A bacterial membrane-disrupting protein stimulates animal metamorphosis by Kyle E. Malter, Tiffany L. Dunbar, Carl Westin, Emily Darin, Josefa Rivera Alfaro, Nicholas J. Shikuma

“…MACs stimulate metamorphosis by injecting a protein effector termed metamorphosis-inducing factor 1 (Mif1) into tubeworm larvae. Here, we show that MACs bind to tubeworm cilia and form visible pores on the cilia membrane surface, which are smaller and less numerous in the absence of Mif1. …”
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Potential to recover a record of Holocene climate and sea ice from Müller Ice Cap, Canada by David Armond Lilien, Niels Fabrin Nymand, Tamara Annina Gerber, Daniel Steinhage, Daniela Jansen, Laura Thomson, Madeline Myers, Steven Franke, Drew Taylor, Prasad Gogineni, Marcos Lemes, Bo Møllesøe Vinther, Dorthe Dahl-Jensen

“…Its high latitude and elevation suggest it experiences relatively little melt and preserves an undisturbed paleoclimate record. Here, we present a suite of field measurements, complemented by remote sensing, that constrain the ice thickness, accumulation rate, temperature, ice-flow velocity, and surface-elevation change of Müller Ice Cap. …”
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ATG8 delipidation is not universally critical for autophagy in plants by Yong Zou, Jonas A. Ohlsson, Sanjana Holla, Igor Sabljić, Jia Xuan Leong, Florentine Ballhaus, Melanie Krebs, Karin Schumacher, Panagiotis N. Moschou, Simon Stael, Suayib Üstün, Yasin Dagdas, Peter V. Bozhkov, Elena A. Minina

“…One notable example is ATG4-dependent delipidation of ATG8, a process that plays critical but distinct roles in autophagosome formation in yeast and mammals. Here, we aim to elucidate the specific contribution of this process to autophagosome formation in species representative of evolutionarily distant green plant lineages: unicellular green alga Chlamydomonas reinhardtii, with a relatively simple set of ATG genes, and a vascular plant Arabidopsis thaliana, harboring expanded ATG gene families. …”
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Microbial metabolic interaction in fermentation ecosystem and cooperation in flavor compounds formation of Chinese cereal vinegar by Yanfang Wu, Jing Liu, Dantong Liu, Mengle Xia, Jia Song, Kai Liang, Chaochun Li, Yu Zheng, Min Wang

“…Shanxi aged vinegar (SAV) is a famous cereal vinegar in China, which is produced through a solid-state fermentation where diverse microbes spontaneously and complex interactions occur. Here, combined with the metatranscriptomics, the microbial co-occurrence network was constructed, indicating that Lactobacillus, Acetobacter and Pediococcus are the most critical genera to maintain the fermentation stability. …”
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The Landbound Chicken and the Deliberate Chameleon yet have their Uses: Yorùbá Art History, Language, and Interpretation. by Kathy Curnow

“…The import of Abiodun’s major contributions regarding Yorùbá art’s history and the validity of his contentions are considered here in light of the varied contributions both foreign and Yorùbá art historians bring to Yorùbá scholarship, in the recognition that working with art of bygone centuries makes all scholars outsiders to a degree.   …”
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The Interannual Variability of Global Burned Area Is Mostly Explained by Climatic Drivers by Andrina Gincheva, Juli G. Pausas, Miguel Ángel Torres‐Vázquez, Joaquín Bedia, Sergio M. Vicente‐Serrano, John T. Abatzoglou, Josep A. Sánchez‐Espigares, Emilio Chuvieco, Sonia Jerez, Antonello Provenzale, Ricardo M. Trigo, Marco Turco

“…However, evaluating the global‐scale temporal variability of fires in response to climate presents a challenge due to the intricate processes at play and the limitation of fire data. Here, we investigate the links between year‐to‐year variability of burned area (BA) and climate using BA data, the Fire Weather Index (FWI), and the Standardized Precipitation Evapotranspiration Index (SPEI) from 2001 to 2021 at ecoregion scales. …”
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Fully integrated wearable control system for micro/nanorobot navigation by Zhanxiang Zhang, Lin Wang, Fengqi Jiang, Shimin Yu, Fengtong Ji, Tianhao Sun, He Zhang, Yanhe Zhu, Hao Chang, Tianlong Li, Jie Zhao

“…The navigation of swimming micro/nanorobots with temporal and spatial precision is critical for fulfilling the demand of applications. Here, we introduced a fully integrated wearable control system for micro/nanorobots navigation and manipulation, which is composed of a multifunctional sensor array, an artificial intelligence (AI) planner, and a magnetic field generator. …”
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Intravenous Administration of Adipose-Derived Stem Cell Protein Extracts Improves Neurological Deficits in a Rat Model of Stroke by Kai Zhao, Rui Li, Changcong Gu, Long Liu, Yulong Jia, Xize Guo, Wanping Zhang, Chunying Pei, Linlu Tian, Bo Li, Jianrong Jia, Huakun Cheng, Hongwei Xu, Lixian Li

