Estrogen-dependent activation of TRX2 reverses oxidative stress and metabolic dysfunction associated with steatotic disease by Alfredo Smiriglia, Nicla Lorito, Marina Bacci, Angela Subbiani, Francesca Bonechi, Giuseppina Comito, Marta Anna Kowalik, Andrea Perra, Andrea Morandi

“…Abstract Metabolic dysfunction-associated steatotic liver disease (MASLD) encompasses a spectrum of hepatic disorders, ranging from simple steatosis to steatohepatitis, with the most severe outcomes including cirrhosis, liver failure, and hepatocellular carcinoma. Notably, MASLD prevalence is lower in premenopausal women than in men, suggesting a potential protective role of estrogens in mitigating disease onset and progression. …”
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Cutaneous Metastases from Primary Hepatobiliary Tumors as the First Sign of Tumor Recurrence following Liver Transplantation by Adam T. Hauch, Joseph F. Buell, Margit McGowan, Parisha Bhatia, Eleanor Lewin, Mary Killackey, Nathan J. Shores, Luis A. Balart, Martin Moehlen, Bob Saggi, Anil S. Paramesh

“…We report our experience with two cases of cutaneous metastases from both hepatocellular carcinoma and mixed hepatocellular/cholangiocarcinoma following liver transplantation, along with a review of the literature.…”
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Nutrition Therapy for Liver Diseases Based on the Status of Nutritional Intake by Kenichiro Yasutake, Motoyuki Kohjima, Manabu Nakashima, Kazuhiro Kotoh, Makoto Nakamuta, Munechika Enjoji

“…As a substitutive treatment, low-iron diet therapy, which is relatively safe and effective for preventing hepatocellular carcinoma, is also recommended for CHC patients. …”
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Global perspectives and hotspots of VEGF signaling pathway in liver disease from 2008 to 2023: A bibliometric analysis and visualization by Yi He, Jiaxin Huang, Xiaofan Liang, Chang Shao, Xiguang Sun, Junjie Zhang

“…Keywords and research hotspots analysis indicated that researchers are very concerned about the application and clinical research status of anti-angiogenic drugs in hepatocellular carcinoma (HCC). Continuing to deepen the research on the use of anti-angiogenic drugs alone and in combination is necessary. …”
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Role of HNF6 in liver homeostasis and pathophysiology by Miaomiao Tian, Weizhen Gao, Shujun Ma, Huiling Cao, Yu Zhang, Fuxiang An, Jianni Qi, Zhen Yang

“…Additionally, HNF6 controls the migration and adhesion of hepatocellular carcinoma cells and plays a significant role in liver metabolism. …”
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OSAS-Related Inflammatory Mechanisms of Liver Injury in Nonalcoholic Fatty Liver Disease by Elena Paschetta, Paola Belci, Anna Alisi, Daniela Liccardo, Renato Cutrera, Giovanni Musso, Valerio Nobili

“…Several studies suggest that the chronic intermittent hypoxia (CIH) of OSAS patients may per se trigger liver injury, inflammation, and fibrogenesis, promoting NAFLD development and the progression from steatosis to steatohepatitis, cirrhosis, and hepatocellular carcinoma. In NAFLD patients, liver disease may be caused by hypoxia both indirectly by promoting inflammation and insulin resistance and directly by enhancing proinflammatory cytokine production and metabolic dysregulation in liver cells. …”
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A Rare Tumor in a Patient with Hepatic Hydatic Cyst: Adrenal Hepatoid Adenocarcinoma by Fatma Umit Malya, Suleyman Bozkurt, Mustafa Hasbahceci, Gokhan Cipe, Issam Cheikh Ahmad, Zuhal Gucin, Oguzhan Karatepe, Mahmut Muslumanoglu

“…Hepatoid adenocarcinoma (HAC) is a very rare type of extrahepatic adenocarcinoma which has a clinicopathologic and morphologic similarity to hepatocellular carcinoma (HCC). Although it is not common, it can be seen in organs other than the liver. …”
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SiameseNet based on multiple instance learning for accurate identification of the histological grade of ICC tumors by Zhizhan Fu, Fazhi Feng, Xingguang He, Tongtong Li, Xiansong Li, Jituome Ziluo, Zixing Huang, Jinlin Ye

“…BackgroundAfter hepatocellular carcinoma (HCC), intrahepatic cholangiocarcinoma (ICC) is the second most common primary liver cancer. …”
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Abernethy Malformation in Combination with Gilbert’s Syndrome by N. B. Gubergrits, E. L. Bondar, E. A. Dyadyk, E. V. Berezhnaya, Yu. E. Chirkov, N. V. Byelyayeva, G. M. Lukashevich, T. L. Mozhyna

“…Diagnosis of Abernethy malformation is important for choosing the right treatment for the timely correction of complications of the disease and early detection of adenoma or hepatocellular carcinoma.…”
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Hepatitis Delta Infections in Toronto, Ontario by S. Victor Feinman, Barnet Berris, John L. Gerin, Robert H. Purcell

“…It was not present in the three patients with hepatocellular carcinoma. The clinical course of the two patients with acute hepatitis and delta markers was similar to patients with hepatitis B alone and both made a complete recovery. …”
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Association between Nonalcoholic Fatty Liver Disease and Endocrinopathies: Clinical Implications by Ana-Maria Singeap, Carol Stanciu, Laura Huiban, Cristina Maria Muzica, Tudor Cuciureanu, Irina Girleanu, Stefan Chiriac, Sebastian Zenovia, Robert Nastasa, Catalin Sfarti, Camelia Cojocariu, Anca Trifan

