TOPS-speed complex-valued convolutional accelerator for feature extraction and inference by Yunping Bai, Yifu Xu, Shifan Chen, Xiaotian Zhu, Shuai Wang, Sirui Huang, Yuhang Song, Yixuan Zheng, Zhihui Liu, Sim Tan, Roberto Morandotti, Sai T. Chu, Brent E. Little, David J. Moss, Xingyuan Xu, Kun Xu

“…In parallel with the successes and extensive efforts made in electronics, optical neuromorphic hardware is promising to achieve ultra-high computing performances due to its inherent analog architecture and wide bandwidth. Here, we report a complex-valued optical convolution accelerator operating at over 2 Tera operations per second (TOPS). …”
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Electrically chargeable inorganic persistent luminescence in an alternating current driven electroluminescent device by Cunjian Lin, Rujun Yang, Zishuang Wu, Yajing Wang, Chenhan Zhan, Hirohisa Miyata, Xiankan Zeng, Yuantian Zheng, Shihai You, Ying Lv, Yixi Zhuang, Rong-Jun Xie, Jumpei Ueda

“…Despite the promise of electric power-driven PersL for lighting and display device applications due to its convenience and manageability, studies on electrically driven inorganic PersL are lacking. Here, we report an inorganic PersL in electroluminescent devices, which shows an energy storage effect that persists beyond 24 h after charging with an alternating current electric field at 250 K. …”
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Proteomic signature of HIV-associated subclinical left atrial remodeling and incident heart failure by Tess E. Peterson, Virginia S. Hahn, Ruin Moaddel, Min Zhu, Sabina A. Haberlen, Frank J. Palella, Michael Plankey, Joel S. Bader, Joao A. C. Lima, Robert E. Gerszten, Jerome I. Rotter, Stephen S. Rich, Susan R. Heckbert, Gregory D. Kirk, Damani A. Piggott, Luigi Ferrucci, Joseph B. Margolick, Todd T. Brown, Katherine C. Wu, Wendy S. Post

“…Mechanisms are unclear but have been linked to inflammation and premature aging. Here we obtain plasma proteomics concurrently with cardiac magnetic resonance imaging in two independent study populations to identify parallels between HIV-related and aging-related immune dysfunction that could contribute to atrial remodeling and clinical heart failure. …”
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Cortical Reorganization following Injury Early in Life by Moran Artzi, Shelly Irene Shiran, Maya Weinstein, Vicki Myers, Ricardo Tarrasch, Mitchell Schertz, Aviva Fattal-Valevski, Elka Miller, Andrew M. Gordon, Dido Green, Dafna Ben Bashat

“…Knowledge of structural reorganization and its consequences following perinatal injury is sparse. Here we studied changes in brain tissue volume, morphology, perfusion, and integrity in children with hemiplegia compared to typically developing children, using MRI. …”
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Proteomic Identification of Heat Shock-Induced Danger Signals in a Melanoma Cell Lysate Used in Dendritic Cell-Based Cancer Immunotherapy by Fermín E. González, Alexey Chernobrovkin, Cristián Pereda, Tamara García-Salum, Andrés Tittarelli, Mercedes N. López, Flavio Salazar-Onfray, Roman A. Zubarev

“…The identification of newly or differentially expressed proteins under defined stress conditions is relevant for understanding the lysate immunogenicity. Here, we characterized the proteomic profile of TRIMEL in response to HS treatment. …”
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Metasurface higher-order poincaré sphere polarization detection clock by Hui Yang, Kai Ou, Qiang Liu, Meiyu Peng, Zhenwei Xie, Yuting Jiang, Honghui Jia, Xinbin Cheng, Hui Jing, Yueqiang Hu, Huigao Duan

“…The comprehensive detection of SoP on the higher-order Poincaré sphere (HOPS), however, continues to be a huge challenge. Here, we propose a general polarization metrology method capable of fully detecting SoP on any HOPS through a single measurement. …”
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Knowledge, attitudes and practices of Australian dairy goat farmers towards the control of gastrointestinal parasites by Endris A. Ali, Ghazanfar Abbas, Ian Beveridge, Sandra Baxendell, Berwyn Squire, Mark A. Stevenson, Abdul Ghafar, Abdul Jabbar

