Le nivellement des aqueducs de Lyon et leurs aménagements de régulation et de ralentissement : analyse et mise en perspective by Laetitia Borau

“…In addition, a decision had to be made about the type of canal to be built, as this would affect the speed of construction and hence the overall cost of the project, but would also affect ease of maintenance: we can therefore distinguish between the simplest cases –slab-covered concrete canals– and conduits with masonry walls and a vaulted roof through which a maintenance man could walk.The objective here is to put into perspective, on the one hand, the means employed to guarantee a constant slope and to control the flows (regulation and maintenance structures), and on the other hand to overcome the obstacles, particularly the steep slopes (with chutes or dropshafts) and to compare them with other aqueducts in the Roman world, mainly in the western part.The examination of the four conduits demonstrated the small number of regulation and/or decantation structures found across the whole of the Lyon hydraulic network, with three exceptions. …”
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Constraints on Relativistic Jets from the Fast X-Ray Transient 210423 Using Prompt Radio Follow-up Observations by Dina Ibrahimzade, R. Margutti, J. S. Bright, P. Blanchard, K. Paterson, D. Lin, H. Sears, A. Polzin, I. Andreoni, G. Schroeder, K. D. Alexander, E. Berger, D. L. Coppejans, A. Hajela, J. Irwin, T. Laskar, B. D. Metzger, J. C. Rastinejad, L. Rhodes

“…This is at least partially a consequence of limited multiwavelength follow-up of this class of transients in real time. Here we present deep optical ( g - and i -band) photometry with Keck, and prompt radio observations with the Very Large Array of FXT 210423 obtained at δ t ≈ 14–36 days since the X-ray trigger. …”
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E. Coli cytotoxic necrotizing factor-1 promotes colorectal carcinogenesis by causing oxidative stress, DNA damage and intestinal permeability alteration by Michela Tozzi, Alessia Fiore, Sara Travaglione, Francesca Marcon, Gabriella Rainaldi, Elena Angela Pia Germinario, Ilenia Laterza, Simona Donati, Daniele Macchia, Massimo Spada, Omar Leoni, Maria Cristina Quattrini, Donatella Pietraforte, Sofia Tomasoni, Filippo Torrigiani, Ranieri Verin, Paola Matarrese, Lucrezia Gambardella, Francesca Spadaro, Maria Carollo, Agostina Pietrantoni, Francesca Carlini, Concetta Panebianco, Valerio Pazienza, Filomena Colella, Donatella Lucchetti, Alessandro Sgambato, Antonella Sistigu, Federica Moschella, Marco Guidotti, Olimpia Vincentini, Zaira Maroccia, Mauro Biffoni, Roberta De Angelis, Laura Bracci, Alessia Fabbri

“…Despite this evidence, a definitive causal link between CNF1 and CRC was missing. Here we investigated whether CNF1 plays an active role in CRC onset by analyzing pro-carcinogenic key effects specifically induced by the toxin in vitro and in vivo. …”
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Three-dimensional direct lithography of stable quantum dots in hybrid glass by Dezhi Zhu, Shangben Jiang, Ying Wang, Dejun Liu, Weijia Bao, Liwei Liu, Junle Qu, Yiping Wang, Changrui Liao

“…However, the fabrication of stable QDs with designed functional structures has long been challenging. Here, we propose a strategy for three-dimensional direct lithography of desired QDs within a hybrid medium with specific protection properties. …”
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Apaf-1 is an evolutionarily conserved DNA sensor that switches the cell fate between apoptosis and inflammation by Jie Ruan, Xuxia Wei, Suizhi Li, Zijian Ye, Linyi Hu, Ru Zhuang, Yange Cao, Shaozhou Wang, Shengpeng Wu, Dezhi Peng, Shangwu Chen, Shaochun Yuan, Anlong Xu

“…Although Apaf-1 structurally resembles animal NOD-like receptor (NLR) and plant resistance (R) proteins, whether it is directly involved in innate immunity is still largely unknown. Here, we found that Apaf-1-like molecules from lancelets, fruit flies, mice, and humans have conserved DNA sensing functionality. …”
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Midostaurin shapes macroclonal and microclonal evolution of FLT3-mutated acute myeloid leukemia by Romane Joudinaud, Augustin Boudry, Laurène Fenwarth, Sandrine Geffroy, Mikaël Salson, Hervé Dombret, Céline Berthon, Arnaud Pigneux, Delphine Lebon, Pierre Peterlin, Simon Bouzy, Pascale Flandrin-Gresta, Emmanuelle Tavernier, Martin Carre, Sylvie Tondeur, Lamya Haddaoui, Raphael Itzykson, Sarah Bertoli, Audrey Bidet, Eric Delabesse, Mathilde Hunault, Christian Récher, Claude Preudhomme, Nicolas Duployez, Pierre-Yves Dumas

