Modulation of glymphatic system by visual circuit activation alleviates memory impairment and apathy in a mouse model of Alzheimer’s disease by Wen Wu, Yubai Zhao, Xin Cheng, Xiaoru Xie, Yixiu Zeng, Quan Tao, Yishuai Yang, Chuan Xiao, Zhan Zhang, Jiahui Pang, Jian Jin, Hongbo He, Yangyang Lin, Boxing Li, Junxian Ma, Xiaojing Ye, Wei-Jye Lin

“…Abstract Alzheimer’s disease is characterized by progressive amyloid deposition and cognitive decline, yet the pathological mechanisms and treatments remain elusive. Here we report the therapeutic potential of low-intensity 40 hertz blue light exposure in a 5xFAD mouse model of Alzheimer’s disease. …”
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L’insegnamento dell’italiano in Germania nell’era digitale by Ines de Florio-Hansen

“…These areas need to be given greater consideration not only with regard to learning here and now, but also for students’ future lives. …”
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LBP-CD155 Liposome Nanovaccine Efficiently Resist Colorectal Cancer and Enhance ICB Therapy by Yan Y, Duan T, Xue X, Yang X, Liu M, Ma B, Duan X, Su C

“…Therefore, to improve the current prophylaxis and treatment scheme, offering a favorable strategy efficient against CRC is urgently needed.Methods: Here, we developed a nanovaccine (LBP-CD155L NVs) loaded with CD155 gene in liposome, which was modified by Lycium barbarum polysaccharides (LBP) through electrostatic interaction. …”
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Unusual congenital polydactyly in mini-pigs from the breeding group of the Institute of Cytology and Genetics (Novosibirsk, Russia) by S. V. Nikitin, S. P. Knyazev, V. A. Trifonov, A. A. Proskuryakova, Yu. D. Shmidt, K. S. Shatokhin, V. I. Zaporozhets, D. S. Bashur, E. V. Korshunova, V. I. Ermolaev

“…This anomaly was first found here in 2017 in adult animals intended for culling due to incorrect positioning of the legs caused by flexor tendon laxity and resulting in weight-bearing on the palmar surface of the proximal phalanges (“bear’s paw”). …”
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Ideas and perspectives: Microorganisms in the air through the lenses of atmospheric chemistry and microphysics by B. Ervens, P. Amato, P. Amato, K. Aregahegn, K. Aregahegn, M. Joly, A. Khaled, T. Labed-Veydert, F. Mathonat, L. Nuñez López, R. Péguilhan, R. Péguilhan, M. Zhang, M. Zhang

“…The perspectives presented here aim to motivate future experimental and modeling studies to disentangle the complex interplay of chemical and microphysical factors with the atmospheric microbiome. …”
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Novel role of microphthalmia-associated transcription factor in modulating the differentiation and immunosuppressive functions of myeloid-derived suppressor cells by Yoon Kyung Jeon, Aram Lee, Haesun Park, Soyoung Lim, Jihyun Lim, Jaemoon Koh, Young Yang, Myeong-Sok Lee, Jong-Seok Lim

“…However, the roles of MITF in immunosuppressive myeloid cells, including myeloid-derived suppressor cells (MDSCs), remain unclear. Here, we investigated the role of MITF in the differentiation process of MDSCs during tumor development.Methods In vitro-generated murine MDSCs and primary MDSCs from breast cancer-bearing mice or lung carcinoma-bearing mice were used to determine the expression level of MITF and the activity of MDSCs. …”
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Genomic and phenotypic stability of fusion-driven pediatric sarcoma cell lines by Merve Kasan, Florian H. Geyer, Jana Siebenlist, Martin Sill, Rupert Öllinger, Tobias Faehling, Enrique de Álava, Didier Surdez, Uta Dirksen, Ina Oehme, Katia Scotlandi, Olivier Delattre, Martina Müller-Nurasyid, Roland Rad, Konstantin Strauch, Thomas G. P. Grünewald, Florencia Cidre-Aranaz

