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10001
Tacedinaline (CI-994), a class I HDAC inhibitor, targets intrinsic tumor growth and leptomeningeal dissemination in MYC-driven medulloblastoma while making them susceptible to anti...
Published 2023-01-01“…Therefore, targeting epigenetic modifiers for cancer treatment has gained increasing interest, and inhibitors for various epigenetic modulators have been intensively studied in clinical trials. Here, we report a cross-entity, epigenetic drug screen to evaluate therapeutic vulnerabilities in MYC amplified MB, which sensitizes them to macrophage-mediated phagocytosis by targeting the CD47-signal regulatory protein α (SIRPα) innate checkpoint pathway.Methods We performed a primary screen including 78 epigenetic inhibitors and a secondary screen including 20 histone deacetylase inhibitors (HDACi) to compare response profiles in atypical teratoid/rhabdoid tumor (AT/RT, n=11), MB (n=14), and glioblastoma (n=14). …”
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10002
Is it Time to Recognize Political Anxiety as a Social Determinant of Health?
Published 2024-12-01“…In the past month alone, there have been countless reported variations on a single theme: “Early polling shows the presidential race to be neck and neck, but here’s an alternative data point that might make you feel very strong.” …”
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10003
Application of Fuzzy Hierarchy Analysis method to identify factors on the professional development of newly graduated teachers from Farhangian University
Published 2024-11-01“…What is very important here is the professional growth and development of the teacher as a result of the activity in the study groups and the effort to rebuild and improve. …”
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10004
CAR-CIK vs. CAR-T: benchmarking novel cytokine-induced killer cells as solid tumor immunotherapy in ErbB2+ rhabdomyosarcoma
Published 2025-02-01“…CIK cells are a heterogenous population of predominantly T cells with a mixed natural killer (NK) phenotype and combine non-MHC-restricted cytotoxicity with potent anti-tumor capacity of the adaptive immune system. Here, we characterize and compare efficacy, phenotypic subpopulations and modes of action of CAR-CIK cells and conventional CAR-T cells from same-donor samples in ErbB2+ rhabdomyosarcoma (RMS).MethodsTo benchmark CAR-CIK against conventional CAR-T cells, effector cells were generated from same-donor samples and lentivirally transduced with a second generation CD28-CD3ζ CAR. …”
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10005
Le camp légionnaire romain de Mayence/Mogontiacum (Allemagne) : nouveaux résultats sur l’enceinte et la chronologie
Published 2022-12-01“…De facto, it is only now that we can assume that the two legions XIV Gemina and XVI Gallica were permanently stationed here. During the occupation period, with its flexibly operating units, there is no historical evidence for a double legionary fortress, nor is one to be expected. …”
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10006
The MBH–M∗ Relation up to z ∼ 2 through Decomposition of COSMOS-Web NIRCam Images
Published 2025-01-01“…Our knowledge of relations between supermassive black holes and their host galaxies at z ≳ 1 is still limited, even though being actively sought out to z ∼ 6. Here, we use the high resolution and sensitivity of JWST to measure the host galaxy properties for 107 X-ray-selected type-I active galactic nuclei (AGNs) at 0.68 < z < 2.5 with rest-frame optical/near-infrared imaging from COSMOS-Web and PRIMER. …”
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10007
COOL-LAMPS. VII. Quantifying Strong-lens Scaling Relations with 177 Cluster-scale Strong Gravitational Lenses in DECaLS
Published 2025-01-01“…Additionally, the correlations described here should have utility in ranking strong-lensing candidates in upcoming imaging surveys—such as Rubin/Legacy Survey of Space and Time—in which an algorithmic treatment of strong lenses will be needed due to the sheer volume of data these surveys will produce.…”
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10008
The JADES Transient Survey: Discovery and Classification of Supernovae in the JADES Deep Field
Published 2025-01-01“…We also conducted multiband follow-up NIRCam observations of a subset of the SNe to better constrain their light curves and classify their types. Here, we present the survey, sample, search parameters, spectral energy distributions, light curves, and classifications. …”
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10009
Myofibroblasts emerge during alveolar regeneration following influenza-virus-induced lung injury
Published 2025-02-01“…The current paradigm is that certain aspects of lung organogenesis are mimicked during injury repair in the adult stage. Here, we employ a longitudinal single-cell transcriptomic survey to fate map lung mesenchymal cells throughout development and adulthood. …”
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10010
Gaia-4b and 5b: Radial Velocity Confirmation of Gaia Astrometric Orbital Solutions Reveal a Massive Planet and a Brown Dwarf Orbiting Low-mass Stars
