Blood-based epigenome-wide association study and prediction of alcohol consumption by Elena Bernabeu, Aleksandra D. Chybowska, Jacob K. Kresovich, Matthew Suderman, Daniel L. McCartney, Robert F. Hillary, Janie Corley, Maria Del C. Valdés-Hernández, Susana Muñoz Maniega, Mark E. Bastin, Joanna M. Wardlaw, Zongli Xu, Dale P. Sandler, Archie Campbell, Sarah E. Harris, Andrew M. McIntosh, Jack A. Taylor, Paul Yousefi, Simon R. Cox, Kathryn L. Evans, Matthew R. Robinson, Catalina A. Vallejos, Riccardo E. Marioni

“…Instead, molecular data such as blood-based DNA methylation (DNAm) could be used to derive a more objective measure of alcohol consumption by incorporating information from cytosine-phosphate-guanine (CpG) sites known to be linked to the trait. Here, we explore the epigenetic architecture of self-reported weekly units of alcohol consumption in the Generation Scotland study. …”
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Optogenetic control of horizontally acquired genes prevent stuck fermentations in yeast by David Figueroa, Diego Ruiz, Nicolò Tellini, Matteo De Chiara, Eduardo I. Kessi-Pérez, Claudio Martínez, Gianni Liti, Amparo Querol, José M. Guillamón, Francisco Salinas

“…Nitrogen limitation in grape must reduces yeast biomass and fermentation rate, resulting in incomplete fermentations with high levels of residual sugar, undesired by-products, and microbiological instability. Here, we used an optogenetic approach to demonstrate that expression of genes within region A is necessary to complete fermentations under low nitrogen availability. …”
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Effects of olive leaf extract on exercise performance and muscle mitochondrial response in young healthy adults by Clément Lanfranchi, Nadège Zanou, Jérôme Feige, Umberto DeMarchi, Aurélie Hermant, Ornella Cominetti, Eugenia Migliavacca, Alba Moreno-Asso, Astrid Hostrman, Sara Mistro, Nicolas Place

“…Olive leaf extract (OLE) is a natural compound that triggers mitochondrial Ca2+ uptake and activates PDH in mouse skeletal muscle [2]. Here we tested the hypothesis that OLE would contribute to exercise performance improvement by increasing muscle mitochondrial response and PDH activation in human participants performing MICT. …”
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TCR transgenic clone selection guided by immune receptor analysis and single-cell RNA expression of polyclonal responders by Nincy Debeuf, Sahine Lameire, Manon Vanheerswynghels, Julie Deckers, Caroline De Wolf, Wendy Toussaint, Rein Verbeke, Kevin Verstaen, Hamida Hammad, Stijn Vanhee, Bart N Lambrecht

“…Constructing TCR transgenic mice from T cell hybridomas is a labor-intensive and sometimes erratic process, since the best clones are selected based on antigen-induced CD69 upregulation or IL-2 production in vitro, and TCR chains are polymerase chain reaction (PCR)-cloned into expression vectors. Here, we exploited the rapid advances in single-cell sequencing and TCR repertoire analysis to select the best clones without hybridoma selection, and generated CORSET8 mice (CORona Spike Epitope specific CD8 T cell), carrying a TCR specific for the Spike protein of SARS-CoV-2. …”
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Pathogenic PDE12 variants impair mitochondrial RNA processing causing neonatal mitochondrial disease by Lindsey Van Haute, Petra Páleníková, Jia Xin Tang, Pavel A Nash, Mariella T Simon, Angela Pyle, Monika Oláhová, Christopher A Powell, Pedro Rebelo-Guiomar, Alexander Stover, Michael Champion, Charulata Deshpande, Emma L Baple, Karen L Stals, Sian Ellard, Olivia Anselem, Clémence Molac, Giulia Petrilli, Laurence Loeuillet, Sarah Grotto, Tania Attie-Bitach, Jose E Abdenur, Robert W Taylor, Michal Minczuk

“…The PDE12 gene encodes the poly(A)-specific exoribonuclease, involved in the quality control of mitochondrial non-coding RNAs. Here, we report that disease-causing PDE12 variants in three unrelated families are associated with mitochondrial respiratory chain deficiencies and wide-ranging clinical presentations in utero and within the neonatal period, with muscle and brain involvement leading to marked cytochrome c oxidase (COX) deficiency in muscle and severe lactic acidosis. …”
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RNA Polymerase RPOTp is Involved in C‐to‐U RNA Editing at Multiple Sites in Arabidopsis Chloroplasts by Nadia Ahmed Ali, Wenjian Song, Yayi Zhang, Jiani Xing, Kexing Su, Xingxing Sun, Yujia Sun, Yizhou Jiang, Dianxing Wu, Xiaobo Zhao

