Evaluation of Lymphocyte Response to the Induced Oxidative Stress in a Cohort of Ageing Subjects, including Semisupercentenarians and Their Offspring by Federico Sizzano, Sebastiano Collino, Ornella Cominetti, Daniela Monti, Paolo Garagnani, Rita Ostan, Chiara Pirazzini, Maria Giulia Bacalini, Daniela Mari, Giuseppe Passarino, Claudio Franceschi, Alessio Palini

“…However, little is known about the capability of the immune cells of elderly individuals to dynamically counteract the oxidative stress. Here, the response of the main lymphocyte subsets to the induced oxidative stress in semisupercentenarians (CENT), their offspring (OFF), elderly controls (CTRL), and young individuals (YO) was analyzed using flow cytometry. …”
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Oxidative stress caused by 3-monochloro-1,2-propanediol provokes intestinal stem cell hyperproliferation and the protective role of quercetin by Zongzhong Liu, Yanfei He, Yuhan Wang, Kefeng Ren, Pengpeng Xia, Binbin Xie, Tian Wei

“…However, the specific impacts and mechanisms of 3-MCPD on intestinal health remain elusive. Here, we employed the adult intestine of Drosophila melanogaster, a notable invertebrate model organism, to investigate the intestinal toxicity of 3-MCPD and its underlying mechanisms. …”
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Pigmented Maize (Zea mays L.) Contains Anthocyanins with Potential Therapeutic Action Against Oxidative Stress - A Review by Jesús Miguel Magaña Cerino, Héctor Arturo Peniche Pavía, Axel Tiessen, Carmen Magdalena Gurrola Díaz

“…Could the maize anthocyanins play a curative, preventive or complementary role in the treatment of chronic diseases? Here, we describe the occurrence of anthocyanins from pigmented maize and their chemical structures. …”
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Novel machine learning-driven comparative analysis of CSP, STFT, and CSP-STFT fusion for EEG data classification across multiple meditation and non-meditation sessions in BCI pipel... by Nalinda D. Liyanagedera, Corinne A. Bareham, Heather Kempton, Hans W. Guesgen

“…This novel study focuses on using multiple sessions of EEG data from a single individual to train a machine learning pipeline, and then using a new session data from the same individual for the classification. Here, two meditation techniques, LKM-Self and LKM-Others were compared with non-meditation EEG data for 12 participants. …”
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The Progression of Mycosis Fungoides During Treatment with Mogamulizumab: A BIO-MUSE Case Study of the Tumor and Immune Response in Peripheral Blood and Tissue by Angelica Johansson, Eirini Kalliara, Emma Belfrage, Teodor Alling, Paul Theodor Pyl, Anna Sandström Gerdtsson, Urban Gullberg, Anna Porwit, Kristina Drott, Sara Ek

“…To address these challenges, the non-interventional BIO-MUSE trial was initiated. Here, we report on a case study involving one patient, where combined omics analysis of tissue and blood was used to reveal the unique molecular features associated with the progression of the disease. …”
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Evaluating Sampling Designs to Survey Fish Diversity in Lakes From Northern Temperate Zones by Erik García‐Machado, Eric Normandeau, Guillaume Côté, Isabeau Caza‐Allard, Charles Babin, Louis Bernatchez

“…However, under certain conditions where spatial information is available, sampling design and sequencing depth can be optimized to reduce effort and cost. Here, we evaluate different subsampling approaches to identify sampling strategies that are both easily implemented in the field and provide optimal recovery of species diversity for a given sampling effort. …”
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Molecular Identification and Antimicrobial Potential of Streptomyces Species from Nepalese Soil by Karan Khadayat, Dawa Dindu Sherpa, Krishna Prakash Malla, Sunil Shrestha, Nabin Rana, Bishnu P. Marasini, Santosh Khanal, Binod Rayamajhee, Bibek Raj Bhattarai, Niranjan Parajuli

