Structural insights into isoform-specific RAS-PI3Kα interactions and the role of RAS in PI3Kα activation by Daniel Czyzyk, Wupeng Yan, Simon Messing, William Gillette, Takashi Tsuji, Mitsuhiro Yamaguchi, Shinji Furuzono, David M. Turner, Dominic Esposito, Dwight V. Nissley, Frank McCormick, Dhirendra K. Simanshu

“…Disrupting RAS-PI3Kα interaction enhances survival in lung and skin cancer models and reduces tumor growth and angiogenesis, although the structural details of this interaction remain unclear. Here, we present structures of KRAS, RRAS2, and MRAS bound to the catalytic subunit (p110α) of PI3Kα, elucidating the interaction interfaces and local conformational changes upon complex formation. …”
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Cyclin-dependent protein kinases and cell cycle regulation in biology and disease by Ilenia Pellarin, Alessandra Dall’Acqua, Andrea Favero, Ilenia Segatto, Valentina Rossi, Nicole Crestan, Javad Karimbayli, Barbara Belletti, Gustavo Baldassarre

“…Most of these kinases play fundamental roles the normal physiology of eucaryotic cells; therefore, their deregulation is associated with the onset and/or progression of multiple human disease including but not limited to neoplastic and neurodegenerative conditions. Here, we describe the functions of CDKs, categorized into the three main functional groups in which they are classified, highlighting the most relevant pathways that drive their expression and functions. …”
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Decreased Cardiovascular Risk after Roux-en-Y Gastric Bypass Surgery in Chinese Diabetic Patients with Obesity by Xue Zhao, Wenyan Duan, Chenglin Sun, Zhuo Li, Yujia Liu, Xianchao Xiao, Gang Wang, Xiaokun Gang, Guixia Wang

“…The influence of bariatric surgery on cardiovascular risks in Chinese diabetic patients remains unclear. Here, we aimed to explore the impact of Roux-en-Y gastric bypass surgery (RYGB) on cardiovascular risks in Chinese diabetic patients with obesity. …”
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SPAGRM: effectively controlling for sample relatedness in large-scale genome-wide association studies of longitudinal traits by He Xu, Yuzhuo Ma, Lin-lin Xu, Yin Li, Yufei Liu, Ying Li, Xu-jie Zhou, Wei Zhou, Seunggeun Lee, Peipei Zhang, Weihua Yue, Wenjian Bi

“…However, this approach is challenging for large-scale GWAS of complex traits, such as longitudinal traits. Here we propose a scalable and accurate analysis framework, SPAGRM, which controls for sample relatedness via a precise approximation of the joint distribution of genotypes. …”
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A Novel Gel Polymer Electrolyte by Thiol-Ene Click Reaction Derived from CO2-Based Polycarbonate for Lithium-Ion Batteries by Wenhan Luo, Kuirong Deng, Shuanjin Wang, Shan Ren, Dongmei Han, Yufei Wang, Min Xiao, Yuezhong Meng

“…Here, we describe the synthesis of a CO2-based polycarbonate with pendent alkene groups and its functionalization by grafting methoxypolyethylene glycol in view of its application possibility in gel polymer electrolyte lithium-ion batteries. …”
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Litostratigrafia spodnotriasových súvrství Západných Karpát by Mário Olšavský

“…The sedimentary development is more diverse here, and the Lower Triassic has several specific lithological members. …”
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A broad spectrum Shigella vaccine based on VirG53 – 353 multiepitope region produced in a cell-free system by Girmay Desalegn, Charlotte Abrahamson, K. Ross Turbyfill, Lucy Pill-Pepe, Leslie Bautista, Chitradevi S. Tamilselvi, Dylan Dunn, Neeraj Kapoor, Barbara Sullinger, Matheo Herrera, Edwin V. Oaks, Jeff Fairman, Marcela F. Pasetti

“…The target antigen refinement and production improvement described here will facilitate the first-in-human studies.…”
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High Frequency Response of Volatile Memristors by Ioannis Messaris, Alon Ascoli, Ahmet S. Demirkol, Vasileios Ntinas, Dimitrios Prousalis, Ronald Tetzlaff

“…In accordance with well‐established models for these devices, their resistances depend on their body temperatures, which evolve over time following Newton's Law of Cooling. Here, it is demonstrated that HP's NbO2‐Mott memristor can manifest up to three distinct steady‐state oscillatory behaviors under a suitable high‐frequency periodic voltage input, showcasing increased versatility despite its volatile nature. …”
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Probabilistic estimation of rheological properties in subduction zones using sequences of earthquakes and aseismic slip by Tobias Köhne, Rishav Mallick, Mark Simons

“…Our second set of tests considers the similarities of surface displacement timeseries between synthetic models that model the plate interface either as a shear zone described by power-law viscosity, or a surface described by rate-dependent friction. Here, we find that the ability to fit surface observations using functional or mechanical models assuming frictional behavior does not constitute sufficient evidence to actually infer frictional behavior at depth, as the surface expressions are virtually indistinguishable from deformation generated from models with depth-variable power-law viscous behavior. …”
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Resurgence of common respiratory viruses and mycoplasma pneumoniae after ending the zero-COVID policy in Shanghai by Pengcheng Liu, Menghua Xu, Lijuan Lu, Xunhua Zhu, Ran Jia, Niuniu Dong, Liyun Su, Jin Xu

“…However, China has begun to end the zero-COVID policies in late 2022. Here, we reported a resurgence of common respiratory viruses and Mycoplasma pneumoniae with unique epidemiological characteristics among children after ending the zero-COVID policy in Shanghai, China, 2023. …”
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Observation of momentum-gap topology of light at temporal interfaces in a time-synthetic lattice by Yudong Ren, Kangpeng Ye, Qiaolu Chen, Fujia Chen, Li Zhang, Yuang Pan, Wenhao Li, Xinrui Li, Lu Zhang, Hongsheng Chen, Yihao Yang

