Canadian Consensus Conference on the Management of Viral Hepatitis by Association for Study of the Liver (CASL) Consensus Conference Rapporteur Group

“…These proceedings of a consensus conference on the management of viral hepatitis were sponsored by the Canadian Association for Study of the Liver (CASL) and Health Canada. Experts in various aspects of viral hepatitis presented a review of the medical literature on assigned topics. …”
Get full text

HIV Disease Progression to CD4 Count <200 Cells/μL and Death in Saskatoon, Saskatchewan by Stephanie Konrad, Stuart Skinner, Germain Bukassa Kazadi, Kali Gartner, Hyun June Lim

Get full text

Immunization - Must Be Safe or We Will All Be Sorry by Greg Hammond

Get full text

A Randomized Trial of Yoga for Adolescents with Irritable Bowel Syndrome by Leora Kuttner, Christine T Chambers, Janine Hardial, David M Israel, Kevan Jacobson, Kathy Evans

Get full text

Contemporary Antiviral Drug Regimens for the Prevention and Treatment of Orolabial and Anogenital Herpes Simplex Virus Infection in the Normal Host: Four Approved Indications and 1... by Fred Y Aoki

“…Four drugs: acyclovir, famciclovir, valacyclovir and penciclovir, are currently licensed by the Therapeutics Products Directorate of Health Canada for the management of HSV infections. Although these drugs are only approved for four orolabial and anogenital infections in healthy persons, their efficacy and safety for 13 other related uses in this population have been demonstrated in controlled clinical trials, so called off-label uses. …”
Get full text

Asthma Education Program for First Nations Children: An exemplar of the Knowledge-to-Action Framework by Maureen L Douglas, Shawna L McGhan, Danielle Tougas, Nancy Fenton, Christopher Sarin, Oxana Latycheva, A Dean Befus

Get full text

A Case Report of Dramatically Increased Thyroglobulin after Lymph Node Biopsy in Thyroid Carcinoma after Total Thyroidectomy and Radioiodine by Mandana Moosavi, Stuart Kreisman

Get full text

Detection of Antibody to Envelope (E2) Antigen of Hepatitis C Virus by RK Chaudhary, E Burres

Get full text

In Vitro Activities of Ceftobiprole and Doripenem Tested against Frequently Encountered Aerobic and Facultative Gram-Positive and Gram-Negative Bacterial Pathogens Isolated from Pa... by James A Karlowsky, Mel DeCorby, Daryl J Hoban, George G Zhanel

“…BACKGROUND: In 2008, ceftobiprole was approved by Health Canada for the treatment of patients with complicated skin and skin structure infections including diabetic foot infections; approval of ceftobiprole by the United States Food and Drug Administration is pending. …”
Get full text

Potential Capsule Switching from Serogroup Y to B: The Characterization of Three such Neisseria meningitidis Isolates Causing Invasive Meningococcal Disease in Canada by Raymond SW Tsang, Dennis KS Law, Shaun D Tyler, Gwen S Stephens, Mark Bigham, Wendell D Zollinger

Get full text

The Emergence of Extensively Drug-Resistant Tuberculosis (TB): TB/HIV Coinfection, Multidrug-Resistant TB and the Resulting Public Health Threat from Extensively Drug-Resistant TB,... by Paul E Alexander, Prithwish De

Get full text

Putting the Evidence into Preceptor Preparation by Florence Myrick, Florence Luhanga, Diane Billay, Vicki Foley, Olive Yonge

Get full text

Readability and Suitability of COPD Consumer Information by Kathryn Fullmann, David F. Blackburn, Mark E. Fenton, Holly Mansell

“…COPD inhalers were identified from the Health Canada Drug Product Database. Medication information and instructions for inhaler use were analyzed for readability by seven formulas, with an acceptability threshold of grades 6–8. …”
Get full text

