High quality genome assembly of the brown hare (Lepus europaeus) with chromosome-level scaffolding by Michell, Craig, Collins, Joanna, Laine, Pia K., Fekete, Zsófia, Tapanainen, Riikka, Wood, Jonathan M. D., Goffart, Steffi, Pohjoismäki, Jaakko L. O.

“…We present here a high-quality genome assembly of the brown hare (Lepus europaeus Pallas), based on a fibroblast cell line of a male specimen from Liperi, Eastern Finland. …”
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Metabolic reprogramming in cancer: Mechanisms and therapeutics by Shiqi Nong, Xiaoyue Han, Yu Xiang, Yuran Qian, Yuhao Wei, Tingyue Zhang, Keyue Tian, Kai Shen, Jing Yang, Xuelei Ma

“…Therefore, understanding how multiple metabolic pathways in cancer cells change can provide a reference for the development of new therapies for tumor treatment. Here, we systemically reviewed the metabolic changes and their alteration factors, together with the current tumor regulation treatments and other possible treatments that are still under investigation. …”
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Loading monocytes with magnetic nanoparticles enables their magnetic control without toxicity by Laura Mödl, Laura Mödl, Lucas R. Carnell, Rene Stein, Andrea Kerpes, Felix Pfister, Barbara Wirthl, Wolfgang A. Wall, Christoph Alexiou, Christina Janko

“…., for immunotherapy with chimeric antigen receptor (CAR) monocytes. Here, we investigated the loading of monocytic THP-1 cells with SPIONs, analyzed their impact on the viability and cellular reactive oxygen species (ROS) generation and their magnetic enrichment. …”
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Inhibition of NLRP3 enhances pro-apoptotic effects of FLT3 inhibition in AML by Helene Sieberer, Michela Luciano, Diana Amend, Constantin Blöchl, Anna Eglseer, Alina Steinkellner, Sebastian Rieser, Ancuela Andosch, Philip Steiner, Laura Hummer, Peter W. Krenn, Hieu-Hoa Dang, Christian G. Huber, Fritz Aberger, Theresa Neuper, Jutta Horejs-Hoeck

“…Recent research has identified the NLRP3 inflammasome as a potential new driver in AML. Here, we investigated the efficacy of different NLRP3 inhibitors in targeting AML cells in vitro. …”
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Machine learning validation of the AVAS classification compared to ultrasound mapping in a multicentre study by Katerina Lawrie, Petr Waldauf, Peter Balaz, Radoslav Bortel, Ricardo Lacerda, Emma Aitken, Krzysztof Letachowicz, Mario D’Oria, Vittorio Di Maso, Pavel Stasko, Antonio Gomes, Joana Fontainhas, Matej Pekar, Alena Srdelic, VAVASC Study Group, Stephen O’Neill

“…It’s been previously validated in a clinical study. Here, AVAS performance was tested against multiple ultrasound mapping measurements using machine learning. …”
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Subjective cognition in schizophrenia and bipolar disorder: Investigation of group differences and associations with objective cognition and clinical characteristics using a novel... by Kristoffer Grimstad, Håkon Sørensen, Anja Vaskinn, Christine Mohn, Stine Holmstul Olsen, Ole A. Andreassen, Trine Vik Lagerberg, Ingrid Melle, Merete Glenne Øie, Torill Ueland, Beathe Haatveit

“…The person's subjective experience of cognitive difficulties is less investigated. Here we investigated subjective cognition in SZ and BD compared to healthy controls (HC).Subjective and objective cognition were assessed in 91 SZ participants, 55 BD participants and 55 HC, applying a novel measure of subjective cognition, the self-assessed cognitive complaints scale (SACCS) and a clinically relevant neuropsychological test battery. …”
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Thermodynamic qualification of knitted spacer fabrics for use as insulation box insert in the context of refrigerated transport containers in the logistics sector by Julia Klausmann, Thomas Mutschler, Prisca Holderied, Dominik Güther, Thomas Freitag, Matthias Hummel, Martin Zeitler, Oliver van Neerven, Marcus Oliver Weber, Christof Breckenfelder

“…The aim of the research presented here is therefore to develop a knitted box that is designed as a volume-reducible, rigid but foldable box. …”
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Learning and forecasting open quantum dynamics with correlated noise by Xinfang Zhang, Zhihao Wu, Gregory A. L. White, Zhongcheng Xiang, Shun Hu, Zhihui Peng, Yong Liu, Dongning Zheng, Xiang Fu, Anqi Huang, Dario Poletti, Kavan Modi, Junjie Wu, Mingtang Deng, Chu Guo