Published 2025-01-01“…Gaia astrometry of nearby stars is precise enough to detect the tiny displacements induced by substellar companions, but radial velocity (RV) data are needed for definitive confirmation. Here we present RV follow-up observations of 28 M and K stars with candidate astrometric substellar companions, which led to the confirmation of two systems, Gaia-4b and Gaia-5b, identification of five systems that are single lined but require additional data to confirm as substellar companions, and the refutation of 21 systems as stellar binaries. …”
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10011
Étude de trois grands tonneaux mis au jour à Reims/Durocortorum (Marne) : le savoir-faire des tonneliers antiques
Published 2020-12-01“…The three large barrels presented here are part of an exceptional assemblage of organic remains, the restoration and exhibition of which was funded by the Champagne House Taittinger in partnership with Inrap. …”
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10012
Exploring the potential of an oyster (Saccostrea mordax) in oligotrophic seas: Effects of starvation on physiological and molecular regulation
Published 2025-03-01“…Its dominant oyster species, Saccostrea mordax, remains unclear regarding starvation tolerance and underlying mechanisms. Here, we treated S. mordax with starvation for four months. …”
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10013
Ground-based Reconnaissance Observations of 21 Exoplanet Atmospheres with the Exoplanet Transmission Spectroscopy Imager
Published 2025-01-01“…One of the most prolific methods of studying exoplanet atmospheres is transmission spectroscopy, which measures the difference between the depth of an exoplanet's transit signal at various wavelengths and attempts to correlate the depth changes to potential features in the exoplanet's atmosphere. Here we present reconnaissance observations of 21 exoplanet atmospheres measured with the Exoplanet Transmission Spectroscopy Imager (ETSI), a recently deployed spectrophotometer on the McDonald Observatory Otto Struve 2.1 m telescope. …”
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10014
A split-GAL4 driver line resource for Drosophila neuron types
Published 2025-01-01“…Split-GAL4 driver lines allow specific targeting of cell types in Drosophila melanogaster and other species. We describe here a collection of 3060 lines targeting a range of cell types in the adult Drosophila CNS and 1373 lines characterized in third-instar larvae. …”
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10015
Observations of Microlensed Images with Dual-field Interferometry: On-sky Demonstration and Prospects
Published 2025-01-01“…The recent development of a dual-field interferometer, GRAVITY Wide, has made it possible to reach out to significantly fainter objects and increase the pool of microlensing events amenable to interferometric observations by 2 orders of magnitude. Here, we present the first successful observation of a microlensing event with GRAVITY Wide and the resolution of microlensed images in the event OGLE-2023-BLG-0061/KMT-2023-BLG-0496. …”
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10016
Decolonization Projects
Published 2023-09-01“…Two key components of cultural sensitivity are worth highlighting here: epistemic and cultural humility. Epistemic humility is an intellectual virtue described as knowing one’s limitations and the limitations of the learning methods employed. …”
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10017
Large range sizes link fast life histories with high species richness across wet tropical tree floras
Published 2025-02-01“…Abstract Understanding how the traits of lineages are related to diversification is key for elucidating the origin of variation in species richness. Here, we test whether traits are related to species richness among lineages of trees from all major biogeographical settings of the lowland wet tropics. …”
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10018
Perceptions of science, science communication, and climate change attitudes in 68 countries – the TISP dataset
Published 2025-01-01“…The questionnaire contained comprehensive measures for individuals’ trust in scientists, science-related populist attitudes, perceptions of the role of science in society, science media use and communication behaviour, attitudes to climate change and support for environmental policies, personality traits, political and religious views and demographic characteristics. Here, we describe the dataset, survey materials and psychometric properties of key variables. …”
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10019
Medical Assistance in Dying for Persons Suffering Solely from Mental Illness in Canada
Published 2025-01-01“…Deontology: The Duty to Recognize Vulnerability and Relieve Suffering The argument here begins with the fundamental focus of deontology—that moral duty lies in an action rather than in its consequences. …”
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10020
The NANOGrav 15 Yr Data Set: Removing Pulsars One by One from the Pulsar Timing Array
Published 2025-01-01“…The methodologies developed here can offer additional tools for application to future, more sensitive data sets. …”
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