“…Very little is known about the gastrointestinal parasite control practices used by Australian dairy goat farmers that are pivotal for achieving sustainable control of economically important parasites. The study reported here provides insights into gastrointestinal parasite control practices of Australian dairy goat farmers based on responses to an online survey. …”
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Hydrophobic deep eutectic solvents as novel, sustainable aids for intracellular protein release from Saccharomyces cerevisiae by Tjalling Gijsbert Tjalsma, Yannick Patrice Didion, Ziran Su, Magdalena Malankowska, Pablo Torres-Montero, José Luis Martínez, Manuel Pinelo

“…However, traditional downstream processing of intracellular compounds often depends on organic solvents and harsh processing conditions. Here, the use of hydrophobic deep eutectic solvents (DESs) as cell wall permeabilization agents for intracellular protein release from Saccharomyces cerevisiae was studied for the first time. …”
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Liquid-induced heat treatment strategy for eliminating anisotropy of IN718 fabricated by laser powder bed fusion by Zhuoyu Li, Xiaogang Hu, Fan Zhou, Zhifang Shi, Zhiwei Lyu, Zhen Xu, Yu Li, Xin Zhao, Hongxing Lu, Qiang Zhu

“…However, the lack of driving force for recrystallization during the post-heat treatment within laser powder bed fusion (LPBF) makes this method inapplicable to the process. Here, we develop a novel liquid-induced heat treatment (LIHT) post-processing. …”
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Identification of a putative novel polycyclic aromatic hydrocarbon-biodegrading gene cluster in a marine Roseobacteraceae bacterium Sagittula sp. MA-2 by Mayuko Abe, Miharu Sakai, Robert A. Kanaly, Jiro F. Mori

“…The knowledge provided here expands our understanding of the physiology of Roseobacteraceae and may be applied to explore biotechnologically useful bacteria that contribute to the remediation of polluted marine environments or high-salinity wastewater.…”
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The Adverse Impact of Muddy Laminae on Conventional SAGD Performance and Improvement Strategy with the Multilateral Well Pattern by Yang Yu, Shangqi Liu, Yu Bao, Lixia Zhang, Jia Xie, Yang Liu, Guangyue Liang, Jiuning Zhou

“…In the research reported here, the reservoir numerical simulation approach is applied to conduct the research. …”
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Effect of Combined Application of Desulfurization Gypsum and Soil Amendment KIA on Saline-Alkali Soil Improvement by Qinghong Xiao, Wei Wei, Hao Wu, Kunyue Wu, Xue Gong, Meng Li, Shiwen Wang, Lina Yin

“…Amelioration of saline-alkali soil is crucial to ensure global food security and promote sustainable agricultural development. Here, the effects of the combined application of soil amendment desulfurization gypsum (G) and KIA (K, an industrial organic by-product) on soil improvement and plant growth were investigated. …”
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MoTe₂ Photodetector for Integrated Lithium Niobate Photonics by Qiaonan Dong, Xinxing Sun, Lang Gao, Yong Zheng, Rongbo Wu, Ya Cheng

“…Two-dimensional materials provide a potential high-efficiency on-chip detection capability. Here, we demonstrate an efficient on-chip photodetector based on a few layers of MoTe₂ on a thin film lithium niobate waveguide and integrate it with a microresonator operating in an optical telecommunication band. …”
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Involvement of p38 MAPK and MAPKAPK2 in promoting cell death and the inflammatory response to ischemic stress associated with necrotic glioblastoma by Soo Yeon Kim, Miaolu Tang, Stephen Y. Chih, Jessica Sallavanti, Yan Gao, Zhiqiang Qiu, Hong-Gang Wang, Wei Li

