Emerging Role of Histone Acetyltransferase in Stem Cells and Cancer by Daniela Trisciuoglio, Marta Di Martile, Donatella Del Bufalo

“…In this context, different hematological and solid tumors are characterized by deregulation of the protein acetylation pattern as a result of genetic or epigenetic changes. …”
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Transition from Ambrisentan to Bosentan in Pulmonary Arterial Hypertension: A Single-Center Prospective Study by Su-Gang Gong, Lan Wang, Bigyan Pudasaini, Ping Yuan, Rong Jiang, Qin-Hua Zhao, Jing He, Rui Zhang, Wen-hui Wu, Jin-Ming Liu, Cai-cun Zhou

“…Conclusions: It is safe for stable PAH patients to transition from ambrisentan to bosentan without hemodynamic or hematologic deterioration.…”
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A Case of TAFRO Syndrome Developed after COVID-19 Vaccination by Hitomi Hirose, Hitoshi Suzuki, Yukako Umezawa, Masako Iwasaki, Hiromitsu Fukuda, Hisatsugu Takahara, Shigeki Tomita, Yusuke Suzuki

“…Several complications, such as renal, hematological, and heart diseases, have been reported; however, its pathogenesis is unclear. …”
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The Missing LNK: Evolution from Cytosis to Chronic Myelomonocytic Leukemia in a Patient with Multiple Sclerosis and Germline SH2B3 Mutation by Krishna Gundabolu, Bhavana J. Dave, Carmelita J. Alvares, Jeffrey J. Cannatella, Vijaya R. Bhatt, Lori J. Maness, Zaid S. Al-Kadhimi, Rana K. Zabad, Allison M. Cushman-Vokoun

“…Chronic myelomonocytic leukemia (CMML) is a rare but distinct hematological neoplasm with overlapping features of myelodysplastic syndrome (MDS) and myeloproliferative neoplasm (MPN). …”
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Acute Toxicity and Antioxidant and Antibacterial Activities of Kyllinga polyphylla Willd. ex Kunth, Cyperaceae Family by Van-Ay Nguyen, Thi-Hang Phung, Thi-Diem-Trang Kieu, Trong-Hong-Phuc Nguyen

“…KP extracts did not cause death at a dose of 5000 mg/kg body weight and did not significantly change the biochemical, hematological, as well as histological structures of internal organs in toxicity-tested mice in comparison with the control. …”
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Coinheritance of the c.-19 G > C and c.315 + 1 G > A Variants in the β-Globin Gene Leads to Thalassemia Disease: A Report from the North of Iran by Hossein Jalali, Mahan Mahdavi, Mohammad Eslamijouybari, Mohammad Reza Mahdavi

“…Up to now, more than 300 pathogenic variants have been identified in the β-globin gene, some of which are categorized as silent mutations that do not change the hematological indices. In the present study, our aim is to introduce the first report of a case with thalassemia intermedia with coinheritance of the c.315 + 1 G > A pathogenic variant and a silent variant (HBB: c.-19 G > C) that was missed during the screening program. …”
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Staphylococcal SSL5 Binding to Human Leukemia Cells Inhibits Cell Adhesion to Endothelial Cells and Platelets by Annemiek M. E. Walenkamp, Jovanka Bestebroer, Ingrid G. J. Boer, Roeline Kruizinga, Henk M. Verheul, Jos A. G. van Strijp, Carla J. C. de Haas

“…These data support the concept that SSL5 could be a lead in the search for novel strategies against hematological malignancies.…”
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Enhancing PDAC therapy: Decitabine-olaparib synergy targets KRAS-dependent tumors by Giorgia Anastasio, Michela Felaco, Alessia Lamolinara, Francesco del Pizzo, Elisa Cacciagrano, Carla Mottini, Margherita Mutarelli, Francesca Di Modugno, Manuela Iezzi, Luca Cardone

“…Previous research indicates that dKRAS-PDAC cells are sensitive to decitabine (DEC), an FDA-approved drug for hematological cancers, though its use in solid tumors is limited by side effects. …”
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Advancements in cellular immunotherapy: overcoming resistance in lung and colorectal cancer by Lijuan Qin, Yuan Li, Juan Liu, Xiaoqin An

“…Among the most promising approaches are cellular therapies, particularly chimeric antigen receptor T-cell (CAR-T) therapy, which has shown remarkable success in hematologic malignancies. However, the application of these therapies to solid tumors, such as lung and colorectal cancers, has faced significant challenges. …”
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Mitochondrial abnormalities as a target of intervention in acute myeloid leukemia by Elissa Tjahjono, Megan R. Daneman, Bernadetta Meika, Alexey V. Revtovich, Natalia V. Kirienko

