Unusual Space Weathering on a CE-5 Metal Grain Indicates Deceptive Surface Signatures of M-type Asteroids by Tian Zhang, Hong Tang, Xiongyao Li, Yuanyun Wen, Bing Mo, Wen Yu, Chuanjiao Zhou, Jianzhong Liu

“…However, recent spectral and radar observations reveal an insufficient number of M-type asteroids in the main belt. Here, we report unusual space weathering characteristics associated with a natural metal grain found in Chang'e 5 lunar soil. …”
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Effects of Bedaquiline on Antimicrobial Activity and Cytokine Secretion of Macrophages Infected with Multidrug-Resistant Mycobacterium tuberculosis Strains by Xia-Li Lyu, Ting-Ting Lin, Jing-Tao Gao, Hong-Yan Jia, Chuan-Zhi Zhu, Zi-Hui Li, Jing Dong, Qi Sun, Wei Shu, Sai-Sai Wang, Li-Ping Pan, Hai-Rong Huang, Zong-De Zhang, Qi Li

“…However, few reported investigations exist regarding Bdq effects on MDR-MTBs-infected macrophages activities and cytokine secretion. Here, Bdq bactericidal activities against MDR-MTBs and related cellular immune mechanisms were explored. …”
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Proteomics unveil candidate biomarkers and pathogenesis of subacute thyroiditis by Litong Ran, Xiufei Liu, Yongfeng Tian, Jiaran Zhu, Zhengyuan Gong, Qiao Qiao, Xin Jiang, Yuren Wang, Guojun Yang, Hongting Zheng, Yi Zheng, Hua Qu

“…Despite gaining new insights into the epidemiology, pathogenesis and treatment of SAT in recent years, the exact pathogenesis and determinants of its clinical progression remain unclear. Here, we profiled thyroid in situ protein alterations in fine-needle aspiration biopsy samples from SAT patients using proteomic analysis and uncovered 57 differentially abundant proteins. …”
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Short-term caloric restriction or resveratrol supplementation alters large-scale brain network connectivity in male and female rats by Judith R. A. van Rooij, Judith R. A. van Rooij, Monica van den Berg, Monica van den Berg, Tamara Vasilkovska, Johan Van Audekerke, Johan Van Audekerke, Lauren Kosten, Daniele Bertoglio, Daniele Bertoglio, Mohit H. Adhikari, Mohit H. Adhikari, Marleen Verhoye, Marleen Verhoye

“…Therefore, we aimed to compare and unravel the sex-specific impact of these dietary interventions on spontaneous brain activity.MethodsHere, we used resting-state fMRI to investigate functional connectivity (FC) changes in five prominent resting-state brain networks (RSNs) in healthy 4 month old male and female F344 rats supplemented to either 40% CR or daily Rsv supplementation (10 mg/kg, oral) for the duration of 1 month.ResultsOur results demonstrated a decreased body weight (BW) in CR rats, as well as an increase in body weight in male Rsv supplemented rats, compared to female Rsv supplemented rats, whereas this difference between sexes was not observed in the control or CR groups. …”
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Memory B cells and their transcriptomic profiles associated with belimumab resistance in systemic lupus erythematosus in the maintenance phase by Takeshi Iwasaki, Takeshi Iwasaki, Hajime Yoshifuji, Koji Kitagori, Shuji Sumitomo, Shuji Akizuki, Ran Nakashima, Hideaki Tsuji, Ryosuke Hiwa, Mirei Shirakashi, Kosaku Murakami, Akira Onishi, Hideo Onizawa, Masao Tanaka, Fumihiko Matsuda, Akio Morinobu, Koichiro Ohmura, Koichiro Ohmura

