Association of HLA-B27 Gene and Rheumatoid Arthritis: Analysis of Potential Role as a Predictive Biomarker by Karzan Ghafur Khidhir, Baban Ahmad, Dana Khdr Sabir

“…The GENT2 revealed that HLA-B27 expression levels vary across different tumor types, most notably in heart tissue. The gene-gene interaction network revealed that KIR3DL1, KIR3DS1, LILRB1, B2M and LILRA1 were the leading genes showing the highest correlations with the HLA-B27. …”
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Inhibitory Effect of Lactobacillus delbrueckii subsp. bulgaricus KSFY07 on Kappa-Carrageenan-Induced Thrombosis in Mice and the Regulation of Oxidative Damage by Pan Wang, Fang Tan, Jianfei Mu, Hongjiang Chen, Xin Zhao, Yanan Xu

“…Meanwhile, LDSB-KSFY07 could raise plasminogen activator inhibitor-1 (PAI-1) mRNA expression and reduce tissue plasminogen activator (t-PA) expression in heart and tail vein vascular tissues of thrombotic mice. …”
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Detection of other pathologies when utilising computer-assisted digital solutions for TB screening by J. Sebastian, I.D. Olaru, A. Giannakis, M. Arentz, S.V. Kik, M. Ruhwald, S. Linsen, G. Günther, P. Wolf, F.J. Herth, T. Weber, C.M. Denkinger

“…The CAD generally detected abnormalities in patients with critical diagnoses such as lung cancer or heart failure. Performance for detecting other abnormalities was variable. …”
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Anatomical and physiological contributions of nasal turbinate vessels and lymphatics to the pathogenesis of nasal congestion in recurrent headaches: a pilot study by Jacob M. Chmielecki, Aishwarya Vemula, Joyce G. Schwartz, Jonathan A. Gelfond, William T. Phillips

“…The scans were evaluated by region of interest (ROI) analysis of nasal and heart max pixel count ratios (NHMRs) to determine an association between nasal blood pooling activity and recurrent headaches at the time of the initial scan and in follow-up evaluations over a period of 3–6 years.ResultsSignificantly greater NHMRs were observed in 122 patients with chronic headaches at the time of referral for their initial whole-body blood pool scan when compared with those patients without recurrent headaches (p = 0.004; OR 10.5; 95% CI 2.22–56.7). …”
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The impact of uric acid on musculoskeletal diseases: clinical associations and underlying mechanisms by Jing Zhang, Na Sun, Wanhao Zhang, Wenjie Yue, Xiaochen Qu, Xiaochen Qu, Zhonghai Li, Zhonghai Li, Gang Xu, Gang Xu

“…This review discusses the mechanisms linking SU to musculoskeletal disorders, as well as the clinical associations of SU with conditions such as sarcopenia, T2D with sarcopenia, McArdle disease, heart failure, gout, OA, IDD, OP and exercise-induced acute kidney injury (EIAKI), offering valuable insights for improved prevention and treatment strategies. …”
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Comorbidity patterns and mortality in atrial fibrillation: a latent class analysis of the EURopean study of Older Subjects with Atrial Fibrillation (EUROSAF) by Huah Shin Ng, Richard Woodman, Nicola Veronese, Alberto Pilotto, Arduino A. Mangoni

“…The model identified phenotype 1 (hypertensive, other circulatory conditions, metabolic diseases; 33%), phenotype 2 (digestive diseases, infection, injury, non-specific clinical and laboratory abnormalities; 26%), and phenotype 3 (heart failure, respiratory diseases; 41%). Overall, 512 patients (25%) died within 12 months. …”
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Cardiovascular Safety of Clonidine and Dexmedetomidine in Critically Ill Patients after Cardiac Surgery by Angelina Grest, Judith Kurmann, Markus Müller, Victor Jeger, Bernard Krüger, Donat R. Spahn, Dominique Bettex, Alain Rudiger

“…Methods. 2769 patients were screened during the 30-month study period. Heart rate (HR), mean arterial pressure (MAP), and norepinephrine requirements were assessed 3-hourly during the first 12 hours of the continuous drug infusion. …”
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Analgesic Effect of Ultrasound-Guided Anterior Quadratus Lumborum Block at the L2 Level in Patients Undergoing Laparoscopic Partial Nephrectomy: A Single-Center, Randomized Control... by Ying He, Mingying Huang, Qiangui Zhong, Huijuan Ni, Zenggui Yu, Xinjian Zhang

“…Comparison of invasive blood pressure (BP) and heart rate (HR) before and after skin incision in group C was statistically significant, but there was no significant difference in group Q. …”
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NT-proBNP and Major Adverse Cardiovascular Events in Patients with ST-Segment Elevation Myocardial Infarction Who Received Primary Percutaneous Coronary Intervention: A Prospective... by Zuoan Qin, Yaoyao Du, Quan Zhou, Xuelin Lu, Li Luo, Zhixiang Zhang, Ning Guo, Liangqing Ge

“…Stent thrombosis, reinfarction, congestive heart failure, unstable angina, and cardiac death were considered as MACEs in this study. …”
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Diabetes Management and Outcomes among Patients with Type 2 Diabetes Attending a Renal Service by Elizabeth Skalkos, Rohit Rajagopal, David Simmons

“…More insulin-treated patients had ischaemic heart disease (46.7% vs. 33.6%, p=0.028), diabetic foot disease (15.6% vs. 4.8%, p=0.003), retinopathy (40.2% vs. 11.0%, p<0.001), and emergency attendance for severe hypoglycaemia (3.8% vs. 0% p=0.042). …”
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Key performance indicators in emergency department simulation: a scoping review by Mohammad Hossein Mehrolhassani, Anahita Behzadi, Elaheh Asadipour