“…Abstract: Despite the use of midostaurin (MIDO) with intensive chemotherapy (ICT) as frontline treatment for Fms-like tyrosine kinase 3 (FLT3)-mutated acute myeloid leukemia (AML), complete remission rates are close to 60% to 70%, and relapses occur in >40% of cases. Here, we studied the molecular mechanisms underlying refractory/relapsed (R/R) disease in patients with FLT3-mutated AML. …”
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CoviWall, a whole-virion-inactivated B.1.617.2 vaccine candidate, induces potent humoral and Th1 cell response in mice and protects against B.1.617.2 strain challenge in Syrian ham... by Jyotsna Dandotiya, Neeta Adhikari, Manas Ranjan Tripathy, Manas Ranjan Tripathy, Kamini Jakhar, Sudipta Sonar, Dibya Ranjan Pati, Vibhu Kanchan, Varsha S. Prasad, Jitendra Kumar, Nitesh K. Senapati, Arti Bharmoria, Neeraj Rani, Monika Lakhanpal, CS. Patil, Nishan Singh, Lovely Khan, Lavit Jambu, Naveen K. Jain, Syed Khalid Ali, Priyanka Priyadarsiny, Amulya K. Panda, Rajesh Jain, Shailendra Mani, Sweety Samal, Amit Awasthi, Amit Awasthi, Zaigham Abbas Rizvi, Zaigham Abbas Rizvi

“…Although most of the vaccines were developed initially with the ancestral Wuhan antigen, here, we report the development and immunological efficacy of a whole-virion–inactivated vaccine candidate (CoviWall) to combat the deadly B.1.617.2 (Delta strain) infection. …”
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RETRACTED: A Synthetic Peptide Designed to Neutralize Lipopolysaccharides Attenuates Metaflammation and Diet-Induced Metabolic Derangements in Mice by Shireen Mohammad, Sura Al Zoubi, Sura Al Zoubi, Debora Collotta, Nadine Krieg, Nadine Krieg, Bianka Wissuwa, Bianka Wissuwa, Gustavo Ferreira Alves, Gareth S. D. Purvis, Gareth S. D. Purvis, Giuseppe Danilo Norata, Giuseppe Danilo Norata, Giuseppe Danilo Norata, Andrea Baragetti, Andrea Baragetti, Alberico Luigi Catapano, Alberico Luigi Catapano, Alberico Luigi Catapano, Egle Solito, Egle Solito, Elisabeth Zechendorf, Tobias Schürholz, Wilmar Correa-Vargas, Klaus Brandenburg, Sina M. Coldewey, Sina M. Coldewey, Massimo Collino, Muhammad M. Yaqoob, Lukas Martin, Lukas Martin, Christoph Thiemermann

“…The role of endogenous antimicrobial peptides (AMPs), such as the cathelicidin LL-37, in T2DM is unknown. We report here for the first time that patients with T2DM compared to healthy volunteers have elevated plasma levels of LL-37. …”
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Robustness and limitations of maximum entropy in plant community assembly by Jelyn Gerkema, Daniel E. Bunker, Andrew M. Cunliffe, Erika Bazzato, Michela Marignani, Tommaso Sitzia, Isabelle Aubin, Stefano Chelli, Julieta A. Rosell, Peter Poschlod, Josep Penuelas, Arildo S. Dias, Christian Rossi, Tanvir A. Shovon, Juan A. Campos, Mark C. Vanderwel, Sharif A. Mukul, Bruno E.L. Cerabolini, Thomas Sibret, Bruno Hérault, Sylvain Schmitt, Pedro Higuchi, James L. Tsakalos, Decky I. Junaedi, Yun-Peng Zhao, Vanessa Minden, Ana Carolina da Silva, Tereza Mašková, Roberto Canullo, Ning Dong, Edwin T. Pos

“…Despite its increasing use, questions regarding its robustness and potential limitations remain. Here, we compared model predictions using either local or database-derived trait values, across different levels of species richness and between different taxonomic levels. …”
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Outcomes with bridging radiation therapy prior to chimeric antigen receptor T-cell therapy in patients with aggressive large B-cell lymphomas by Gohar S. Manzar, Chelsea C. Pinnix, Stephanie O. Dudzinski, Kathryn E. Marqueen, Elaine E. Cha, Lewis F. Nasr, Alison K. Yoder, Michael K. Rooney, Paolo Strati, Sairah Ahmed, Chijioke Nze, Ranjit Nair, Luis E. Fayad, Michael Wang, Loretta J. Nastoupil, Jason R. Westin, Christopher R. Flowers, Sattva S. Neelapu, Jillian R. Gunther, Bouthaina S. Dabaja, Susan Y. Wu, Penny Q. Fang