“…The factors contributing to the treatment efficacy of belimumab in patients with systemic lupus erythematosus (SLE) in the maintenance phase are unknown. Here, we collected blood samples from patients with SLE (n=44) treated with belimumab before and three and six months after treatment. …”
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Flexible reproductive seasonality in Africa-dwelling papionins is associated with low environmental productivity and high climatic unpredictability by Dezeure, Jules, Dagorrette, Julie, Burtschell, Lugdiwine, Chowdhury, Shahrina, Lukas, Dieter, Swedell, Larissa, Huchard, Elise

“…In order to predict how changes in seasonality might affect these animals, it is important to understand which aspects of their diverse patterns of reproductive phenology are linked to either the equally diverse patterns of rainfall seasonality (within-year variations) or instead the marked climatic unpredictability (year-to-year variations) occurring across the intertropical belt. Here, we gather birth and climatic seasonality data from 21 populations of 11 Africa-dwelling primate species from the papionin tribe, occupying a wide range of environments, including equatorial, tropical, temperate and arid climates. …”
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Global decadal measurements of methanol, ethene, ethyne, and HCN from the Cross-track Infrared Sounder by K. C. Wells, D. B. Millet, J. F. Brewer, V. H. Payne, K. E. Cady-Pereira, R. Pernak, S. Kulawik, S. Kulawik, C. Vigouroux, N. Jones, E. Mahieu, M. Makarova, T. Nagahama, I. Ortega, M. Palm, K. Strong, M. Schneider, D. Smale, R. Sussmann, M. Zhou

“…Space-based observations can provide powerful global information to advance our knowledge of these processes and their changes over time. We present here the development of new retrievals for four key VOCs (methanol, ethene, ethyne, and HCN) based on thermal infrared radiance observations from the satellite-borne Cross-track Infrared Sounder (CrIS). …”
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The ASK-16 motorized glider: an airborne eddy covariance platform to measure turbulence, energy, and matter fluxes by I. Wiekenkamp, A. K. Lehmann, A. Bütow, J. Hartmann, S. Metzger, S. Metzger, T. Ruhtz, C. Wille, M. Zöllner, T. Sachs, T. Sachs

“…<p>Airborne eddy covariance measurements can bridge the gap between local (tower-based) and regional (satellite/inversion-derived) flux data, as they provide information about the spatial distribution of turbulent fluxes for larger regions. Here, we introduce an airborne eddy covariance measurement platform based on an ASK-16 touring motor glider (TMG; also referred to as a power glider, hereafter referred to as motorized glider), which is equipped to measure the three-dimensional (3D) wind vector, and atmospheric conditions, and we derive airborne turbulent fluxes for the use of measurement campaigns over European landscapes. …”
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Enhanced Antitumor Efficacy and Reduced Toxicity in Colorectal Cancer Using a Novel Multifunctional Rg3- Targeting Nanosystem Encapsulated with Oxaliplatin and Calcium Peroxide by Xie Y, Zhu M, Bao H, Chen K, Wang S, Dai J, Chen H, Li H, Song Q, Wang X, Yu L, Pei J

“…Oxaliplatin (OXA) is currently the primary chemotherapeutic agent for CRC, but its efficacy is limited by the tumor microenvironment (TME). Here, we present a combined approach of chemotherapy and TME modulation for CRC treatment. …”
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Population Dynamics of the Crocodile Shark, <i>Pseudocarcharias kamoharai</i>, in the Tropical Equatorial Pacific Ocean, Ecuador by Marcos Douglas Calle-Morán, Eugenio Alberto Aragón-Noriega, Ana Rosa Hernández-Téllez, Emigdio Marín-Enríquez, Javier Tovar-Ávila, Juan Francisco Arzola-González, Jorge Payán-Alejo