“…Among them, 12 isolates have shown antibacterial activity against extended-spectrum beta-lactamase- (ESBL-) producing Escherichia coli. Here, we have also analyzed 16S rRNA in 27 Streptomyces species whose whole-genome sequence is available, which has revealed that some species have multiple copies of the 16S gene (∼1.5 kb) with significant variation in nucleotides. …”
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IDO1 inhibits ferroptosis by regulating FTO-mediated m6A methylation and SLC7A11 mRNA stability during glioblastoma progression by Qianting Tian, Guixue Dan, Xuyan Wang, Jiamei Zhu, Chaochun Chen, Dekun Tang, Ziming Wang, Dan Chen, Shan Lei, Chao Yang, Houmei Wang, Bing Guo, Bangming Jin, Tengxiang Chen, Lei Tang

“…This study determined to investigate the impact of IDO1 on glioblastoma multiforme (GBM) cells. Here, we showed that the expression of IDO1 was markedly increased in patients with glioma and associated with GBM progression. …”
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Comparisons of risk factors and outcomes between abdominal aortic aneurysm and peripheral arterial disease: a case-control study by Ian Beeton, Jay Acharya, Bengisu Kesin Meric, James Hobden, Tahir Ali, Thang S. Han

“…ABSTRACT: Background: There is a paucity of data on direct comparison of clinical measures in patients with abdominal aortic aneurysm (AAA) and those with peripheral arterial disease (PAD). Here, we examine the risk factors and outcomes between these 2 conditions. …”
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AOZORA: long-term safety and joint health in paediatric persons with haemophilia A without factor VIII inhibitors receiving emicizumab – protocol for a multicentre, open-label, pha... by Seitaro Yoshida, Masashi Taki, Hideyuki Takedani, Midori Shima, Keiji Nogami, Azusa Nagao, Haruko Yamaguchi-Suita, Yui Kyogoku, Akira Ishiguro, Kaoru Kitsukawa

“…The AOZORA study will evaluate the long-term safety and joint health of paediatric PwHA without factor (F)VIII inhibitors taking emicizumab; here, we report the details of the study protocol and baseline data.Methods and analysis AOZORA is a multicentre, open-label, phase IV clinical study in Japan that aims to enrol approximately 30 PwHA aged <12 years without FVIII inhibitors. …”
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Resource availability and competition shape pollinator trophic specialization in longleaf pine savannas by Pablo Moreno-García, Johanna E. Freeman, Benjamin Baiser, Joshua W. Campbell, Daijiang Li

“…However, the simultaneous effects of resource availability and competition on trophic specialization have yet to be investigated in plant-pollinator networks. Here, we disentangled the effects of resource availability (i.e., blooming plant diversity and abundance), and pollinator competitor pool (i.e., pollinator species richness, and abundance of conspecific and heterospecific pollinator individuals) on pollinator trophic specialization. …”
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Artificial intelligence links CT images to pathologic features and survival outcomes of renal masses by Ying Xiong, Linpeng Yao, Jinglai Lin, Jiaxi Yao, Qi Bai, Yuan Huang, Xue Zhang, Risheng Huang, Run Wang, Kang Wang, Yu Qi, Pingyi Zhu, Haoran Wang, Li Liu, Jianjun Zhou, Jianming Guo, Feng Chen, Chenchen Dai, Shuo Wang

“…Both models outperform corresponding radiomics models and the nephrometry score nomogram. Here we show that the deep learning models can non-invasively predict the likelihood of malignant and aggressive pathology of a renal mass based on preoperative multi-phase CT images.…”
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Assessment tool addresses implementation challenges of ecosystem-based management principles in marine spatial planning processes by Ibon Galparsoro, Natalia Montero, Gotzon Mandiola, Iratxe Menchaca, Ángel Borja, Wesley Flannery, Stelios Katsanevakis, Simonetta Fraschetti, Erika Fabbrizzi, Michael Elliott, Maria Bas, Steve Barnard, GerJan Piet, Sylvaine Giakoumi, Maren Kruse, Ben McAteer, Robert Mzungu Runya, Olga Lukyanova, Telmo Morato, Annaïk Van Gerven, Steven Degraer, Stefan Neuenfeldt, Vanessa Stelzenmüller

“…Abstract Ecosystem-based marine spatial planning is an approach to managing maritime activities while ensuring human well-being and biodiversity conservation as key pillars for sustainable development. Here, we use a comprehensive literature review and a co-development process with experts to build an assessment framework and tool that integrates the fundamental principles of an ecosystem approach to management and translates them into specific actions to be undertaken during planning processes. …”
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Community of trauma care partnering with stakeholders to improve injury outcomes: focus group analysis by Deborah M Stein, Elliott R Haut, Michelle A Price, Pam J Bixby, Anna Newcomb, Rosemary Kozar, Rochelle Dicker, Princess Fortin, Rachel D Appelbaum, Katherine Joseph, Morgan Hennessy, Sue Prentiss, Alexandra McConnell-Hill, Rochelle Flayter

