α 2-Adrenoceptors: Challenges and Opportunities—Enlightenment from the Kidney by William A. Pettinger, Edwin K. Jackson

“…Now α2-ARs lurk on the horizon involving hypertension causality, renal denervation for hypertension, injury from falling in the elderly and prazosin’s mechanism of action in anxiety states such as posttraumatic stress disorder (PTSD). Our goal here is to focus on this horizon and bring into clear view the role of α2-AR-mediated mechanisms in these seemingly unrelated conditions. …”
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ECONOMIC FUTURE OF GLOBALIZATION by A. G. Oleynov

“…The author shows that the main subject of the discussion here are the changes in the understanding of international economic relations, the role of the state and non-state actors in global processes and the global governance. …”
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Quantifying the Effect of ICME Removal and Observation Age for in Situ Solar Wind Data Assimilation by Harriet Turner, Mathew Owens, Matthew Lang, Siegfried Gonzi, Pete Riley

“…This is used to provide solar wind speed hindcasts. Here, we assimilate observations from the Solar Terrestrial Relations Observatory and the near‐Earth data set, OMNI. …”
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A Y178C rhodopsin mutation causes aggregation and comparatively severe retinal degeneration by Sreelakshmi Vasudevan, Paul S.–H. Park

“…A Y178C rhodopsin mutant was investigated here to determine if this relationship applies broadly among mutations that cause misfolding and aggregation of the receptor. …”
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Mapping mitochondrial morphology and function: COX-SBFSEM reveals patterns in mitochondrial disease by Julie Faitg, Tracey Davey, Ross Laws, Conor Lawless, Helen Tuppen, Eric Fitton, Doug Turnbull, Amy E. Vincent

“…One of the main advantages of combining 3D-EM with the COX reaction is the ability to look at how per-mitochondrion oxidative phosphorylation status is spatially distributed within muscle fibres. Here we show a robust spatial pattern in COX-positive and intermediate-fibres and that the spatial pattern is less clear in COX-deficient fibres.…”
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Développement professionnel et paliers de professionnalité : le cas de la formation des professeurs stagiaires en Education Physique et Sportive by Florian Ouitre

“…This work is an attempt to understand the professional practices of the trainees who are the object of the study. Here it is a matter of going beyond the observed appearances of the practice in order to gain an insight into the reasoning of the actors displaying such practices. …”
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New Insights into the Mechanisms of Chinese Herbal Products on Diabetes: A Focus on the “Bacteria-Mucosal Immunity-Inflammation-Diabetes” Axis by Zezheng Gao, Qingwei Li, Xuemin Wu, Xuemin Zhao, Linhua Zhao, Xiaolin Tong

“…Chinese herbs have been traditionally used to treat diabetes, with minimal side and toxic effects. Here, we reviewed monomers such as berberine, ginsenoside, M. charantia extract, and curcumin and herbal formulae such as Gegen Qinlian Decoction, Danggui Liuhuang Decoction, and Huanglian Wendan Decoction. …”
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Intra-specific diversity and adaptation modify regime shifts dynamics under environmental change by Thomas Imbert, Jean-Christophe Poggiale, Mathias Gauduchon

“…However, species can adapt to changes through evolution, and it is unclear how evolution interacts with regime shifts, which restricts ecosystem management strategies. Here, we used a model of prey population with evolution and intra-specific trait diversity, and simulated regime shifts through changes in predation pressure. …”
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Two Endotracheal Tubes in One Trachea with a Traumatic Injury by Andrew Winegarner, Harish Lecamwasam, Mark C. Kendall, Shyamal Asher

“…Traumatic airway injuries often require improvising solutions to altered anatomy under strict time constraints. We describe here the use of two endotracheal tubes simultaneously in the trachea to facilitate securing an airway which has been severely compromised by a self-inflicted wound to the trachea. …”
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Multiplayer games and HIV transmission via casual encounters by Stephen Tully, Monica-Gabriela Cojocaru, Chris T. Bauch

