Hao Li, Yang Wu, Chang Liu, Jing Wang, Jian Shen, Jinsong Zhang, Yayu Wang, Yihua Wang

“…The van der Waals antiferromagnet MnBi2Te4 is theorized to be a QAH in odd-layers but has shown Hall resistivity below the quantization value at zero magnetic field. Here, we perform scanning superconducting quantum interference device (sSQUID) microscopy on these seemingly failed QAH insulators to image their current distribution. …”
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Ontologies in modelling and analysing of big genetic data by N. L. Podkolodnyy, O. A. Podkolodnaya, V. A. Ivanisenko, M. A. Marchenko

“…An approach to building large ontologies using design patterns is discussed, using the ontology of biological attributes (OBA) as an example. Here, most of the classification is automatically computed based on previously created reference ontologies using automated inference, except for a small number of high-level concepts. …”
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RNA m6A-mediated post-transcriptional repression of glucocorticoid receptor in LPS-activated Kupffer cells on broilers by Yulan Zhao, Yidan Jiang, Yue Feng, Ruqian Zhao

“…RNA m6A methylation participates in various metabolic and inflammatory responses, yet it remains elusive whether m6A is involved in GR regulation during immune activation. Here, we observed uncoupled GR responses with increased mRNA yet suppressed protein levels in the LPS-challenged broilers chicken liver, in association with global elevation of RNA m6A methylation, especially in the expression of METTL3 and YTHDF2. …”
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GRK6 palmitoylation dictates triple-negative breast cancer metastasis via recruiting the β-Arrestin 2/MAPKs/NF-κB signaling axis by Wen-Ke Wang, Hui-Yu Lin, Che-Hsuan Lin, Hsun-Hua Lee, Yen-Lin Chen, Yu-Hsien Kent Lin, Hui-Wen Chiu, Shry-Ming Sheen-Chen, Yuan-Feng Lin

“…Western blotting was employed to examine protein phosphorylation, translocation and expression in the designed experiments. Results Here we show that GRK6 upregulation is extensively detected in TNBC compared to normal mammary tissues and other BC subtypes and correlates with an increased risk for distant metastasis in TNBC patients. …”
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Ferroptosis: A novel cell death modality as a synergistic therapeutic strategy with photodynamic therapy by Yuqing Wang, Yiting Xu, Yong Qu, Yifang Jin, Juanmei Cao, Jinshan Zhan, Zhuoxia Li, Chuxing Chai, Changzheng Huang, Min Li

“…Recent research has revealed a close association between PDT and ferroptosis, suggesting that combining ferroptosis inducers with PDT could strengthen their synergistic anti-tumor efficiency. Here in this review, we discuss the rationale for combining PDT with ferroptosis inducers and highlight the progress of single-molecule photosensitizers to induce ferroptosis, as well as the applications of photosensitizers combined with other therapeutic drugs for collaborative therapy. …”
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Curcumin Alters Neural Plasticity and Viability of Intact Hippocampal Circuits and Attenuates Behavioral Despair and COX-2 Expression in Chronically Stressed Rats by Ga-Young Choi, Hyun-Bum Kim, Eun-Sang Hwang, Seok Lee, Min-Ji Kim, Ji-Young Choi, Sung-Ok Lee, Sang-Seong Kim, Ji-Ho Park

“…It has been known for the anti-inflammatory, antistress, and neurotropic effects. Here we examined curcumin effect in neural plasticity and cell viability. 60-channel multielectrode array was applied on organotypic hippocampal slice cultures (OHSCs) to monitor the effect of 10 μM curcumin in long-term depression (LTD) through low-frequency stimulation (LFS) to the Schaffer collaterals and commissural pathways. …”
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Spatially mapping the tumour immune microenvironments of non-small cell lung cancer by Lysanne Desharnais, Mark Sorin, Morteza Rezanejad, Bridget Liu, Elham Karimi, Aline Atallah, Anikka M. Swaby, Miranda W. Yu, Samuel Doré, Saskia Hartner, Benoit Fiset, Yuhong Wei, Baharak Kadang, Roni Rayes, Philippe Joubert, Sophie Camilleri-Broët, Pierre-Olivier Fiset, Daniela F. Quail, Jonathan D. Spicer, Logan A. Walsh

“…The spatial architectural differences between lung adenocarcinoma (LUAD) and lung squamous cell carcinoma (LUSC) are relatively unexplored. Here, we applied imaging mass cytometry to a balanced cohort of LUAD and LUSC patients, matched for clinical factors such as age, sex, and smoking history, to analyze 204 histopathology images of tumours from 102 individuals with non-small cell lung cancer (NSCLC). …”
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The saprotrophic Pleurotus ostreatus species complex: late Eocene origin in East Asia, multiple dispersal, and complex speciation by Jing Li, Li-Hong Han, Xiao-Bin Liu, Zhi-Wei Zhao, Zhu L. Yang

“…Comprehensive sampling from Asia, Europe, North and South America and Africa was used to run phylogenetic analyses of the P. ostreatus species complex based on 40 nuclear single-copy orthologous genes using maximum likelihood and Bayesian inference analyses. Here, we present a robust phylogeny of the P. ostreatus species complex, fully resolved from the deepest nodes to species level. …”
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V-ATPase in glioma stem cells: a novel metabolic vulnerability by Alessandra Maria Storaci, Irene Bertolini, Cristina Martelli, Giorgia De Turris, Nadia Mansour, Mariacristina Crosti, Maria Rosaria De Filippo, Luisa Ottobrini, Luca Valenti, Elisa Polledri, Silvia Fustinoni, Manuela Caroli, Claudia Fanizzi, Silvano Bosari, Stefano Ferrero, Giorgia Zadra, Valentina Vaira

