Training and onboarding initiatives in high energy physics experiments by Allison Reinsvold Hall, Nicole Skidmore, Gabriele Benelli, Ben Carlson, Ben Carlson, Claire David, Jonathan Davies, Wouter Deconinck, David DeMuth, Peter Elmer, Rocky Bala Garg, Stephan Hageböck, Killian Lieret, Valeriia Lukashenko, Valeriia Lukashenko, Sudhir Malik, Andy Morris, Heidi Schellman, Graeme A. Stewart, Jason Veatch, Michel Hernandez Villanueva

“…Recognizing this, a meeting series was held by the HEP Software Foundation (HSF) in 2022 for experiments to showcase their initiatives. Here we document and analyze these in an attempt to determine a set of key considerations for future HEP experiments.…”
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Categorization of early embryonic malformations in broilers by a new classification method combining light microscopy and high-resolution Episcopic Microscopy by Yuval Cinnamon, Natalia Slutsky, Maxim Quint, Olga Genin, Dalit Sela-Donenfeld

“…However, understanding of the types and prevalence of early embryonic malformations in broiler eggs remains incomplete.Here we present a novel tool for categorizing abnormalities in 3-day-old broiler embryos through a standardized classification system. …”
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Glutamine-glutamate centered metabolism as the potential therapeutic target against Japanese encephalitis virus-induced encephalitis by Mengyuan Li, Hang Yuan, Xiaofei Yang, Yingfeng Lei, Jianqi Lian

“…The survival rate, severity of neuroinflammation, and levels of viral replication were assessed to determine the efficacy of glutamine supplementation in JEV-challenged mice. Results Here, we have delineated a novel perspective on the pathogenesis of JE by identifying an aberrant low flux in glutamine-glutamate metabolism both in vivo and in vitro, which was critical in the establishment of JEV infection and progression of JE. …”
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A Case of Acquired Reactive Perforating Dermatosis with Complete Resolution of Eruptions on Upper and Lower Limbs During the Treatment of Diabetes Mellitus and Peripheral Artery Di... by Yoshihito Mima, Tsutomu Ohtsuka, Ippei Ebato, Ryosuke Nishie, Satoshi Uesugi, Makoto Sumi, Yoshimasa Nakazato, Yuta Norimatsu

“…ARPD is strongly associated with systemic diseases such as diabetes mellitus (DM) and chronic renal failure, which may contribute to ARPD through factors including microcirculatory disturbances and the deposition of metabolic byproducts, including advanced glycation end-products and calcium. Here, we report a case of ARPD that improved following DM treatment and catheter-based interventions for peripheral artery disease (PAD). …”
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Morphological and molecular characterization of a Sarcocystis bovifelis-like sarcocyst in American beef by Aditya Gupta, Larissa S. de Araujo, Andrew Hemphill, Asis Khan, Benjamin M. Rosenthal, Jitender P. Dubey

“…Although S. hominis has been reported as prevalent in Europe, the occurrence of thick-walled species in the US remains poorly known. Here, for the first time to our knowldge, we characterize a thick-walled Sarcocystis species from a sample of beef from a local grocery store in Maryland. …”
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Small molecule APOL1 inhibitors as a precision medicine approach for APOL1-mediated kidney disease by Brandon Zimmerman, Leslie A. Dakin, Anne Fortier, Evanthia Nanou, Angelo Blasio, James Mann, Howard Miller, Marissa Fletcher, Tiansheng Wang, Suganthini Nanthakumar, Gizelle McCarthy, Caline Matar, Prachi Matsye, Guanyu Wang, Phillip Snyder, Kevin Daniel, Harsha Swamy, Kelly Sullivan, Franklin Bright, Audrey Powers, Kevin J. Gagnon, Fan Lu, Steven Paula, Suvarna Khare-Pandit, Larry Henry, Martine Hamel, Francois Denis, Olivier Nicolas, Niresh Hariparsad, Shyamesh Kumar, Jennifer Proctor, Timothy Senter, Brinley Furey, Mark E. Bunnage

“…We hypothesized that inhibition of APOL1 could have therapeutic potential for this genetically-defined form of kidney disease. Here we describe the development of preclinical assays and the discovery of potent and specific APOL1 inhibitors with drug-like properties. …”
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Prevalence of lymphedema symptoms across cancer diagnoses and association with depression, pain interference and health-related quality of life by Gitte Sone Larsen, Christoffer Johansen, Annika von Heymann, Bolette Skjødt Rafn