“…This discovery hints at abundant topological phases defined within momentum bands, alongside a wealth of topological boundary states in the time domain. Here, we report the experimental observation of k-gap topology in a large-scale optical temporal synthetic lattice, manifesting as temporal topological boundary states. …”
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Predictive value of systemic immune inflammation index combined with coagulation index in traumatic coagulopathy in patients with severe trauma by Chen Wang, Yongyong Huang, Shiyun Liao, Jiming Song

“…The systemic immune inflammation index (SII), a composite marker of inflammation and immune response, alongside conventional coagulation indices, may hold promise in predicting TIC. Here, this study aimed to evaluate the predictive value of combining SII with coagulation indices for TIC in severe trauma patients, with the goal of enhancing early detection and guiding prompt therapeutic strategies. …”
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KIF5A regulates axonal repair and time-dependent axonal transport of SFPQ granules and mitochondria in human motor neurons by Irune Guerra San Juan, Jessie W. Brunner, Kevin Eggan, Ruud F. Toonen, Matthijs Verhage

“…While KIF5 family members transport a variety of cargos along axons, the specific cargos affected by KIF5A mutations remain poorly understood. Here, we generated KIF5Anull mutant human motor neurons and analyzed the impact on axonal transport and motor neuron outgrowth and regeneration in vitro. …”
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CGH, cDNA and Tissue Microarray Analyses Implicate FGFR2 Amplification in a Small Subset of Breast Tumors by Mervi Heiskanen, Juha Kononen, Maarit Bärlund, Joachim Torhorst, Guido Sauter, Anne Kallioniemi, Olli Kallioniemi

“…However, only relatively few target genes for such amplifications have been identified. Here, we indicate how small‐scale commercially available cDNA and CGH microarray formats combined with the tissue microarray technology enable rapid identification of putative amplification target genes as well as analysis of their clinical significance. …”
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Long-term deprescription in chronic pain and opioid use disorder patients: Pharmacogenetic and sex differences by Muriel Javier, Escorial Mónica, Margarit César, Barrachina Jordi, Carvajal Cristian, Morales Domingo, Peiró Ana M.

“…CYP2D6 poor metabolizers showed the lowest long-term opioid doses. Here, women showed a higher degree of opioid deprescription, but increased use of tramadol and neuromodulators, as well as an increased number of adverse events. …”
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Transitive reasoning in the adult domestic hen in a six-term series task by R. Degrande, O. Amichaud, B. Piégu, F. Cornilleau, P. Jardat, V. H.B. Ferreira, V. Colson, L. Lansade, L. Calandreau

“…Few bird species have been tested for TI to date, which limits our knowledge of the phylogenetic spread of such reasoning ability. Here we tested TI in adult laying hens using a more solid methodology, the 6-term series task, which has not been tested in poultry so far. …”
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Project ChemicalBlooms: Collaborating with citizen scientists to survey the chemical diversity and phylogenetic distribution of plant epicuticular wax blooms by Le Thanh Dien Nguyen, Nicole Groth, Kylie Mondloch, Edgar B. Cahoon, Keith Jones, Lucas Busta

“…However, the ability to synthesize thick layers of visible epicuticular crystals (“wax blooms”) is restricted to specific lineages, and our knowledge of how wax blooms differ from ubiquitous wax layers is less developed. Here, we recruited the help of citizen scientists and middle school students to survey the wax bloom chemistry of 78 species spanning dicot, monocot, and gymnosperm lineages. …”
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Hypoxia-inducible factor 1α is required to establish the larval glycolytic program in Drosophila melanogaster by Yasaman Heidarian, Tess D. Fasteen, Liam Mungcal, Kasun Buddika, Nader H. Mahmoudzadeh, Travis Nemkov, Angelo D'Alessandro, Jason M. Tennessen

“…However, dERR is dynamically regulated during the onset of this metabolic switch, indicating that other factors must be involved. Here we examine the possibility that the Drosophila ortholog of Hypoxia inducible factor 1α (Hif1α) is also required to activate the larval glycolytic program. …”
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Antibody response to Plasmodium vivax in the context of Epstein-Barr virus (EBV) co-infection: A 14-year follow-up study in the Amazon rainforest. by Luiz F F Guimarães, Bárbara A Rodrigues, Michelle H F Dias, Matheus G Barcelos, Maria F A Nascimento, Sâmick L Moreira-Nascimento, Sofia L Afonso, Barbara G S Abreu, Jaap M Middeldorp, Francis B Ntumngia, John H Adams, Camila Fabbri, Stefanie Lopes, Cor J F Fernandes, Flora S Kano, Luzia H Carvalho

“…A recent conceptual study proposed that Epstein-Barr virus (EBV), a highly prevalent human herpesvirus that establishes lifelong persistent infection, may influence P. vivax antibody responses. Here, it was investigated whether EBV could impact the longevity of humoral immune response to P. vivax.…”
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Stabilized Carbon Radical‐Mediated Assembly of Arylthianthrenium Salts, Alkenes and Amino Acid/Peptide Derivatives by Bo Dong, Weiguan Qi, Yifeng Chen, Yufei Zhang, Shiyu Gu, Jianlin Zhao, Qingfa Zhou, Jian Shen, Lan‐Gui Xie

“…Particularly notable is their application in pharmaceutical development, leveraging site‐selective late‐stage functionalization. Here, a visible light‐induced three‐component reaction involving arylthianthrenium salts, amino acid/peptide derivatives, and alkenes are introduced. …”
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