“…BackgroundSelect patients with relapsed/refractory aggressive B cell lymphoma may benefit from bridging radiation (bRT) prior to anti-CD19-directed chimeric antigen receptor T cell therapy (CAR-T). Here, we examined patient and treatment factors associated with outcomes and patterns of failure after bRT and CAR-T.MethodsWe retrospectively reviewed adults with diffuse large B-cell lymphoma (DLBCL) who received bRT prior to axicabtagene ciloleucel, tisagenlecleucel, or lisocabtagene maraleucel between 11/2017-4/2023. …”
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WALLABY Pilot Survey: Star Formation Enhancement and Suppression in Gas-rich Galaxy Pairs by Qifeng Huang, Jing Wang, Xuchen Lin, Se-Heon Oh, Xinkai Chen, B. Catinella, N. Deg, H. Dénes, B. -Q. For, B. S. Koribalski, K. Lee-Waddell, J. Rhee, A. X. Shen, Li Shao, K. Spekkens, L. Staveley-Smith, T. Westmeier, O. I. Wong, A. Bosma

“…Galaxy interactions can significantly affect the star formation in galaxies, but it remains a challenge to achieve a consensus on the star formation rate (SFR) enhancement in galaxy pairs. Here, we investigate the SFR enhancement of gas-rich galaxy pairs detected by the Widefield ASKAP L -band Legacy All-sky Blind surveY. …”
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ERBB4 selectively amplifies TGF-β pro-metastatic responses by Peihong Luo, Huanyu Hong, Baoling Zhang, Jie Li, Shuyi Zhang, Chaomin Yue, Jin Cao, Jia Wang, Yuhan Dai, Qingqing Liao, Pinglong Xu, Bing Yang, Xia Liu, Xia Lin, Yi Yu, Xin-Hua Feng

“…However, the underlying mechanisms of how TGF-β drives the opposing responses remain largely unknown. Here, we report that ERBB4, a member of the ERBB receptor tyrosine kinase family, specifically promotes TGF-β′s metastatic response but not its anti-growth response. …”
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Multimodal lung cancer theranostics via manganese phosphate/quercetin particle by Chong Qiu, Fei Xia, Qingchao Tu, Huan Tang, Yinan Liu, Hongda Liu, Chen Wang, HaiLu Yao, Linying Zhong, Yuanfeng Fu, Pengbo Guo, Weiqi Chen, Xinyu Zhou, Li Zou, Licheng Gan, Jiawei Yan, Yichong Hou, Junzhe Zhang, Huanhuan Pang, Yuqing Meng, Qiaoli Shi, Guang Han, Xijun Wang, Jigang Wang

“…Abstract The diagnosis and treatment of non-small cell lung cancer in clinical settings face serious challenges, particularly due to the lack of integration between the two processes, which limit real-time adjustments in treatment plans based on the patient’s condition and drive-up treatment costs. Here, we present a multifunctional pH-sensitive core-shell nanoparticle containing quercetin (QCT), termed AHA@MnP/QCT NPs, designed for the simultaneous diagnosis and treatment of non-small cell lung cancer. …”
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Les caves de Reims/Durocortorum à travers les exemples de la fouille du tramway by Magalie Cavé

“…AD, with the installation and generalization of hypocausts, concrete floors and mosaics (attested to here, in the fragmentary state). These observations demonstrate the need to systematically consider cellars within their context of discovery, and at all relevant scales of analysis: the site, the city block and the city as a whole, in Antiquity. …”
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Targeting eEF1A reprograms translation and uncovers broad-spectrum antivirals against cap or m6A protein synthesis routes by Elisa Molina Molina, Joan Josep Bech-Serra, Eloi Franco-Trepat, Ignasi Jarne, Daniel Perez-Zsolt, Roger Badia, Eva Riveira-Muñoz, Edurne Garcia-Vidal, Lluís Revilla, Sandra Franco, Ferran Tarrés-Freixas, Núria Roca, Gerardo Ceada, Karl Kochanowski, Dàlia Raïch-Regué, Itziar Erkizia, Rytis Boreika, Antoni E. Bordoy, Laia Soler, Sonia Guil, Jorge Carrillo, Julià Blanco, Miguel Ángel Martínez, Roger Paredes, Alejandro Losada, Pablo Aviles, Carmen Cuevas, Júlia Vergara-Alert, Joaquim Segalés, Bonaventura Clotet, Ester Ballana, Carolina de la Torre, Nuria Izquierdo-Useros

