Succinate supplementation alleviates liver cancer by inhibiting the FN1/SQLE axis-mediated cholesterol biosynthesis by Shuyuan Chang, Ayaka Tomii, Yunfei Zhou, Xun Yang, Yihong Dong, Jun Yan, Aodi Wu, Yumeng Wang, Qingxin Zhang, Hongxue Meng, Lei Yu, Wei Sun, Dabin Liu

“…However, the role of exogenous succinate in hepatocellular carcinoma (HCC) is unclear. Here, we report that the concentration of succinate in HCC tissues is lower compared to adjacent normal tissues, as determined by spatial metabolomics and quantitative metabolomics analysis. …”
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Acute administration of NLX-101, a Serotonin 1A receptor agonist, improves auditory temporal processing during development in a mouse model of Fragile X Syndrome by Xin Tao, Katilynne Croom, Adrian Newman-Tancredi, Mark Varney, Khaleel A. Razak

“…In our previous study, we found that administration of the selective serotonin-1 A (5-HT1A)receptor biased agonist, NLX-101, protected Fmr1 KO mice from auditory hypersensitivity-associated seizures. Here we tested the hypothesis that NLX-101 will normalize EEG phenotypes in developing Fmr1 KO mice. …”
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Clinical Characteristics of 31 Patients with Chest Pain Variant Asthma by Mao W, Gao Y, Sun W, Li J, Wang J, Wang Z, Zhang L, Huang K

“…Although chest pain variant asthma (CPVA) is not common in clinical practice, there are still a few people who only or mainly manifest as chest pain. Here, we aim to introduce the characteristics of their symptoms, lung function and chest imaging features to arouse the attention of physicians to know better of the disease.Patients and Methods: We retrospectively analyzed thirty-one patients who had been diagnosed with CPVA based on clinical data and positive bronchial provocation tests (BPTs).Results: The mean age of all enrolled patients was forty-seven years, and females accounted for 64.5%. …”
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Cannabidiol Rescues Acute Hepatic Toxicity and Seizure Induced by Cocaine by Luciano Rezende Vilela, Lindisley Ferreira Gomides, Bruna Araújo David, Maísa Mota Antunes, Ariane Barros Diniz, Fabrício de Araújo Moreira, Gustavo Batista Menezes

“…The most severe and common complications are seizures, ischemic strokes, myocardial infarction, and acute liver injury. Here, we demonstrated that acute cocaine intoxication promoted seizure along with acute liver damage in mice, with intense inflammatory infiltrate. …”
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Unveiling early-life microbial colonization profile through characterizing low-biomass maternal-infant microbiomes by 2bRAD-M by Shuwen Hou, Yuesong Jiang, Feng Zhang, Tianfan Cheng, Dan Zhao, Jilong Yao, Ping Wen, Ping Wen, Lijian Jin, Shi Huang

“…However, analyzing these samples often faces technical challenges and limitations of low-resolution using conventional approaches due to their low microbial biomass.MethodsHere, we employed the type IIB restriction enzymes site-associated DNA sequencing for microbiome (2bRAD-M) as a reduced metagenomics method to address these issues and profile species-level microbial composition. …”
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Re-annotation of SARS-CoV-2 proteins using an HHpred-based approach opens new opportunities for a better understanding of this virus by Brézellec, Pierre

“…We conclude that the approach described here (or similar approaches) opens up new avenues of research to better understand SARS-CoV-2 and could be used to complement virus annotations, particularly for less-studied viruses.…”
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Strong benefits of hedgerows to bats in three European winegrowing regions by Fernanda Chávez, Martin H. Entling, Rafael Alcalá Herrera, Emilio Benítez, Stefan Möth, Jo Marie Reiff, Silvia Winter, Verena Rösch

“…However, to date, the relationship between bats and the surrounding landscape within a viticultural matrix has received little attention, despite moths being major pests in viticulture. Here, we investigated how bats respond to different landscape elements in three European regions: Rhineland‐Palatinate (Germany), Burgenland (Austria), and Andalusia (Spain). …”
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Effects of Mating and Social Exposure on Cell Proliferation in the Adult Male Prairie Vole (Microtus ochrogaster) by A. E. Castro, L. J. Young, F. J. Camacho, R. G. Paredes, N. F. Diaz, W. Portillo