“…Patients/Material and methods: This cross-sectional study was conducted at the Department of Oncology, Copenhagen University Hospital, from February to April 2021, as part of a broader investigation into cancer-related late effects. Here, we present data from patients in follow-up who received online lymphedema symptom assesments (swelling, heaviness, or tightness). …”
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BMP4 Cooperates with Retinoic Acid to Induce the Expression of Differentiation Markers in Cultured Mouse Spermatogonia by Yongguang Yang, Yanmin Feng, Xue Feng, Shangying Liao, Xiuxia Wang, Haiyun Gan, Lixian Wang, Xiwen Lin, Chunsheng Han

“…However, the molecules controlling these processes remain largely unknown. Here, we developed a simplified high concentration serum-containing system for the culture of mouse SSCs. …”
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Peroxisome Proliferator-Activated Receptor-γ Antagonizes LOX-1-Mediated Endothelial Injury by Transcriptional Activation of miR-590-5p by Lei Xu, Gang Zhao, Hong Zhu, Shijun Wang, Aijun Sun, Yunzeng Zou, Junbo Ge

“…However, the underlying mechanism is unclear. Here we showed that Rosiglitazone treatment significantly attenuated the expressions of LOX-1, ICAM-1, VCAM-1, p47phox, and the atherosclerotic lesions in ApoE-/- mice with high-fat diet. …”
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Skeletal muscle stem cells modulate niche function in Duchenne muscular dystrophy mouse through YY1-CCL5 axis by Yang Li, Chuhan Li, Qiang Sun, Xingyuan Liu, Fengyuan Chen, Yeelo Cheung, Yu Zhao, Ting Xie, Bénédicte Chazaud, Hao Sun, Huating Wang

“…Deregulated MuSC/MP/FAP interactions and the ensuing inflammation and fibrosis are hallmarks of dystrophic muscle. Here we demonstrate intrinsic deletion of transcription factor Yin Yang 1 (YY1) in MuSCs exacerbates dystrophic pathologies by altering composition and heterogeneity of MPs and FAPs. …”
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Cost‐Effective Synthesis of Fe5C2 Catalyst From Nanosized Zero‐Valent Iron to Achieve Efficient Photothermocatalytic CO Hydrogenation to Light Olefins by Yuqing Xu, Yuan Li, Ruizhe Li, Hua Xu, Shuxin Ouyang, Hong Yuan

“…However, iron carbonyls, the raw materials for wet chemical synthesis of Fe5C2, are expensive and toxic, which limits large‐scale preparation. Here, a cost‐effective and versatile method is proposed for the synthesis of Fe5C2 nanoparticles (NPs) with nanosized zero‐valent iron (abbreviated as NZVI, prepared by reducing iron salts or ball‐milling iron powder) instead of iron carbonyls, achieving a cost reduction of 76.8%. …”
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In vitro assessment of the nematicidal potential of Streptomyces violascens strain AS2 against root-knot nematodes (Meloidogyne sp.) by Azlay Latifa, Oubassou Ez-Zahra, Berr Alexandre, Mayad El Hassan, Barakate Mustapha

“…The detrimental environmental impacts and increasing resistance associated with synthetic nematicides have increased the need for biocontrol alternatives. Here, we report for the first time the nematicidal properties of Streptomyces violascens and its viability as a safe and effective solution against nematode infestation. …”
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Conceptualising cultural safety at an Indigenous-focused midwifery practice in Toronto, Canada: qualitative interviews with Indigenous and non-Indigenous clients by Michelle Firestone, Sara H Wolfe, Cheryllee Bourgeois, Janet K Smylie, Mackenzie E Churchill, Helle Moeller

“…We hope that the positive impacts documented here motivate evaluators and healthcare providers to work towards a future where ‘cultural safety’ becomes a standard of care.…”
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Chromatin environment-dependent effects of DOT1L on gene expression in male germ cells by Manon Coulée, Alberto de la Iglesia, Mélina Blanco, Clara Gobé, Clémentine Lapoujade, Côme Ialy-Radio, Lucia Alvarez-Gonzalez, Guillaume Meurice, Aurora Ruiz-Herrera, Pierre Fouchet, Julie Cocquet, Laïla El Khattabi

