Hepatocellular Carcinoma: Consensus, Controversies and Future Directions: A Report from the Canadian Association for the Study of the Liver Hepatocellular Carcinoma Meeting by Kelly Warren Burak, Morris Sherman

“…Hepatocellular carcinoma (HCC) is a leading cause of cancer-related mortality worldwide and its incidence has rapidly increased in North America in recent years. …”
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Lone Hepatocellular Carcinoma: An Isolated Chest Wall Malignancy by Joseph Allencherril, Sebastian Bruera, Ronan Allencherril, Richard J. Hamill

“…Further characterization through computed tomography (CT) of the chest revealed a soft tissue mass in the left anterior lower hemithorax found to be hepatocellular carcinoma (HCC). The liver, spleen, and pancreas were unremarkable. …”
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Radiofrequency Ablation of Hepatocellular Carcinoma: A Literature Review by Yasunori Minami, Masatoshi Kudo

“…Here, we give an overview of the current status of radiofrequency ablation (RFA) for hepatocellular carcinoma (HCC), including its physical properties, to assess the characteristics that make this technique applicable in clinical practice. …”
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Intractable Fasting Hypoglycemia as a Manifestation of Hepatocellular Carcinoma by Justin J. Forde, Ofor Ewelukwa, Tony Brar, Roniel Cabrera

“…We present a case of NICTH in a 54-year-old male with hepatocellular carcinoma (HCC) who presented with symptomatic intractable hypoglycemia (IH) after bowel preparation and fasting for screening upper endoscopy and colonoscopy.…”
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An Overview of In Vitro Models of Alcohol‐Related Hepatocellular Carcinoma by Anoïsia Courtois, Sophie Gérard, Damien Esparteiro, Eric Nguyen‐Khac, Ingrid Marcq, Grégory Fouquet

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Iron metabolism in a mouse model of hepatocellular carcinoma by Dilay Yilmaz, Umesh Tharehalli, Rossana Paganoni, Paul Knoop, Andreas Gruber, Yuexin Chen, Rui Dong, Frank Leithäuser, Thomas Seufferlein, Kerstin Leopold, André Lechel, Maja Vujić Spasić

“…Abstract Hepatocellular carcinoma (HCC) remains the most prevalent type of primary liver cancer worldwide. p53 is one of the most frequently mutated tumor-suppressor genes in HCC and its deficiency in hepatocytes triggers tumor formation in mice. …”
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Probing the Hepatic Progenitor Cell in Human Hepatocellular Carcinoma by Shu-Qin Jia, Jian-Jun Ren, Pei-De Dong, Xing-Kai Meng

“…By exposure of different injuries and different hepatocarcinogenic regimens, the mature hepatocytes can no longer effectively regenerate; stem cells are involved in the pathogenesis of hepatocellular carcinoma. Methods. Immunohistochemistry was performed on 107 paraffin-embedded hepatocellular carcinoma specimens with the marker of hepatocyte and hepatocellular carcinoma (HepPar1), biliary differentiation (CK7,CK19), haemopoietic stem cell (HSC) (c-kit/CD117, CD34, and Thy-1/CD90), HPC specific markers (OV-6), and Ki-67, p53 protein. …”
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The role of inflammasomes in hepatocellular carcinoma: Mechanisms and therapeutic insights by Valentina Arrè, Roberto Negro, Gianluigi Giannelli

Subjects: “…Hepatocellular carcinoma…”
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Immunity revealed: Stratifying hepatocellular carcinoma for precision immunotherapy by Konstantinos Arvanitakis, Georgios Germanidis

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Intratumor Mycoplasma promotes the initiation and progression of hepatocellular carcinoma by Kailiang Qiao, Jingxia Han, Haohao Zhang, Yinan Li, Xiaohui Hou, Yan Jia, Yujie Sun, Huan Wang, Zheng Xu, Haoyang Liu, Heng Zhang, Huijuan Liu, Wei Zhang, Tao Sun

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Prognostic impact of presenting symptoms of patients with hepatocellular carcinoma by Samuel Jun Ming Lim, Ying Hao, George Boon Bee Goh, Jason Pik Eu Chang, Chee Kiat Tan

“…Introduction: It is not known if the nature, number and duration of presenting symptoms at diagnosis of hepatocellular carcinoma impact on overall survival. This study examines whether the presenting symptoms of hepatocellular carcinoma have a significant impact on prognosis. …”
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Association of intratumoral microbiome diversity with hepatocellular carcinoma prognosis by Fengle Jiang, Yuan Dang, Zheting Zhang, Yanan Yan, Yingchao Wang, Yi Chen, Lihong Chen, Jialiang Zhang, Jingfeng Liu, Jianmin Wang

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Immunotherapy for Hepatocellular Carcinoma: Current Advances and Future Expectations by Yingjun Xie, Yien Xiang, Jiyao Sheng, Dan Zhang, Xiaoxiao Yao, Yongsheng Yang, Xuewen Zhang

“…Primary liver cancer is a common kind of digestive cancers with high malignancy, causing 745,500 deaths each year. Hepatocellular carcinoma is the major pathological type of primary liver cancer. …”
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The Value of Serum Midkine Level in Diagnosis of Hepatocellular Carcinoma by Karim Y. A. Shaheen, Abeer I. Abdel-Mageed, Eslam Safwat, Ashraf M. AlBreedy

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Structural insights into antibody-based immunotherapy for hepatocellular carcinoma by Masaud Shah, Muhammad Hussain, Hyun Goo Woo

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Spontaneous Rupture of Renal Metastasis from Hepatocellular Carcinoma by Osamu Kinoshita, Yusuke Ichijo, Masayuki Yoneda, Atsushi Ikai, Tetsuro Yamashita

“…We report a rare life-threatening case of spontaneous rupture of renal metastasis from hepatocellular carcinoma (HCC) that was managed by emergent transcatheter arterial embolization (TAE). …”
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Research progress of MRI-based radiomics in hepatocellular carcinoma by Xiao-Yun Xie, Rong Chen

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Atypical imaging presentation of hepatocellular carcinoma - Case series by Divya S, Geetha G, Ashwin Kumar A

Subjects: “…hepatocellular carcinoma; atypical imaging presentations; portal vein tumor thrombus…”
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Fibrolamellar hepatocellular carcinoma presenting with early recurrent thrombosis by Hacer Kundakcioglu, Sabahattin Destek, Zuhal Gucin, Kamuran Cumhur Değer

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The Role of Matrix Metalloproteinases in the Epithelial-Mesenchymal Transition of Hepatocellular Carcinoma by Cristian Scheau, Ioana Anca Badarau, Raluca Costache, Constantin Caruntu, Gratiela Livia Mihai, Andreea Cristiana Didilescu, Carolina Constantin, Monica Neagu

“…The epithelial-mesenchymal transition (EMT) is a transformation process mandatory for the local and distant progression of many malignant tumors, including hepatocellular carcinoma (HCC). Matrix metalloproteinases (MMPs) play significant roles in cellular regeneration, programmed death, angiogenesis, and many other essential tissular functions, involved in the normal development and also in pathological processes, such as the EMT. …”
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