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Persistent and emerging threats to Arctic biodiversity and ways to overcome them: a horizon scan
Published 2025-01-01Get full text
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52044
Sdd3 regulates the biofilm formation of Candida albicans via the Rho1-PKC-MAPK pathway
Published 2025-02-01“…As an upstream component of the pathway and lacking a homolog in mammals, Sdd3 has the potential to serve as an antifungal target for biofilm infections.IMPORTANCEThe human fungal pathogen Candida albicans is categorized as a critical priority pathogen on the World Health Organization’s Fungal Priority Pathogens List. …”
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52045
Dual role of ramR mutation in enhancing immune activation and elevating eravacycline resistance in Klebsiella pneumoniae
Published 2024-12-01“…Abstract The rise of Klebsiella pneumoniae resistant to last‐resort antimicrobials poses an urgent threat to global health. The ramR‐ramA regulatory system critically influences drug resistance by regulating the AcrAB‐TolC efflux pump, which also plays a crucial role in the pathogenicity of K. pneumoniae. …”
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Projeto de extensão universitária ‘SaúHDe renal’: Efeitos na qualidade de vida e na aptidão física
Published 2025-02-01“…Palavras-chave: Exercício Físico; Forma Física; Reabilitação; Força Muscular; Insuficiência Renal Crônica University extension project renal health: Effects on quality of life and physical fitness Abstract: This study aimed to analyze the effects of a university extension program based on physical training (PT) on the physical fitness and quality of life (QoL) of patients on hemodialysis (HD). …”
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52048
Jaringan Syaraf Tiruan Perambatan Balik untuk Klasifikasi Covid-19 Berbasis Tekstur Menggunakan Orde Pertama Berdasarkan Citra Chest X-Ray
Published 2022-08-01“…The Covid-19 pandemic has had a fatal impact on public health. It is crucial to detect positive cases as early as possible to prevent the further spread of this virus. …”
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52049
Unravelling hybridization in Phytophthora using phylogenomics and genome size estimation
Published 2021-07-01Get full text
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Integrative deep immune profiling of the elderly reveals systems-level signatures of aging, sex, smoking, and clinical traitsResearch in context
Published 2025-02-01“…Our findings highlight clinically relevant immune signatures that enhance our understanding of aging-related diseases and could guide future research into new treatments, offering translational insights into human health and aging. Funding: Deutsche Forschungsgemeinschaft (DFG, German Research Foundation) under Germany's Excellence Strategy—EXC 2155—project number 390874280.…”
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52051
Optimal dietary vitamin E level facilitates ovarian development of female largemouth bass (Micropterus salmoides) broodstock
Published 2025-04-01“…The current study was designed to explore the effects of dietary vitamin E on the ovarian development and health of female largemouth bass (Micropterus salmoides). …”
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A pan-immune panorama of bacterial pneumonia revealed by a large-scale single-cell transcriptome atlas
Published 2025-01-01“…Abstract Bacterial pneumonia is a significant public health burden, contributing to substantial morbidity, mortality, and healthcare costs. …”
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52053
Inflammatory Gene Signature Identified by Machine Algorithms Reveals Novel Biomarkers of Coronary Artery Disease
Published 2025-02-01“…Xing Liu,1,* Yuanyuan Zhang,1,* Yan Wang,2,3,* Yanfeng Xu,2,4,5 Wenhao Xia,2,5– 7 Ruiming Liu,4,5 Shiyue Xu2,5,6 1Department of Cardiology, The Third Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, People’s Republic of China; 2Department of Hypertension and Vascular Disease, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, People’s Republic of China; 3Health Management Center, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, People’s Republic of China; 4Laboratory of General Surgery, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, People’s Republic of China; 5National - Guangdong Joint Engineering Laboratory for Diagnosis and Treatment of Vascular Diseases, Sun Yat-sen University, Guangzhou, Guangdong, People’s Republic of China; 6NHC Key Laboratory of Assisted Circulation, Sun Yat-sen University, Guangzhou, Guangdong, People’s Republic of China; 7Department of Cardiovascular Medicine, Guangxi Hospital Division of The First Affiliated Hospital of Sun Yat-sen University, Nanning, Guangxi, People’s Republic of China*These authors contributed equally to this workCorrespondence: Shiyue Xu, Department of Hypertension and Vascular Disease, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, 510080, People’s Republic of China, Email xushy25@mail.sysu.edu.cn Ruiming Liu, Laboratory of General Surgery, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, 510080, People’s Republic of China, Email liuruim@mail2.sysu.edu.cnPurpose: Inflammatory activation of immune cells plays a pivotal role in the development of coronary artery diseases (CAD). …”
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Two-Layer Retrieval-Augmented Generation Framework for Low-Resource Medical Question Answering Using Reddit Data: Proof-of-Concept Study
Published 2025-01-01“…ObjectiveThis paper aims to develop a retrieval-augmented generation (RAG) architecture for medical question answering pertaining to clinicians’ queries on emerging issues associated with health-related topics, using user-generated medical information on social media. …”
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Effect of Scalp-acupuncture Treatment on Language Reorganization in Poststroke Aphasia:A Functional Near-Infrared Spectroscopy
Published 2024-01-01“…The control group received conventional speech rehabilitation therapy (speech training,language imitation,figure-word matching,numerical reading/writing/calculating and social communication skills training,etc. ),medication and health education; the observation group received scalp acupuncture on the basis of the control group,selecting the language function area (2/5 below the parietal anterior temporal diagonal line and the anterior temporal line),and then stabbing it either flatly or obliquely,and then retained for 30 minutes post-needling sensation (deqi),and the speech and language treatment was carried out by the speech rehabilitation therapist in the process. …”
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Effect of regional crosstalk between sympathetic nerves and sensory nerves on temporomandibular joint osteoarthritic pain
Published 2025-01-01“…Abstract Temporomandibular joint osteoarthritis (TMJ-OA) is a common disease often accompanied by pain, seriously affecting physical and mental health of patients. Abnormal innervation at the osteochondral junction has been considered as a predominant origin of arthralgia, while the specific mechanism mediating pain remains unclear. …”
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Artificial intelligence for quantifying immune infiltrates interacting with stroma in colorectal cancer
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Diagnosis and Treatment of Patients with Autoimmune Hepatitis (Experts’ Agreement)
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Plasma EphA2 level is a superior biomarker to Del-1 for sepsis diagnosis and prognosis
Published 2025-01-01“…Sepsis severity was assessed using the Acute Physiology and Chronic Health Evaluation (APACHE) II and the Sequential Organ Failure Assessment (SOFA) scores.ResultsThe Median plasma EphA2 levels increased progressively from healthy controls to SIRS and sepsis cases (154.29, 293.52, and 554.24 pg/mL; all p < 0.05). …”
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