ТHE BEGINNING OF THE WORLD ACCORDING TO HESIODS AS THE BIRTH OF PHILOSOPHICAL ONTOLOGY by Ігор ПАВЛЕНКО

“…The vision of Chaos in Hesiod proposed here is the first step towards a hermeneutic reconstruction of the primary foundations of ancient Greek philosophy and its mythological and poetic origins. …”
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Discovery and development of ANV419, an IL-2/anti-IL-2 antibody fusion protein with potent CD8+ T and natural killer cell-stimulating capacity for cancer immunotherapy by Patrizia Murer, Barbara Brannetti, Jean-Michel Rondeau, Laetitia Petersen, Nicole Egli, Simone Popp, Catherine Regnier, Kirsten Richter, Andreas Katopodis, Christoph Huber

“…Novel engineered IL-2 agonists strive to increase the therapeutic window of aldesleukin (human IL-2) by increasing selectivity toward effector over regulatory T cells and reducing dose-limiting toxicities. Here we describe ANV419, an IL-2/anti-IL2 antibody fusion protein designed for selective IL-2 receptor βγ (IL-2 Rβγ) activation by sterically hindering IL-2 from binding to IL-2 Rα. …”
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Comprehensive characterization of higher order structure changes in methionine oxidized monoclonal antibodies via NMR chemometric analysis and biophysical approaches by Mingyue Li, Victor A. Beaumont, Shahajahan Akbar, Hannah Duncan, Arch Creasy, Wenge Wang, Kelly Sackett, Lisa Marzilli, Jason C. Rouse, Hai-Young Kim

“…The NMR methods described here to probe HOS changes are highly reliable and practical in biopharmaceutical characterization.…”
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Refining δ15N isotopic fingerprints of local NOx for accurate source identification of nitrate in PM2.5 by Hao Xiao, Qinkai Li, Shiyuan Ding, Wenjing Dai, Gaoyang Cui, Xiaodong Li

“…However, the absence of a systematic study on the δ15N values of domestic NOx sources hinders accurate identification of NO3– sources in China. Here, we systematically determined and refined δ15N values for six categories of NOx sources in Tianjin using an active sampling method. …”
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Intestinal Organoids in Colitis Research: Focusing on Variability and Cryopreservation by Talke F. zur Bruegge, Andrea Liese, Sören Donath, Stefan Kalies, Maike Kosanke, Oliver Dittrich-Breiholz, Sandra Czech, Verena N. Bauer, André Bleich, Manuela Buettner

“…After their initial hype, concerns regarding their standardization have been raised. Here, we aim to provide some insights into our experience in standardizing murine colonic epithelial organoids, which we use as a replacement method for research on inflammatory bowel disease. …”
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Glucagon-Like Peptide-1 Receptor Agonist Liraglutide Ameliorates the Development of Periodontitis by Noritaka Sawada, Kei Adachi, Nobuhisa Nakamura, Megumi Miyabe, Mizuho Ito, Shuichiro Kobayashi, Shin-ichi Miyajima, Yuki Suzuki, Takeshi Kikuchi, Makoto Mizutani, Taku Toriumi, Masaki Honda, Akio Mitani, Tatsuaki Matsubara, Keiko Naruse

“…The prevention of periodontitis is especially important in diabetic patients because the relationship between diabetes and periodontitis is bidirectional. Here, we evaluated the impacts of glucagon-like peptide-1 (GLP-1) receptor agonist liraglutide on the amelioration of periodontitis. …”
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Proton motive force generated by microbial rhodopsin promotes extracellular electron transfer by Wenqi Ding, Tong Lin, Yun Yang, Wen-Wei Li, Shaoan Cheng, Hao Song

