Strategies to Identify Recognition Signals and Targets of SUMOylation by Elisa Da Silva-Ferrada, Fernando Lopitz-Otsoa, Valérie Lang, Manuel S. Rodríguez, Rune Matthiesen

“…The strategies and analysis presented here should contribute to the understanding of SUMO-controlled functions and provide rational approach to identify biomarkers or choose possible targets for intervention in processes where SUMOylation plays a critical role.…”
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A Novel Hypothesis for Migraine Disease Mechanism: The Creation of a New Attractor Responsible for Migraine Disease Symptoms by Elham Baradari, Farnaz Garehdaghi, Yashar Sarbaz

“…Despite the high prevalence, the pathophysiology of the disease has not been clearly understood yet. Here, the brain is considered as a dynamical system. …”
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Rapid life-history evolution reinforces competitive asymmetry between invasive and resident species by Chapuis, Elodie, Jarne, Philippe, David, Patrice

“…However, the actual impact of such shifts on competition are seldom studied. Here, we study competition between two freshwater snails from Guadeloupe (French Antilles), the native Aplexa marmorata and the introduced Physa acuta. …”
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Ischemic Colitis after Colonoscopy with Bisacodyl Bowel Preparation: A Report of Two Cases by Chris Shamatutu, Daljeet Chahal, Isabella T. Tai, Peter Kwan

“…Bisacodyl bowel preparations are still used in Canada. Cases. Here, we present two cases of ischemic colitis in previously healthy women aged 57 and 69 who underwent screening colonoscopy using bisacodyl bowel preparation. …”
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E. coli-Produced BMP-2 as a Chemopreventive Strategy for Colon Cancer: A Proof-of-Concept Study by Saravanan Yuvaraj, Sa’ad H. Al-Lahham, Rajesh Somasundaram, Patrick A. Figaroa, Maikel P. Peppelenbosch, Nicolaas A. Bos

“…Delivery of proteins with anticancer activity through genetically modified bacteria provides an interesting, potentially specific, economic and effective approach here. Interestingly, bone morphogenetic protein 2 (BMP-2) is an important and powerful tumour suppressor in the colon and is thus an attractive candidate protein for delivery through genetically modified bacteria. …”
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Improvement of the knock-in effciency in the genome of human induced pluripotent stem cells using the CRISPR/Cas9 system by М. М. Gridina

“…A low survival rate of hiPS cells following genome editing experiments is another difculty on the way towards successful knock-in, and here several highly effective approaches addressing it are proposed. …”
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¡No en mi patio trasero!: el caso de la comunidad ecológica de Peñalolén by Roberto Mardones Arévalo

“…The conflict analyzed here is of a territorial nature, in which authorities reach decisions regarding housing solutions that imply the occupation of lands considered by its inhabitants to be an ecological reserve. …”
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Isolation and Characterization of 89K Pathogenicity Island-Positive ST-7 Strains of Streptococcus suis Serotype 2 from Healthy Pigs, Northeast China by Shujie Wang, Peng Liu, Chunyu Li, Yafang Tan, Xuehui Cai, Dongsheng Zhou, Yongqiang Jiang

“…In China, most of the S. suis infections in humans were reported in the southern areas with warm and humid climates, but little attention had been paid to the northern areas. Data presented here showed that the virulent serotypes 1, 2, 7, and 9 of S. suis could be steadily isolated from the healthy pigs in the pig farms in all the three provinces of Northeast China. …”
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Decoding the molecular, cellular, and functional heterogeneity of zebrafish intracardiac nervous system by Andrea Pedroni, Elanur Yilmaz, Lisa Del Vecchio, Prabesh Bhattarai, Inés Talaya Vidal, Yu-Wen E. Dai, Konstantinos Koutsogiannis, Caghan Kizil, Konstantinos Ampatzis

“…The classification and characterization of the IcNS presented here serve as a valuable resource for further exploration into the mechanisms underlying heart functionality and the pathophysiology of associated cardiac disorders.…”
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Facile colorimetric detection of As(V) in Rice with immobilized acid phosphatase on hollow metal-organic frameworks hybrid with peroxidase-like activity by Zhiyang Qin, Zhuolan Xu, Yixin Liu, Xinguang Qin, Gang Liu, Xinlin Wei, Haizhi Zhang