“…In addition, the management (vision, objectives, and strategies) has been positioned at the heart of the framework. Result Initially, 4257 articles were retrieved, and 125 articles were included after screening. …”
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Effect of Health Education on Healthy Nutrition and Physical Activity among Female Teachers Aged 40–60 Years in Asmara, Eritrea: A Quasiexperimental Study by Helen Gebretatyos, Soliana Amanuel, Lidia Ghirmai, Ghidey Gebreyohannes, Eyasu H. Tesfamariam

“…Moreover, chronic illness such as diabetes, hypertension, heart diseases, and osteoporosis are prevalent at this time. …”
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Clinical Predictors of Hospital-acquired Pneumonia Associated with Acute Ischemic by Alexis Suárez Quesada, Ezequiel López Espinosa, Noelsis García Verdecia, Miguel Ángel Serra Valdés

“…The following independent factors were identified: Glasgow Coma Scale ≤ 11 (OR: 26.099; 95 % CI 7.164-85.075), history of chronic obstructive pulmonary disease (OR: 8.896; 95 % CI 1.203-65.779), dysphagia (OR: 7.652; 95 % CI 2.369- 24.720), history of heart failure (OR: 4.583; 95 % CI 1.240- 16.932) and dysarthria/severe motor aphasia (OR: 4.222; 95 % CI 1.374- 12.975). …”
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Evaluation of physicians&apos; screening practices and knowledge levels regarding atrial fibrillation in patients over 65 years of age: A prospective study by Emre Bulbul, Erhan Simsek, Muhammet Kizmaz

“…Early detection and management are essential to mitigate severe complications such as stroke and heart failure. These efforts are crucial in primary care, where family medicine practitioners are key. …”
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Validating the Hypoglycaemic and Hypotensive Roles of Salvia serotina (Chicken Weed) in Normal Healthy Sprague–Dawley Rats by Tameika Bartley, Paul Reese, Sophie Turfus, Ruby Alexander-Lindo

“…Aqueous, hexane, ethyl acetate, and methanol crude extracts of S. serotina L. were investigated for their anti-oxidant activities and hypoglycaemic and hypotensive effects in normal, healthy Sprague–Dawley rats using the 2,2-diphenyl-1-picrylhydrazyl (DPPH) assay, oral glucose tolerance test (OGTT), and the CODA noninvasive blood pressure system to determine systolic blood pressure (SBP), diastolic blood pressure (DBP), mean arterial pressure (MAP), and heart rate (HR). The aqueous extract caused a free radical scavenging effect with an IC50 value of 10.2 ± 1.01 µg/mL versus vitamin C (9.42 ± 1.01 µg/mL). …”
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Examining the etiology and pregnancy outcomes of 152 critically ill pregnant patients in the Intensive Care Unit by Weiman Liu, Junyou Su, Sumei Wang

“…Results The results showed that the main obstetric factors leading to ICU admission were pregnancy-related hypertensive disease, postpartum hemorrhage, and acute fatty liver of pregnancy; the non-obstetric factors included either pregnancy complicated by heart disease, sepsis, or malignant tumors. The maternal mortality rate was higher in the non-obstetric direct factor group than in the obstetric direct factor group (22.12% vs. 6.25%, p = 0.016). …”
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hERGAT: predicting hERG blockers using graph attention mechanism through atom- and molecule-level interaction analyses by Dohyeon Lee, Sunyong Yoo

“…Abstract The human ether-a-go-go-related gene (hERG) channel plays a critical role in the electrical activity of the heart, and its blockers can cause serious cardiotoxic effects. …”
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Study on thermal and physiological responses during summer while moving between academic buildings under different walking conditions by Jiahao Yang, Haiyan Li, Zhaosong Fang, Yongcai Li, Fangqi Lu, Tongye Guo, Xiang Zhang, Chang Lin, Jun Lu

“…The findings are as follows: (1) Subjects exposed to short-term sunlight showed an average HR (heart rate) increase of 3.4 beats/min (0.8 m/s), 3.9 beats/min (1.2 m/s), and 4.2 beats/min (1.6 m/s) compared to non-exposed individuals; the maximum Tac (auditory canal temperature) difference was 0.15 °C, and the maximum differences in metabolic rate and heat storage were 14.8 W/m2 and 12.2 W/m2, respectively; (2) Walking speeds should be kept below 2.09 m/s (non-exposed) and 1.53 m/s (expose) to avoid heat risks; (3) There is a discrepancy between the simulated and actual thermal indices. …”
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The impact of chronic disease diagnoses on smoking behavior change and maintenance: Evidence from China by Xinxin Chi, Xihua Liu, Cong Li, Wen Jiao

“…We found that diagnoses of cancer, heart disease, and stroke reduced smoking rates by 16% (95% CI: -24 – -8), smoking intensity by 0.31 (95% CI: -0.46 – -0.15), and had lasting impacts on smoking cessation behavior (one wave after diagnosis ATT= -0.17; 95% CI: -0.34 – -0.00, two waves after diagnosis ATT= -0.17; 95% CI: -0.37–0.03). …”
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High-Flow Nasal Cannula: A Promising Oxygen Therapy for Patients with Severe Bronchial Asthma Complicated with Respiratory Failure by Wanru Geng, Wuliji Batu, Shuhong You, Zhaohui Tong, Hangyong He

“…However, HFNC was more efficient than COT in elevating PO2 in patients with severe bronchial asthma complicated with respiratory failure, while no statistically significant difference in PCO2 reduction was found between the two groups. Heart rate (HR) and respiratory rate (RR) between the two groups on admission (0 h) and at 2, 8, 24, and 48 h after admission were compared. …”
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