Donor Small-Droplet Macrovesicular Steatosis Affects Liver Transplant Outcome in HCV-Negative Recipients by Flaminia Ferri, Quirino Lai, Antonio Molinaro, Edoardo Poli, Lucia Parlati, Barbara Lattanzi, Gianluca Mennini, Fabio Melandro, Francesco Pugliese, Federica Maldarelli, Alessandro Corsi, Mara Riminucci, Manuela Merli, Massimo Rossi, Stefano Ginanni Corradini

“…No data are available on liver transplantation (LT) outcome and donor liver steatosis, classified as large droplet macrovesicular (Ld-MaS), small-droplet macrovesicular (Sd-MaS), and true microvesicular (MiS), taking into account the recipient Hepatitis C virus (HCV) status. Aim. We investigate the impact of allograft steatosis reclassified according to the Brunt classification on early graft function and survival after LT. …”
Get full text

Senile cataract — features of development and outcomes of surgical treatment in patients with hepatitis B and C viruses by B.N. Hatsukova, G.M. Chernakova, S.A. Kochergin, E.A. Kleshcheva, E.Yu. Malinnikova, K.K. Kyuregyan, M.M. Mikhailov

“…<br> <br> <b>Key words:</b> cataract, phacoemulsification, hepatitis B, hepatitis C.<br> <b>For citation:</b> Hatsukova B.N., Chernakova G.M., Kochergin S.A. et al. …”
Get full text

Hepatitis B and C Viruses’ Infection and Associated Factors among Pregnant Women Attending Antenatal Care in Hospitals in the Amhara National Regional State, Ethiopia by Mulat Dagnew, Yihenew Million, Mucheye Gizachew, Setegn Eshetie, Gashaw Yitayew, Lakachew Asrade, Mulat Adefris, Feleke Moges, Moges Tiruneh

“…Serum samples were tested for hepatitis B surface antigen (HBsAg) and anti-hepatitis C virus antibody (anti-HCV) using ELISA. SPSS version 20 was used for data analysis, and a multivariable logistic regression analysis was used to assess the relationship between factors associated with hepatitis B virus and hepatitis virus C infection. …”
Get full text

Possible scenarios for the spread of mpox outside the endemic focus in Africa by Eskild Petersen, Ulrik Hvid, Oyewale Tomori, Anders Gorm Pedersen, Jacco Wallinga, Richard Pebody, Orlando Cenciarelli, Preben Aavitsland, David Van Laeken, Viggo Andreasen, Uffe Schneider, Julia Kinane Simonsen, Marlies Jilles Francine Goedknegt, Caroline Klint Johannesen, Jens D. Lundgren, Anders Koch, Bolette Søborg, Anna Mia Ekström, Hannah Nohynek, Frank M. Aarestrup, Tyra G. Krause, Lone Simonsen

Get full text

Liver damage in patients living with HIV on antiretroviral treatment with normal baseline liver function and without HBV/HCV infection: an 11-year retrospective cohort study in Gua... by Jun Yu, Hao Liang, Fengxiang Qin, Junjun Jiang, Chunwei Qin, Yunxuan Huang, Bingyu Liang, Yuexiang Xu, Jiegang Huang, Zhiliang Xu, Chuanyi Ning, Yanyan Liao, Ning Zang, Jingzhen Lai, Wudi Wei, Li Ye, Xionglin Qin

“…Objective To characterise the association between duration of exposure to antiretroviral treatment (ART) and liver damage in HIV patients with an initially normal baseline liver function and without hepatitis B virus (HBV)/hepatitis C virus (HCV) infection.Methods A retrospective cohort study was conducted in HIV-infected individuals with normal liver function parameters at ART initiation and without HBV/HCV infection, from 14 April 2004 to 13 April 2015 in Guigang city, Guangxi, China. …”
Get full text

Combining Charlson comorbidity and VACS indices improves prognostic accuracy for all-cause mortality for patients with and without HIV in the Veterans Health Administration by Kathleen A. McGinnis, Amy C. Justice, Amy C. Justice, Vincent C. Marconi, Vincent C. Marconi, Maria C. Rodriguez-Barradas, Maria C. Rodriguez-Barradas, Ronald G. Hauser, Ronald G. Hauser, Krisann K. Oursler, Krisann K. Oursler, Sheldon T. Brown, Kendall J. Bryant, Janet P. Tate, Janet P. Tate, for the Veterans Aging Cohort Study