“…This is particularly challenging for temporarily correlated noise. Here we propose a physics-inspired supervised machine learning approach to efficiently and accurately predict the functioning of quantum processors in the presence of correlated noise, which only requires data from randomized benchmarking experiments. …”
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Prediction of Inadequate Bowel Preparation Using Total and Segmental Colon Transit Time in Patients with Chronic Constipation: Some Different Outcomes by Chunying Zhai, Qiyang Huang, Ningli Chai, Wengang Zhang, Enqiang Linghu

“…Radio-opaque markers have been widely used in the study of colon motility in patients with chronic functional constipation (FC). Here, we evaluate the relationship between the colon transit time (CTT) and the Boston Bowel Preparation Scale (BBPS) to determine whether CTT is a sufficient predictor of bowel preparation in patients with chronic functional constipation. …”
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A Case of Solitary Necrotic Nodule Treated with Laparoscopic Hepatectomy: Spontaneous Regression of Hepatocellular Carcinoma? by Hirokazu Tomishige, Zenichi Morise, Yoshikazu Mizoguchi, Norihiko Kawabe, Hidetoshi Nagata, Hisanori Ohshima, Jin Kawase, Satoshi Arakawa, Rie Yoshida, Masashi Isetani

“…The pathogenetic mechanism is still unclear. We here describe a case of SNN, whose central reticulin fibers within the nodule suggest the origin as hepatocellular carcinoma or other hepatocyte-origin tumors, treated with laparoscopic anatomical segmentectomy of the liver. …”
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A visual cortical-lateral posterior thalamic nucleus circuit regulates depressive-like behaviors in male mice by Fangfang Wu, Chenxi Gu, Rui Xu, Junwei Ma, Lei Gao, Youjiao Zhang, Siyuan Bu, Qingbo Lu, Te Zhao, Yijun Han, Chen Guo, Yihui Cui, Jianhua Ding, Gang Hu, Zhijun Zhang

“…However, the precise circuits mediating the impact of V1 on depressive-like behaviors are poorly understood. Here, we demonstrate that the V1, specifically the lateral posterior nucleus of the thalamus (LP)-projecting V1 glutamatergic subpopulation (GluV1→LP neurons), shows reduced activity after chronic restraint stress (CRS) in male mice, leading to depressive-like behaviors. …”
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Targeting ATAD3A Phosphorylation Mediated by TBK1 Ameliorates Senescence‐Associated Pathologies by Yujiao He, Yanchen Liu, Mingyue Zheng, Yuxiu Zou, Mujie Huang, Linsheng Wang, Ge Gao, Zhongjun Zhou, Guoxiang Jin

“…Abstract Targeting cellular senescence, one of the hallmarks of aging and aging‐related pathologies emerges as an effective strategy for anti‐aging and cancer chemotherapy. Here, a switch from TBK1‐OPTN axis to TBK1‐ATAD3A axis to promote cellular senescence is shown. …”
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Nephronectin Is Required for Vascularization in Zebrafish and Sufficient to Promote Mammalian Vessel‐Like Structures in Hydrogels for Tissue Engineering by Chinmoy Patra, Amey Rayrikar, Ganesh Wagh, Florian Kleefeldt, Kaveh Roshanbinfar, Florian Cop, Iva Nikolic, Mirko H. H. Schmidt, Amparo Acker‐Palmer, Süleyman Ergün, Felix B. Engel

“…How vessels are formed during organogenesis is not fully understood, and vascularization of engineered tissues remains a significant challenge. Methods and Results Here, we show that the extracellular matrix protein nephronectin is required for vascularization during zebrafish development as well as adult fin regeneration and is sufficient to promote mammalian vessel formation and maturation. …”
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Removal of dissolved organic carbon in the West Pacific hadal zones by Mengfan Chu, Rui Bao, Michael Strasser, Ken Ikehara, Yang Ding, Kejian Liu, Mingzhi Liu, Li Xu, Yonghong Wang, Piero Bellanova, Troy Rasbury, Martin Kölling, Natascha Riedinger, Min Luo, Christian März, Kana Jitsuno, Zhirong Cai, Cecilia McHugh, Ellen Druffel