“…Microtus ochrogaster is a rodent with a monogamous reproductive strategy characterized by strong pair bond formation after 6 h of mating. Here, we determine whether mating-induced pair bonding increases cell proliferation in the subventricular zone (SVZ), rostral migratory stream (RMS), and dentate gyrus (DG) of the hippocampus in male voles. …”
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Discovering CRISPR-Cas system with self-processing pre-crRNA capability by foundation models by Wenhui Li, Xianyue Jiang, Wuke Wang, Liya Hou, Runze Cai, Yongqian Li, Qiuxi Gu, Qinchang Chen, Peixiang Ma, Jin Tang, Menghao Guo, Guohui Chuai, Xingxu Huang, Jun Zhang, Qi Liu

“…With protein large language models (LLMs) evolving, there is potential for Cas system modeling without extensive training data. Here, we introduce CHOOSER (Cas HOmlog Observing and SElf-processing scReening), an AI framework for alignment-free discovery of CRISPR-Cas systems with self-processing pre-crRNA capability using protein foundation models. …”
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Unconventional Hexagonal Close‐Packed High‐Entropy Alloy Surfaces Synergistically Accelerate Alkaline Hydrogen Evolution by Ting‐Hsin Hu, Cheng‐Yu Wu, Zong Ying He, Yi Chen, Liang‐Ching Hsu, Chih‐Wen Pao, Jui‐Tai Lin, Chun‐Wei Chang, Shang‐Cheng Lin, Rachel Osmundsen, Lee Casalena, Kun Han Lin, Shan Zhou, Tung‐Han Yang

“…Abstract Accelerating the alkaline hydrogen evolution reaction (HER), which involves the slow cleavage of HO‐H bonds and the adsorption/desorption of hydrogen (H*) and hydroxyl (OH*) intermediates, requires developing catalysts with optimal binding strengths for these intermediates. Here, the unconventional hexagonal close‐packed (HCP) high‐entropy alloy (HEA) atomic layers are prepared composed of five platinum‐group metals to enhance the alkaline HER synergistically. …”
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Prisoners in the community: the open prison model in Catalonia by Marta Martí

“…As a contribution to the comparative study of open prisons, I describe here how Catalan open prisons are run and discuss the concept of ‘openness’ with reference, above all, to the open prisons that exist in Scandinavian countries. …”
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Inflammatory microglia correlate with impaired oligodendrocyte maturation in multiple sclerosis by J. Q. Alida Chen, Dennis D. Wever, Niamh B. McNamara, Morjana Bourik, Joost Smolders, Jörg Hamann, Jörg Hamann, Inge Huitinga, Inge Huitinga

“…The molecular and cellular mechanisms that drive remyelination remain poorly understood. Here, we studied the relation between microglia activation and remyelination activity in MS.MethodsWe correlated regenerative (CD163+) and inflammatory (iNOS+) microglia with BCAS1+ oligodendrocytes, subdivided into early-stage (<3 processes) and late-stage (≥3 processes) cells in brain donors with high or low remyelinating potential in remyelinated lesions and active lesions with ramified/amoeboid (non-foamy) or foamy microglia. …”
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Dietary Supplementation with Inulin Modulates the Gut Microbiota and Improves Insulin Sensitivity in Prediabetes by Xiaojing Wang, Tong Wang, Qian Zhang, Li Xu, Xinhua Xiao

“…The prebiotic inulin has been frequently reported to exert beneficial effects on the host metabolism. Here, we aimed to evaluate whether dietary supplementation with inulin modulates gut microbiota structure in prediabetes, affecting glucose and lipid metabolism. …”
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Th2 Regulation of Viral Myocarditis in Mice: Different Roles for TLR3 versus TRIF in Progression to Chronic Disease by Eric D. Abston, Michael J. Coronado, Adriana Bucek, Djahida Bedja, Jaewook Shin, Joseph B. Kim, Eunyong Kim, Kathleen L. Gabrielson, Dimitrios Georgakopoulos, Wayne Mitzner, DeLisa Fairweather

