Blood-based biomarkers in patients with non-small cell lung cancer treated with immune checkpoint blockade by Yo-Ting Tsai, Jeffrey Schlom, Renee N. Donahue

“…In response, there has been a growing emphasis on the development of “liquid biopsy”‒ derived biomarkers, which offer a minimally invasive means to dynamically monitor the immune status of NSCLC patients either before and/or during the course of treatment. Here we review studies in which multiple blood-based biomarkers encompassing circulating soluble analytes, immune cell subsets, circulating tumor DNA, blood-based tumor mutational burden, and circulating tumor cells have shown promising associations with the clinical response of NSCLC patients to ICI therapy. …”
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Efficient calculation of self magnetic field, self-force, and self-inductance for electromagnetic coils with rectangular cross-section by Matt Landreman, Siena Hurwitz, Thomas M. Antonsen

“…Due to the efficiency of the model here, it is well suited for use inside design optimization.…”
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An Analytical Perspective on Determination of Free Base Nicotine in E-Liquids by Vinit V. Gholap, Rodrigo S. Heyder, Leon Kosmider, Matthew S. Halquist

“…The second is the without-dilution approach followed by 1H NMR method. Here, we carried out controlled experiments using five e-liquids of different flavors using these two approaches. …”
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New genetic tools for plant defense against parasitic nematodes by A. V. Kochetov, T. A. Gavrilenko, O. S. Afanasenko

“…Nematodes belong to economically important pests. Here we reviewed the recent data on molecular mechanisms of plant resistance to cyst and gall nematodes including the most devastating Globodera rostochiensis, G. pallida, Heterodera schachtii, Meloidogyne chitwoodi, and M. incognita. …”
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Oral Hygiene Practices among Saudi Arabian Children and Its Relation to Their Dental Caries Status by M. F. A. Quadri, M. A. Shubayr, A. H. Hattan, S. A. Wafi, A. H. Jafer

“…Dental caries is one of the most common preventable diseases occurring among children. The aim here is to survey the oral hygiene practices that are commonly followed by Arab children and to see its relationship with their dental caries status. …”
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High Throughput Approaches to Unravel the Mechanism of Action of a New Vanadium-Based Compound against Trypanosoma cruzi by M. Florencia Mosquillo, Pablo Smircich, Analía Lima, Sergio A. Gehrke, Gonzalo Scalese, Ignacio Machado, Dinorah Gambino, Beatriz Garat, Leticia Pérez-Díaz

“…In this work, we study a new prospective antitrypanosomal drug based on vanadium, here named VIVO(5Brsal)(aminophen). We found a good IC50 value, (3.76 ± 0.08) μM, on CL Brener epimastigotes. …”
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Waterflood Management Using Hybrid Approach of Streamline-Based Interwell Flux Information and Finite Volume Reservoir Simulation by Zhouyuan Zhu, Zhengdong Lei, Zhangxin Chen

“…We have introduced two basic modules here: a commercial reservoir simulator and our own streamline tracing and waterflood management program. …”
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Efficiency of a macroroughness block ramp in reducing the impact of low-head dams on riverine fish dispersion by Tomanova Sylvie, Courret Dominique, Richard Sylvain, Mercier Olivier, Guillemin Axel, Labedan Mathilde, Sagnes Pierre

“…In comparison with the efficiency results available for other types of fishways, the macroroughness ramp studied here ranks among the most efficient devices for fish movement restoration.…”
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Sorbitol induces flavonoid accumulation as a secondary signal via the nanoencapsulated SPc/lncRNA809-MmNAC17 module against Alternaria alternata in Malus micromalus by Tingting Du, Dong Meng, Hongyan Cao, Yi Lian, Rui Wu, Tengyue Liu, Tianyi Wang, Cai Qin, Zhihua Song, Biying Dong, Yujie Fu, Qing Yang

“…Nanomaterials as an emerging technology tool can efficiently deliver lncRNA to target cells. Here, we found nanoencapsulated lncRNA809 (SPc/lncRNA809) exhibits significant resistance to R1strain. …”
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Loss of SNHG4 Attenuated Spinal Nerve Ligation-Triggered Neuropathic Pain through Sponging miR-423-5p by Xia Pan, Cheng Shen, Yayi Huang, Long Wang, Zhongyuan Xia

“…However, the molecular mechanisms of SNHG4 in neuropathic pain remain barely documented. Here, we evaluated the function of SNHG4 in spinal nerve ligation (SNL) rat models. …”
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Des semis et des clones by Malou Delplancke, Yildiz Aumeeruddy-Thomas