“…We aimed to capture stakeholder perspectives to ensure research is meaningful, respectful, and relevant to the injured patient and their caregivers.Methods A multiphase, inductive exploratory qualitative study was performed, the first phase of which is described here. Virtual focus groups to elicit stakeholder perspectives and preferences were conducted across 19 trauma centers in the USA during 2022. …”
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Monetary Fines in EU Mergers: In Need for More Regulation by Nora Memeti

“…An obvious deficiency is the absence of a legal basis, regardless of whether manifested in hard or soft law. Here it is relevant to inquire in what manner the EC imposes fines and why it occasionally mirrors the fining guidelines applicable to other pillars of EU Competition Law. …”
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Coherent harmonic generation of magnons in spin textures by Guibin Lan, Kang-Yuan Liu, Zhenyu Wang, Fan Xia, Hongjun Xu, Tengyu Guo, Yu Zhang, Bin He, Jiahui Li, Caihua Wan, Gerrit E. W. Bauer, Peng Yan, Gang-Qin Liu, Xin-Yu Pan, Xiufeng Han, Guoqiang Yu

“…For spin-waves in ferromagnetic materials, great progress has been made in the generation higher harmonics, however probing the coherence of these higher harmonics is challenging. Here, using in-situ diamond sensors, we study the coherent harmonic generation of spin waves in a soft ferromagnet. …”
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Charge-transfer complexation of coordination cages for enhanced photochromism and photocatalysis by Gen Li, Zelin Du, Chao Wu, Yawei Liu, Yan Xu, Roy Lavendomme, Shihang Liang, En-Qing Gao, Dawei Zhang

“…Zr-MOCs represent a type of robust discrete hosts for such a design, but their host-guest chemistry in solution is hampered by the limited solubility. Here, by using pyridinium-derived cationic ligands with tetrakis(3,5-bis(trifluoromethyl)phenyl)borate (BArF −) as solubilizing counteranions, we report the preparation of soluble Zr-MOCs of different shapes (1-4) that are otherwise inaccessible through a conventional method. …”
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Learnings from COVID-19 Forced Lockdown on Regional Air Quality and Mitigation Potential for South Asia by Abhishek Upadhyay, Parth Sarathi Mahapatra, Praveen Kumar Singh, Sishir Dahal, Suresh Pokhrel, Amit Bhujel, Indu Bikram Joshi, Shankar Prasad Paudel, Siva Praveen Puppala, Bhupesh Adhikary

“…In this context the country lockdown initiated to combat the COVID-19 pandemic (during March and April 2020 that is the pre-monsoon season) provides an unique opportunity for studying the relative impacts of different emission sources in the region. Here, we analyze changes in levels of air quality species across the region during selected lockdown periods using satellite and in-situ datasets. …”
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Study of Highly Stable Nitrogen-Doped a-InGaSnO Thin-Film Transistors by Wenyang Zhang, Li Lu, Chenfei Li, Weijie Jiang, Wenzhao Wang, Xingqiang Liu, Ablat Abliz, Da Wan

“…Overall, the strategy presented here is effective for preparing a-IGTO TFTs with enhanced stability for potential applications in future optoelectronic displays.…”
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Osteogenesis from Dental Pulp Derived Stem Cells: A Novel Conditioned Medium Including Melatonin within a Mixture of Hyaluronic, Butyric, and Retinoic Acids by Margherita Maioli, Valentina Basoli, Sara Santaniello, Sara Cruciani, Alessandro Palmerio Delitala, Roberto Pinna, Egle Milia, Regina Grillari-Voglauer, Vania Fontani, Salvatore Rinaldi, Roberta Muggironi, Gianfranco Pigliaru, Carlo Ventura

“…Vascular endothelial growth factor A (VEGF A) has been recently reported to act as a major conductor of osteogenesis in vitro and in vivo. Here, we attempted to prime endogenous VEGF A expression without the need for viral vector mediated gene transfer technologies. …”
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