Requirements and special considerations for drug trials with children across six jurisdictions: 2. Ethics review in the regulatory approval process by Breanne Stewart, Pirkko Lepola, Gunter F. Egger, Fahimeda Ali, Albert J. Allen, Albert J. Allen, Alysha K. Croker, Andrew J. Davidson, Pamela Dicks, Saul N. Faust, Saul N. Faust, Dionna Green, Collin Hovinga, Collin Hovinga, Agnes V. Klein, Robyn Langham, Hidefumi Nakamura, Laura Pioppo, Shiva Ramroop, Michiyo Sakiyama, Isabel Sanchez Vigil de la Villa, Junko Sato, Donna L. Snyder, Mark A. Turner, Mark A. Turner, Sarah Zaidi, Kanecia Zimmerman, Kanecia Zimmerman, Thierry Lacaze-Masmonteil

Get full text

Spatial Variability and Application of Ratios between BTEX in Two Canadian Cities by Lindsay Miller, Xiaohong Xu, Amanda Wheeler, Dominic Odwa Atari, Alice Grgicak-Mannion, Isaac Luginaah

Get full text

Characterizing Radon Among Public Buildings and Small/Medium-Sized Businesses in a Canadian Province by Lily X. Yang, Tracy L. Kirkham, Laura Boksman, Anne-Marie Nicol, Paul A. Demers

“…The radon measurements ranged from <4 to 566 Bq/m³, with a median of 26 Bq/m³, arithmetic mean of 40.2 Bq/m³, and geometric mean of 26.9 Bq/m³. Using the Health Canada and Ontario labor guideline of 200 Bq/m³, 2.5% of participating workplaces had at least one measurement above this level; 7.2% were above the World Health Organization guideline. …”
Get full text

Percutaneous vacuum-assisted tumor thrombectomy using angiovac and penumbra lightning 12 aspiration systems by Murtaza Jafri, BSc, Brittany Stojak, MD, Owen Mooney, MD, Andrew Macdiarmid, MD, Ian W. Gibson, MD, Surinder Dhaliwal, MD

“…The patient's disease was not amenable to surgical resection and thrombolytic therapy was contraindicated due to associated intratumor hemorrhage, thus prompting consideration of thrombectomy under emergency approval from Health Canada. The patient underwent an overall successful total aspiration thrombectomy of the intracardiac tumor thrombus with subsequent resolution of her right heart strain, using the extracorporeal AngioVac aspiration system and partial aspiration of the extensive pulmonary emboli using the Penumbra Indigo Lightning 12 system. …”
Get full text

Improving predictability of IgE-high type 2 chronic sinusitis with nasal polyps in the biologic era by Austin Heffernan, Jobanjit Phulka, Andrew Thamboo

“…Omalizumab is an anti-IgE biologic that was recently approved by the FDA and Health Canada for use in severe CRS with nasal polyps (CRSwNP) recalcitrant to intranasal corticosteroids. …”
Get full text

Do shorter delays to care and mental health system renewal translate into better occupational outcome after mental disorder diagnosis in a cohort of Canadian military personnel who... by David Boulos, Mark A Zamorski

Get full text

Comparative, cross-sectional study of the format, content and timing of medication safety letters issued in Canada, the USA and the UK by Jeremy M Grimshaw, Margaret C Watson, Lise M Bjerre, Matthew Hogel, Cody D Black, Simon Parlow, David de Launay, Donald R Mattison

“…Objectives To assess consistency in the format and content, and overlap of subject and timing, of medication safety letters issued by regulatory health authorities to healthcare providers in Canada, the USA and the UK.Design A cross-sectional study comparing medication safety letters issued for the purpose of alerting healthcare providers to newly identified medication problems associated with medications already on the market.Setting Online databases operated by Health Canada, the US Food and Drug Administration and the UK Medicines and Healthcare products Regulatory Agency were searched to select medication safety letters issued between 1 January 2010 and 31 December 2014. …”
Get full text