“…However, the role of hadal zones, particularly hadal trenches (water depth > 6 km), in the oceanic dissolved organic carbon (DOC) cycle is not thoroughly investigated. Here we report distinct DOC signatures in the Japan Trench bottom water. …”
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Influenza A Virus H7 nanobody recognizes a conserved immunodominant epitope on hemagglutinin head and confers heterosubtypic protection by Zhao-Shan Chen, Hsiang-Chi Huang, Xiangkun Wang, Karin Schön, Yane Jia, Michael Lebens, Danica F. Besavilla, Janarthan R. Murti, Yanhong Ji, Aishe A. Sarshad, Guohua Deng, Qiyun Zhu, Davide Angeletti

“…Nanobodies, with their unique characteristics and binding capacity, offer a promising avenue to identify such epitopes. Here, we isolate and purify a hemagglutinin (HA)-specific nanobody that recognizes an H7 subtype of influenza A virus. …”
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Verification of the Functional Antioxidant Activity and Antimelanogenic Properties of Extracts of Poria cocos Mycelium Fermented with Freeze-Dried Plum Powder by Kyung-Yun Kang, Yun-Ho Hwang, Sung-Ju Lee, Ho-Yeol Jang, Seong-Gyeol Hong, Seul-Ki Mun, Su-Jin Kim, Jong-Jin Kim, Kuyng-Wuk Park, Kyoung-Sun Seo, Seung-Eon Ban, Seong-Woo Jin, Hyuck-Joo Kim, Sung-Tae Yee

“…Here we examine the effects of extracts of Poria cocos mycelium fermented with freeze-dried plum powder (PPE) on the α-melanocyte stimulating hormone (α-MSH)-stimulated melanogenesis in cultured murine B16 melanoma cells (B16 cells), relative to the effects of Prunus extract. …”
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Molecular detection and genomic characterization of Samak Micromys paramyxovirus-1 and -2 in Micromys minutus, Republic of Korea by Augustine Natasha, Sarah E. Pye, Seung Hye Cho, Haryo Seno Pangestu, Jieun Park, Kyungmin Park, Sara P. Prayitno, Bohyeon Kim, Jong Sun Lee, Jongwoo Kim, Shailesh Budhathoki, Yeonsu Oh, Jin-Won Song, Carolina B. López, Jun Gyo Suh, Won-Keun Kim

“…However, it is unknown whether Paramyxoviridae is present in Micromys minutus, another common rodent. Method Here, we screened M. minutus collected from the Gangwon Province in the ROK for paramyxoviruses using nested polymerase chain reaction and confirm positive samples by next-generation metagenomic sequencing. …”
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Mono-allelic epigenetic regulation of polycistronic transcription initiation by RNA polymerase II in Trypanosoma brucei by Rudo Kieft, Laura Cliffe, Haidong Yan, Robert J. Schmitz, Stephen L. Hajduk, Robert Sabatini

“…The initial step in TLF-mediated lysis of T.b.brucei requires high affinity haptoglobin/hemoglobin receptor (HpHbR) binding. Here, we demonstrate that by in vitro selection with TLF, resistance is obtained in a stepwise process correlating with loss of HpHbR expression at an allelic level. …”
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Invasion of glioma cells through confined space requires membrane tension regulation and mechano-electrical coupling via Plexin-B2 by Chrystian Junqueira Alves, Theodore Hannah, Sita Sadia, Christy Kolsteeg, Angela Dixon, Robert J. Wiener, Ha Nguyen, Murray J. Tipping, Júlia Silva Ladeira, Paula Fernandes da Costa Franklin, Nathália de Paula Dutra de Nigro, Rodrigo Alves Dias, Priscila V. Zabala Capriles, José P. Rodrigues Furtado de Mendonça, Paul A. Slesinger, Kevin D. Costa, Hongyan Zou, Roland H. Friedel

“…Abstract Glioblastoma (GBM) is a malignant brain tumor with diffuse infiltration. Here, we demonstrate how GBM cells usurp guidance receptor Plexin-B2 for confined migration through restricted space. …”
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Enhanced Generation of Human Induced Pluripotent Stem Cells from Peripheral Blood and Using Their Mesoderm Differentiation Ability to Regenerate Infarcted Myocardium by Ju-Young Kim, Han-Mo Yang, Joo-Eun Lee, Mika Jeon, Sang-Bum Bang, Jihye You, Joonoh Kim, Jaewon Lee, Jin Hur, Hyo-Soo Kim

“…Recently, we succeeded in isolating and culturing human heart-derived circulating cells called circulating multipotent stem (CiMS) cells. Here, we investigated the generation efficiency of CiMS-derived iPSCs (CiMS-iPSCs) and tested their differentiation potential into mesodermal lineages and cardiovascular cells. …”
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