Toward autism spectrum disorders and Williams-Beuren syndrome co-occurrence condition in Tunisian patients: Genetic insights by Rim Khelifi, Afef Jelloul, Houda Ajmi, Wafa Slimani, Sarra Dimassi, Khouloud Rjiba, Manel Dardour, Moez Gribaa, Ali Saad, Soumaya Mougou-Zerelli

“…IntroductionWilliams-Beuren syndrome (WBS) is a rare genetic disorder characterized by congenital heart defects, dysmorphic features, intellectual delay, and a distinctive social behavioral profile. …”
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Integrative Bioinformatics Analysis to Identify Key Ferroptosis-Related Genes and Immune Infiltration in Aortic Aneurysm and Dissection: Implication of PTGS2 by An W, Luo J, Zhang C, Xiao Q

“…Weiwei An,1,2 Jun Luo,3 Cheng Zhang,3 Qingzhong Xiao2 1Laboratory of Cardiovascular Science, Beijing Clinical Research Institute, Beijing Friendship Hospital, Capital Medical University, Beijing, 100050, People’s Republic of China; 2William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, EC1M 6BQ, United Kingdom; 3Department of Cardiothoracic Surgery, The First Affiliated Hospital of Chongqing Medical University, Chongqing, 400016, People’s Republic of ChinaCorrespondence: Qingzhong Xiao, Centre for Clinical Pharmacology and Precision Medicine, William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, Heart Centre Charterhouse Square, London, EC1M 6BQ, United Kingdom, Tel +44(0)2078826584, Email q.xiao@qmul.ac.uk Cheng Zhang, Department of Cardiothoracic Surgery, The First Affiliated Hospital of Chongqing Medical University, Chongqing, 400016, People’s Republic of China, Email zhangcs05223@163.comBackground: Aortic aneurysm and dissection (AAD) represent a highly lethal cardiovascular condition. …”
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Early Myocardial Strain Reduction and miR-122-5p Elevation Associated with Interstitial Fibrosis in Anthracycline-Induced Cardiotoxicity by María de Regla Caballero-Valderrama, Elisa Bevilacqua, Miriam Echevarría, Francisco Javier Salvador-Bofill, Antonio Ordóñez, José Eduardo López-Haldón, Tarik Smani, Eva M. Calderón-Sánchez

“…Epirubicin treatment caused structural heart changes in rats, highlighting miR-122-5p as a potential fibrosis marker that correlated with echocardiographic parameters.…”
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Tisser dans le désert : interactions et adaptations autour d’un ouvroir missionnaire au Mzab (1892-1950) by Mélina Joyeux

“…Missionary action therefore focused on minorities, quickly nullifying the initial apostolic strategy.At the dawn of the 20th century, the mission was reorganized to place the workshop at the heart of the missionary works. The paper then focuses on the role of weaving in the nuns’ strategy, and how they turned the workshop into a major center for colonial crafts. …”
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Clarithromycin-Associated Acute Liver Failure Leading to Fatal, Massive Upper Gastrointestinal Hemorrhage from Profound Coagulopathy: Case Report and Systematic Literature Review by Ahmed I. Edhi, Seifeldin Hakim, Christienne Shams, Damanpreet Bedi, Mitual Amin, Mitchell S. Cappell

“…The six previously reported cases were limited by failure to exclude hepatitis E (4), lack of liver biopsy (2), and uninterpretable liver biopsy (1) and by confounding potential etiologies including disulfiram, israpidine, or recent acetaminophen use (3), clarithromycin overdose (1), active alcohol use (1), and severe heart failure (1). Review of 6 previously reported and current case of clarithromycin-associated ALF revealed that patients had AST and ALT values in the thousands. …”
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Analysis of the cardiotoxic and myorelaxant effects of camphor on fish of the Nile tilapia species (Oreochromis niloticus) (Linnaeus 1758) by Clarissa Araújo da Paz, Suzane Maia de Oliveira, Maria Klara Otake Hamoy, Murilo Farias dos Santos, Anthony Lucas Gurgel do Amaral, Anara de Sousa Barbosa, Luciana Eiró-Quirino, Daércio José de Macedo Ribeiro Paixão, Luis André Luz Barbas, Dielly Catrina Favacho Lopes, Marcelo Ferreira Torres, Moisés Hamoy

