Ice speed of a Greenlandic tidewater glacier modulated by tide, melt, and rain by S. Sugiyama, S. Sugiyama, S. Tsutaki, S. Tsutaki, D. Sakakibara, D. Sakakibara, I. Asaji, K. Kondo, Y. Wang, E. Podolskiy, G. Jouvet, G. Jouvet, M. Funk

“…Short-term speed variations are key to understanding the physical processes controlling glacial motion, but studies on Greenlandic tidewater glaciers, particularly near the calving front, are sparse. Here, we present high-frequency ice speed measurements performed at 0.5–4 km from the front of Bowdoin Glacier, a tidewater glacier in northwestern Greenland. …”
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KPC pancreatic cancer cells are a novel immunocompetent murine model supporting human adenovirus replication and tumor oncolysis by Marc Otero-Mateo, Francesc Estrany Jr, Sabrina Arcas-Márquez, Laura Moya-Borrego, Giancarlo Castellano, Miquel Castany, Ramon Alemany, Cristina Fillat

“…However, the limited capacity of murine cells to produce infectious viral progeny precludes the full evaluation of the virotherapy in a suitable immunocompetent mouse model. Here, we report that the murine KPC-I cell line, established from pancreatic tumors developed in LSL-KrasG12D; LSL-Trp53R172H; Pdx-Cre mice, is susceptible to adenoviral replication and generates a progeny of infective virions similar to those from infected human A549 cells. …”
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Detection and classification of long terminal repeat sequences in plant LTR-retrotransposons and their analysis using explainable machine learning by Jakub Horvath, Pavel Jedlicka, Marie Kratka, Zdenek Kubat, Eduard Kejnovsky, Matej Lexa

“…Conclusions Our results show that the models used here recognized biologically relevant motifs, such as core promoter elements in the LTR detection task, and a development and stress-related subclass of transcription factor binding sites in the family classification task. …”
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β-Nicotinamide Mononucleotide Reduces Oxidative Stress and Improves Steroidogenesis in Granulosa Cells Associated with Sheep Prolificacy via Activating AMPK Pathway by Yu Cai, Hua Yang, Hui Xu, Shanglai Li, Bingru Zhao, Zhibo Wang, Xiaolei Yao, Feng Wang, Yanli Zhang

“…However, the mechanisms behind metabolite heterogeneity and its effects on GCs’ function remain poorly understood. Here, we identified elevated nicotinamide levels in the follicular fluid of high-prolificacy sheep, correlated with oxidative stress in GCs, by an integrated analysis. …”
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A minimal gene set characterizes TIL specific for diverse tumor antigens across different cancer types by Zhen Zeng, Tianbei Zhang, Jiajia Zhang, Shuai Li, Sydney Connor, Boyang Zhang, Yimin Zhao, Jordan Wilson, Dipika Singh, Rima Kulikauskas, Candice D. Church, Thomas H. Pulliam, Saumya Jani, Paul Nghiem, Suzanne L. Topalian, Patrick M. Forde, Drew M. Pardoll, Hongkai Ji, Kellie N. Smith

“…Mutation-associated neoantigen (MANA) -specific CD8+ tumor-infiltrating lymphocytes (TIL) have been shown to express high levels of CXCL13 and CD39 (ENTPD1), and low IL-7 receptor (IL7R) levels in many cancer types, but their collective relevance to T cell functionality has not been established. Here we present an integrative tool to identify MANA-specific TIL using weighted expression levels of these three genes in lung cancer and melanoma single-cell RNAseq datasets. …”
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Recombinant Production of Bovine α_S1-Casein in Genome-Reduced <i>Bacillus subtilis</i> Strain IIG-Bs-20-5-1 by Lennart Biermann, Lea Rahel Tadele, Elvio Henrique Benatto Perino, Reed Nicholson, Lars Lilge, Rudolf Hausmann

“…Background: Cow’s milk represents an important protein source. Here, especially casein proteins are important components, which might be a promising source of alternative protein production by microbial expression systems. …”
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All‐Inorganic Perovskite Quantum‐Dot Optical Neuromorphic Synapses for Near‐Sensor Colored Image Recognition by Yung‐Chi Yao, Chia‐Jung Lee, Yong‐Jun Chen, Jun‐Zhi Feng, Hongseok Oh, Chin‐Shan Lue, Jinn‐Kong Sheu, Ya‐Ju Lee

