A sweeping view of avian mycoplasmas biology drawn from comparative genomic analyses by Elhem Yacoub, Vincent Baby, Pascal Sirand-Pugnet, Yonathan Arfi, Helmi Mardassi, Alain Blanchard, Salim Chibani, Boutheina Ben Abdelmoumen Mardassi

“…Extensive genomic data are available for many avian mycoplasmas, yet no comparative studies focusing on this group of mycoplasmas have been undertaken so far. Results Here, based on the comparison of forty avian mycoplasma genomes belonging to ten different species, we provide insightful information on the phylogeny, pan/core genome, energetic metabolism, and virulence of these avian pathogens. …”
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Assessment of Impact of Meteorology and Precursor in Long-term Trends of PM and Ozone in a Tropical City by Christian Mark G. Salvador, Angeles D. Alindajao, Karen B. Burdeos, Mark Anthony M. Lavapiez, Jhon Robin Yee, Angel T. Bautista, Preciosa Corazon B. Pabroa, Rey Y. Capangpangan

“…Abstract Long-term trends of atmospheric pollutants, particularly ozone (O3) and particulate matter (PM) provide a direct evaluation of the response of the atmosphere to the environmental policies and the variability of anthropogenic and biogenic emissions. Here, we report the assessment of the temporal evolution of the air quality in a tropical urban city (Butuan) in the southern Philippines by evaluating the trends of meteorological conditions (i.e., temperature, R.H., boundary layer height), air pollutants (i.e., PM2.5, NO2, O3) and their precursors (Benzene, Toluene, and Xylene) from 2014 to 2020. …”
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Lymphatic-derived oxysterols promote anti-tumor immunity and response to immunotherapy in melanoma by Mengzhu Sun, Laure Garnier, Romane Chevalier, Martin Roumain, Chen Wang, Julien Angelillo, Julien Montorfani, Robert Pick, Dale Brighouse, Nadine Fournier, David Tarussio, Stéphanie Tissot, Jean-Marc Lobaccaro, Tatiana V. Petrova, Camilla Jandus, Daniel E. Speiser, Manfred Kopf, Caroline Pot, Christoph Scheiermann, Krisztian Homicsko, Giulio G. Muccioli, Abhishek D. Garg, Stéphanie Hugues

“…In human melanoma, LECs also upregulate Ch25h, and its expression correlates with the lymphatic vessel signature, infiltration of pro-inflammatory macrophages, better patient survival, and better response to immunotherapy. We identify here in mechanistic detail an important LEC function that supports anti-tumor immunity, which can be therapeutically exploited in combination with immunotherapy.…”
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From Continent to Ocean: Investigating the Multi-Element and Precious Metal Geochemistry of the Paraná-Etendeka Large Igneous Province Using Machine Learning Tools by J. J. Lindsay, H. S. R. Hughes, C. M. Yeomans, J. C. Ø. Andersen, I. McDonald

“…The PELIP presents an opportunity to observe magma geochemistry as the continent and sub-continental lithospheric mantle (SCLM) are progressively removed from a melting environment. Here, we use an unsupervised machine learning approach (featuring the PCA, t-SNE and k-means clustering algorithms) to investigate the geochemistry of a set of (primarily basaltic) onshore and offshore PELIP lavas. …”
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Coalescence of multiple topological orders in quasi-one-dimensional bismuth halide chains by Jingyuan Zhong, Ming Yang, Wenxuan Zhao, Kaiyi Zhai, Xuan Zhen, Lifu Zhang, Dan Mu, Yundan Liu, Zhijian Shi, Ningyan Cheng, Wei Zhou, Jianfeng Wang, Weichang Hao, Zhenpeng Hu, Jincheng Zhuang, Jinhu Lü, Yi Du

“…The conjoined topology, however, is still elusive in experiments due to the lack of suitable material platforms. Here we use scanning tunneling microscopy, angle-resolved photoemission spectroscopy, and theoretical calculations to investigate the doping-driven band structure evolution of a quasi-one-dimensional material system, bismuth halide, which contains rare multiple band inversions in two time-reversal-invariant momenta. …”
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Transcriptome analysis reveals the anticancer effects of fenbendazole on ovarian cancer: an in vitro and in vivo study by Xin Wang, Wenda Tian, Ning Wang, Xiangqun Yang, Zhenyan Liu, Lvzhou Li, Taoyu Zhao, Chuanlin Wang, Hongping Zhang, Hongying Yang, Yue Jia