“…Viral infections are able to induce autoimmune inflammation in the heart. Here, we investigated the role of virus-activated Toll-like receptor (TLR)3 and its adaptor TRIF on the development of autoimmune coxsackievirus B3 (CVB3) myocarditis in mice. …”
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Fluvial terrace formation in a mountainous area (2): influence of eustatism, tectonics and altitudinal distribution of watersheds based on an allostratigraphic study (Albania) by Mugnier, Jean-Louis, Guzmán, Oswaldo, Vassallo, Riccardo,  Matraku, Kristina, Jouanne, François

“…The thickness of the sedimentary units above the strath surfaces is mostly influenced by the altitudinal distribution of the river catchments: thin strath terraces are found in the low elevation catchments, while thick fill terraces are found in large catchments and we suggest here that the deposition of fill terrace sediments occurred very rapidly at the cold-warm transitions when the high elevation areas of the large catchments were not protected by vegetation and heavily affected by hillslope processes that delivered a large volume of sediments. …”
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A next-generation Fab library platform directly yielding drug-like antibodies with high affinity, diversity, and developability by Fortunato Ferrara, Adeline Fanni, Andre A. R. Teixeira, Esteban Molina, Camila Leal-Lopes, Ashley DeAguero, Sara D’Angelo, M. Frank Erasmus, Laura Spector, Luis Antonio Rodriguez Carnero, Jianquan Li, Thomas J. Pohl, Nikolai Suslov, Klervi Desrumeaux, Conor McMahon, Sagar Kathuria, Andrew R. M. Bradbury

“…In addition to being developable, antibodies generated using our platform were extremely diverse, with most campaigns yielding sub-nanomolar binders. Here, we describe a platform advancement that incorporates Fab phage display followed by single-chain antibody-binding fragment Fab (scFab) yeast display. …”
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Multiomics approach identifies dysregulated lipidomic and proteomic networks in Parkinson’s disease patients mutated in TMEM175 by Federica Carrillo, Marco Ghirimoldi, Giorgio Fortunato, Nicole Piera Palomba, Laura Ianiro, Veronica De Giorgis, Shahzaib Khoso, Tiziana Giloni, Sara Pietracupa, Nicola Modugno, Elettra Barberis, Marcello Manfredi, Teresa Esposito

“…Abstract Parkinson’s disease (PD) represents one of the most frequent neurodegenerative disorders for which clinically useful biomarkers remain to be identified and validated. Here, we adopted an untargeted omics approach to disclose lipidomic, metabolomic and proteomic alterations in plasma and in dermal fibroblasts of PD patients carrying mutations in TMEM175 gene. …”
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Hybrid Nanocomposite Mini-Tablet to Be Applied into the Post-Extraction Socket: Matching the Potentialities of Resveratrol-Loaded Lipid Nanoparticles and Hydroxyapatite to Promote... by Viviana De Caro, Giada Tranchida, Cecilia La Mantia, Bartolomeo Megna, Giuseppe Angellotti, Giulia Di Prima

“…<b>Conclusions</b>: The here-proposed mini-tablet offers an innovative therapeutic approach for alveolar wound healing promotion as they led to a standardized dose administration, while being handy and stable in terms of physical solid identity as long as it takes to suture the wound.…”
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MicroVi: A Cost-Effective Microscopy Solution for Yeast Cell Detection and Count in Wine Value Chain by Ismael Benito-Altamirano, Sergio Moreno, David M. Vaz-Romero, Anna Puig-Pujol, Gemma Roca-Domènech, Joan Canals, Anna Vilà, Joan Daniel Prades, Ángel Diéguez

“…In this scenario, we present here a new tool, MicroVi, a cost-effective chip-sized microscopy solution to detect and count yeast cells in wine samples. …”
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Rescue RM/CS-AKI by blocking strategy with one-dose anti-myoglobin RabMAb by Xinyue Wang, Ning Li, Lu Han, Ou Qiao, Xin Chen, Pengtao Wang, Lancao Zhang, Yingjie Hou, Fengjiao Bao, Herui Hao, Sania Saeed, Li Zhang, Zizheng Li, Xiaohong Duan, Shuquan Rao, Zichuan Liu, Yanhua Gong

“…The critical pathogenic factor of RM/CS-AKI is the excessive free myoglobin (Mb) in blood circulation. Here, based on the concept of creating a “mobile barrier”, we develop an anti-Mb rabbit monoclonal antibody (RabMAb) with high specificity, affinity, stability, and broad species reactivity. …”
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