“…This approach aims to reduce data movement between sensory and computing units, minimizing the need for data transfer and conversion at the sensor‐processor interface. Here, an optical neuromorphic synaptic (ONS) device is demonstrated by homogeneously integrating optical‐sensing and synaptic functionalities into a unified material platform, constructed exclusively by all‐inorganic perovskite CsPbBr3 quantum dots (QDs). …”
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Oleanolic Acid Induces Differentiation of Neural Stem Cells to Neurons: An Involvement of Transcription Factor Nkx-2.5 by You Ning, Jianhua Huang, Bill Kalionis, Qin Bian, Jingcheng Dong, Junzhen Wu, Xiantao Tai, Shijin Xia, Ziyin Shen

“…Thus far, few drugs have been developed for controlling NSC functions. Here, the effect as well as mechanism of oleanolic acid (OA), a pentacyclic triterpenoid, on NSC function was investigated. …”
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Growing meat on autoclaved vegetables with biomimetic stiffness and micro-patterns by Ye Liu, Anqi Gao, Tiantian Wang, Yongqian Zhang, Gaoxiang Zhu, Sida Ling, Zhaozhao Wu, Yuhong Jin, Haoke Chen, Yuming Lai, Rui Zhang, Yuchen Yang, Jianyong Han, Yulin Deng, Yanan Du

“…Current meat-engineering technologies struggle to achieve scalable cell production, efficient cell differentiation, and tissue maturation in one single culture system. Here we propose an autoclaving strategy to transform common vegetables into muscle- and adipose-engineering scaffolds, without undergoing conventional plant decellularization. …”
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Genetic Rescue of the Dinaric Lynx Population: Insights for Conservation From Genetic Monitoring and Individual‐Based Modelling by Elena Pazhenkova, Matej Bartol, Barbara Boljte, Urša Fležar, Andrea Gazzola, Tomislav Gomerčić, Marjeta Konec, Ivan Kos, Miha Krofel, Jakub Kubala, Ladislav Paule, Mihai Pop, Hubert Potočnik, Barbara Promberger, Robin Rigg, Teodora Sin, Magda Sindičić, Vedran Slijepčević, Astrid Vik Stronen, Ira Topličanec, Tomaž Skrbinšek

“…The Dinaric lynx population serves as a compelling example of genetic rescue. The lessons learnt here will be essential for ensuring the viability of the Dinaric lynx in the future and also provide a useful template for conservation of other populations and species facing similar threats.…”
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A covalent peptide-based lysosome-targeting protein degradation platform for cancer immunotherapy by Youmei Xiao, Zhuoying He, Wanqiong Li, Danhong Chen, Xiaoshuang Niu, Xin Yang, Wenxuan Zeng, Mengfan Wang, Yuzhen Qian, Ye Su, Feiyu Luo, Guanyu Chen, Juan Liu, Xinghua Sui, Xiuman Zhou, Yanfeng Gao

“…The ability of antibody-based LYTACs to penetrate solid tumor is limited as well, especially to cross the blood-brain barrier (BBB). Here, we propose a covalent chimeric peptide-based targeted degradation platform (Pep-TACs) by introducing a long flexible aryl sulfonyl fluoride group, which allows proximity-enabled cross-linking upon binding with the protein of interest. …”
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GmERF13 mediates salt inhibition of nodulation through interacting with GmLBD16a in soybean by Xinfang Zhu, Xifeng Yan, Weijun Li, Mengyue Zhang, Junchen Leng, Qianqian Yu, Like Liu, Dawei Xue, Dajian Zhang, Zhaojun Ding

“…Abstract While the genetic regulation of nodule formation has been well explored, the molecular mechanisms by which abiotic stresses, such as salt stress, impede nodule formation remain largely elusive. Here, we identify four APETALA2/Ethylene Responsive Factor (AP2/ERF) transcription factors, GmERF13s, that are induced by salt stress and play key roles in salt-repressed nodulation. …”
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A lead-free KNN-based, co-fired multilayered piezoceramic energy harvester with a high output current and power by Qiong Wu, Faqiang Zhang, Bing Wang, Zhi Cheng, Song Liu, Ronglei Zhu, Yuheng Huang, Jianglei Chang, Zhifu Liu, Shuxiang Dong