“…Acute myeloid leukemia (AML) is an aggressive hematological malignancy; it is the most common acute leukemia in adults. …”
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Combination of AAV-CCL19 and GPC3 CAR-T Cells in the Treatment of Hepatocellular Carcinoma by Min Meng, Yi-chen Wu

“…Chimeric antigen receptor-modified T cell (CAR-T) therapy has great potential for treating malignant tumors, especially hematological malignancies. However, the therapeutic effect of solid tumors is limited. …”
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A Rare Case of Stroke Secondary to Iron Deficiency Anemia in a Young Female Patient by Kavitha Gopalratnam, Kevin Andrew Woodson, Jigarkumar Rangunwala, Kanaga Sena, Manisha Gupta

“…Possible etiologies of strokes include cardioembolic disease, hematologic disorders, connective tissue disorders, and substance abuse or can be cryptogenic. …”
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iPSC Technology Revolutionizes CAR-T Cell Therapy for Cancer Treatment by Jiepu Zong, Yan-Ruide Li

“…CAR-T cell therapy has demonstrated notable efficacy in the treatment of hematological malignancies, solid tumors, and various infectious diseases. …”
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Loading of CAR‐T cells with magnetic nanoparticles for controlled targeting suppresses inflammatory cytokine release and switches tumor cell death mechanism by Felix Pfister, Lucas R. Carnell, Lisa Löffler, Philipp Boosz, Niels Schaft, Jan Dörrie, René Stein, Malte Lenz, Erdmann Spiecker, Christian M. Huber, Sami Haddadin, Carola Berking, Christoph Alexiou, Christina Janko

“…Abstract Therapies against hematological malignancies using chimeric antigen receptors (CAR)‐T cells have shown great potential; however, therapeutic success in solid tumors has been constrained due to limited tumor trafficking and infiltration, as well as the scarcity of cancer‐specific solid tumor antigens. …”
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Serological estimation of values for urea, uric acid, and creatinine as a prognostic marker in oral submucous fibrosis patients: An institutional clinic-biochemical study by Vishal Mehrotra, Kriti Garg, Rahul Srivastava, Shazia Aslam, Jyoti Kiran, Vinayak Rai

“…Background: The changes observed in the hematological/serological values and histopathological findings in oral submucous fibrosis (OSMF) patients may help in providing insight into the pathogenesis of this premalignant condition. …”
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Hemoglobin Variant (Hemoglobin Aalborg) Mimicking Interstitial Pulmonary Disease by Vasiliki Panou, Peter-Diedrich Mathias Jensen, Jan Freddy Pedersen, Lars Pilegaard Thomsen, Ulla Møller Weinreich

“…Hemoglobin Aalborg is a moderately unstable hemoglobin variant with no affiliation to serious hematological abnormality or major clinical symptoms under normal circumstances. …”
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Peripherally Embolizing Aortic Thrombus: The Work-Up, Management, and Outcome of Primary Aortic Thrombus by Ramy Mando, Robert Gemayel, Ashish Chaddha, Julian J. Barbat, Elvis Cami

“…Infectious, autoimmune, hematologic, and oncologic work-up were all unyielding. …”
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Oral and Dental Findings of Dyskeratosis Congenita by Mine Koruyucu, Pelin Barlak, Figen Seymen

“…Dryness on the lips and commisuras, ectropion on his eyes, and epiphora were observed. Hematologic tests were performed and showed aplastic anemia at the age of 2. …”
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An Unusual Presentation of Tumor Lysis Syndrome in a Patient with Advanced Gastric Adenocarcinoma: Case Report and Literature Review by Danica Maria Vodopivec, Jose Enrique Rubio, Alessia Fornoni, Oliver Lenz

“…TLS is caused by rapid release of intracellular contents by dying tumor cells, a condition that is expected to be common in hematologic malignancies. However, TLS rarely occurs with solid tumors, and here we present the second chemotherapy-induced TLS in a patient with advanced gastric adenocarcinoma to be reported in the literature. …”
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Spectrum of Intracerebral Hemorrhage in Children: A Report from PICU of a Resource Limited Country by Qalab Abbas, Qurat ul Ain Merchant, Bushra Nasir, Anwar ul Haque, Basit Salam, Gohar Javed

“…CT scan was done in 98% patients and MRI in 34%, while 6% underwent conventional angiography. 60% patients were managed conservatively, 36% underwent neurosurgical intervention, and 6% underwent radiological vascular intervention. Hematologic causes were identified in 52% patients and vascular malformations in 14% and in 26% no cause could be identified. 26% of patients expired.…”
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