“…Recent reports showed that highly mutated adult carcinoma cell lines (mainly HeLa and MCF-7) present striking diversity across laboratories and that long-term continuous culturing results in genomic/transcriptomic heterogeneity with strong phenotypical implications. Here, we hypothesize that oligomutated pediatric sarcoma cell lines mainly driven by a fusion transcription factor, such as Ewing sarcoma (EwS), are genetically and phenotypically more stable than the previously investigated adult carcinoma cell lines. …”
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Profiles and natural drivers of antibiotic resistome in multiple environmental media in penguin-colonized area in Antarctica by Yongpeng Zhang, Bo Zhang, Imtiaz Ahmed, Hanshu Zhang, Yiliang He

“…Profiles and driving mechanisms of antibiotic resistome in the polar region are important for exploring the natural evolution of antibiotic resistance genes (ARGs). Here, we evaluated the profiles of antibiotic resistome in multiple media on Inexpressible Island, Terra Nova Bay, Antarctica. …”
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Enhanced Solubility of the Support in an FDM-Based 3D Printed Structure Using Hydrogen Peroxide under Ultrasonication by Seong Je Park, Ji Eun Lee, Jean Ho Park, Nak Kyu Lee, Min-Young Lyu, Keun Park, Myung Sool Koo, Sung Hwan Cho, Yong Son, Suk-Hee Park

“…Thus, the support removal is an essential postprocessing step after the FDM process. Here, we present an efficient and rapid method to remove the support part of an FDM-manufactured product using the phenomenon of oxidative degradation of hydrogen peroxide. …”
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The effects of vessel speed and size on the lethality of strikes of large whales in U.S. waters by Lance P. Garrison, Niki E. Lisi, Meghan Gahm, Eric M. Patterson, Hannah Blondin, Hannah Blondin, Caroline P. Good

“…Vessel speed restrictions are one of the primary approaches to reduce the risk of vessel strikes to whales in the face of continued industrialization of the oceans, and the model presented here will help better inform management efforts.…”
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Fatal toxoplasmic encephalitis triggered by anti-TNF therapy by Rodrigo A. Montoro, Michael Moran, Katherine A. Overmyer, Andrew Periaccante, Joshua J. Coon, Swapnil Lanjewar, Laura J. Knoll, Rob Striker

“…Serologic evidence of a possible latent T. gondii infection in humans is common worldwide, so why anti-TNF-α reactivation isn't more common is unknown. Here we present a 74-year-old woman who developed fatal cerebral toxoplasmosis after anti-tumor necrosis factor-α (TNF-α). …”
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Predictive value of dendritic cell-related genes for prognosis and immunotherapy response in lung adenocarcinoma by Zihao Sun, Mengfei Hu, Xiaoning Huang, Minghan Song, Xiujing Chen, Jiaxin Bei, Yiguang Lin, Size Chen

“…Dendritic cells (DCs) play a significant role in the tumor microenvironment and the DCs-related gene signature may be used to predict treatment outcome. Here, we screened for DC-related genes to construct a prognostic signature to predict prognosis and response to immunotherapy in LUAD patients. …”
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Multiplexed SSR marker analysis of Diplocarpon coronariae reveals clonality within samples from Middle Europe and genetic distance from Asian and North American isolates by Thomas Oberhänsli, Anna Dalbosco, Virginie Leschenne, Anne Bohr, Sascha Buchleither, Lucius Tamm, Lukas Wille, Srđan G. Aćimović, Fatemeh Khodadadi, Young-Hyun Ryu, Bruno Studer, Hans-Jakob Schärer, Andrea Patocchi

“…Conclusions The twelve newly developed SSR markers reported here provide a useful tool to characterize the population genetic diversity and structure of Dc in Europe. …”
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Comparison of intraoperative neurophysiological monitoring between propofol and remimazolam during total intravenous anesthesia in the cervical spine surgery: a prospective, double... by Myoung Hwa Kim, Jinyoung Park, Yoon Ghil Park, Yong Eun Cho, Dawoon Kim, Dong Jun Lee, Kyu Wan Kwak, Jongyun Lee, Dong Woo Han