“…Rooted in time and space, an almond tree is a link between generations, between the living and the forebears, tradition and modernity, but also between what originates from here (beldi) and what comes from elsewhere (romi). …”
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Multivariate quantitative analysis of glycan impact on IgG1 effector functions by Tamara Cvijić, Matej Horvat, Jakob Plahutnik, Ana Golob, Jaka Marušič

“…The regression models developed here provide a quantitative explanation and prediction of the impact of individual glycan features on the binding to FcγRs and bioactivity of the therapeutic protein. …”
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A New Species of the Durophagous Mosasaurid <i>Carinodens</i> from the Late Maastrichtian Phosphates of Morocco and Implications for Maastrichtian Mosasaurid Diversity by Nicholas R. Longrich, Xabier Pereda-Suberbiola, Nour-Eddine Jalil, Nathalie Bardet

“…<i>belgicus</i> previously reported from the Maastrichtian Phosphates of Morocco. Here, we report a new species of <i>Carinodens</i>, <i>C</i>. …”
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Listeria monocytogenes use multiple mechanisms to disseminate from the intestinal lamina propria to the mesenteric lymph nodes by Joshua S. Nowacki, Grant S. Jones, Sarah E. F. D'Orazio

“…Previous studies indicated that L. monocytogenes associated with both monocytes and dendritic cells in the intestinal lamina propria. We show here that CCR2−/− mice had a significant reduction in Ly6Chi monocytes in the MLN but no change in bacterial burden following foodborne infection; thus, dissemination of L. monocytogenes associated with monocytes is not required for colonization of the MLN. …”
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Mast Cells Exert Anti-Inflammatory Effects in an IL10−/− Model of Spontaneous Colitis by E. M. Lennon, L. B. Borst, L. L. Edwards, A. J. Moeser

“…Together, the results presented here demonstrate that mast cells exert anti-inflammatory properties in an established model of chronic, spontaneous IBD. …”
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Inkjet-printed electronics for rapid and low-cost prototyping of digital microfluidic devices using an off-the-shelf printer by Babak Kamali Doust Azad, Amirhossein Roozbahani, Seyed Mohammad Tabatabaei, Amirali Valinejad, Alireza Fazelian, Kimia Shahmoradi, Fatemeh Khatami, Seyed Mohammad Kazem Aghamir, Mohammadreza Kolahdouz

“…To accelerate translation to real-life applications, it is crucial to devise rapid and low-cost methods for prototyping to test various design ideas. Here, we present one such method using an unmodified desktop inkjet printer and inexpensive materials. …”
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Downregulation of an Evolutionary Young miR-1290 in an iPSC-Derived Neural Stem Cell Model of Autism Spectrum Disorder by Dalia Moore, Brittney M. Meays, Lepakshe S. V. Madduri, Farah Shahjin, Subhash Chand, Meng Niu, Abrar Albahrani, Chittibabu Guda, Gurudutt Pendyala, Howard S. Fox, Sowmya V. Yelamanchili

“…Based on our earlier published study and the observations from the data presented here, we conclude that miR-1290 regulation could play a critical role during neuronal differentiation in early brain development.…”
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Genomic characterization of noroviruses from an outbreak associated with oysters by Annika Flint, Jennifer Harlow, Madison McLeod, Madeleine Blondin-Brosseau, Kelly Weedmark, Neda Nasheri

“…In 2022, a multi-jurisdictional norovirus outbreak associated with contaminated oysters occurred that involved hundreds of illnesses. Here, we conducted genetic analysis on 30 clinical samples associated with this oyster outbreak. …”
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Digging for clues: Stick tools used for honey digging in a second community of ‘forest fragment chimpanzees’ outside the Budongo and Bugoma Forests, Uganda by Matthew R. McLennan, Georgia A. Lorenti, Simon Mugenyi, Jonan Muganzi, Jacqueline Rohen

“…Some chimpanzee populations use sticks to dig out subterranean nests of stingless bees (Meliponini) to access the underground honey stores, a tool-assisted foraging behaviour referred to here as ‘honey digging’. Honey digging has been reported mostly from sites in Central and West-Central Africa, and appears less common in East Africa. …”
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Development and validation of a nomogram to predict the probability of death after surgical evacuation for traumatic intracranial hemorrhage by Yan-Chao Zheng, Jun-Wei Qian, An-Ni Li, Yi-Nuo Yuan, Sen-Lin Ma, Mingquan Chen

“…Abstract Here we describe the derivation and validation of a prognostic nomogram for patients with Traumatic Intracranial Hemorrhage (tICH) after surgical evacuation. …”
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