“…Abstract New treatment strategies for ovarian cancer, which is the deadliest female reproductive tract malignancy, are urgently needed. Here, we investigated the anticancer effects of fenbendazole (FBZ), a benzimidazole compound, on the regulation of apoptosis and mitotic catastrophe in A2780 and SKOV3 human epithelial ovarian cancer cells. …”
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Enhancement of 316 L stainless steel mechanical properties through TiC particle introduction via metal powder injection molding by Gu Da, Wu Dun, Chen Zexu, Cao Zheng, Cheng Junfeng, Wang Dong, Lu Xiangyu, Liu Chunlin

“…As the industry grows with upgraded techniques, the standard for next generation material strength has improved tremendously. Here we present a practical method strengthening SS 316 L via MIM technique, which might provide a pathway for exploration of high strength materials. …”
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Relativistic Binary Precession: Impact on Eccentric Massive Binary Black Hole Accretion and Hydrodynamics by Stanislav DeLaurentiis, Zoltán Haiman, John Ryan Westernacher-Schneider, Luke Major Krauth, Jordy Davelaar, Jonathan Zrake, Andrew MacFadyen

“…Recent hydrodynamical simulations have shown that circumbinary gas disks drive the orbits of massive binary black holes (BHs) to become eccentric, even when general relativistic (GR) corrections to the orbit are significant. Here, we study the GR apsidal precession of eccentric equal-mass massive binary BHs in circumbinary disks via two-dimensional hydrodynamical simulations. …”
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Digital twin-enhanced three-organ microphysiological system for studying drug pharmacokinetics in pregnant women by Katja Graf, José Martin Murrieta-Coxca, Tobias Vogt, Sophie Besser, Daria Geilen, Tim Kaden, Tim Kaden, Anne-Katrin Bothe, Diana Maria Morales-Prieto, Behnam Amiri, Behnam Amiri, Stephan Schaller, Ligaya Kaufmann, Martin Raasch, Ramy M. Ammar, Ramy M. Ammar, Christian Maass, Christian Maass

“…To address this issue, we used a three-organ microphysiological system (MPS) combined with a digital twin framework, to predict pharmacokinetics and fetal drug exposure.MethodsThe here shown human MPS integrated gut, liver, and placenta models, interconnected via the corresponding vasculature. …”
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Spherical Accretion in the Schwarzschild Spacetime in the Newtonian Analogous Construct by Shubhrangshu Ghosh, Souvik Ghose, Kalyanbrata Pal, Arunabha Bhadra, Tapas K. Das

“…As a further application, here we explore the extent to which TR13 NAP could describe a transonic hydrodynamical spherical accretion flow in Schwarzschild spacetime within the framework of standard Newtonian hydrodynamics. …”
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De Novo Assembly of the Polyhydroxybutyrate (PHB) Producer <i>Azohydromonas lata</i> Strain H1 Genome and Genomic Analysis of PHB Production Machinery by Daniele Traversa, Carlo Pazzani, Pietro D’Addabbo, Lucia Trisolini, Matteo Chiara, Marta Oliva, Angelo Marzella, Camilla Mandorino, Carla Calia, Guglielmina Chimienti, Caterina Manzari, Graziano Pesole, Maria Scrascia

“…<i>Azohydromonas lata</i> strain H1 has been reported to accumulate PHB by using simple, inexpensive carbon sources. Here, we present the first de novo genome assembly of the <i>A. lata</i> strain H1. …”
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Early life microbial succession in the gut follows common patterns in humans across the globe by Guilherme Fahur Bottino, Kevin S. Bonham, Fadheela Patel, Shelley McCann, Michal Zieff, Nathalia Naspolini, Daniel Ho, Theo Portlock, Raphaela Joos, Firas S. Midani, Paulo Schüroff, Anubhav Das, Inoli Shennon, Brooke C. Wilson, Justin M. O’Sullivan, Robert A. Britton, Deirdre M. Murray, Mairead E. Kiely, Carla R. Taddei, Patrícia C. B. Beltrão-Braga, Alline C. Campos, Guilherme V. Polanczyk, Curtis Huttenhower, Kirsten A. Donald, Vanja Klepac-Ceraj

“…Abstract Characterizing the dynamics of microbial community succession in the infant gut microbiome is crucial for understanding child health and development, but no normative model currently exists. Here, we estimate child age using gut microbial taxonomic relative abundances from metagenomes, with high temporal resolution (±3 months) for the first 1.5 years of life. …”
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Mental health in the UK during the COVID-19 pandemic: cross-sectional analyses from a community cohort study by Elizabeth Broadbent, Carol Coupland, Trudie Chalder, Kavita Vedhara, Ru Jia, Kieran Ayling, Adam Massey

