A Nomogram utilizing ECG P-wave parameters to predict recurrence risk following catheter ablation in paroxysmal atrial fibrillation by Li-juan Yu, Xue-Hai Chen, Zhe Xu, Ke-Zeng Gong, Fei-Long Zhang

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Experience of instantaneous transaction coronary bypass surgery with carotid endarterectomy by B.M. Todurov, G.I. Kovtun, A.I. Matvijchuk, О.М. Postupalsky, А.О. Shpachuk, S.O. Sheludko, O.V. Revenko, O.A. Loskutov, M.A. Taranov

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PCSK9-antibodies fail to block PCSK9-induced inflammation in macrophages and cannot recapitulate protective effects of PCSK9-deficiency in experimental myocardial infarction by Simon Rauterberg, Simon Rauterberg, Carmen Härdtner, Jennifer Hein, Paola Schrepf, Remi Peyronnet, Christoph Koentges, Tamara A. Vico, Carolin Ehlert, Bianca Dufner, Diana Lindner, Constantin von zur Mühlen, Dennis Wolf, Dirk Westermann, Ingo Hilgendorf, Alexander von Ehr

“…Cardiac function was assessed via echocardiography and isolated working heart model experiments. Gene expression changes were evaluated using RNA sequencing, and inflammatory responses in bone marrow-derived macrophages (BMDMs) were analyzed in vitro.ResultsPCSK9 was expressed in murine heart tissue at levels comparable to the liver, despite minimal heart RNA expression. …”
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Estrogens as Antioxidant Modulators in Human Fertility by A. Mancini, S. Raimondo, M. Persano, C. Di Segni, M. Cammarano, G. Gadotti, A. Silvestrini, A. Pontecorvi, E. Meucci

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Contribution of hypoxia-inducible factor 1alpha to pathogenesis of sarcomeric hypertrophic cardiomyopathy by Sarala Raj Murthi, Andreas Petry, Bachuki Shashikadze, Jan B. Stöckl, Manuel Schmid, Gianluca Santamaria, Karin Klingel, Damir Kračun, Xinpei Chen, Sabine Bauer, Joachim P. Schmitt, Florian Flenkenthaler, Josh Gorham, Christopher N. Toepfer, David Potěšil, Pavel Hruška, Zbyněk Zdráhal, Zsuzsanna Mayer, Mathieu Klop, Luisa Lehmann, Yishi Qin, Laura Papanakli, Nadine Spielmann, Alessandra Moretti, Thomas Fröhlich, Peter Ewert, Stefan Holdenrieder, Jonathan G. Seidman, Christine E. Seidman, Agnes Görlach, Cordula M. Wolf

“…Abstract Hypertrophic cardiomyopathy (HCM) caused by autosomal-dominant mutations in genes coding for structural sarcomeric proteins, is the most common inherited heart disease. HCM is associated with myocardial hypertrophy, fibrosis and ventricular dysfunction. …”
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Synergistic Effects of Simvastatin and Irinotecan against Colon Cancer Cells with or without Irinotecan Resistance by Hyun Joo Jang, Eun Mi Hong, Juah Jang, Jung Eun Choi, Se Woo Park, Hyun Woo Byun, Dong Hee Koh, Min Ho Choi, Sea Hyub Kae, Jin Lee

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Prolonged pain-to-balloon time still impairs midterm left ventricular function following STEMI by Dominik Felbel, Sabrina Fackler, Rachel Michalke, Michael Paukovitsch, Matthias Gröger, Mirjam Keßler, Nicoleta Nita, Yannick Teumer, Leonhard Schneider, Armin Imhof, Dominik Buckert, Wolfgang Rottbauer, Sinisa Markovic

“…Abstract Background ST-elevation myocardial infarction (STEMI) demands near-time reperfusion to reduce the risk of long-term heart failure. This study evaluates the proportion of impaired left ventricular ejection fraction (LVEF) following STEMI in the context of current healthcare settings at a tertiary care center equipped with the most advanced and up-to-date standards of care. …”
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Hemodynamic and Lesion Characteristics Associated with Discordance between the Instantaneous Wave-Free Ratio and Fractional Flow Reserve by Hiroyuki Arashi, Natsuko Satomi, Issei Ishida, Kanintorn Soontorndhada, Suguru Ebihara, Kazuki Tanaka, Hisao Otsuki, Masashi Nakao, Kentaro Jujo, Junichi Yamaguchi, Nobuhisa Hagiwara

“…We included only patients who underwent right heart catheterization and had blood pressure and heart rates recorded immediately prior to iFR and FFR. …”
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Corrigendum to “The “L-Sandwich” Strategy for True Coronary Bifurcation Lesions: A Randomized Clinical Trial” by Quan Guo, Liang Peng, Lixin Rao, Cao Ma, Kang Zhao, Zhenzhou Zhao, Haiyu Tang, Muwei Li

