Secreted PD-L1 alleviates inflammatory arthritis in mice through local and systemic AAV gene therapy by Wenjun Li, Wenjun Li, Junjiang Sun, Susi Feng, Ariana La Rosa, Panli Zhang, Eveline Y. Wu, Richard Loeser, Chengwen Li, Chengwen Li, Chengwen Li

“…IntroductionRheumatoid arthritis (RA) primarily affects the joints but can also affect multiple organs and profoundly impacts patients’ ability to carry out daily activities, mental health, and life expectancy. Current treatments for RA are limited in terms of duration, efficacy, and adverse effects. …”
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Resistome phylodynamics of multidrug-resistant Shigella isolated from diarrheal patients by Asaduzzaman Asad, Md. Abu Jaher Nayeem, Md. Golam Mostafa, Ruma Begum, Shah Nayeem Faruque, Suraia Nusrin, Israt Jahan, Shoma Hayat, Zhahirul Islam

“…ABSTRACT Multi-drug resistance (MDR) in Shigella continues to pose a significant public health challenge, particularly in developing countries. …”
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Air pollution exposure and prevalence of non-alcoholic fatty liver disease and related cirrhosis: A systematic review and meta-analysis by Xingyi He, Shipeng Zhang, Qinglin Bai, Moshen Pan, Yanjie Jiang, Weiwei Liu, Wei Li, Yuanyuan Gong, Xueping Li

“…Through this study, we hope to clarify the potential public health risks of air pollution as an environmental exposure factor. …”
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HbA1c Cutoff Point of 5.9% Better Identifies High Risk of Progression to Diabetes among Chinese Adults: Results from a Retrospective Cohort Study by Kai Liang, Chuan Wang, Fei Yan, Lingshu Wang, Tianyi He, Xiuping Zhang, Chengqiao Li, Weifang Yang, Zeqiang Ma, Aixia Ma, Xinguo Hou, Li Chen

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Annual Changes in the Ecological Environment and Microbial Community Structure and Their Correlation Analyses in the Core Area of Dalian National Sea Cucumber Stock Field of China by Xiaotong ZHU, Xiaojun RONG, Bin LI, Yingeng WANG, Jianlong GE, Meijie LIAO, Jinjin WANG, Yanqiang WU, Xintao ZHAO, Guojun SHI

“…The results of LEfSe analyses of water and sediment flora in different seasons showed that 73 and 66 significantly different bacteria were screened in water and sediment samples in different seasons, respectively (P < 0.05), among which the representative bacteria in the winter sediment contained Vibrionaceae and Psychromonadaceae, which highlights the potential threat of vibrio to the health of sea cucumber in winter. The correlation analysis between environmental factors and microbial community structure showed that temperature, pH, and salinity were the major environmental factors affecting the microbial community structure in the water body, whereas organic carbon, sulfide, heavy metal copper, and lead were the chief environmental factors affecting the microbial community structure in the sediments. …”
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Neuroimaging stratification reveals the striatal vulnerability to stress as a risk for schizophrenia by Xiaoqian Ma, Nana Feng, Lena Palaniyappan, Luolong Cao, Zixin Gu, Jujiao Kang, Liu Yuan, Lijun Ouyang, Yujue Wang, Chunwang Li, Ke Jin, Xiaogang Chen, Jianfeng Feng, Ying He, Qiang Luo

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Effects of traditional concurrent training and multicomponent training composed by strength training and dance classes on functional and cognitive capacity of older adults: a study... by Eduarda Blanco-Rambo, Nadyne Rubin, Marcelo Bandeira-Guimarães, Caroline Muraro, Débora Marques, Andressa Fergutz, Greyse Dornelles, Caroline Pietta-Dias, Eduardo Lusa Cadore

“… The combination of strength and aerobic training (concurrent training - TG) has been a widely used intervention for improving health outcomes. Also, dance has been well described as a great aerobic activity and can be an interesting option to compose an alternative multicomponent training program. …”
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Hubungan Lingkar Abdomen (Lingkar Perut) dengan Tekanan Darah by Marini Khairana Sari, Nur Indrawati Lipoeto, Rahmatina B. Herman

“…T</em><em>he objective of t</em><em>his study </em><em>wa</em><em>s to determine the correlation </em><em>of </em><em>abdominal circumference </em><em>on</em><em> blood pressure in the employees at Faculty of Medicine, Faculty of Dentistry and Faculty of Public Health</em><em> from </em><em>Andalas University. …”
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Phthalates esters disrupt demersal fish behavior: Unveiling the brain-gut axis impact by Liuqingqing Liu, Xinyao Li, Xianxiang Luo, Xiao Wang, Linjia Liu, Zixi Yuan, Cuizhu Sun, Hao Zheng, Elvis Genbo Xu, Fengmin Li

