Intraspinal Transplantation of the Adipose Tissue-Derived Regenerative Cells in Amyotrophic Lateral Sclerosis in Accordance with the Current Experts’ Recommendations: Choosing Opti... by Magdalena Kuzma-Kozakiewicz, Andrzej Marchel, Anna Kaminska, Malgorzata Gawel, Jan Sznajder, Anna Figiel-Dabrowska, Arkadiusz Nowak, Edyta Maj, Natalia Ewa Krzesniak, Bartlomiej H. Noszczyk, Krystyna Domanska-Janik, Anna Sarnowska

“…They combine clinical, neurophysiological, and functional assessment together with monitoring of the cytokine level. Here, we describe a pilot study on transplantation of autologous adipose-derived regenerative cells (ADRC) into the spinal cord of the patients with ALS and monitoring of the results in accordance with the current recommendations. …”
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Noninvasive prenatal diagnosis (NIPD) of non-syndromic hearing loss (NSHL) for singleton and twin pregnancies in the first trimester by Huanyun Li, Shaojun Li, Zhenhua Zhao, Lingrong Kong, Xinyu Fu, Jingqi Zhu, Jun Feng, Weiqin Tang, Di Wu, Xiangdong Kong

“…However, previous research is limited to the second trimester and the application in twin pregnancies is blank. Here we provide a novel algorithmic approach to assess singleton and twin pregnancies in the first trimester. …”
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Soy polysaccharide maintains colonic homeostasis to protect from dextran sulphate sodium-induced colitis by modulating gut microbiota and intestinal epithelial regeneration by Nana Zhang, Jianlin Liu, Weiyue Zhang, Xinxin Guo, Shuying Li, Hongtai Zhang, Minjie Wang, Bei Fan, Fengzhong Wang

“…Soy polysaccharide (SP) has been reported to possess the properties of modulating gut microbiome diversity. Here, we aimed to explore the protective effects of SP against dextran sulphate sodium (DSS)-induced colitis. …”
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DDO-adjuvanted influenza A virus nucleoprotein mRNA vaccine induces robust humoral and cellular type 1 immune responses and protects mice from challenge by Victoria Gnazzo, Hanaa Saleh, Ítalo A. Castro, Adrianus C. M. Boon, Amelia K. Pinto, James D. Brien, Carolina B. López

“…ABSTRACT A challenge in viral vaccine development is to produce vaccines that generate both neutralizing antibodies to prevent infection and cytotoxic CD8+ T-cells that target conserved viral proteins and can eliminate infected cells to control virus spread. mRNA technology offers an opportunity to design vaccines based on conserved CD8-targeting epitopes, but achieving robust antigen-specific CD8+ T-cells remains a challenge. Here, we tested the viral-derived oligonucleotide DDO268 as an adjuvant in the context of a model influenza A virus (IAV) nucleoprotein (NP) mRNA vaccine in C57BL/6 mice. …”
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MCT1 lactate transporter blockade re-invigorates anti-tumor immunity through metabolic rewiring of dendritic cells in melanoma by Camille Niveau, Mélanie Cettour-Cave, Stéphane Mouret, Eleonora Sosa Cuevas, Mylene Pezet, Benoît Roubinet, Hugo Gil, Florence De Fraipont, Ludovic Landemarre, Julie Charles, Philippe Saas, Caroline Aspord

“…DC metabolic reprogramming could induce immune subversion and tumor immune escape. Here we explore metabolic features of human DC subsets (cDC2s, cDC1s, pDCs) in melanoma, at single cell level, using the flow cytometry-based SCENITH (Single-Cell ENergetIc metabolism by profiling Translation inHibition) method. …”
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Human blood cell transcriptomics unveils dynamic systemic immune modulation along colorectal cancer progression by Pedro J Romero, Mauro Delorenzi, Amaia Martínez-Usatorre, Laura Ciarloni, Noushin Hadadi, Eric Durandau, Sylvain Monnier-Benoit, Paolo Angelino, Victoria Wosika, Alessandra Jordano Conforte, Sara S Fonseca Costa, Hector Fabio Satizabal, Jérémie Despraz, Andres Perez-Uribe, Stephan Morgenthaler, Brian Hashemi, Sahar Hosseinian-Ehrensberger