“…We model a player's strategy as their probability of being engaged in a casual unprotected sex encounter ($ USE $), which may lead to HIV transmission; however, we do not incorporate a transmission model here. We study the sensitivity of Nash strategies with respect to varying preference rankings, and the impact of a prophylactic vaccine introduced in players of youngest age groups. …”
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Strategies to Identify Recognition Signals and Targets of SUMOylation by Elisa Da Silva-Ferrada, Fernando Lopitz-Otsoa, Valérie Lang, Manuel S. Rodríguez, Rune Matthiesen

“…The strategies and analysis presented here should contribute to the understanding of SUMO-controlled functions and provide rational approach to identify biomarkers or choose possible targets for intervention in processes where SUMOylation plays a critical role.…”
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A Novel Hypothesis for Migraine Disease Mechanism: The Creation of a New Attractor Responsible for Migraine Disease Symptoms by Elham Baradari, Farnaz Garehdaghi, Yashar Sarbaz

“…Despite the high prevalence, the pathophysiology of the disease has not been clearly understood yet. Here, the brain is considered as a dynamical system. …”
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Mechanical Coupling between Endoderm Invagination and Axis Extension in Drosophila. by Claire M Lye, Guy B Blanchard, Huw W Naylor, Leila Muresan, Jan Huisken, Richard J Adams, Bénédicte Sanson

“…How genetic programs generate cell-intrinsic forces to shape embryos is actively studied, but less so how tissue-scale physical forces impact morphogenesis. Here we address the role of the latter during axis extension, using Drosophila germband extension (GBE) as a model. …”
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Rapid life-history evolution reinforces competitive asymmetry between invasive and resident species by Chapuis, Elodie, Jarne, Philippe, David, Patrice

“…However, the actual impact of such shifts on competition are seldom studied. Here, we study competition between two freshwater snails from Guadeloupe (French Antilles), the native Aplexa marmorata and the introduced Physa acuta. …”
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Ischemic Colitis after Colonoscopy with Bisacodyl Bowel Preparation: A Report of Two Cases by Chris Shamatutu, Daljeet Chahal, Isabella T. Tai, Peter Kwan

“…Bisacodyl bowel preparations are still used in Canada. Cases. Here, we present two cases of ischemic colitis in previously healthy women aged 57 and 69 who underwent screening colonoscopy using bisacodyl bowel preparation. …”
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E. coli-Produced BMP-2 as a Chemopreventive Strategy for Colon Cancer: A Proof-of-Concept Study by Saravanan Yuvaraj, Sa’ad H. Al-Lahham, Rajesh Somasundaram, Patrick A. Figaroa, Maikel P. Peppelenbosch, Nicolaas A. Bos

“…Delivery of proteins with anticancer activity through genetically modified bacteria provides an interesting, potentially specific, economic and effective approach here. Interestingly, bone morphogenetic protein 2 (BMP-2) is an important and powerful tumour suppressor in the colon and is thus an attractive candidate protein for delivery through genetically modified bacteria. …”
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Improvement of the knock-in effciency in the genome of human induced pluripotent stem cells using the CRISPR/Cas9 system by М. М. Gridina

“…A low survival rate of hiPS cells following genome editing experiments is another difculty on the way towards successful knock-in, and here several highly effective approaches addressing it are proposed. …”
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¡No en mi patio trasero!: el caso de la comunidad ecológica de Peñalolén by Roberto Mardones Arévalo

“…The conflict analyzed here is of a territorial nature, in which authorities reach decisions regarding housing solutions that imply the occupation of lands considered by its inhabitants to be an ecological reserve. …”
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Isolation and Characterization of 89K Pathogenicity Island-Positive ST-7 Strains of Streptococcus suis Serotype 2 from Healthy Pigs, Northeast China by Shujie Wang, Peng Liu, Chunyu Li, Yafang Tan, Xuehui Cai, Dongsheng Zhou, Yongqiang Jiang

“…In China, most of the S. suis infections in humans were reported in the southern areas with warm and humid climates, but little attention had been paid to the northern areas. Data presented here showed that the virulent serotypes 1, 2, 7, and 9 of S. suis could be steadily isolated from the healthy pigs in the pig farms in all the three provinces of Northeast China. …”
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A model for simulating the active dispersal of juvenile sea turtles with a case study on western Pacific leatherback turtles. by Philippe Gaspar, Maxime Lalire

“…This model applies to all sea turtle species but is calibrated here for leatherback turtles (Dermochelys coriacea). …”
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