“…These biological parameters were used in all the models considered here. The <i>M</i> estimations were 0.14 to 0.28 based on six models for chondrichthyans and osteichthyes. …”
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The neural activity of auditory conscious perception by Kate L. Christison-Lagay, Aya Khalaf, Noah C. Freedman, Christopher Micek, Sharif I. Kronemer, Mariana M. Gusso, Lauren Kim, Sarit Forman, Julia Ding, Mark Aksen, Ahmad Abdel-Aty, Hunki Kwon, Noah Markowitz, Erin Yeagle, Elizabeth Espinal, Jose Herrero, Stephan Bickel, James Young, Ashesh Mehta, Kun Wu, Jason Gerrard, Eyiyemisi Damisah, Dennis Spencer, Hal Blumenfeld

“…To determine whether there are shared mechanisms for perceptual consciousness across sensory modalities, here we test within the auditory domain. Participants completed an auditory threshold task while undergoing intracranial electroencephalography. …”
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Multiple action sites of ultrasound on Escherichia coli and Staphylococcus aureus by Xinyu Liao, Jiao Li, Yuanjie Suo, Shiguo Chen, Xingqian Ye, Donghong Liu, Tian Ding

“…Those microbial cells who had not enter the valid area of ultrasonic cavitation might be injected with free radicals produced by ultrasound and experienced interior injury with intact exterior structure, and others who were in close proximity to the ultrasonic wave field would be immediately and completely disrupted into debris by high power mechanic forces. These findings here try to provide extension for the inactivation mechanisms of ultrasound on microorganisms. …”
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ROS-induced cytosolic release of mitochondrial PGAM5 promotes colorectal cancer progression by interacting with MST3 by Shiyang Wang, Xi Wu, Wenxin Bi, Jiuzhi Xu, Liyuan Hou, Guilin Li, Yuwei Pan, Hanfu Zhang, Mengzhen Li, Sujuan Du, Mingxin Zhang, Di Liu, Shuiling Jin, Xiaojing Shi, Yuhua Tian, Jianwei Shuai, Maksim V. Plikus, Moshi Song, Zhaocai Zhou, Lu Yu, Cong Lv, Zhengquan Yu

“…However, precise molecular mechanism by which mtROS contribute to epithelial cancer progression remains only partially understood. Here, using colorectal cancer (CRC) models, we show that upon sensing excessive mtROS, phosphatase PGAM5, which normally localizes to the mitochondria, undergoes aberrant cleavage by presenilin-associated rhomboid-like protein (PARL), becoming released into the cytoplasm. …”
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Enhanced solar hydrogen production via reconfigured semi-polar facet/cocatalyst heterointerfaces in GaN/Si photocathodes by Wei Chen, Danhao Wang, Weiyi Wang, Xin Liu, Yuying Liu, Chao Wang, Yang Kang, Shi Fang, Xudong Yang, Wengang Gu, Dongyang Luo, Yuanmin Luo, Zongtao Qu, Chengjie Zuo, Yi Kang, Lin Cheng, Wensheng Yan, Wei Hu, Ran Long, Jr-Hau He, Kang Liang, Sheng Liu, Yujie Xiong, Haiding Sun

“…Abstract The development of an efficient and durable photoelectrode is critical for achieving large-scale applications in photoelectrochemical water splitting. Here, we report a unique photoelectrode composed of reconfigured gallium nitride nanowire-on-silicon wafer loaded with Au nanoparticles as cocatalyst that achieved an impressive applied bias photon-to-current efficiency of 10.36% under AM 1.5G one sun illumination while exhibiting stable PEC hydrogen evolution over 800 h at a high current density. …”
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Comparative Effects of Glenzocimab and Eptifibatide on Bleeding Severity in 2 Mouse Models of Intracranial Hemorrhage by Sébastien Dupont, Héloïse Lebas, Sabrina Mavouna, Eloïse Pascal, Astride Perrot, Adrien Cogo, Marie‐Charlotte Bourrienne, Carine Farkh, Mialitiana Solo Nomenjanahary, Véronique Ollivier, Fatima Zemali, Bernhard Nieswandt, Stéphane Loyau, Martine Jandrot‐Perrus, Eric Camerer, Jean‐Philippe Desilles, Mikael Mazighi, Yacine Boulaftali, Benoît Ho‐Tin‐Noé