“…Objectives Previous pandemics have resulted in significant consequences for mental health. Here, we report the mental health sequelae of the COVID-19 pandemic in a UK cohort and examine modifiable and non-modifiable explanatory factors associated with mental health outcomes. …”
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Excitation of ULF, ELF, and VLF Resonator and Waveguide Oscillations in the Earth–Atmosphere–Ionosphere System by Lightning Current Sources Connected with Hunga Tonga Volcano Erupt... by Yuriy G. Rapoport, Volodymyr V. Grimalsky, Andrzej Krankowski, Asen Grytsai, Sergei S. Petrishchevskii, Leszek Błaszkiewicz, Chieh-Hung Chen

“…The simulations presented here are based on the observational data of lightning electric currents associated with the eruption of the Hunga Tonga volcano in January 2022. …”
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Delineating urban flooding when incorporating community stormwater knowledge by Madeline Scolio, Peleg Kremer, Virginia Smith, Achira Amur, Bridget Wadzuk, Kate Homet, Eric Devlin, Md Abdullah Al Mehedi, Laura Moore

“…An array of data, including remotely sensed satellite imagery after major flooding events, Federal Emergency Management Agency’s Special Flood Hazard Areas, First Street Foundation’s Flood Factor, road closures, National Flood Insurance Program claims, and community surveys, were compared for the study areas. Here we show how stakeholder surveys can illuminate the weight of firsthand and communal knowledge on local understandings of stormwater and flood risk. …”
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Recipient sex and donor leukemic cell characteristics determine leukemogenesis in patient-derived models by Anna MP. Stanger, Marlon Arnone, Pauline Hanns, Lucca M. Kimmich, Jessica Kübler, Sarah Gekeler, Elsa S. Görsch, Lea Kramer, Marcelle Baer, Jan C. Schroeder, Taylor S. Mills, Martina Konantz, Saskia S. Rudat, Claudia Lengerke

“… In acute myeloid leukemia (AML), leukemogenesis depends on cell-intrinsic genetic aberrations and thus, studies on AML require investigations in an in vivo setting as provided by patient derived xenografts (PDX) models. Here we report that, next to leukemic cell characteristics, recipient sex highly influences the outgrowth of AML cells in PDX models, with females being much better repopulated than males in primary as well as secondary transplantation assays. …”
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A novel method to determine background concentrations and spatial distributions of heavy metals in soil at large scale using machine learning coupled with remote sensing-terrain at... by Magboul M. Sulieman, Fuat Kaya, Abdullah S. Al-Farraj, Eric C. Brevik

“…Thus, preventing pollution and protecting pristine soils and preindustrial areas from human activities that lead to the concentration of heavy metals (HMs) is a priority. Here, a novel methodology was proposed to establish background concentrations of eight soil HMs, cobalt (Co), chromium (Cr), copper (Cu), iron (Fe), manganese (Mn), nickel (Ni), lead (Pb), and zinc (Zn), and digitally map their spatial distributions in an area (i.e., harrats region) that has not yet been impacted by industrial activity. …”
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Encapsulation of docosahexaenoic acid (DHA) using self-assembling food-derived proteins for efficient biological functions by Yumeng Liu, Kaixin Cao, Tong Li, Delun Mu, Naiqi Zhang, Ying Wang, Rina Wu, Junrui Wu

“…However, the application of DHA has been limited due to poor aqueous solubility and susceptible to oxidation. Here, ovalbumin (O), myosin (M), 7S soy globulin (S), and β-lactoglobulin (β), hydrolyzed by chymotrypsin, self-assembled into micelles, respectively. …”
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miR-21 Overexpression Promotes Esophageal Squamous Cell Carcinoma Invasion and Migration by Repressing Tropomyosin 1 by Zhuojian Shen, Xia Xu, Liangzhan Lv, Honglue Dai, Ju Chen, Baishen Chen

“…The migration and invasion of esophageal squamous cell carcinoma are associated with clinical outcomes, however, the mechanisms remain poorly understood. Here, we found that miR-21 is significantly overexpressed in ESCC, lung cancer, and bladder cancer compared with the adjacent normal tissue. …”
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A hammerhead ribozyme selects mechanically stable conformations for catalysis against viral RNA by Man Lu, Zhiqiang Cao, Luoan Xiong, Hongying Deng, Kangkang Ma, Ning Liu, Yanding Qin, Shen-Bo Chen, Jun-Hu Chen, Yao Li, Yijin Liu, Zhongbo Yu

“…Particularly, the role of conformational dynamics in ribozyme catalysis remains elusive. Here, we use single-molecule magnetic tweezers to reveal a concerted catalysis mechanism of mechanical conformational selection for a mini hammerhead ribozyme against a viral RNA sequence from the SARS-CoV-2. …”
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