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  1. 52041
  2. 52042
  3. 52043
  4. 52044

    Sdd3 regulates the biofilm formation of Candida albicans via the Rho1-PKC-MAPK pathway by Li Mei Pang, Guisheng Zeng, Eve Wai Ling Chow, Xiaoli Xu, Ning Li, Yee Jiun Kok, Shu Chen Chong, Xuezhi Bi, Jiaxin Gao, Chaminda Jayampath Seneviratne, Yue Wang

    Published 2025-02-01
    “…As an upstream component of the pathway and lacking a homolog in mammals, Sdd3 has the potential to serve as an antifungal target for biofilm infections.IMPORTANCEThe human fungal pathogen Candida albicans is categorized as a critical priority pathogen on the World Health Organization’s Fungal Priority Pathogens List. …”
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  5. 52045

    Dual role of ramR mutation in enhancing immune activation and elevating eravacycline resistance in Klebsiella pneumoniae by Wei Yu, Peiyao Jia, Xiaobing Chu, Shengjie Li, Xinmiao Jia, Ying Zhu, Xiaoyu Liu, Yingchun Xu, Qiwen Yang

    Published 2024-12-01
    “…Abstract The rise of Klebsiella pneumoniae resistant to last‐resort antimicrobials poses an urgent threat to global health. The ramR‐ramA regulatory system critically influences drug resistance by regulating the AcrAB‐TolC efflux pump, which also plays a crucial role in the pathogenicity of K. pneumoniae. …”
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  6. 52046
  7. 52047

    Projeto de extensão universitária ‘SaúHDe renal’: Efeitos na qualidade de vida e na aptidão física by Jordana Letícia Buratti, Thaís Severo Dutra, Moane Marchesan Krug, Clara Suemi da Costa Rosa, Paulo Ricardo Moreira, Robelius De-Bortoli, Rodrigo de Rosso Krug

    Published 2025-02-01
    “…Palavras-chave: Exercício Físico; Forma Física; Reabilitação; Força Muscular; Insuficiência Renal Crônica University extension project renal health: Effects on quality of life and physical fitness    Abstract: This study aimed to analyze the effects of a university extension program based on physical training (PT) on the physical fitness and quality of life (QoL) of patients on hemodialysis (HD). …”
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  8. 52048

    Jaringan Syaraf Tiruan Perambatan Balik untuk Klasifikasi Covid-19 Berbasis Tekstur Menggunakan Orde Pertama Berdasarkan Citra Chest X-Ray by Muchtar Ali Setyo Yudono, Eki Ahmad Zaki Hamidi, Jumadi Jumadi, Abdul Haris Kuspranoto, Aryo De Wibowo Muhammad Sidik

    Published 2022-08-01
    “…The Covid-19 pandemic has had a fatal impact on public health. It is crucial to detect positive cases as early as possible to prevent the further spread of this virus. …”
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  9. 52049
  10. 52050

    Integrative deep immune profiling of the elderly reveals systems-level signatures of aging, sex, smoking, and clinical traitsResearch in context by Lennart Riemann, Rodrigo Gutierrez, Ivan Odak, Joana Barros-Martins, Lennart M. Roesner, Ximena Leon Lara, Christine Falk, Thomas F. Schulz, Gesine Hansen, Thomas Werfel, Reinhold Förster, Berislav Bošnjak, Felix Jenniches, Norman Klopp, Till Robin Lesker, Martin Stangel

    Published 2025-02-01
    “…Our findings highlight clinically relevant immune signatures that enhance our understanding of aging-related diseases and could guide future research into new treatments, offering translational insights into human health and aging. Funding: Deutsche Forschungsgemeinschaft (DFG, German Research Foundation) under Germany's Excellence Strategy—EXC 2155—project number 390874280.…”
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  11. 52051

    Optimal dietary vitamin E level facilitates ovarian development of female largemouth bass (Micropterus salmoides) broodstock by Qiuyu Gao, Qiao Feng, Dong Zhou, Zhili Ding, Changle Qi, Youqin Kong, Qiyou Xu

    Published 2025-04-01
    “…The current study was designed to explore the effects of dietary vitamin E on the ovarian development and health of female largemouth bass (Micropterus salmoides). …”
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  12. 52052

    A pan-immune panorama of bacterial pneumonia revealed by a large-scale single-cell transcriptome atlas by Kun Xiao, Yan Cao, Zhihai Han, Yuxiang Zhang, Laurence Don Wai Luu, Liang Chen, Peng Yan, Wei Chen, Jiaxing Wang, Ying Liang, Xin Shi, Xiuli Wang, Fan Wang, Ye Hu, Zhengjun Wen, Yong Chen, Yuwei Yang, Haotian Yu, Lixin Xie, Yi Wang

    Published 2025-01-01
    “…Abstract Bacterial pneumonia is a significant public health burden, contributing to substantial morbidity, mortality, and healthcare costs. …”
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  13. 52053

