Two Patients with Extremely Elevated Tumor Markers: Where Is the Malignancy? by Patrick P. J. van der Veek, Wouter H. de Vos tot Nederveen Cappel, Alexandra M. J. Langers, Bart van Hoek

“…Extensive imaging showed no signs of hepatocellular carcinoma or other cancer, and treatment with Prednisone led to rapid normalization of both liver enzymes and aFP. …”
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A Case of Hepatic Malignant Solitary Fibrous Tumor: A Case Report and Review of the Literature by Zhiyan Fu, Evita B. Henderson-Jackson, Barbara A. Centeno, Gregory Y. Lauwers, Mihaela Druta, Daniel A. Anaya, Yukihiro Nakanishi

“…Contrast-enhanced CT abdomen showed a large left hepatic lobe mass with early enhancement and delayed venous washout, concerning for hepatocellular carcinoma. Fine needle aspiration showed numerous spindle cells with malignant nuclear features, suggestive of malignant spindle cell neoplasm. …”
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Co-infection with hepatitis B and human immunodeficiency virus: epidemiology, pathogenesis, and treatment by Yaozu He, Weiyin Lin, Fei Gu, Xianglong Lan, Linghua Li, Haijuan Wang

“…HIV affects the development of chronic HBV infection, leading to higher HBV DNA levels, cirrhosis, and end-stage liver duisease, and potentially leading to hepatocellular carcinoma. One of the leading causes of mortality and morbidity in HIV-infected individualsis liver disease, despite the administration of antiretroviral therapy for HIV and HBV. …”
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Induction of MASH in three-dimensional bioprinted human liver tissue. by Vaidehi Joshi, Dwayne Carter, Alice E Chen, Keith Murphy, J William Higgins, Mediha Gurel, Daisy Chilin Fuentes, Sara Brin Rosenthal, Kathleen M Fisch, Tatiana Kisseleva, David A Brenner

“…Metabolic dysfunction-associated steatohepatitis (MASH), formerly known as nonalcoholic steatohepatitis (MASH), is a major risk factor for cirrhosis and hepatocellular carcinoma (HCC) and a leading cause of liver transplantation. …”
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Navigating the complex role of senescence in liver disease by Qiuting Li, Lin Wang, Yuanyuan Ji

“…Under physiological conditions, senescence aids organ repair and regeneration, but its accumulation due to aging or pathological stress significantly contributes to chronic liver diseases, including alcoholic liver disease, metabolic dysfunction-associated steatohepatitis, liver fibrosis, and hepatocellular carcinoma. Senescence is identified by a range of cellular and molecular changes, such as morphological alterations, expression of cell cycle inhibitors, senescence-associated β-galactosidase activity, and nuclear membrane changes. …”
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Associations between Extracellular Matrix Protein 1 Gene Polymorphism and Progression of Liver Disease by Xiuting He, Ting Liu, Rui Zhang, Xu Li

“…Of the disease group, 104 cases had chronic hepatitis B (CHB), 266 had LC, and 286 had hepatocellular carcinoma (HCC). Subjects were frequency-matched according to age and gender. …”
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Microwave ablation vs. single-needle radiofrequency ablation for the treatment of HCC up to 4 cm: A randomized-controlled trial by Katsutoshi Sugimoto, Kento Imajo, Hidekatsu Kuroda, Go Murohisa, Kazue Shiozawa, Kentaro Sakamaki, Takuya Wada, Hirohito Takeuchi, Kei Endo, Tamami Abe, Takashi Matsui, Takahiro Murakami, Masato Yoneda, Atsushi Nakajima, Shigehiro Kokubu, Takao Itoi

“…Background &amp; Aims: Radiofrequency ablation (RFA) is the standard treatment for small hepatocellular carcinoma (HCC), specifically for tumors <3 cm in size and numbering fewer than three, excluding surgical candidates. …”
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Secretion of One Adipokine Nampt/Visfatin Suppresses the Inflammatory Stress-Induced NF-κB Activity and Affects Nampt-Dependent Cell Viability in Huh-7 Cells by Yi-Ching Lin, Hui-Chung Wu, Chen-Chung Liao, Yi-Chih Chou, Shwu-Fen Pan, Chi-Ming Chiu

“…However, its function in chronic inflammation and carcinogenesis in hepatocellular carcinoma (HCC) has not been well-defined. Here we use Huh-7 hepatoma cells as a model to determine how Nampt/visfatin affects cellular survival under oxidative stress. …”
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Dual-Modality Monitoring of Tumor Response to Cyclophosphamide Therapy in Mice with Bioluminescence Imaging and Small-Animal Positron Emission Tomography by Xibo Ma, Zhaofei Liu, Xin Yang, Qiujuan Gao, Shouping Zhu, Chenghu Qin, Kai Liu, Bo Zhang, Dong Han, Fan Wang, Jie Tian

“…Firefly luciferase (fLuc) transfected HCC-LM3-fLuc human hepatocellular carcinoma cells were injected subcutaneously into BALB/c nude mice to establish the experimental tumor model. …”
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Nitrile-aminothiol bioorthogonal near-infrared fluorogenic probes for ultrasensitive in vivo imaging by Weiping Xu, Shujuan Yi, Jie Liu, Yuyan Jiang, Jiaguo Huang