“…Abstract Plitidepsin is an antitumoral compound safe for treating COVID-19 that targets the translation elongation factor eEF1A. Here we detect that plitidepsin decreases de novo cap-dependent translation of SARS-CoV-2 and non-viral RNAs but affects less than 13% of the host proteome, thus preserving cellular viability. …”
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A Universal Break in Energy Functions of Three Hyperactive Repeating Fast Radio Bursts by Q. Wu, F. Y. Wang, Z. Y. Zhao, P. Wang, H. Xu, Y. K. Zhang, D. J. Zhou, J. R. Niu, W. Y. Wang, S. X. Yi, Z. Q. Hua, S. B. Zhang, J. L. Han, W. W. Zhu, K. J. Lee, D. Li, X. F. Wu, Z. G. Dai, B. Zhang

“…However, so far there has been no decisive evidence for this speculation. Here we report the energy functions of the three most active repeating FRBs, which show a universal break around 10 ^38 erg. …”
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Towards a high-quality in situ observation network for oxygenated volatile organic compounds (OVOCs) in Europe: transferring metrological traceability to the field by M. Iturrate-Garcia, T. Salameh, P. Schlauri, A. Baldan, M. K. Vollmer, E. Stratigou, S. Dusanter, J. Li, S. Persijn, A. Claude, R. Holzinger, C. Sutour, T. Macé, Y. Elshorbany, A. Ackermann, C. Pascale, S. Reimann

“…However, for many oxygenated VOCs (OVOCs), such RGMs and working standards are not available at an atmospheric amount of substance fraction levels (<span class="inline-formula">&lt;</span> 10 <span class="inline-formula">nmol mol⁻¹</span>). Here, we present the protocols developed to transfer SI traceability to the field by producing two types of SI-traceable working standards for selected OVOCs. …”
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Bug off or bug out: mapping flight secrets of Triatoma garciabesi (Hemiptera: Reduviidae) through climate, geography, and greenery by Thaiane Verly, Thaiane Verly, Federico G. Fiad, Ana Laura Carbajal-de-la-Fuente, Ana Laura Carbajal-de-la-Fuente, Sebastián Pita, Romina V. Piccinali, Romina V. Piccinali, Patricia A. Lobbia, Paz Sánchez-Casaccia, Paz Sánchez-Casaccia, Paz Sánchez-Casaccia, Antonieta Rojas de Arias, María José Cavallo, Gisel V. Gigena, Claudia S. Rodríguez, María C. Vega-Gómez, Miriam Rolón, Julieta Nattero, Julieta Nattero, Julieta Nattero

“…These lineages occur across the species distribution range and coincide with different ecological regions. Here, we aim to examine how phenotypic variation in flight-related traits is structured, determine the association between these traits and geographic distance, and identify the climatic, geographic, and/or vegetation cover variables that best explain the morphometric variation in flight-related traits.MethodsA total of 198 males of T. garciabesi from 24 populations in Argentina and Paraguay were included in this study, covering almost the entire T. garciabesi distribution range. …”
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Hybridization-based discovery of novel quinazoline-2-indolinone derivatives as potent and selective PI3Kα inhibitors by Changqun Liu, Yuening Cao, Yi Zuo, Chaozheng Zhang, Senmiao Ren, Xin Zhang, Chuanqi Wang, Yingjie Zeng, Jie Ling, Yilan Liu, Zixian Chen, Xiujun Cao, Zhengzhi Wu, Chuantao Zhang, Jun Lu

“…The biological evaluation of compound 8 was performed by transwell, flow cytometry, laser scanning confocal microscopy, Western blot, CTESA and immunohistochemistry. Results: Here, we employed molecular hybridization methods to construct a series of quinazoline-2-indolinone derivatives as PI3Kα selective inhibitors. …”
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Intranigral Administration of β-Sitosterol-β-D-Glucoside Elicits Neurotoxic A1 Astrocyte Reactivity and Chronic Neuroinflammation in the Rat Substantia Nigra by Claudia Luna-Herrera, Irma A. Martínez-Dávila, Luis O. Soto-Rojas, Yazmin M. Flores-Martinez, Manuel A. Fernandez-Parrilla, Jose Ayala-Davila, Bertha A. León-Chavez, Guadalupe Soto-Rodriguez, Victor M. Blanco-Alvarez, Francisco E. Lopez-Salas, Maria E. Gutierrez-Castillo, Bismark Gatica-Garcia, America Padilla-Viveros, Cecilia Bañuelos, David Reyes-Corona, Armando J. Espadas-Alvarez, Linda Garcés-Ramírez, Oriana Hidalgo-Alegria, Fidel De La Cruz-lópez, Daniel Martinez-Fong

“…Chronic consumption of β-sitosterol-β-D-glucoside (BSSG), a neurotoxin contained in cycad seeds, leads to Parkinson’s disease in humans and rodents. Here, we explored whether a single intranigral administration of BSSG triggers neuroinflammation and neurotoxic A1 reactive astrocytes besides dopaminergic neurodegeneration. …”
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