Serological and Molecular Characterization of the Hepatitis B Virus in Blood Donors in Maputo City, Mozambique by Olga Maquessene, Osvaldo Laurindo, Lúcia Chambal, Nalia Ismael, Nédio Mabunda

“…Hepatitis B virus (HBV) is a major public health concern responsible for hepatitis and hepatocellular carcinoma (HCC) worldwide. In Mozambique, HBsAg prevalence is high and endemic, and despite the strategies to mitigate the spread of the disease, the HCC incidence is still high and one of the highest in the world. …”
Get full text

Synthesis of Some Polysubstituted Nicotinonitriles and Derived Pyrido[2,3-d]pyrimidines as In Vitro Cytotoxic and Antimicrobial Candidates by Hassan M. Faidallah, Sherif A. F. Rostom, Khalid A. Khan

“…They were evaluated for their in vitro cytotoxic effects against three different human tumor cell lines (human colon carcinoma HT29, hepatocellular carcinoma Hep-G2, and Caucasian breast adenocarcinoma MCF7). …”
Get full text

Relaparotomy Two Years after Incisional Hernia Repair Using a Free Fascia Lata Graft by Yuuki Sekine, Hiroyuki Sugo, Naoki Iwanaga, Shigefumi Neshime, Ikuo Watanobe

“…A 79-year-old man underwent open hepatectomy for hepatocellular carcinoma. One year later, abdominal computed tomography revealed a locally recurrent tumor 1.5 cm in diameter and a giant incisional hernia measuring approximately 15×6 cm on the supraumbilical midline. …”
Get full text

Analytical and Clinical Evaluation of a Chemiluminescent Immunoassay to Detect Serum Chitinase-3-like Protein 1 in HBV-Related Liver Diseases by Yanqiang Liao, Se Peng, Lesheng Huang, Zhong Li, Jian Hu, Rui Xu, Wenzhi Tang, Jialing Zhuang

“…Serum chitinase-3-like protein 1 (CHI3L1) is a diagnostic marker for liver diseases, such as hepatocellular carcinoma (HCC). Herein, we aimed to evaluate the analytical performance of a chemiluminescent immunoassay (CLIA) for the quantitative detection of CHI3L1 and its application in hepatitis B virus (HBV)-related liver diseases. …”
Get full text

Prognostic impact of primary versus secondary resistance to sorafenib in patients with HCC by Jin Lei, Hongyuan Dai, Ya Zhang, Guangling Ou, Zhi Peng Liang, Yinying Lu, Haiyang Li

“…Background: Sorafenib is a first-line treatment option for patients with hepatocellular carcinoma (HCC). However, the impact of sorafenib resistance type on patient survival prediction and choice of second-line treatment regimen is unknown. …”
Get full text

Nuclear Imaging to Detect Diaphragmatic Perforation as a Rare Complication of Microwave Ablation by Stephanie Cull, Gebran Khneizer, Abhishek Krishna, Razi Muzaffar, Sameer Gadani, Zafar Jamkhana

“…Acquired diaphragmatic perforation leading to massive hepatic hydrothorax and respiratory failure is a rare complication of microwave ablation (MWA) of hepatocellular carcinoma (HCC). Imaging modalities to detect pleuroperitoneal communication remain poorly described. …”
Get full text

The Interaction of lncRNA-HEIH and lncRNA-HULC with HBXIP in Hepatitis B Patients by Lingjuan Ruan, Lifei Huang, Lilai Zhao, Qiang Wang, Xiaocheng Pan, Anmin Zhang, Qiuping Bai, Zongjun Lv

“…Hepatitis B virus (HBV) infection is a major risk factor for the development of hepatic cirrhosis (HC) and hepatocellular carcinoma (HCC), which are associated with very high morbidity and mortality rates worldwide. …”
Get full text

Chronic hepatitis C course at elderly and therapeutic approach by M. V. Mayevskaya, M. A. Morozova

“…In series of studies it was demonstrated, that elderly age is independent risk factor of development of both LC, and hepatocellular carcinoma. Expediency of prescription of antiviral therapy to elderly patients should be solved individually, taking into account patient’s activity and quality of life. …”
Get full text

Multiple FNH-Like Lesions in a Patient with Chronic Budd-Chiari Syndrome: Gd-EOB-Enhanced MRI and BR1 CEUS Findings by Caroline Newerla, Fabienne Schaeffer, Luigi Terracciano, Joachim Hohmann

“…Differentiation between regenerative nodules like LRN and hepatocellular carcinoma (HCC) in cirrhotic livers is crucial, and the target sign in the hepatobiliary phase of Gd-EOB-DTPA as well as the centrifugal arterial enhancement followed by an isoenhancement during a CEUS might be useful for establishing the correct diagnosis of such hypervascular lesions with proliferated and likely aberrant bile ducts.…”
Get full text

Role of High-Density Lipoprotein Cholesterol (HDL-C) as a Clinical Predictor of Decompensation in Patients with Chronic Liver Disease (CLD) by Harshavardhan Rao B, Priya Nair, Anoop K. Koshy, S. Krishnapriya, C. R. Greeshma, Rama P. Venu

“…Patients with cholestatic liver disease and hepatocellular carcinoma were excluded. Fasting lipids were measured in all patients at the time of recruitment. …”
Get full text