    Inflammatory Gene Signature Identified by Machine Algorithms Reveals Novel Biomarkers of Coronary Artery Disease by Liu X, Zhang Y, Wang Y, Xu Y, Xia W, Liu R, Xu S

    Published 2025-02-01
    “…Xing Liu,1,* Yuanyuan Zhang,1,* Yan Wang,2,3,* Yanfeng Xu,2,4,5 Wenhao Xia,2,5– 7 Ruiming Liu,4,5 Shiyue Xu2,5,6 1Department of Cardiology, The Third Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, People’s Republic of China; 2Department of Hypertension and Vascular Disease, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, People’s Republic of China; 3Health Management Center, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, People’s Republic of China; 4Laboratory of General Surgery, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, People’s Republic of China; 5National - Guangdong Joint Engineering Laboratory for Diagnosis and Treatment of Vascular Diseases, Sun Yat-sen University, Guangzhou, Guangdong, People’s Republic of China; 6NHC Key Laboratory of Assisted Circulation, Sun Yat-sen University, Guangzhou, Guangdong, People’s Republic of China; 7Department of Cardiovascular Medicine, Guangxi Hospital Division of The First Affiliated Hospital of Sun Yat-sen University, Nanning, Guangxi, People’s Republic of China*These authors contributed equally to this workCorrespondence: Shiyue Xu, Department of Hypertension and Vascular Disease, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, 510080, People’s Republic of China, Email xushy25@mail.sysu.edu.cn Ruiming Liu, Laboratory of General Surgery, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, 510080, People’s Republic of China, Email liuruim@mail2.sysu.edu.cnPurpose: Inflammatory activation of immune cells plays a pivotal role in the development of coronary artery diseases (CAD). …”
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  14. 52054

    Two-Layer Retrieval-Augmented Generation Framework for Low-Resource Medical Question Answering Using Reddit Data: Proof-of-Concept Study by Sudeshna Das, Yao Ge, Yuting Guo, Swati Rajwal, JaMor Hairston, Jeanne Powell, Drew Walker, Snigdha Peddireddy, Sahithi Lakamana, Selen Bozkurt, Matthew Reyna, Reza Sameni, Yunyu Xiao, Sangmi Kim, Rasheeta Chandler, Natalie Hernandez, Danielle Mowery, Rachel Wightman, Jennifer Love, Anthony Spadaro, Jeanmarie Perrone, Abeed Sarker

    Published 2025-01-01
    “…ObjectiveThis paper aims to develop a retrieval-augmented generation (RAG) architecture for medical question answering pertaining to clinicians’ queries on emerging issues associated with health-related topics, using user-generated medical information on social media. …”
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  15. 52055

    Effect of Scalp-acupuncture Treatment on Language Reorganization in Poststroke Aphasia:A Functional Near-Infrared Spectroscopy by LIN Bingbing, NI Jinglei, XIONG Xiao, HUANG Yunshi, HUANG Jia

    Published 2024-01-01
    “…The control group received conventional speech rehabilitation therapy (speech training,language imitation,figure-word matching,numerical reading/writing/calculating and social communication skills training,etc. ),medication and health education; the observation group received scalp acupuncture on the basis of the control group,selecting the language function area (2/5 below the parietal anterior temporal diagonal line and the anterior temporal line),and then stabbing it either flatly or obliquely,and then retained for 30 minutes post-needling sensation (deqi),and the speech and language treatment was carried out by the speech rehabilitation therapist in the process. …”
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  16. 52056
  17. 52057

    Effect of regional crosstalk between sympathetic nerves and sensory nerves on temporomandibular joint osteoarthritic pain by Zhangyu Ma, Qianqian Wan, Wenpin Qin, Wen Qin, Janfei Yan, Yina Zhu, Yuzhu Wang, Yuxuan Ma, Meichen Wan, Xiaoxiao Han, Haoyan Zhao, Yuxuan Hou, Franklin R. Tay, Lina Niu, Kai Jiao

    Published 2025-01-01
    “…Abstract Temporomandibular joint osteoarthritis (TMJ-OA) is a common disease often accompanied by pain, seriously affecting physical and mental health of patients. Abnormal innervation at the osteochondral junction has been considered as a predominant origin of arthralgia, while the specific mechanism mediating pain remains unclear. …”
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  18. 52058
  19. 52059
  20. 52060

    Plasma EphA2 level is a superior biomarker to Del-1 for sepsis diagnosis and prognosis by Eun Hye Lee, Mi Hwa Shin, Se Hyun Kwak, Ji Soo Choi, Ah Young Leem, Su Hwan Lee, Kyung Soo Chung, Young Sam Kim, Sang-Guk Lee, Moo Suk Park

    Published 2025-01-01
    “…Sepsis severity was assessed using the Acute Physiology and Chronic Health Evaluation (APACHE) II and the Sequential Organ Failure Assessment (SOFA) scores.ResultsThe Median plasma EphA2 levels increased progressively from healthy controls to SIRS and sepsis cases (154.29, 293.52, and 554.24 pg/mL; all p < 0.05). …”
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