“…However, whether RPOTp is involved in chloroplast RNA editing remains unclear. Here, the role of RPOTp in C‐to‐U RNA editing at multiple sites in Arabidopsis chloroplasts is uncovered. …”
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Single dose of recombinant baculovirus vaccine expressing sigma B and sigma C genes provides good protection against novel duck reovirus challenge in ducks by Yufei Wang, Siyi Xu, Xia Chen, Yunlong Dou, Xingzhu Yang, Zenglei Hu, Shuang Wu, Xiaoquan Wang, Jiao Hu, Xiufan Liu

“…However, currently, no commercial vaccines are available to alleviate NDRV infection throughout the world. Here, we developed two subunit vaccine candidates for NDRV based on the insect cell-baculovirus expression system (IC-BEVS). …”
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Blue rings in trees and shrubs as indicators of early and late summer cooling events at the northern treeline by Agata Buchwal, Agata Buchwal, Pawel Matulewski, Ylva Sjöberg, Alma Piermattei, Alma Piermattei, Alan Crivellaro, Alan Crivellaro, Angela Balzano, Maks Merela, Luka Krže, Katarina Čufar, Alexander V. Kirdyanov, Alexander V. Kirdyanov, Tatiana Bebchuk, Tito Arosio, Ulf Büntgen, Ulf Büntgen, Ulf Büntgen

“…However, wood anatomical anomalies that likely reflect temperature-induced reductions in cell wall lignification, the so-called Blue Rings (BRs), have not yet been systematically investigated in trees and shrubs in northern Europe. Here, we present frontier research on the occurrence of BRs in Pinus sylvestris trees and Juniperus communis (L) s.l. shrubs from the upper treeline in northern Norway (69°N) in relation to instrumental temperature data covering the last ca. 150 years. …”
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Lattice Stabilized and Emission Tunable Pure‐Bromide Quasi‐2D Perovskite for Air‐Processed Blue Light‐Emitting Diodes by Yangyang Guo, Penghui Yang, Fan Dong, Huixin Li, Jialiang Gao, Zeyi Cheng, Jiandong Wu, Yadong Xu, Hongyue Wang, Hongqiang Wang

“…However, the intrinsically inferior thermodynamic stability and laborious crystallization kinetics control under humidity interference limit the fabrication of blue perovskite emitters in ambient air. Here, air‐processed pure‐bromide quasi‐2D blue perovskite films are achieved with stabilized lattice and tunable emission by interstitial doping of trivalent metallic cations. …”
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Seroprevalence of Human Herpesvirus Infections in Newly Diagnosed HIV-Infected Key Populations in Dar es Salaam, Tanzania by Doreen Kamori, Agricola Joachim, Mucho Mizinduko, Godfrey Barabona, Macdonald Mahiti, Upendo Kibwana, Mtebe Majigo, Salim Masoud, Ambele M. Mwandigha, Takamasa Ueno, Elia Mmbaga, Eligius Lyamuya

“…In the population at high risk of HIV infection, also termed as key populations (female sex workers (FSW), men who have sex with men (MSM), and people who inject drugs (PWID)), and their sexual partners, HHV infections can potentially compromise the efforts to prevent and control HIV infection. Here, we investigated the seroprevalence of HHV infections among HIV-infected key populations in Dar es Salaam, Tanzania. …”
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G3BP1 ribonucleoprotein complexes regulate focal adhesion protein mobility and cell migration by Liana C. Boraas, Mengwei Hu, Pieter Martino, Lauren Thornton, Charles E. Vejnar, Gang Zhen, Longhui Zeng, Dylan M. Parker, Andy L. Cox, Antonio J. Giraldez, Xiaolei Su, Christine Mayr, Siyuan Wang, Stefania Nicoli

“…However, whether other mRNAs and RBPs also localize at FAs remains unclear. Here, we identify hundreds of mRNAs that are enriched at FAs (FA-mRNAs). …”
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Acquired vulnerability against EGF receptor inhibition in gastric cancer promoted by class I histone deacetylase inhibitor entinostat by Tamara Zenz, Robert Jenke, Denys Oliinyk, Sandra Noske, René Thieme, Tim Kahl, Ines Gockel, Florian Meier-Rosar, Achim Aigner, Thomas RH Büch

“…This highlights the need for the identification of underlying reasons, which may also provide the basis for possible combination therapies. Here, we delineated the effects of HDACi on components of EGFR signalling in gastric cancer cells. …”
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Impact of Annually Variable Dust Activity on the Recession of the Martian South Polar Seasonal Cap by Zhibin Li, Jianjun Liu, Renhao Tian, Zhaopeng Chen, Qing Zhang, Jingjing Zhang, Wei Yan, Qiang Fu, Shaoran Liu, Nannan Ma

“…Continuous observations of SPSC/South Polar Residual Cap (SPRC) across several Martian years, alongside segmented analyses of annual dust activity, will provide new insights into the climate conditions of Martian south polar region. Here, we performed a combined analysis on the extents of SPSC from MY28-MY31 and MY36, together with the concurrent Martian atmospheric optical thickness, to assess the influence of dust activity at various recession time steps. …”
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The OsEBF1-OsEIL5-OsPP91 module regulates rice heat tolerance via ubiquitination and transcriptional activation by Jianping Liu, Ke Wang, Guining Wang, Zhi Peng, Tao Wang, Yang Meng, Jinli Huang, Jiaohan Huo, Xin Li, Xiaoqi Zhu, Feiyun Xu, Qian Zhang, Zhengrui Wang, Hao Chen, Ya Wang, Weifeng Xu