“…The ECG and opercular beat recordings demonstrated a decrease in heart and respiratory rates, with changes in the recorded tracings being more evident at higher concentrations. …”
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Effect and Safety of Transcutaneous Auricular Vagus Nerve Stimulation on Recovery of Upper Limb Motor Function in Subacute Ischemic Stroke Patients: A Randomized Pilot Study by Dandong Wu, Jingxi Ma, Liping Zhang, Sanrong Wang, Botao Tan, Gongwei Jia

“…The assessment included the upper limb Fugl-Meyer assessment (FMA-U), the Wolf motor function test (WMFT), the Functional Independence Measurement (FIM), and Brunnstrom stage. Heart rate (HR) and blood pressure (BP) were measured before and after each taVNS intervention. …”
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CMV Pancreatitis in an Immunocompromised Patient by Jaffer Ahmad, Najia Sayedy, Raghavendra Sanivarapu, Jagadish Akella, Javed Iqbal

“…However, in the immunocompromised patient, prognosis can be deadly as CMV can disseminate to the retina, liver, lungs, heart, and GI tract. We present a case of CMV pancreatitis afflicting an immunocompromised patient. …”
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Comparing clinical only and combined clinical laboratory models for ECPR outcomes in refractory cardiac arrest by Chun-Chieh Chiu, Yu-Jun Chang, Chun-Wen Chiu, Ying-Chen Chen, Yung-Kun Hsieh, Shun-Wen Hsiao, Hsu-Heng Yen, Fu-Yuan Siao

“…Patients who met the following criteria were enrolled in the ECPR program: age 18–75 years, CCPR started with CA in < 5 min, CA was assumed to be of heart origin, and refractory CA. Survivors had similar underlying diseases and younger age without statistical significance (57.0 vs. 61.0 years, p = 0.117). …”
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Systemic delivery of AAV5, AAV8, and AAV9 packaging a C5-12-microdystrophin-FLAG expression cassette in non-human primates by Mengping Liu, Erica Cook, Yanshan Dai, Erich Ehlert, Francois du Plessis, Jacek Lubelski, Bogdan G. Sleczka, Petia Shipkova, Zhuyin Li, Joshua Gamse, David Gordon, Leonard P. Adam, Paul C. Levesque, Glen B. Banks

“…The C5-12 promoter was highly selective for heart and skeletal muscles, when compared to off-target tissues such as peripheral blood mononuclear cells, lung, liver, and kidney. …”
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Medication patterns and potentially inappropriate medication in patients with metastatic breast cancer: results of the BRE-BY-MED study by Lilly Sophia Brandstetter, Anna Grau, Peter U. Heuschmann, Max Müller-Reiter, Jessica Salmen, Stefan Störk, Achim Wöckel, Jens-Peter Reese

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The relationship between walking speed and changes in cardiovascular risk factors during a 12-day walking tour to Santiago de Compostela: a cohort study by Frank L J Visseren, Yolanda van der Graaf, Wilko Spiering, Remy H H Bemelmans, Paulus P Blommaert, Annemarie M J Wassink, Blai Coll

“…A 1 km/h higher walking speed was related to an increase in HDL-c (0.24; 95% CI 0.12 to 0.30 mmol/l), LDL-c (0.18; 95% CI −0.16 to 0.42 mmol/l) and total cholesterol (0.36; 95% CI 0.12 to 0.60 mmol/l), adjusted for age, gender, smoking, body mass index and heart rate, during the whole walking tour.Conclusions Walking the same distance faster improves HDL-c more, while LDL-c and total cholesterol decrease more with lower walking speed independent of changes in body weight in healthy middle-aged subjects.…”
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Prognostic Value of the Tricuspid Regurgitation Impact on Outcomes (TRIO) Score in Patients Undergoing Transcatheter Aortic Valve Implantation by Jizhong Wang, Yuanwei Chen, Xuxing Zhang, Songyuan Luo, Jie Li, Fang Pei, Jianfang Luo