“…Nevertheless, the impact of PMF on the EET efficiency remains ambiguous, while the microbial rhodopsin offers a simple and efficient avenue for non-photosynthetic cells to harness PMF. Here, we studied the function of three microbial rhodopsins (Arch, Mac, and cR-1) in facilitating EET via their heterologous expression in S. oneidensis, a model electroactive microorganism. …”
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Long-Term Safety of Transplanting Human Bone Marrow Stromal Cells into the Extravascular Spaces of the Choroid of Rabbits by Adi Tzameret, Sapir E. Kalish, Ifat Sher, Lea Twito, Amilia Meir, Itay Levy, Shlomo Margel, Iris Moroz, Mordechai Rosner, Avraham J. Treves, Arnon Nagler, Michael Belkin, Ygal Rotenstreich

“…Assessing the safety of hBMSC treatment and graft survival in a large animal is a crucial step before initiating clinical trials. Here, we transplanted hBMSCs into the EVSC compartment of New Zealand White rabbits. …”
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MeHg Developing Exposure Causes DNA Double-Strand Breaks and Elicits Cell Cycle Arrest in Spinal Cord Cells by Fabiana F. Ferreira, Dib Ammar, Gilian F. Bourckhardt, Karoline Kobus-Bianchini, Yara M. R. Müller, Evelise M. Nazari

“…The neurotoxicity caused by methylmercury (MeHg) is well documented; however, the developmental neurotoxicity in spinal cord is still not fully understood. Here we investigated whether MeHg affects the spinal cord layers development. …”
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Airborne observations reveal the fate of the methane from the Nord Stream pipelines by Friedemann Reum, Julia Marshall, Henry C. Bittig, Lutz Bretschneider, Göran Broström, Anusha L. Dissanayake, Theo Glauch, Klaus-Dirk Gottschaldt, Jonas Gros, Heidi Huntrieser, Astrid Lampert, Michael Lichtenstern, Scot M. Miller, Martin Mohrmann, Falk Pätzold, Magdalena Pühl, Gregor Rehder, Anke Roiger

“…So far, studies on the fate of this dissolved methane rely on pipeline volumetric estimates or spatially sparse concentration measurements and ocean models. Here, we use atmospheric measurements with broad spatial coverage obtained from an airborne platform to estimate outgassing of 19-48 t h−1 on 5 October 2022. …”
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The gut microbiota predicts and time-restricted feeding delays experimental colitis by Hannah K. Ruple, Eva Haasis, Anna Bettenburg, Carina Maier, Carolin Fritz, Laura Schüle, Sarah Löcker, Yvonne Soltow, Lynn Schintgen, Nina S. Schmidt, Celine Schneider, Axel Lorentz, W. Florian Fricke

“…Dysbiosis of the gastrointestinal microbiota and disruption of the biological clock have been implicated and studied as diagnostic and therapeutic targets. Here, we examine the relationship of IBD to biological clock and gut microbiota by using the IL-10 deficient (IL-10-/-) mouse model for microbiota-dependent spontaneous colitis in combination with altered (4 h/4 h) light/dark cycles to disrupt and time-restricted feeding (TRF) to restore circadian rhythmicity. …”
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Amplifying and Reversing the Chiral Bias in Asymmetric Photo‐Polymerization Reaction by Dingdong Liu, Xiangxiang Xu, Zeyu Feng, Chutian Zhang, Jialei Li, Yifan Xie, Jingguo Li, Hongli Zhang, Gang Zou

“…Nonetheless, little is known about how the spin angular momentum of light competes with the chiral electromagnetic field in the vicinity of a chiral nanoparticle during the chiral induction and amplification process. Here, an asymmetric photo‐polymerization system is presented where the chiral bias can be selectively regulated by the combination of chiral fields CPL and Ag nanoparticles, either constructively or destructively. …”
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Characterization of demethylating DNA glycosylase ROS1 from Nicotiana tabacum L. by D. V. Petrova, N. V. Permyakova, I. R. Grin, D. O. Zharkov

“…Homologues of DME and ROS1 are present in all plant groups; however, outside A. thaliana, they are poorly studied. Here we report the properties of a recombinant fragment of the ROS1 protein from Nicotiana tabacum (NtROS1), which contains all main structural domains required for catalytic activity. …”
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Development of Bifunctional Three-Dimensional Cysts from Chemically Induced Liver Progenitors by Yu Huang, Yusuke Sakai, Takanobu Hara, Takeshi Katsuda, Takahiro Ochiya, Tomohiko Adachi, Masaaki Hidaka, Wei-Li Gu, Susumu Eguchi