“…Summary: Understanding the regulatory mechanisms underlying the plant heat stress response is important for developing climate-resilient crops, including rice (Oryza sativa). Here, we report that OsEIL5, one member of the ETHYLENE INSENSITIVE3-LIKE family, positively regulates rice heat tolerance at the seedling and reproductive stages. …”
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Functional interaction between receptor tyrosine kinase MET and ETS transcription factors promotes prostate cancer progression by Elisa Carouge, Clémence Burnichon, Martin Figeac, Shéhérazade Sebda, Nathalie Vanpouille, Audrey Vinchent, Marie‐José Truong, Martine Duterque‐Coquillaud, David Tulasne, Anne Chotteau‐Lelièvre

“…However, the collaboration of these factors in prostate cancer progression has not yet been investigated. Here, we show, using cell models of advanced prostate cancer, that ETS translocation variant 1 (ETV1) and transcriptional regulator ERG (ERG) transcription factors (members of the ETS family) promote tumour properties, and that activation of MET signalling enhances these effects. …”
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Cancer stem cells and tumor-associated macrophages as mates in tumor progression: mechanisms of crosstalk and advanced bioinformatic tools to dissect their phenotypes and interacti... by Francesco Verona, Sebastiano Di Bella, Roberto Schirano, Camilla Manfredi, Francesca Angeloro, Giulia Bozzari, Matilde Todaro, Matilde Todaro, Giuseppe Giannini, Giuseppe Giannini, Giorgio Stassi, Veronica Veschi

“…Moreover, the combination of biology and computational data will lead to the development of innovative target therapies dampening CSC-TME interaction. Here, we aim to elucidate the most recent insights on CSCs biology and their complex interactions with TME immune cells, specifically TAMs, tracing an exhaustive scenario from the primary tumor to metastasis formation.…”
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Synthetic CB1 Cannabinoids Promote Tunneling Nanotube Communication, Cellular Migration, and Epithelial–Mesenchymal Transition in Pancreatic PANC-1 and Colorectal SW-620 Cancer Cel... by David A. Bunsick, Leili Baghaie, Yunfan Li, Abdulrahman M. Yaish, Emilyn B. Aucoin, Elizabeth Skapinker, Rashelle Aldbai, Myron R. Szewczuk

“…During this reprogramming process, cancer cells’ metabolism and other cellular activities are integrated and mutually regulated by tunneling nanotube communications to alter their specific metabolic functional drivers of tumor growth and progression. Here, we investigated the in vitro effects of the synthetic CB1 cannabinoids AM-404, arvanil, and olvanil on human pancreatic PANC-1 and colorectal SW-620 cancer cell lines to understand further cellular behaviors and the potential risks of their use in cancer therapy. …”
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Intraplaque Expression of C-Reactive Protein Predicts Cardiovascular Events in Patients with Severe Atherosclerotic Carotid Artery Stenosis by Aldo Bonaventura, François Mach, Aline Roth, Sébastien Lenglet, Fabienne Burger, Karim J. Brandt, Aldo Pende, Maria Bertolotto, Giovanni Spinella, Bianca Pane, Domenico Palombo, Franco Dallegri, Michele Cea, Nicolas Vuilleumier, Fabrizio Montecucco, Federico Carbone

“…Serum c-reactive protein (CRP) was suggested for the assessment of intermediate cardiovascular (CV) risk. Here, systemic or intraplaque CRP levels were investigated as predictors of major adverse cardiovascular events (MACEs) in patients with severe carotid stenosis. …”
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Long-term Radio Monitoring of the Fast X-Ray Transient EP 240315a: Evidence for a Relativistic Jet by Roberto Ricci, Eleonora Troja, Yu-Han Yang, Muskan Yadav, Yuan Liu, Hui Sun, Xuefeng Wu, He Gao, Bing Zhang, Weimin Yuan

“…Multiwavelength observations of FXRTs and their counterparts are key to characterize the properties of their outflows and, ultimately, identify their progenitors. Here, we report our long-term radio monitoring of EP 240315A, a long-lasting (∼1000 s) high-redshift ( z = 4.9) FXRT associated to gamma-ray burst (GRB) 240315C. …”
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Plant-microbe interactions influence plant performance via boosting beneficial root-endophytic bacteria by Sai Guo, Rubin Pan, Yan Zhang, Quanwei Gu, Qirong Shen, Jian Yang, Luqi Huang, Zongzhuan Shen, Rong Li

“…., healthy and disease) shape the assembly of root-endophytic microorganisms and the functional importance of these microorganisms in improving plant performance remains largely unknown. Results Here, we investigated the assembly of root-endophytic microorganisms in medicinal plants with different growth status and its links with plant performance improvement. …”
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