“…The V-ATPase proton pump has been described as a crucial factor in sustaining GSC viability and tumorigenicity. Here we studied how patients-derived GSCs rely on V-ATPase activity to sustain mitochondrial bioenergetics and cell growth. …”
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Multiscale X-ray scattering elucidates activation and deactivation of oxide-derived copper electrocatalysts for CO2 reduction by J. de Ruiter, V. R. M. Benning, S. Yang, B. J. den Hartigh, H. Wang, P. T. Prins, J. M. Dorresteijn, J. C. L. Janssens, G. Manna, A. V. Petukhov, B. M. Weckhuysen, F. T. Rabouw, W. van der Stam

“…Identification of the active phase under working conditions, but also deactivation factors after prolonged operation, are of the utmost importance to further improve electrocatalysts for electrochemical CO2 conversion. Here, we present a multiscale in situ investigation of activation and deactivation pathways of oxide-derived copper electrocatalysts under CO2 reduction conditions. …”
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Red Stellar Populations and Dust Extinction toward W3 by J. L. Campbell, P. G. Martin, S. Song, M. Rahman, L. Einstein

“…The methods developed here, which are based on known stellar populations, enable us to identify 82 new OB candidates that are confidently within the cloud. …”
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Metformin reverts aortic calcifications and elastin loss induced by an experimental metabolic syndrome by Lucas Streckwall, Nancy Martini, Claudia Sedlinsky, León Schurman, María Virginia Gangoiti, Antonio Desmond McCarthy

“…Metformin (MET) inhibits this transdifferentiation in vitro. Here, we evaluate the in vivo efficacy of oral MET to reduce AC in a model of MetS. …”
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Pharmacokinetic Evaluation of [C]CEP-32496 in Nude Mice Bearing BRAF Mutation-Induced Melanomas by Cuiping Jiang MMSc, Lin Xie MD, PhD, Yiding Zhang BSc, Masayuki Fujinaga PhD, Wakana Mori MSc, Yusuke Kurihara PhD, Tomoteru Yamasaki PhD, Feng Wang MD, PhD, Ming-Rong Zhang MD, PhD

“…CEP-32496, also known as RXDX-105 or Agerafenib, is a new orally active inhibitor for the mutated v-raf murine sarcoma viral oncogene homolog B1 (BRAF V600E ), which has attracted considerable attention in clinical trials for the treatment of human cancers. Here, we used carbon-11-labeled CEP-32496 ([ 11 C]CEP-32496) as a positron emission tomography (PET) radiotracer to evaluate its pharmacokinetic properties and explore its potential for in vivo imaging. …”
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Changes in Intestinal Microbiota Are Associated with Islet Function in a Mouse Model of Dietary Vitamin A Deficiency by Yunting Zhou, Junming Zhou, Yumin Zhang, Jun Tang, Bo Sun, Wei Xu, Xiaohang Wang, Yang Chen, Zilin Sun

“…Recent evidence suggests that intestinal microbiota is closely linked to the metabolic syndrome. Here, we explored whether and how intestinal microbiota affects glucose homeostasis in VA-deficient diet-fed mice. …”
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Unusual Thermo‐Enhanced Second Harmonic Generation in Organic Configurationally‐Locked Polyene Crystals by Yi Liu, Pengfei Zhu, Qingshun Fan, Zihao Zhao, Linjie Wei, Yu Ma, Haojie Xu, Wuqian Guo, Junhua Luo, Zhihua Sun

“…Organic configurationally‐locked polyene represents an exciting NLO family with large second harmonic generation (SHG) effects, whereas it is a huge blank to switch and modulate their NLO property through external stimuli. For the first time, here present unusual thermo‐enhanced SHG activities are presented in a polyene‐based NLO compound, 2‐{3‐[2‐(4‐pyrrolidinphenyl)vinyl]‐5,5‐dimethylcyclohex‐2‐enylidene}malononitrile (1), giving a record‐high magnitude of SHG enhancement up to ≈170% during its isomorphic phase transition. …”
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The presence of iteroparous salmonid spawning grounds affects the stable isotope signatures of food web components in Swedish boreal streams by Rahmat Naddafi, Magnus Enbom, Carin Magnhagen, Nazila Hajizadeh Koupayh, Daniel Holmqvist, Hans Lundqvist

“…Yet there is limited knowledge on the transport of marine nutrients by Atlantic salmon (Salmo salar) and sea trout (Salmo trutta) from the Baltic Sea and their incorporation into the trophic system of the boreal streams. Here, stable carbon (δ13C) and nitrogen (δ15N) isotopes were measured in food web components (periphyton, benthic macroinvertebrates, and a predatory fish (freshwater-resident brown trout) of four sites with and without salmonid spawning grounds. …”
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The pet trade of native species outside of their natural distributions within Australia is a biosecurity risk by Adam Toomes, Oliver C. Stringham, Stephanie Moncayo, Katherine G. W. Hill, Jacob Maher, Freyja Watters, Sebastian Chekunov, Pablo García‐Díaz, Lewis Mitchell, Joshua V. Ross, Phillip Cassey

“…So‐called “domestic non‐natives” have established new populations across several countries and, in some cases, become invasive. Here, we investigated the extent of the domestic trade of native Australian pet species outside of their natural distributions and determined whether such locations were climatically suitable for potential alien establishments. …”
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TIESA IR TIKRUMAS WITTGENSTEINO FILOSOFIJOJE by Albinas Plėšnys

“…The conception of truth here turns into a basis of distinguishing between what can be talked about and what should be passed over in silence. …”
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