“…However, the tumor-signal-dependent nature of this approach results in low sensitivity in precancerous and early CRC stages. Here we propose the host immune response to the onset of cancer as an alternative approach for early detection of CRC.Methods We perform whole transcriptome analysis of peripheral blood mononuclear cells (PBMCs) isolated from individuals with CRC, precancerous lesions or negative colonoscopy in two independent cohorts using next-generation sequencing.Results We discover and validate novel early CRC RNA biomarkers. …”
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Distinct genome stabilization procedures lead to phenotypic variability in newly generated interspecific yeast hybrids by Pablo Murath, Pablo Murath, Stephanie Hoffmann, Beatriz Herrera-Malaver, Beatriz Herrera-Malaver, Beatriz Herrera-Malaver, Luis Bustamante, Kevin Verstrepen, Kevin Verstrepen, Kevin Verstrepen, Jan Steensels, Jan Steensels, Jan Steensels

“…Interestingly, however, merging two different genomes into one cell causes genomic instability and rearrangements, ultimately leading to a reorganized but more stable hybrid genome. Here, we investigate how different parameters influence this genome stabilization trajectory and ultimately can lead to variants with different industrial phenotypes. …”
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Wide‐Bandgap Nickel Oxide with Tunable Acceptor Concentration for Multidimensional Power Devices by Yunwei Ma, Yuan Qin, Matthew Porter, Joseph Spencer, Zhonghao Du, Ming Xiao, Boyan Wang, Yifan Wang, Alan G. Jacobs, Han Wang, Marko Tadjer, Yuhao Zhang

“…A key obstacle to developing such devices in many wide‐bandgap (WBG) and ultra‐wide bandgap (UWBG) semiconductors is the difficulty of native p‐type doping. Here the WBG nickel oxide (NiO) as an alternative p‐type material is investigated. …”
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Legionella pneumophila subverts the antioxidant defenses of its amoeba host Acanthamoeba castellanii by Alban Hay, Willy Aucher, Romain Pigeault, Joanne Bertaux, Alexandre Crépin, Quentin Blancart Remaury, Yann Héchard, Ascel Samba-Louaka, Romain Villéger

“…In addition, it has been shown in macrophages that L. pneumophila WT decreases ROS at 24 h p.i.; here we confirm this result in amoebae and suggest that this decrease could be partly explained by L. pneumophila differentially regulated host antioxidant defense transcripts at 6 h p.i.. …”
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New acorane-sesequiterpenes and anti-retinoblastoma constituents from the marine algicolous fungus Trichoderma harzianum NTU2180 guided by molecular networking strategy by Andrea Gu, Fan-Li Lin, Chung-Kuang Lu, Tz-Wei Yeh, Yih-Fung Chen, Ho-Cheng Wu, Tzong-Huei Lee

“…Results The feature-based molecular networking (FBMN) analysis showed that T. harzianum NTU2180 fermented on germinated brown rice (GBR) produced more terpenoids. Here, two new acorane-sesequiterpenes, trichospirols A (1) and B (2), and 12 known compounds (3 − 14) were isolated from the EtOAc layer of T. harzianum NTU2180 fermentation on GBR. …”
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Assessing the Changes of Mumps Characteristics with Different Vaccination Strategies Using Surveillance Data: Importance to Introduce the 2-Dose Schedule in Quzhou of China by Chunting Zhou, Wei Song, Zhiying Yin, Sheng Li, Xiaoying Gong, Quanjun Fang, Shuangqing Wang

“…These include the use of MuCV as a self-supported vaccine, the introduction of one-dose MMR to the Expanded Program on Immunization (EPI), and the administration of two-dose MuCV following supplementary immunization activities (SIAs) using MM. Here, using surveillance data, we assessed the epidemiology of mumps during the three stages. …”
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Clinical and molecular response to alpha1‐oleate treatment in patients with bladder cancer by Farhan Haq, Samudra Sabari, Jaromir Háček, Antonín Brisuda, Ines Ambite, Michele Cavalera, Parisa Esmaeili, Murphy Lam Yim Wan, Shahram Ahmadi, Marek Babjuk, Catharina Svanborg

“…Materials and Methods Here, patients with NMIBC were treated by intravesical instillation of increasing concentrations of alpha1‐oleate (1.7, 8.5, or 17 mM) and the treatment response was defined relative to a placebo group. …”
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Differential responses of root and leaf-associated microbiota to continuous monocultures by Hao-Ran Li, Xiang-Yu Zhang, Kai-Ling He, Xin Xu, Xin-Wen Chen, Yaseen Ullah, Ting-Ting Zhang, Yan Chen, Chuan-Chao Dai, Wei Zhang

“…In comparison, little is known about how leaf-associated microbiota respond to continuous monocultures. Here, we profiled root and leaf-associated microbiota of peanut plants under monocropping and rotation conditions. …”
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Biochemical Pattern of Methylmalonyl-CoA Epimerase Deficiency Identified in Newborn Screening: A Case Report by Evelina Maines, Roberto Franceschi, Francesca Rivieri, Giovanni Piccoli, Björn Schulte, Jessica Hoffmann, Andrea Bordugo, Giulia Rodella, Francesca Teofoli, Monica Vincenzi, Massimo Soffiati, Marta Camilot