Hereditary Tyrosinemia Type 1 in Jordan: A Retrospective Study by Noor A. Megdadi, Ahmad K. Almigdad, Mo’men O. Alakil, Shahrazad M. Alqiam, Sumaia G. Rababah, Moshera A. Dwiari

“…The untreated disease progresses into life-threatening liver failure with an increased risk of hepatocellular carcinoma. Methods. From April 2010 to March 2021, eighteen patients were diagnosed with HT1 in the metabolic department at Queen Rania Al Abdullah Hospital for Children in Jordan. …”
Get full text

Metabolic and Genetic Determinants of Lipid Metabolism Disruption in Non-Alcoholic Fatty Liver Disease by O. Yu. Kytikova, T. P. Novgorodtseva, Yu. K. Denisenko, D. A. Kovalevsky

“…NAFLD is a widespread disease progressing from steatosis to non-alcoholic steatohepatitis (NASH), increasing the risk of cirrhosis, liver failure and hepatocellular carcinoma. Progression of NAFLD and the development of NASH are closely related to lipid metabolism disorders caused not only by insufficient alimentary intake of fatty acids, but also by a decrease in the efficiency of their endogenous processing. …”
Get full text

Functionalization of selenium nanoparticles with olive polyphenols – impact on toxicity and antioxidative activity by Galić Emerik, Radić Kristina, Golub Nikolina, Mlinar Jakov, Čepo Dubravka Vitali, Vinković Tomislav

“…SeNPs showed lower toxicity on human hepatocellular carcinoma (HepG2) and human colorectal adenocarcinoma (Caco2) cells compared to selenite. …”
Get full text

Increased diagnosis of hepato-biliary-pancreatic cancer after cholecystectomy: a population-based study by Young Ae Kim, Hak Jun Kim, Mee Joo Kang, Sung-Sik Han, Hyeong Min Park, Sang-Jae Park

“…Specifically, the risk of diagnosis of extrahepatic bile duct cancer (IRR 1.92), intrahepatic bile duct cancer (1.78), hepatocellular carcinoma (1.22), and pancreatic cancer (1.13) was significantly increased in the cholecystectomy group. …”
Get full text

Toxicity Associated with Pembrolizumab Monotherapy in Patients with Gastrointestinal Cancers: A Systematic Review of Clinical Trials by Nikolas Naleid, Amit Mahipal, Sakti Chakrabarti

“…Tumor types encompassed were colorectal (12%), esophagogastric (46%), hepatocellular carcinoma (24%), and other GI tumor types (18%). …”
Get full text

Progesterone Increases Apoptosis and Inversely Decreases Autophagy in Human Hepatoma HA22T/VGH Cells Treated with Epirubicin by Wen-Tsan Chang, Hsiao-Ling Cheng, Bau-Shan Hsieh, Chien-Chih Chiu, King-Teh Lee, Kee-Lung Chang

“…Hepatocellular carcinoma (HCC) is the leading cause of cancer-related deaths worldwide. …”
Get full text

Dietary Interventions and Physical Activity as Crucial Factors in the Prevention and Treatment of Metabolic Dysfunction-Associated Steatotic Liver Disease by Paweł Rajewski, Jakub Cieściński, Piotr Rajewski, Szymon Suwała, Alicja Rajewska, Maciej Potasz

“…MASLD is one of the leading causes of hepatocellular carcinoma, cirrhosis, and liver transplantation, as well as a significant risk factor for cardiovascular disease and mortality. …”
Get full text

What Are the Precursor and Early Lesions of Peripheral Intrahepatic Cholangiocarcinoma? by Yasuni Nakanuma, Akemi Tsutsui, Xiang Shan Ren, Kenichi Harada, Yasunori Sato, Motoko Sasaki

“…Herein, we surveyed these candidate precursor lesions in the background liver of 37 cases of peripheral ICC and controls (perihilar CC, 34 cases; hepatocellular carcinoma, 34 cases and combined hepatocellular cholangiocarcinoma, 25 cases). …”
Get full text

Inferior Right Hepatic Vein: A Useful Anatomic Variation for Isolated Resection of Segment VIII by Klaus Steinbrück, Reinaldo Fernandes, Giuliano Bento, Rafael Vasconcelos, Gustavo Stoduto, Thomas Auel, Lúcio F. Pacheco-Moreira

“…Herein we describe a case of a cirrhotic patient that was submitted to segmentectomy VIII in bloc with the main trunk of the RHV, due to hepatocellular carcinoma. The resection could only be performed because a well developed inferior right hepatic vein (IRHV) was present. …”
Get full text

Association of dietary intake with cancer of the digestive system: a cross-sectional study by Xinxin Qin, Litao Ge, Song Wu, Wei Li

“…Categorical variables were described as percentages, and p-values were calculated using weighted chi-square tests.ResultsWe found that protein, vitamin B1, calcium, and iron intake were positively associated with colorectal cancer; vitamin B2 and phosphorus intake were negatively related to colorectal cancer; dietary folate and vitamin B12 intake were negatively associated with gastric cancer; vitamin D and copper intake were positively associated with gastric cancer; vitamin E intake was negatively related to the development of hepatocellular carcinoma; and lycopene, vitamin B2, calcium, iron, and zinc intake was positively associated with the development of liver cancer. …”
Get full text