“…Yet while the efficacy of such adjuvant strategies has been shown to be highly time dependent, antiplatelet therapy at the acute phase of ischemic stroke cannot be envisioned until the diagnosis of stroke and its ischemic nature have been confirmed because of the presumed risk of worsening bleeding in case of intracranial hemorrhage (ICH). Here, we investigated this risk for 2 antiplatelet drugs currently being tested in clinical trials for ischemic stroke, glenzocimab and eptifibatide, in 2 mouse models of ICH. …”
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Hyperspectral imaging for precision nitrogen management: A comparative exploration of two methodological approaches to estimate optimal nitrogen rate in processing tomato by Vito Aurelio Cerasola, Francesco Orsini, Giuseppina Pennisi, Gaia Moretti, Stefano Bona, Francesco Mirone, Jochem Verrelst, Katja Berger, Giorgio Gianquinto

“…Hyperspectral imaging is widespread in crop nitrogen (N) monitoring for precision agriculture, although approaches that address the agronomical recommendation of the optimal N rate are still lacking. Here, two approaches are explored in defining the optimal N rate to be supplied in fertigated processing tomatoes through hyperspectral imaging. …”
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Genomic data suggest parallel dental vestigialization within the xenarthran radiation by Emerling, Christopher A, Gibb, Gillian C, Tilak, Marie-Ka, Hughes, Jonathan J, Kuch, Melanie, Duggan, Ana T, Poinar, Hendrik N, Nachman, Michael W, Delsuc, Frédéric

“…We tested these competing hypotheses by examining 11 core dental genes in most living species of Xenarthra, characterizing shared inactivating mutations and patterns of relaxed selection during their radiation. Here we report evidence of independent and distinct events of dental gene loss in the major xenarthran subclades. …”
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Granulocyte-Macrophage Colony-Stimulating Factor-Activated Neutrophils Express B7-H4 That Correlates with Gastric Cancer Progression and Poor Patient Survival by Zhi-guo Shan, Zong-bao Yan, Liu-sheng Peng, Ping Cheng, Yong-sheng Teng, Fang-yuan Mao, Kun Fan, Yuan Zhuang, Yong-liang Zhao

“…However, the phenotype, regulation, and clinical relevance of neutrophils in human GC are presently unknown. Here, immunohistochemistry, real-time PCR, and flow cytometry analyses were performed to examine levels and phenotype of neutrophils in samples from 41 patients with GC, and also isolated, stimulated, and/or cultured neutrophils for in vitro regulation assays. …”
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L’apport de la géomatique à la connaissance de la partie terminale de l’aqueduc du Gier à Lyon by Éric Leroy

“…However, its mapping on a regional scale masks certain uncertainties which can only be observed through analysis at a more local scale. Here, we propose to evaluate the contributions of geomatics, analysis and spatial modelling to the study of the aqueduct route. …”
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FutureMS cohort profile: a Scottish multicentre inception cohort study of relapsing-remitting multiple sclerosis by David Hunt, Siddharthan Chandran, Peter Connick, Peter Foley, Patrick K A Kearns, Sergio E Baranzini, Adam D Waldman, Sarah J Martin, Elizabeth Freyer, F J Carod-Artal, Lee Murphy, Amy Stenson, Jessie Chang, Rozanna Meijboom, Elizabeth N York, Yingdi Chen, Christine Weaver, Katarzyna Hafezi, Stacey Thomson, Adil Harroud, Margaret McLeod, Jonathon O'Riordan, Niall J J MacDougall

“…Recruitment, baseline assessment and follow-up at year 1 is complete. Here, we describe the cohort design and present a profile of the participants at baseline and 1 year of follow-up.Future plans A third follow-up wave for the cohort has recently begun at 5 years after first visit and a further wave of follow-up is funded for year 10. …”
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