“…To address this issue, here we present a PEH assembled with lead-free potassium sodium niobate (KNN) based co-fired multilayered piezoceramics (MLPCs), which show a high output current and power. …”
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Transcriptome and weighted gene co-expression network analysis of jujube (Ziziphus jujuba Mill.) fruit reveal putative genes involved in proanthocyanin biosynthesis and regulation by Wenqiang Wang, Yunfeng Pu, Hao Wen, Dengyang Lu, Min Yan, Minzhe Liu, Minyu Wu, Hongjin Bai, Lirong Shen, Cuiyun Wu

“…However, the molecular mechanisms underlying PA biosynthesis in jujube fruit have not been investigated. Here, the profiling of PA, (+)-catechin and (–)-epicatechin and transcriptome sequencing of three jujube cultivars from Xinjiang Uyghur Autonomous Region of China at five developmental stages were analyzed. …”
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The symbiont Wolbachia increases resistance to bifenthrin in Ectropis grisescens by regulating the host detoxification function by Tian Gao, Yong Zhang, Wanpeng Sun, Qiangkun Li, Xueyu Huang, Dian Zhi, Huabin Zi, Ruijie Ji, Yanhua Long, Chunmei Gong, Yunqiu Yang

“…Recent studies suggest that insect symbionts play a role in influencing insecticide resistance, however, their specific involvement in E. grisescens remains unclear. Here, we initially selected appropriate antibiotic mixtures at a concentration of 300 μg ml−1. …”
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High-level production of free fatty acids from lignocellulose hydrolysate by co-utilizing glucose and xylose in yeast by Xin Ni, Jingjing Li, Wei Yu, Fan Bai, Zongbao K. Zhao, Jiaoqi Gao, Fan Yang, Yongjin J. Zhou

“…However, the challenges associated with the co-utilization of xylose and glucose often hinders the efficiency of lignocellulose bioconversion. Here, we engineered yeast Ogataea polymorpha to effectively produce free fatty acids from lignocellulose. …”
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pH-Dependent preferential adsorption and stability of humic substances on goethite: The dual role of aromatic and aliphatic moieties by Long Wang, Yanan Ren, Mengke Jia, Jinkang Yang, Hongen Liu, Peng Zhao, Jihua Tang, Jie Ma, Liping Weng, Yongtao Li

“…Preferential adsorption occurs during interaction between humic substances (HS) and metal (hydr)oxides, however, the preferential adsorption and thermal stability mechanism remains poorly understood. Here we show that solution pH can modify the configuration of humic acid (HA) and fulvic acid (FA), and thereby altering their fractionation and thermal stability in relation to goethite. …”
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Contractile Protein Expression and Phosphorylation and Contractility of Gastric Smooth Muscles from Obese Patients and Patients with Obesity and Diabetes by Wen Li, Kent C. Sasse, Yulia Bayguinov, Sean M. Ward, Brian A. Perrino

“…Diabetes impairs gastric muscle function, but the mechanisms underlying diabetes-induced gastric muscle dysfunction are unknown. Here, we compared the expression and phosphorylation of Ca2+ sensitization and contractile proteins in human gastric muscles from obese nondiabetic and diabetic patients. …”
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Novel Graphical Analyses of Runs of Homozygosity among Species and Livestock Breeds by Laura Iacolina, Astrid V. Stronen, Cino Pertoldi, Małgorzata Tokarska, Louise S. Nørgaard, Joaquin Muñoz, Anders Kjærsgaard, Aritz Ruiz-Gonzalez, Stanisław Kamiński, Deirdre C. Purfield

“…The comparative methodology presented here permits visual identification of regions of interest for selection, breeding programs, and conservation.…”
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Modeling and simulations of hydrodynamic shocks in a plasma flowing across randomized ICF scale laser beams by Hüller, S., Ludwig, J. D. T., Rose, H. A., Bruulsema, C., Farmer, W., Michel, P., Milder, A. L., Swadling, G. F., Rozmus, W.

“…This scenario has been predicted theoretically and is confirmed here by our hydrodynamic simulations in two dimensions with speckled beams and in one dimension with a reduced model. …”
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