“…However, the mechanisms underlying cell death in this context and how damaged tissue contributes to tumor progression remain unclear. Here, we identified p38 mitogen-activated protein kinases (p38 MAPK, a.k.a. p38) as a key player in promoting cell death and the inflammatory response to ischemic stress associated with necrotic tumors. …”
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Gene–Environment Interaction: Small Deletions (DELs) and Transcriptomic Profiles in Non-Melanoma Skin Cancer (NMSC) and Potential Implications for Therapy by Farzana Jasmine, Armando Almazan, Yuliia Khamkevych, Maria Argos, Mohammad Shahriar, Tariqul Islam, Christopher R. Shea, Habibul Ahsan, Muhammad G. Kibriya

“…From a six-year follow-up study on 7000 adults exposed to As, we reported the associations of single-nucleotide variation in tumor tissue and gene expression. Here, we identify the associations of small deletions (DELs) and transcriptomic profiles in NMSC. …”
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Oxyuris spp. Infection in Green Iguana (Iguana iguana) Under Different Cage Types by shelly kusumarini, Rafi Dzakir Ghalib, Garvasilus Privantio Tegar Virgiawan Huler, Reza Yesica, Nanis Nurhidayah, Haris Muhamad, Nuha Fairusya

“…One of the most common health problems in the green iguana is caused by infection of the gastrointestinal nematode (GIN), Oxyuris spp. Here, we conducted a study to identify Oxyuris spp. infection in the green iguana under different cage types in Malang Raya, East Java. …”
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A Novel Tool for High-Throughput Screening of Granulocyte-Specific Antibodies Using the Automated Flow Cytometric Granulocyte Immunofluorescence Test (Flow-GIFT) by Xuan Duc Nguyen, Thomas Dengler, Monika Schulz-Linkholt, Harald Klüter

“…The flow cytometric granulocyte immunofluorescence test (Flow-GIFT) has been introduced for routine use when investigating patients and healthy blood donors. Here we describe a novel tool in the automation of the Flow-GIFT that enables a rapid screening of blood donations. …”
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Synthesis and kinetic evaluation of analogs of (E)-4-amino-3-methylbut-2-en-1-yl diphosphate, a potent inhibitor of the IspH metalloenzyme by Petit, Benoît Eric, Jobelius, Hannah, Bianchino, Gabriella Ines, Guérin, Mélina, Borel, Franck, Chaignon, Philippe, Seemann, Myriam

“…AMBPP has substantial limitations for drug development due to its poor metabolic stability. Here, we investigate the replacement of the diphosphate moiety of AMBPP by more stable mimics: sulfonate, phosphonate or phosphinophosphonate. …”
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Chronic Gastroesophageal Reflux Dysregulates Proteostasis in Esophageal Epithelial CellsSummary by Kodisundaram Paulrasu, Ravindran Caspa Gokulan, Wael El-Rifai, Zhibin Chen, Jianwen Que, Timothy C. Wang, Olivier G. Boutaud, Karoline Briegel, Sergey I. Dikalov, Monica T. Garcia-Buitrago, Alexander I. Zaika

“…These products of lipid peroxidation rapidly interact with cellular proteins forming protein adducts. Here, we investigated the interrelationship between isoLG adduction and aggregation of cellular proteins. …”
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Clade 2.3.4.4b but not historical clade 1 HA replicating RNA vaccine protects against bovine H5N1 challenge in mice by David W. Hawman, Thomas Tipih, Eddie Hodge, E. Taylor Stone, Nikole Warner, Natalie McCarthy, Brian Granger, Kimberly Meade-White, Shanna Leventhal, Kiara Hatzakis, Stephanie Park, Karen Gaffney, Kyle Rosenke, Jesse H. Erasmus, Heinz Feldmann

“…It is unclear if these stockpiled vaccines will need to be updated to match the contemporary H5N1 strains. Here we show that a replicating RNA vaccine expressing the HA of an H5N1 isolated from a US dairy cow confers complete protection against homologous lethal challenge in mice. …”
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