“…Herein we report a nitrile-aminothiol (NAT) bioorthogonal fluorogenic probe (CyNA P -SS-FK) for ultrasensitive diagnosis of orthotopic hepatocellular carcinoma. This probe comprises a nitrile-substituted hemicyanine scaffold with a cysteine tail dually locked with biomarker-responsive moieties. …”
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Design, Synthesis, and Biological Evaluation of Triazolyl- and Triazinyl-Quinazolinediones as Potential Antitumor Agents by Abeer N. Al-Romaizan, Nesreen S. Ahmed, Sherin M. Elfeky

“…The antitumor activity of the synthesized compounds was evaluated against two human cell lines: human colon carcinoma HCT116 and human hepatocellular carcinoma HEP-G2. Some of the tested compounds showed significant potency compared to the reference drug staurosporin.…”
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Retrospective evaluation of a novel ultrasound-based imaging analysis software for predicting radiofrequency ablation areas. by Masaya Sato, Ryosuke Tateishi, Yogev Zohar, Jiro Sato, Takeyuki Watadani, Makoto Moriyama, Taijiro Wake, Ryo Nakagomi, Mizuki Nishibatake Kinoshita, Takuma Nakatsuka, Tatsuya Minami, Koji Uchino, Kenichiro Enooku, Hayato Nakagawa, Yoshinari Asaoka, Ryo Yamada, Nitzan Even, Inbal Amitai, Yossi Abu, Mitsuhiro Fujishiro, Kazuhiko Koike

“…<h4>Objective</h4>This study aimed to introduce and evaluate a novel software-based system, BioTrace, designed for real-time monitoring of thermal ablation tissue damage during image-guided radiofrequency ablation for hepatocellular carcinoma (HCC).<h4>Methods</h4>BioTrace utilizes a proprietary algorithm to analyze the temporo-spatial behavior of thermal gas bubble activity during ablation, as seen in conventional B-mode ultrasound imaging. …”
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The dynamics of a delay model of hepatitis B virus infection with logistic hepatocyte growth by Steffen Eikenberry, Sarah Hews, John D. Nagy, Yang Kuang

“…Chronic HBV affects 350 million people and can lead to death through cirrhosis-inducedliver failure or hepatocellular carcinoma. We analyze the dynamics of a model consideringlogistic hepatocyte growth and a standard incidence function governing viral infection.This model also considers an explicit time delay in virus production. …”
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Modulatory effects of rutin on the expression of cytochrome P450s and antioxidant enzymes in human hepatoma cells by Karakurt Sedar

“…The flavonoid rutin was investigated for its anti-carcinogen and protective effects as well as modulatory action on CYPs and phase II enzymes in human hepatocellular carcinoma cells. Rutin inhibited proliferation of HEPG2 cells in a dose-dependent manner with the IC50 value of 52.7 μmol L-1 and invasion of HEPG2 cells (21.6 %, p = 0.0018) and colony formation of those invaded cells (57.4 %, p < 0.0001). …”
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Unfavorable Tumor Responses to Immunotherapy in the Liver: Lessons Learned from Clinical and Preclinical Studies by Li-Chun Lu, Gen-Sheng Feng, Chih-Hung Hsu

“…Results: In patients with advanced hepatocellular carcinoma or esophageal cancer, non-small cell lung cancer, or melanoma with liver metastases, the efficacy of ICI-based therapy was generally lower in the liver than in other organs. …”
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The MAPK MEK1/2-ERK1/2 Pathway and Its Implication in Hepatocyte Cell Cycle Control by Jean-Philippe Guégan, Christophe Frémin, Georges Baffet

“…Moreover, its disregulation has been associated with the promotion of tumor cell growth of a variety of tumors, including hepatocellular carcinoma. Whereas the strict specificity of action of ERK1 and ERK2 is still debated, the MAPKs may have specific biological functions under certain contexts and according to the differentiation status of the cells, notably hepatocytes. …”
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Effect of Intervention of Vaccination and Treatment on the Transmission Dynamics of HBV Disease: A Mathematical Model Analysis by Firaol Asfaw Wodajo, Temesgen Tibebu Mekonnen

“…Since people do not give attention, it will develop into cirrhosis and hepatocellular carcinoma that leads to liver transplantation and death. …”
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Exploring the association between air pollution and the incidence of liver cancers by Xin Wu, Xin Zhang, Xiaopeng Yu, Hongyuan Liang, Shaoshan Tang, Yao Wang

“…Liver cancer, namely hepatocellular carcinoma (HCC), is a major global health concern deeply influenced by environmental factors. …”
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Virological Mechanisms in the Coinfection between HIV and HCV by Maria Carla Liberto, Emilia Zicca, Grazia Pavia, Angela Quirino, Nadia Marascio, Carlo Torti, Alfredo Focà

“…Several studies demonstrated that HIV worsens the course of HCV infection, increasing the risk of cirrhosis and hepatocellular carcinoma. Also, HCV might increase immunological defects due to HIV and risk of comorbidities. …”
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Cost-effectiveness of Triple Therapy with Telaprevir for Chronic Hepatitis C Virus Patients in Germany by Jona T. Stahmeyer, Svenja Schauer, Siegbert Rossol, Hans Heinrich Wedemeyer, Daniel Wirth, Florence Bianic, Christian Krauth

“…Long-term consequences are the development of liver cirrhosis and hepatocellular carcinoma. The introduction of first generation protease inhibitors has significantly improved the treatment of hepatitis C genotype 1 patients. …”
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