“…The widespread use of plasticizers like phthalate esters (PAEs) has led to environmental and health concerns. The neurobehavioral toxicity of these compounds in marine environments, particularly regulated by the “brain-gut” axis, remains unclear, especially concerning wild demersal fish of high ecological value. …”
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Effects of macitentan and selexipag across prognostic age groups in patients with pulmonary arterial hypertension by Richard Channick, MD, Sarah Medrek, MD, Marion Delcroix, MD, Sean Gaine, MD, Pavel Jansa, MD, PhD, Irene Lang, MD, Vallerie McLaughlin, MD, Sanjay Mehta, MD, Tomas Pulido, MD, Bhagavatula Sastry, MD, Rogerio Souza, MD, PhD, Adam Torbicki, MD, Carol Zhao, MS, Paul Strachan, MD, Peter Agron, PhD, Joseph Yen, PhD, Olivier Sitbon, MD, PhD

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Evaluation of efficacy and safety of generic tacrolimus (Suprotac®) compared to reference tacrolimus (Prograf^®) in kidney transplantation: a phase IV study by Behzad Einollahi, Mohsen Nafar, Mohammad Javanbakht, Amirhesam Alirezaei, Jalal Azmandian, Abbas Etminan, Mohammad Reza Ardalan, Jalal Etemadi, Roghayeh Akbari, Vahid Pourfarziani, Seyed Sadraddin Rasi Hashemi, Seyed Maryam Rahbar, Shahrzad Shahidi, Javid Safa, Hamid Tayyebi Khosroshahi, Sima Abedi Azar, Shahrzad Ossareh, Abdolamir Atapour, Bahareh Marghoob, Fatemeh Nazemian, Hamidreza Kafi, Araz Sabzvari

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Balancing act: optimizing blue light for melanogenesis while minimizing cellular damage in primary human skin cells by Augustin C. Barolet, Augustin C. Barolet, Augustin C. Barolet, Augustin C. Barolet, Brice Magne, Brice Magne, Brice Magne, Karel Ferland, Karel Ferland, Karel Ferland, Natallia E. Uzunbajakava, Daniel Barolet, Daniel Barolet, Lucie Germain, Lucie Germain, Lucie Germain

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Characterizing local forest structural complexity based on multi-platform and -sensor derived indicators by Patrick Kacic, Ursula Gessner, Christopher R. Hakkenberg, Stefanie Holzwarth, Jörg Müller, Kerstin Pierick, Dominik Seidel, Frank Thonfeld, Michele Torresani, Claudia Kuenzer

“…Global climate change, biodiversity decline, and increasing disturbances are challenging the health and resilience of forests. In this regard, forest managers have sought to promote enhanced structural complexity (ESC) which utilizes the positive correlation between structural complexity and biodiversity or resilience to inform management practices. …”
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Evaluation of in-vitro and in-silico antidiabetic potential, glucose metabolism, antioxidant, cytotoxicity and phytochemical content of Ipomoea bolusiana Schinz and Ipomoea crassip... by Garland Kgosi More, Nolitha Nkobole, Charmy Twala, Sechaba Machedi, Tebogo Amos Moswetsa, Ramakwala Christinah Chokwe

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Pembrolizumab, radiotherapy, and an immunomodulatory five-drug cocktail in pretreated patients with persistent, recurrent, or metastatic cervical or endometrial carcinoma: Results... by Emiel A. De Jaeghere, Sandra Tuyaerts, An M. T. Van Nuffel, Ann Belmans, Kris Bogaerts, Regina Baiden-Amissah, Lien Lippens, Peter Vuylsteke, Stéphanie Henry, Xuan Bich Trinh, Peter A. van Dam, Sandrine Aspeslagh, Alex De Caluwé, Eline Naert, Diether Lambrechts, An Hendrix, Olivier De Wever, Koen K. Van de Vijver, Frédéric Amant, Katrien Vandecasteele, Hannelore G. Denys