“…Quantitative analysis of As(V) in rice is of great significance for food safety and heavy metal pollution control. Here, a facile colorimetric method for As(V) detection was constructed by using immobilized acid phosphatase (ACP) in hollow metal-organic frameworks hybrid. …”
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Cyclodehydrogenation of molecular nanographene precursors catalyzed by atomic hydrogen by Rafal Zuzak, Pawel Dabczynski, Jesús Castro-Esteban, José Ignacio Martínez, Mads Engelund, Dolores Pérez, Diego Peña, Szymon Godlewski

“…The hydrogen-catalyzed cyclodehydrogenation reaction reported here leads towards the integration of graphene derivatives in optoelectronic devices as well as developing the field of on-surface synthesis by means of catalytic transformations. …”
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EEG-to-EEG: Scalp-to-Intracranial EEG Translation Using a Combination of Variational Autoencoder and Generative Adversarial Networks by Bahman Abdi-Sargezeh, Sepehr Shirani, Antonio Valentin, Gonzalo Alarcon, Saeid Sanei

“…The identification of IEDs is crucial in clinical practice. Here, the proposed VAE-cGAN is firstly employed to map the scEEG to iEEG. …”
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TEICHI and the Tools Paradox by Sebastian Pape, Christof Schöch, Lutz Wegner

“…To showcase the particular strengths and possible use cases of our framework, we compare our tool to other currently available systems. Here, we focus on those tools which are suitable for textual scholars new to Digital Humanities and the TEI who would like to use the powerful encoding mechanisms provided by the TEI but have relatively little technical expertise. …”
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<i>Klebsiella pneumoniae</i> Phage M198 and Its Therapeutic Potential by Lika Leshkasheli, Ia Kusradze, Darejan Bolkvadze, Lia Askilashvili, Maria Chichashvili, Giorgi Tsertsvadze, Elisabed Zaldastanishvili

“…In this work, we describe a <i>K. pneumoniae</i> phage, which also infects strains of <i>Klebsiella oxytoca</i>. Here, we characterize phage M198 in terms of its biological and genetic properties. …”
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Evaluation of biases in mid-to-high-latitude surface snowfall and cloud phase in ERA5 and CMIP6 using satellite observations by F. Hellmuth, T. Carlsen, A. S. Daloz, R. O. David, H. Che, T. Storelvmo

“…Understanding the origin(s) of the biases identified here is, therefore, crucial for improving the overall reliability of climate models.…”
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Le traitement funéraire des enfants décédés avant un an dans l’Antiquité : études de cas by Frédérique Blaizot, Gersende Alix, Emmanuel Ferber

“…In comparison to the adults, the burials of these babies exhibit the same funerary investment in the graves (architecture, abundant and diversified objects). The groups examined here do not show a very clear difference in the treatment of the children according to whether death was perinatal or post neo-natal. …”
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Biocompatible autonomous self-healing PVA-CS/TA hydrogels based on hydrogen bonding and electrostatic interaction by Xiaogang Yu, Jinxin Huang, Chengwei Wu, Wei Zhang

“…Compared with the reported self-healing hydrogels with similar biocompatibility and self-healing properties, whose tensile strength is usually less than 300 kPa, the PVA-CS/TA hydrogel prepared here shows a significant improvement in the tensile strength.…”
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Generation of barcoded plasmid libraries for massively parallel analysis of chromatin position effects by M. O. Lebedev, L. A. Yarinich, A. V. Ivankin, A. V. Pindyurin

“…Importantly, all improvements and modifications of the techniques described here can be applied to a wide range of experiments involving barcoded plasmid libraries.…”
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Partitioned Strong Coupling of Discrete Elements with Large Deformation Structural Finite Elements to Model Impact on Highly Flexible Tension Structures by Klaus Bernd Sautter, Tobias Teschemacher, Miguel Ángel Celigueta, Philipp Bucher, Kai-Uwe Bletzinger, Roland Wüchner

“…Thus, the strong coupling approach is presented here, where the convergence is achieved in an iterative manner within each time step. …”
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Development of a unique crosslinked glycosaminoglycan for soft tissue repair: Treatment of interstitial cystitis/bladder pain syndrome. by Richard W Heidebrecht, Thomas H Jozefiak, Harrison C Shain, Eugene M Skrabut, Debra Saunders, Nataliya Smith, Rheal A Towner, Robert Hurst

“…The synthesis presented here allows for control of molecular weight while avoiding formation of an extended block gel. …”
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