“…While the Veterans Aging Cohort (VACS) Index 2.0 accurately predicts mortality in PWH using age and clinical biomarkers, the only included comorbidity is hepatitis C. We asked whether adding comorbid disease groupings from the Charlson Comorbidity Index (CCI) improves the accuracy of VACS Index.MethodsTo maximize our ability to model mortality among older age groups, we began with PWoH in Veterans Health Administration (VA) from 2007–2017, divided into development and validation samples. …”
Get full text

Virological and serological outcomes in people with HIV-HBV coinfection who had discontinued tenofovir-containing antiretroviral therapy: Results from a prospective cohort study by Amir M. Mohareb, Patrick Miailhes, Julie Bottero, Caroline Lascoux-Combe, Julie Chas, Sarah Maylin, Audrey Gabassi, Hayette Rougier, Emily P. Hyle, Constance Delaugerre, Karine Lacombe, Anders Boyd

“…ALT elevation was associated with positive hepatitis C antibody serology (p = 0.012). Conclusions: This proof-of-concept study shows that selected people with HIV-HBV coinfection may not lose virologic control of HBV when off tenofovir. …”
Get full text

Protein tyrosine phosphatase delta is a STAT3-phosphatase and suppressor of metabolic liver disease by Thomas F Baumert, Charlotte Bach, Patrick Pessaux, Catherine Schuster, Frank Jühling, Sarah C Durand, Yujin Hoshida, Fabien Zoulim, Atish Mukherji, Naoto Fujiwara, Marine A Oudot, Armando Andres Roca Suarez, Michel L Tremblay, Barbara Testoni, Joachim Lupberger, Romain Parent, Laurent Mailly, Nassim Dali-Youcef, Emanuele Felli, Maria Saez-Palma, Julien Moehlin, Alessia Virzì, Nicolas Brignon, Eugenie Schaeffer, Romain Martin, Laura Meiss-Heydmann, Zakaria Boulahtouf, Lea Girard, Emma Osswald, Carole Jamey, Daniel Brumaru, Bhuvaneswari Koneru

“…Objective Impaired hepatic expression of protein tyrosine phosphatase delta (PTPRD) is associated with increased STAT3 transcriptional activity and reduced survival from hepatocellular carcinoma in patients with chronic hepatitis C virus infection. However, the PTPRD-expressing hepatic cell types, signalling pathways responsive to PTPRD and their role in non-viral liver disease are largely unknown.Methods We studied PTPRD expression in single-cell and bulk liver transcriptomic data from mice and humans, and established a Ptprd-deficient mouse model for metabolic dysfunction-associated steatohepatitis (MASH). …”
Get full text

Hepatic changes during a carrageenan induced granuloma in rats by J. Muntané, Y. Fernandez, S. Mitjavila, M. T. Mitjavila

“…The continuous increase in hepatic cAMP observed during acute and chronic phases could be related to adenylate cyclase stimulation by mediators, and could be an initial step in the hepatocyte adaptation leading to the increased level of hepatic caeruloplasmin, to the reduction of cytochrome P-450 level and to the modifications of Ca2+ sequestration by microsomes.…”
Get full text

Organizing Pneumonia Associated with Pegylated Interferon α and Ribavirin Therapy by Amit Chopra, Creticus Marak, Narendrakumar Alappan, Chang Shim

“…Hepatitis C virus infection is the leading cause of chronic liver disease in the United States of America. …”
Get full text

An Unexpected Interaction between Sofosbuvir/Ledipasvir and Atorvastatin and Colchicine Causing Rhabdomyolysis in a Patient with Impaired Renal Function by Shyam Patel, Jennifer Andres, Kamran Qureshi

“…Hepatitis C virus (HCV) infection affects roughly 170 million people worldwide. …”
Get full text

Complement Receptors C5aR and C5L2 Are Associated with Metabolic Profile, Sex Hormones, and Liver Enzymes in Obese Women Pre- and Postbariatric Surgery by Reza Rezvani, Jessica Smith, Marc Lapointe, Picard Marceau, Andre Tchernof, Katherine Cianflone

“…While plasma ASP was lower in pre- versus postmenopausal women (P<0.01), the hepatic C5L2/C5aR mRNA ratio was increased (P<0.001) and correlated positively with estrone (P<0.01) and estradiol (P<0.001) and negatively with circulating ApoB and liver enzymes ALT, AST, and GGT (all P<0.05). …”
Get full text