“…Three-dimensional (3D) structures generated from liver progenitor cells possess wide applications in cell transplantation, disease model, and drug testing. Here, we report on the spontaneous formation of 3D cystic structures comprising maturing rat CLiPs on gelatin-coated dishes. …”
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GEN-27, a Newly Synthetic Isoflavonoid, Inhibits the Proliferation of Colon Cancer Cells in Inflammation Microenvironment by Suppressing NF-κB Pathway by Yajing Wang, Ping Lu, Weifeng Zhang, Qianming Du, Jingjing Tang, Hong Wang, Jinrong Lu, Rong Hu

“…Nonresolving inflammation is one of the consistent features of the tumor microenvironment in the intestine and plays a critical role in the initiation and development of colon cancer. Here we reported the inhibitory effects of GEN-27, a new derivative of genistein, on the inflammation-related colon cancer cell proliferation and delineated the mechanism of its action. …”
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Melanoma extracellular vesicles membrane coated nanoparticles as targeted delivery carriers for tumor and lungs by María Sancho-Albero, Alessandra Decio, Reha Akpinar, Ada De Luigi, Raffaella Giavazzi, Luigi M. Terracciano, Luisa De Cola

“…Extracellular vesicles (EVs) have a similar ability in target only certain organs or to return to their original cells, showing home behavior. Here we report a strategy inspired by nature, using a combination of NPs and the targeting cell membranes of EVs. …”
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Scaling Behavior of Ionic Conductance Dependent on Surface Charge Inside a Single-Digit Nanopore by Anping Ji, Lang Zhou, Qiming Xiao, Jigang Liu, Wenqian Huang, Yun Yu, Zhengwei Zhang, Junhao Pi, Chenxi Yang, Haoxuan Chen

“…However, precisely measuring surface charge density in a single-digit nanopore remains a challenge. Here, we propose a methodology for exploring the power-law variation of ionic conductance, with potential leakage taken into account. …”
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Honeys from the Argentine Phytogeographic Provinces Chaqueña and Monte in Catamarca and La Rioja by Aimará Ayelen Poliero, Inés Aubone, Marisa Amadei Enghelmayer, Valeria Soledad Rosso, Sandra Rosa Fuselli, Rosa Maria Alonso-Salces

“…The contents of sugars and total soluble solids, moisture, pH, EC and color of honeys from Catamarca and La Rioja are published here for the first time. This study contributes to the typification of honeys from these provinces, which will provide them an added value and allow them to access to new markets.…”
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Entomological assessment of hessian fabric transfluthrin vapour emanators as a means to protect against outdoor-biting Aedes after providing them to households for routine use in P... by Chicoye Supreme, Obrillant Damus, Joseph Frederick, Jean-Frantz Lemoine, Christian Raccurt, Justin McBeath, Nosrat Mirzai, Sheila B Ogoma, Vincent Corbel, Daniel Impoinvil, Gerry F Killeen, Cyrille Czeher

“…<h4>Background</h4>A simple treated fabric device for passively emanating the volatile pyrethroid transfluthrin was recently developed in Tanzania that protected against nocturnal Anopheles and Culex mosquitoes for several months. Here these transfluthrin emanators were assessed in Port-au-Prince, Haiti against outdoor-biting Aedes.…”
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The Bacterial and pathogenic landscape of African buffalo (Syncerus caffer) whole blood and serum from Kenya by Richard Nyamota, Earl A. Middlebrook, Hussein M. Abkallo, James Akoko, Francis Gakuya, Lillian Wambua, Bernard Ronoh, Isaac Lekolool, Athman Mwatondo, Mathew Muturi, Bernard Bett, Jeanne M. Fair, Andrew W. Bartlow

“…The sequences for the corresponding OTUs were also used to generate phylogenetic trees and thus infer evolution for the OTUs of interest. Results Here, we demonstrate that buffaloes harbor many bacteria in their blood. …”
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