“…Background Although total intravenous anesthesia (TIVA) with propofol and remifentanil is frequently used to optimize intraoperative neurophysiological monitoring (IONM), the exact effect of remimazolam on IONM remains unknown. Here, we compared the effects of propofol and remimazolam along with remifentanil on IONM during TIVA. …”
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Sorafenib enhanced the function of myeloid-derived suppressor cells in hepatocellular carcinoma by facilitating PPARα-mediated fatty acid oxidation by Chunxiao Li, Liting Xiong, Yuhan Yang, Ping Jiang, Junjie Wang, Mengyuan Li, Shuhua Wei, Suqing Tian, Yuexuan Wang, Mi Zhang, Jie Tang

“…The impact of sorafenib on tumor growth, MDSC infiltration, differentiation, and immunosuppressive function was assessed, alongside the modulation of these processes by PPARα. Results Here, we revealed increased infiltration and enhanced function of MDSCs in TME after treatment with sorafenib. …”
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Inconspicuous taxa in citizen science-based botanical research: actual contribution, limitations, and new opportunities for non-vascular cryptogams by Carlos Cerrejón, Carlos Cerrejón, Marion Noualhaguet, Nicole J. Fenton, Marc-Frédéric Indorf, Mariano J. Feldman, Mariano J. Feldman

“…However, the contribution of CS in botanical research, and more particularly regarding inconspicuous taxonomic groups such as cryptogams remains largely unexplored. Here we assess the current status and contribution of CS in botanical research, with a special focus on non-vascular “cryptogams” (bryophytes, lichens, fungi, and algae). …”
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Investigating charge dynamics at lead halide perovskite single crystal surfaces by Birgit Kammlander, Alberto García-Fernández, Sebastian Svanström, Erika Giangrisostomi, Ruslan Ovsyannikov, Håkan Rensmo, Ute B Cappel

“…Additionally, this method enables us to follow compositional changes and surface degradation and distinguish these from purely electronic effects. Here we investigated the charge dynamics of two distinct lead halide perovskite single crystal surfaces (CsPbBr _3 , Cs-doped FAPbI _3 ) using TR-PES in different timescales (ps to μ s and s to min). …”
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Sex-biased prevalence in infections with heterosexual, direct, and vector-mediated transmission: a theoretical analysis by Andrea Pugliese, Abba B. Gumel, Fabio A. Milner, Jorge X. Velasco-Hernandez

“…Three deterministic Kermack-McKendrick-type models for studying the transmission dynamics of an infection in a two-sex closed population are analyzed here. In each model it is assumed that infection can be transmitted through heterosexual contacts, and that there is a higher probability of transmission from one sex to the other than vice versa. …”
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Adaptive evolution of stress response genes in parasites aligns with host niche diversity by Armando J. Cruz-Laufer, Maarten P. M. Vanhove, Lutz Bachmann, Maxwell Barson, Hassan Bassirou, Arnold R. Bitja Nyom, Mare Geraerts, Christoph Hahn, Tine Huyse, Gyrhaiss Kapepula Kasembele, Samuel Njom, Philipp Resl, Karen Smeets, Nikol Kmentová

“…Despite this importance, our understanding of the evolution of molecular pathways dealing with environmental stressors in parasitic animals remains limited. Here, we tested the link between adaptive evolution of parasite stress response genes and their ecological diversity and species richness. …”
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Criminal justice in a small Nordic country: The case of Iceland by Helgi Gunnlaugsson

“…These non-custodial sanctions include electronic surveillance, additional community service work and an increased possibility to serve time in open prison units. It is contended here that a combination of practical budget concerns and rehabilitation sentiments lies behind this criminal policy development. …”
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