“…The primary outcome was all-cause mortality, while secondary outcomes included complications defined by the Valve Academic Research Consortium 2 (VARC-2) criteria and major adverse cardiovascular events (MACEs), including mortality, stroke, and heart failure rehospitalization. …”
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Construction and evaluation of a triage assessment model for patients with acute non-traumatic chest pain: mixed retrospective and prospective observational study by Xuan Zhou, Gangren Jian, Yuefang He, Yating Huang, Jie Zhang, Shengfang Wang, Yunxian Wang, Ruofei Zheng

“…Results Multiple logistic regression analysis showed that age, smoking, coronary heart disease, hypertension, diabetes, hyperlipidemia, pain site, concomitant symptoms, and electrocardiograph, all of which are independent predictors of high-risk chest pain patients. …”
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Association between Serum Adiponectin and Atrial Fibrillation: A Case-Control Study Stratified by Age and Gender by Tongjian Zhu, Zhuo Wang, Songyun Wang, Wei Hu, Hui Chen, Jing Xie, Meng Wang, Kezhong Ma, Hong Jiang

“…All participants underwent echocardiography and heart rate variability tests. Biochemical parameters and adiponectin levels were also evaluated. …”
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Prevalence, cessation, and geographical variation of smoking among middle-aged and elderly adults in China: A population-based study by Qingjia Zeng, Chongyang Zhang, Feiyu Su, Yanli Wan, Wen-jun Tu, Hongpu Hu

“…Additionally, the dose-response relationship indicated a more pronounced association between higher smoking pack-years and elevated health risks, including hypertension (aOR=1.30, 95% CI: 1.24-1.36), diabetes (aOR=1.26, 95% CI: 1.20-1.33), hyperlipidemia (aOR=1.22, 95% CI: 1.16-1.28), heart disease (aOR=1.40, 95% CI: 1.26-1.54), and stroke (aOR=1.23, 95% CI: 1.10-1.36). …”
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Clinical manifestations, para-clinical features and outcome of Iranian adults with respiratory syncytial virus (RSV) infection: a report from hospitalized patients by Maryam Shafaati, Abbas Shakoori Farahani, Mohammadreza Salehi, Mohammad Arabzadeh, Helya Bolouki Azari, Arman Soleimany, Maryam Edalatifard, Vahid Salimi, Alireza Abdollahi

“…Dyspnea, productive cough, and fever were the most common symptoms, with a mean symptom duration of 10.50 days. Ischemic heart disease, hypertension, and liver failure were common underlying conditions. …”
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Impact of Novel Guidelines on Multifactorial Control and Its Association with Mortality in Adult Patients with Hypertension and Newly Diagnosed Type 2 Diabetes: A 4-Year Prospectiv... by Ngoc-Thanh-Van Nguyen, Hoa Ngoc Chau, Nam Hoai Le, Hai Hoang Nguyen, Hoai-An Nguyen

“…At baseline, ischemic heart disease, dyslipidemia, and chronic kidney disease (CKD) were present in 54.9%, 67.1%, and 41.1% of patients. …”
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Inhibition of the mTOR Pathway Exerts Cardioprotective Effects Partly through Autophagy in CLP Rats by Wen Han, Hao Wang, Longxiang Su, Yun Long, Na Cui, Dawei Liu

“…Recent studies have indicated that autophagy and myocardial energy depletion play a major role in myocardial dysfunction during sepsis, a mechanistic target of rapamycin (mTOR) as a master sensor of energy status and autophagy mediator; however, there are little data describing its role during sepsis in the heart. Methods. Cecal ligation and puncture (CLP) or sham operation (SHAM) was performed in rats. …”
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Alteration of Sarcoplasmic Reticulum Ca2+ Release in Skeletal Muscle from Calpain 3-Deficient Mice by Govindan Dayanithi, Isabelle Richard, Cédric Viero, Elsa Mazuc, Sylvie Mallie, Jean Valmier, Nathalie Bourg, Muriel Herasse, Isabelle Marty, Gérard Lefranc, Paul Mangeat, Stephen Baghdiguian

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