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Minimally invasive excision of aortic valve fibroelastoma by B.М. Тоdurov, M.D. Glagola, G.I. Darvish, O.G. Bitsadze, А.V. Ivanyuk, N.V. Shatelen, O.S. Bolgova, S.I. Dorofeeva

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Publisher Correction: Critical functions for STAT5 tetramers in the maturation and survival of natural killer cells by Jian-Xin Lin, Ning Du, Peng Li, Majid Kazemian, Tesfay Gebregiorgis, Rosanne Spolski, Warren J. Leonard

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Cardiovascular Responses Associated with Daily Walking in Subacute Stroke by Sanjay K. Prajapati, Avril Mansfield, William H. Gage, Dina Brooks, William E. McIlroy

“…The purpose of this study is to determine if (1) walking-related heart rate responses reached the minimum intensity necessary for therapeutic aerobic exercise (40%–60% heart rate reserve) or (2) heart rate responses during bouts of walking revealed excessive workload that may limit walking (>80% heart rate reserve). …”
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Clinical Outcomes of Transcatheter Aortic Valve Replacement in Nonagenarians: A Systematic Review and Meta-Analysis by Yan Liu, Yu Du, Mingjie Fu, Yue Ma, Deguang Wang, Jinglin Zhang, Wei Liu, Yingxin Zhao, Yujie Zhou

“…TAVR remains an option for nonagenarian patients with severe aortic stenosis and should be comprehensively evaluated by the heart valve team.…”
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Pregnancy-related chronic type A aortic dissection highlights the importance of thorough prenatal maternal examination by Cristina M. Șulea, Anna B. Kiss, Bence Ágg, Kálmán Benke, Elektra Bartha, Bálint Szilveszter, Roland Stengl, Máté Csonka, Zoltán Szabolcs, Miklós Pólos

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Therapeutic Options for the Management of the Cardiorenal Syndrome by Katerina Koniari, Marinos Nikolaou, Ioannis Paraskevaidis, John Parissis

“…Patients with heart failure often present with impaired renal function, which is a predictor of poor outcome. …”
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Reversible Pulmonary Arterial Hypertension Associated with Interferon-Beta Treatment for Multiple Sclerosis by E Gibbons, S Promislow, RA Davies, G Chandy, DJ Stewart, V Contreras-Dominguez, C Pugliese, R Dunne, LM Mielniczuk

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Transcatheter Closure of Patent Ductus Arteriosus in Elderly Patients: Initial and One-Year Follow-Up Results—Do We Have the Proper Device? by Michal Galeczka, Malgorzata Szkutnik, Jacek Bialkowski, Sebastian Smerdzinski, Mateusz Knop, Adam Sukiennik, Roland Fiszer

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Towards a Vaccine Against Rheumatic Fever by L. Guilherme, K. C. Faé, F. Higa, L. Chaves, S. E. Oshiro, S. Freschi de Barros, C. Puschel, M. A. Juliano, A. C. Tanaka, G. Spina, J. Kalil

“…Carditis, the most serious manifestation of the disease, leads to severe and permanent valvular lesions, causing chronic rheumatic heart disease (RHD). We have been studying the mechanisms leading to pathological autoimmunity in RF/RHD for the last 15 years. …”
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Simplified Outcome Prediction in Patients Undergoing Transcatheter Tricuspid Valve Intervention by Survival Tree-Based Modelling by Vera Fortmeier, MD, Mark Lachmann, MD, Lukas Stolz, MD, Jennifer von Stein, MD, Karl-Philipp Rommel, MD, Mohammad Kassar, MD, Muhammed Gerçek, MD, Anne R. Schöber, MD, Thomas J. Stocker, MD, Hazem Omran, MD, Michelle Fett, Jule Tervooren, Maria I. Körber, MD, Amelie Hesse, Gerhard Harmsen, PhD, Kai Peter Friedrichs, MD, Shinsuke Yuasa, MD, PhD, Tanja K. Rudolph, MD, Michael Joner, MD, Roman Pfister, MD, Stephan Baldus, MD, Karl-Ludwig Laugwitz, MD, Stephan Windecker, MD, Fabien Praz, MD, Philipp Lurz, MD, Jörg Hausleiter, MD, Volker Rudolph, MD

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Mitral Stenosis Berat pada Penyakit Jantung Rematik by Cokorda Istri Padmi Suwari, Widyawati Desak Gede

“…Rheumatic Heart Disease (RHD) has high morbidity and mortality. …”
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