“…Cell-free extracts from ADSC (ADSC-E) may be a feasible approach that could overcome these limitations. Here, we aim to explore the potential usage of ADSC-E in treating rat transient middle cerebral artery occlusion (tMCAO). …”
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Magnitude of Multidrug Resistance among Bacterial Isolates from Surgical Site Infections in Two National Referral Hospitals in Asmara, Eritrea by Eyob Yohannes Garoy, Yacob Berhane Gebreab, Oliver Okoth Achila, Nobiel Tecklebrhan, Hermon Michael Tsegai, Alex Zecarias Hailu, Abrehet Marikos Buthuamlak, Tewelde Ghide Asfaga, Mohammed Elfatih Hamida

“…The World Health Organization has emphasized the importance of understanding the epidemiology of MDR organisms from a local standpoint. Here, we report on a spectrum of bacteria associated with surgical site infections in two referral hospitals in Eritrea and the associated antibiotic susceptibility patterns. …”
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Geospatial perspective for monitoring SDG 6.6.1 based on spatial and temporal analysis of lake water storage variations in Dongting Lake, China by Huanhua Peng, Zihan Tang, Zhiming Chen, Yating Wu, Yuan Yuan, Qian Shi, Lelin Li, Hao Chen

“…Study focus: Lakes play a crucial role in Sustainable Development Goal (SDG) 6, which focuses on water-related ecosystems. Here, we devised a methodology to estimate Dongting Lake water storage and analyze their dynamic changes for monitoring SDG 6.6.1 from 2001 to 2020. …”
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A comparative study of the developability of full-length antibodies, fragments, and bispecific formats reveals higher stability risks for engineered constructs by Itzel Condado-Morales, Fabian Dingfelder, Isabel Waibel, Oliver M. Turnbull, Bhargav Patel, Zheng Cao, Jais Rose Bjelke, Susanne Nedergaard Grell, Anja Bennet, Alissa M. Hummer, Matthew I. J. Raybould, Charlotte M. Deane, Thomas Egebjerg, Nikolai Lorenzen, Paolo Arosio

“…However, the translation of these non-natural molecules into successful therapeutics can be hampered by developability challenges. Here, we systematically analyzed 64 different antibody constructs targeting Tumor Necrosis Factor (TNF) which cover 8 distinct molecular format families, encompassing full-length antibodies, various types of single chain variable fragments, and bispecifics. …”
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Single‐Cell Simultaneous Metabolome and Transcriptome Profiling Revealing Metabolite‐Gene Correlation Network by Xiying Mao, Dandan Xia, Miao Xu, Yan Gao, Le Tong, Chen Lu, Weiqi Li, Runmin Xie, Qinghuai Liu, Dechen Jiang, Songtao Yuan

“…However, the current single cell metabolome (SCM) study using mass spectroscopy has difficulty giving a complete view of the metabolic activity in the cell, and the prediction of the metabolism‐phenotype relationship is limited by the potential inconsistency between transcriptomic and metabolic levels. Here, the single‐cell simultaneous metabolome and transcriptome profiling method (scMeT‐seq) is developed at one single cell, based on sub‐picoliter sampling from the cell for the initial metabolome profiling followed by single cell transcriptome sequencing. …”
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Measurement report: A comparative analysis of an intensive incursion of fluorescing African dust particles over Puerto Rico and another over Spain by B. Sarangi, D. Baumgardner, A. I. Calvo, B. Bolaños-Rosero, R. Fraile, A. Rodríguez-Fernández, D. Fernández-González, C. Blanco-Alegre, C. Gonçalves, E. D. Vicente, O. L. Mayol-Bracero, O. L. Mayol-Bracero

“…In general, it is not possible to directly determine the specific biological identity from fluorescence signatures; however, measurements of these types of bioaerosols in laboratory studies allow us to compare ambient fluorescence patterns with whole microbial cells measured under controlled conditions. Here we introduce some new metrics that offer a more quantitative approach for comparing FAP characteristics derived from particles measured under different environmental conditions. …”
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Development and internal validation of a nomogram for predicting cognitive impairment after mild ischemic stroke and transient ischemic attack based on cognitive trajectories: a pr... by Panpan Zhao, Panpan Zhao, Lin Shi, Guimei Zhang, Chunxiao Wei, Weijie Zhai, Yanxin Shen, Yongchun Wang, Zicheng Wang, Li Sun