“…Grade ≥ 3 treatment-related adverse events were reported in 10 (55.6%) cervical cancer patients and 9 (36.0%) endometrial cancer patients. Health-related quality of life was generally stable over time. …”
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Vulnerability, Resilience and Adaptation of Lagos Coastal Communities to Flooding by Prince Emeka Ndimele, Akinloye Emmanuel Ojewole, Gabriel Olarinde Mekuleyi, Lateef Akorede Badmos, Christopher Monday Agosu, Emmanuel Sunday Olatunbosun, Oluseyi Olaide Lawal, Jamiu Adebayo Shittu, Olufemi Olabode Joseph, Kehinde Moyosola Ositimehin, Felix Chinsom Ndimele, Catherine Oluwalopeye Ojewole, Iman Olawunmi Abdulganiy, Odunayo Temitope Ayodele

“…Surviving in flood-prone cities like Lagos is a daunting task because flood affects livelihood, human health, and can even cause death. Specifically, the 2020 flood incidence in Nigeria affected about 40% of the local government areas, and 97% of the states, displacing over 120,000 persons and killing 68 persons aside from properties and farmlands destroyed. …”
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Effect of an Internet-Based Pilates Telerehabilitation Intervention in People With Multiple Sclerosis: Protocol for a Randomized Controlled Trial by Andrea Tacchino, Michela Ponzio, Paolo Confalonieri, Letizia Leocani, Matilde Inglese, Diego Centonze, Eleonora Cocco, Paolo Gallo, Damiano Paolicelli, Marco Rovaris, Loredana Sabattini, Gioacchino Tedeschi, Luca Prosperini, Francesco Patti, Edoardo Sessa, Elisabetta Pedrazzoli, Mario Alberto Battaglia, Giampaolo Brichetto

“… BackgroundPhysical activity (PA) has been recommended in multiple sclerosis (MS) to maintain good physical fitness and mental health, reduce the severity of symptoms and risk of relapse, and improve quality of life. …”
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Prevalence and Related Risk Factors of Intestinal Parasitosis among Private School-Going Pupils of Dharan Submetropolitan City, Nepal by Bijay Kumar Shrestha, Manita Tumbahangphe, Jenish Shakya, Anu Rai, Kabita Dhakal, Bidhya Dhungana, Romika Shrestha, Jyoti Limbu, Kabiraj Khadka, Santoshi Ghimire, Sujata Chauhan, Lata Chalise, Ashu Ghimire

“…The strong associated risk factors of intestinal parasitic infections were nail-biting habit, source of drinking water, biannual deworming, thumb-sucking, hand sanitation before having food and after toilet, knowledge of parents on parasitosis, health and sanitation, keeping cat/dog as pet, and wearing protective shoes during play (P=0.001). …”
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Population structure, floral diversity, habitat geography, and conservation status of Himalayan horse chestnut (Aesculus indica) in western Himalayan moist temperate forest ecosyst... by Urwa Irfan, Hamayun Shaheen, Muhammad Manzoor, Muhammad Manzoor, Sidra Nasar, Raja Waqar Ahmed Khan, Syed Waseem Gillani, Syed Waseem Gillani, Abdulwahed Fahad Alrefaei, Arbaz Attique, Asif Kamal, Sarah Abdul Razak, Malik Talha Riaz

“…It is recommended to formulate effective conservation measures such as promoting sustainable forest practices, controlling invasive species, restoring degraded habitats, controlled grazing practices, community-based conservation initiatives, sustainable harvesting policies, educating local communities, and promoting alternative livelihoods that support local communities to ensure the preservation of A. indica populations as well as ecosystem health. The study emphasizes the urgent need for effective conservation measures to safeguard A. indica and its associated floral diversity in the western Himalayan region.…”
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Meeting Report on “The International Congress on Autoimmune Pre-disease (2024)” by Justus Ohmes, Afsaneh Mehrpouyan, Julia Wimmer-Groß, Abdul Razzaque Ahmed, Kyle T. Amber, Swayanka Biswas, Angela Christiano, Shirin Emtenani, Stephanie Goletz, Jennifer Elisabeth Hundt, Laura Kirchhoff, Khalaf Kridin, Julie Lasselin, Matthias Laudes, Wing Yu Lee, Ralf J. Ludwig, Sripriya Murthy, Sadegh Mousavi, Tamas Nemeth, Mareike Neumann, Isa Popken, Rochi Saurabh, Alessia Maria Sbaraglia, Jovan Schanzenbacher, Carolin Schmidt, Leon F. Schmidt-Jimènez, Christian Willi Scheiner, Mareile Schlotfeldt, Nora Schoell, Farbod Bahreini, Sarah Stenger

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