“…A dedicated test for MCEE deficiency is not included in the newborn screening (NBS) panels but it can be incidentally identified when investigating methylmalonic acidemia and propionic acidemia. Here, we report for the first time the biochemical description of a case detected by NBS. …”
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Recent advances in detection techniques for vitamin analysis: A comprehensive review by Xiangrui Li, Huan Lv, Wencan Luo, WenJia Yang, Linghong Kong, Qiujin Zhu, Lu Zeng

“…In recent years, significant advancements have been made in vitamin analysis. Here, we propose a comprehensive and critical evaluation of detection methods for water- and fat-soluble vitamins that have been studied over the past five years, including microbiology-, spectroscopy-, liquid chromatography–mass spectrometry-, electrochemistry-, sensor-, and immunoassay-based analysis techniques. …”
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Methyl 3-Bromo-4,5-dihydroxybenzoate Attenuates Inflammatory Bowel Disease by Regulating TLR/NF-κB Pathways by Jing Huang, Lei Li, Liyan Xu, Lixin Feng, Yuxin Wang, Attila Gabor SIK, Meng Jin, Rongchun Wang, Kechun Liu, Xiaobin Li

“…Inflammatory bowel disease (IBD) is characterized by uncontrolled, chronic relapsing inflammation in the gastrointestinal tract and has become a global healthcare problem. Here, we aimed to illustrate the anti-inflammatory activity and the underlying mechanism of methyl 3-bromo-4,5-dihydroxybenzoate (MBD), a compound derived from marine organisms, especially in IBD, using a zebrafish model. …”
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Formation and fate of freshwater on an ice floe in the Central Arctic by M. M. Smith, N. Fuchs, E. Salganik, D. K. Perovich, I. Raphael, M. A. Granskog, K. Schulz, M. D. Shupe, M. D. Shupe, M. Webster

“…The fate of this freshwater, whether in surface melt ponds or thin layers underneath the ice and in leads, impacts atmosphere–ice–ocean interactions and their subsequent coupled evolution. Here, we combine analyses of datasets from the Multidisciplinary drifting Observatory for the Study of Arctic Climate (MOSAiC) expedition (June–July 2020) for a process study on the formation and fate of sea ice freshwater on ice floes in the Central Arctic. …”
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Distribution of fungal agents in the respiratory system of patients with underlying lung diseases; molecular identification and antifungal susceptibility profiles by Parviz Hassanpour, Seyed Jamal Hashemi, Sanam Nami, Roshanak Daie Ghazvini, Behrouz Naghili Hokmabadi, Abbas Rahimi Foroushani, Kazem Ahmadikia, Zahra Ramezanalipour, Saeid Firouzi Abriz

“… Background and Objectives: Airway fungal infection is a severe clinical problem, especially in patients with compromised immune functions. Here, we examined the distribution and antifungal susceptibility profiles of fungal agents isolated from respiratory tract of symptomatic patients hospitalized in pulmonary units. …”
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Contribution of Short-Time Occlusion of the Amblyopic Eye to a Passive Dichoptic Video Treatment for Amblyopia beyond the Critical Period by Lauren Sauvan, Natacha Stolowy, Danièle Denis, Frédéric Matonti, Frédéric Chavane, Robert F. Hess, Alexandre Reynaud

“…The addition of a short-term monocular occlusion to the dichoptic training shows promising trends but was not significant for the sample size used here. The passive movie approach combined with interocular contrast balancing even over such a short period as 2 weeks has potential as a clinical therapy to treat amblyopia in older children and adults.…”
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Monitoring changes of forest height in California by Samuel Favrichon, Jake Lee, Yan Yang, Yan Yang, Ricardo Dalagnol, Ricardo Dalagnol, Fabien Wagner, Le Bienfaiteur Sagang, Le Bienfaiteur Sagang, Sassan Saatchi, Sassan Saatchi, Sassan Saatchi

“…Mapping and monitoring the structure of these forests at high spatial resolution provides the necessary data to better manage forest health, mitigate wildfire risks, and improve carbon sequestration. Here, we use LiDAR measurements of top of canopy height metric (RH98) from NASA’s Global Ecosystem Dynamics Investigation (GEDI) mission to map vegetation height across the entire California for two different time periods (2019–2020 and 2021–2022) and explore the impact of disturbance. …”
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