“…Decision curve analysis and cross-validation showed excellent clinical applicability.DiscussionHere, we developed two simple and easy-to-use predictive models of post-stroke cognitive trajectories based on a LCGA, which are presented in the form of nomograms suitable for clinical application. …”
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Characteristics of Small Bowel Polyps Detected in Cowden Syndrome by Capsule Endoscopy by Keita Saito, Eiki Nomura, Yu Sasaki, Yasuhiko Abe, Nana Kanno, Naoko Mizumoto, Rika Shibuya, Kazuhiro Sakuta, Makoto Yagi, Kazuya Yoshizawa, Daisuke Iwano, Takeshi Sato, Shoichi Nishise, Yoshiyuki Ueno

“…Small bowel polyps can occur in Cowden syndrome; however, they are difficult to detect by conventional examination, including double-contrast X-ray study. Here, we report three cases of Cowden syndrome with small bowel polyps, which were detected by capsule endoscopy. …”
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Dimensional control of interface coupling-induced ferromagnetism in CaRuO3/SrCuO2 superlattices by Li Zhe, Shi Wenxiao, Zhang Jine, Zheng Jie, Wang Mengqin, Zhu ZhaoZhao, Han Furong, Zhang Hui, Xie Liming, Yunzhong Chen, Fengxia Hu, Baogen Shen, Yuansha Chen, Jirong Sun

“…Understanding and controlling the coupling effects at the oxide interface are prerequisites for designing emergent interfacial phases with desired functionalities. Here, we report the dimensional control of the interface coupling-induced ferromagnetic (FM) phase in perovskite-CaRuO3/infinite-layered-SrCuO2 superlattices. …”
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An atomically controlled insulator-to-metal transition in iridate/manganite heterostructures by Enyang Men, Deyang Li, Haiyang Zhang, Jingxin Chen, Zhihan Qiao, Long Wei, Zhaosheng Wang, Chuanying Xi, Dongsheng Song, Yuhan Li, Hyoungjeen Jeen, Kai Chen, Hong Zhu, Lin Hao

“…Abstract All-insulator heterostructures with an emerging metallicity are at the forefront of material science, which typically contain at least one band insulator while it is not necessary to be. Here we show emergent phenomena in a series of all-correlated-insulator heterostructures that composed of insulating CaIrO3 and insulating La0.67Sr0.33MnO3. …”
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Co-creating and hosting PxP: a conference about patient engagement in research for and by patient partners by Dawn P. Richards, Hetty Mulhall, Joletta Belton, Savia de Souza, Trudy Flynn, Alex Haagaard, Linda Hunter, Amy Price, Sara Riggare, Janice Tufte, Rosie Twomey, Karim M. Khan

“…These resources were recommended by the PxP Steering Committee members, speakers, and others who attended the 2023 conference. Here we lead you through how the idea for PxP was generated; how the international patient partner Steering Committee was convened and supported; how PxP was brought to life over nine months; the PxP 3-day event and feedback collected to improve future efforts; trade-offs, challenges and learnings; and resources required to support this type of event. …”
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Segmental analysis of human hair reveals intra-annual variation in 25(OH)D3 concentrations in modern and archaeological individuals by Kate Britton, Orsolya Czére, Eléa Gutierrez, Linda M. Reynard, Eamon Laird, Gary Duncan, Baukje de Roos

“…Abstract Vitamin D is essential for healthy skeletal growth and is increasingly recognised for its role in chronic disease development, inflammation and immunity. 25-hydroxyvitamin D3 (25(OH)D3) concentrations are an indicator of vitamin D status and are normally analysed in plasma or serum samples in clinical settings, while archaeological studies rely on the identification of skeletal markers of vitamin D deficiency, such as rickets. Here, we determined 25(OH)D3 concentrations in hair specimens (‘locks’) that had been sampled close to the root, aligned by cut end, and sliced into sequential segments from participants (n = 16), from Aberdeen, Scotland, using a modified protocol designed to minimise sample size. …”
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Neuroeconomically dissociable forms of mental accounting are altered in a mouse model of diabetes by Chinonso A. Nwakama, Romain Durand-de Cuttoli, Zainab M. Oketokoun, Samantha O. Brown, Jillian E. Haller, Adriana Méndez, Mohammad Jodeiri Farshbaf, Y. Zoe Cho, Sanjana Ahmed, Sophia Leng, Jessica L. Ables, Brian M. Sweis

“…Abstract Those with diabetes mellitus are at high-risk of developing psychiatric disorders, especially mood disorders, yet the link between hyperglycemia and altered motivation has not been thoroughly explored. Here, we characterized value-based decision-making behavior of a streptozocin-induced diabetic mouse model on Restaurant Row, a naturalistic neuroeconomic foraging paradigm capable of behaviorally capturing multiple decision systems known to depend on dissociable neural circuits. …”
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