“…Abstract The H3K79 methyltransferase DOT1L is essential for multiple aspects of mammalian development where it has been shown to regulate gene expression. Here, by producing and integrating epigenomic and spike-in RNA-seq data, we decipher the molecular role of DOT1L during mouse spermatogenesis and show that it has opposite effects on gene expression depending on chromatin environment. …”
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Long-term trends in the burden of multiple myeloma in China: a Joinpoint regression and age-period-cohort analysis based on GBD 2021 by Yanyu Zhang, Quanxin Su, Jiawen Yu, Xiuli Sun

“…PurposeMultiple myeloma (MM) is a hematologic malignancy originating from plasma cells with clinical manifestations such as hypercalcemia, cytopenias (most commonly anemia) and renal failure. Here, we analyzed the disease burden and changing trends of MM in China from 1990 to 2021, aiming to provide a scientific and effective basis for the prevention and control of MM disease in China.MethodsWe extracted MM related data from the Global Burden of Diseases (GBD) 2021 database from 1990 to 2021. …”
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Bioprocess exploitation of microaerobic auto-induction using the example of rhamnolipid biosynthesis in Pseudomonas putida KT2440 by Jakob Grether, Holger Dittmann, Leon Willems, Tabea Schmiegelt, Elvio Henrique Benatto Perino, Philipp Hubel, Lars Lilge, Rudolf Hausmann

“…The exploitation of the inherent tolerance of Pseudomonas putida KT2440, an obligate aerobic bacterium, to microaerobic conditions has received little attention so far. Here low-oxygen inducible promoters were characterized in biosensor strains and exploited for process control under reduction of foam formation by low aeration and stirring rates during biosynthesis of rhamnolipids. …”
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Healthy lifestyle reduces cardiovascular risk in women with genetic predisposition to hypertensive disorders of pregnancy by Sang‑Hyuk Jung, Haemin Kim, Young Mi Jung, Manu Shivakumar, Brenda Xiao, Jaeyoung Kim, Beomjin Jang, Jae-Seung Yun, Hong-Hee Won, Chan-Wook Park, Joong Shin Park, Jong Kwan Jun, Dokyoon Kim, Seung Mi Lee

“…However, the effects of lifestyle and metabolic syndrome on atherosclerotic cardiovascular disease have not been evaluated. Here, we assess the long-term association between these factors and atherosclerotic cardiovascular disease in women with genetic risk for hypertensive disorders of pregnancy. …”
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Novel source/drain contact structure for a-IGZO devices: Oxygen-scavenger-layer metal-interlayer-semiconductor (OSL MIS) approach by Sungjoo Song, Jong-Hyun Kim, Jongyoun Park, Seung-Hwan Kim, Dongjin Ko, Hyejung Choi, Seiyon Kim, Hyun-Yong Yu

“…Despite various attempts to address the high contact resistance issue, including the metal-interlayer-semiconductor (MIS) contact structure, a novel approach is needed. Here, we propose an oxygen-scavenger-layer MIS (OSL MIS) contact structure which employs oxygen areal density (OAD) modulated OSL as the interlayer. …”
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Mesenchymal Stem/Stromal Cells Derived from Induced Pluripotent Stem Cells Support CD34pos Hematopoietic Stem Cell Propagation and Suppress Inflammatory Reaction by Mohsen Moslem, Irina Eberle, Iuliia Weber, Reinhard Henschler, Tobias Cantz

“…Substantial self-renewing of stem cells can be achieved by reprogramming cells into induced pluripotent stem cells (iPSCs) that can be easily expanded as undifferentiated cells even in mass culture. Here, we investigated a differentiation protocol enabling the generation and selection of human iPSC-derived MSCs exhibiting relevant surface marker expression profiles (CD105 and CD73) and functional characteristics. …”
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Lifestyle as Risk Factor for Infectious Causes of Death in Young Dogs: A Retrospective Study in Southern Italy (2015–2017) by Lorena Cardillo, Giuseppe Piegari, Valentina Iovane, Maurizio Viscardi, Flora Alfano, Anna Cerrone, Ugo Pagnini, Serena Montagnaro, Giorgio Galiero, Giuseppe Pisanelli, Giovanna Fusco

“…Identifying the cause of death is often a challenge, and broad diagnostic analysis is often needed. Here, we aimed to determine the infectious causes of death in young dogs aged up to 1 year, examining how it relates to age (under and over 6 months), lifestyle (owned versus ownerless), breed (purebred and crossbreed), and gender. …”
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