“…Its potential for evolution towards liver cirrhosis and hepatocellular carcinoma, as well as associations with extrahepatic manifestations, represents a double burden for patients and physicians alike. …”
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Genome-Wide Expression of MicroRNAs Is Regulated by DNA Methylation in Hepatocarcinogenesis by Jing Shen, Shuang Wang, Abby B. Siegel, Helen Remotti, Qiao Wang, Iryna Sirosh, Regina M. Santella

“…Previous studies, including ours, have examined the regulation of microRNAs (miRNAs) by DNA methylation, but whether this regulation occurs at a genome-wide level in hepatocellular carcinoma (HCC) is unclear. Subjects/Methods. …”
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Morphologic Features of Extrahepatic Manifestations of Hepatitis C Virus Infection by Huaibin M. Ko, Juan C. Hernandez-Prera, Hongfa Zhu, Steven H. Dikman, Harleen K. Sidhu, Stephen C. Ward, Swan N. Thung

“…Cirrhosis and hepatocellular carcinoma are the prototypic complications of chronic hepatitis C virus infection in the liver. …”
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伴门静脉癌栓的肝癌手术预后相关基因的筛选

“…【目的】 全基因芯片技术筛选伴肉眼门静脉癌栓(PVTT)肝细胞癌患者的基因谱,并进一步分析筛选出的基因的临床预测价值【方法】 40例伴有PVTT的肝癌根据术后中位生存期分为2组:长生存期组与短生存期组,采用全基因芯片技术和交叉检验重复抽样方法筛选出具有表达差异的基因谱,并进一步采用免疫组织化学方法验证筛选出的基因的临床意义【结果】本研究共筛选出的10个表达差异显著的基因,包括AKR1C1TARDBPEIF4EMFN1SNRNP25LOC55908ARPP19RORCPEX11B和EGFR2,对伴有PVTT的肝癌术后长生存期患者的预测准确性达95%,特异性100%,假阳性率0其中肝癌相关基因TD26 (Hepatocellular carcinoma associated-gene TD26) 在长生存期组中表达明显上调 (P < 0.001),免疫组化染色验证TD26蛋白在长生存期组病例中表达显著高于短生存期组(P = 0.016)【结论】 本研究筛选出的10个基因有可能作为伴有PVTT的肝细胞癌患者手术预后的预测指标;TD26在伴PVTT的肝癌术后长期生存患者中表达增高…”
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Synthesis and Biological Evaluation of New (−)-Gossypol-Derived Schiff Bases and Hydrazones by Vu Van Vu, Trinh Thi Nhung, Nguyen Thi Thanh, Luu Van Chinh, Vu Dinh Tien, Vu Thu Thuy, Do Thi Thao, Nguyen Hai Nam, Angela Koeckritz, Tran Khac Vu

“…Compound 8a showed the greatest cytotoxic effect against hepatocellular carcinoma (HepG2), lung carcinoma (LU-1), and breast cancer (MCF-7) cell lines with IC50 values of 20.93, 13.58, and 9.40 μM, respectively. …”
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Potential of albumin dialysis at terminal liver failure in patients with chronic liver diseases by O. E. Nikiforova, Ye. N. Bessonova, O. M. Lesnyak, O. A. Stroganova

“…In relation to etiology of disease all patients were divided into three groups: 1) cirrhoses of the nontoxic etiology as an outcome of viral hepatitis, primary biliary cirrhosis, primary sclerosing cholangitis; 2) cirrhosis of toxic (alcohol-induced) etiology and 3) focal liver lesions – hepatocellular carcinoma (HCC).Results. Among patients, receiving treatment with albumin dialysis the stage of hepatic encephalopathy at patients in the subgroup with cirrhosis of toxic (alcohol-induced) etiology significantly decreased (р&lt;0,01). …”
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Constitutive Androstane Receptor-Mediated Inhibition of Metformin on Phase II Metabolic Enzyme SULT2A1 by Xiaowen Hu, Mengsiyu Li, Chunxue Zhang, Shuguang Pang

“…Methods. The hepatocellular carcinoma cell line, HepaRG, was cultured with different concentrations of metformin. …”
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Nonalcoholic Fatty Liver Disease-Related Chronic Kidney Disease by Camelia Cojocariu, Ana-Maria Singeap, Irina Girleanu, Stefan Chiriac, Cristina M. Muzica, Catalin Victor Sfarti, Tudor Cuciureanu, Laura Huiban, Carol Stanciu, Anca Trifan

“…The proportion of patients with liver cirrhosis and those with hepatocellular carcinoma due to nonalcoholic liver disease on the liver transplant waiting list has increased in the last years. …”
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Kupffer Cells Promote the Differentiation of Adult Liver Hematopoietic Stem and Progenitor Cells into Lymphocytes via ICAM-1 and LFA-1 Interaction by Deping Meng, Yuhong Qin, Nan Lu, Keke Fang, Yuan Hu, Zhigang Tian, Cai Zhang

“…These findings provide important insight into understanding liver extramedullary hematopoiesis and its significance, particularly under the state of some liver diseases, such as hepatitis, nonalcoholic fatty liver disease (NAFLD), and hepatocellular carcinoma (HCC).…”
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Hepatitis C pada Anak by Yusri Dianne Jurnalis, Yorva Sayoeti, Adria Russelly

“…Acute HCV infection may end up with cirrhosis and hepatocellular carcinoma after the third decade (around 20%), due to a slower progression of HCV infection of hepatitis B virus infection. …”
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