A novel approach for target deconvolution from phenotype-based screening using knowledge graph by Xiaohong Wang, Meifang Zhang, Jianliang Xu, Xin Li, Jing Xiong, Haowei Cao, Fangkun Dou, Xue Zhai, Hua Sun

Get full text

Network pharmacology uncovers that secoisolariciresinol diglucoside ameliorate premature ovarian insufficiency via PI3K/Akt pathway by Yiqing Zhang, Xialu Liu, Zitong Zheng, Haiqiang Huang, Yurou Wang, Shuqin Wu, Yuan Shu, Yuxin Yang, Yufei Zhong, Pengfei Liao, Yongsong Wang, Zezheng Pan

“…Abstract As one of the essential lignan derivative found in traditional Chinese medicinal herbs, secoisolariciresinol diglucoside (SDG) was proved to promote women’s health through its phytoestrogenic properties. Increasingly studies indicated that this compound could be a potential drug capable of preventing estrogen-related diseases. …”
Get full text

Real-life use of delamanid: results from the European post-authorisation safety study by N. Schönfeld, L. Barkane, I. Davoliene, M. Danilovits, S. Miliauskas, F. Ader, O.M. Kon, C. Lange, A. Duvignaud, M. Heiss-Neumann, N. Hittel, N. Lazarević, I. Knebel, A. Martin, B. Eschenbach, E. van Heumen, V. George

Get full text

Factors affecting hematological abnormality in HIV-infected patients at Dr. Wahidin Sudirohusodo Hospital Makassar, Indonesia by I. Nyoman Yogi Wiraguna, Andi Fachruddin Benyamin, Risna Halim, Syakib Bakri, Sahyuddin Saleh, Hasyim Kasim, Andi Alfian Zainuddin

Get full text

miR-24-3p/FGFR3 Signaling as a Novel Axis Is Involved in Epithelial-Mesenchymal Transition and Regulates Lung Adenocarcinoma Progression by Pengyu Jing, Nan Zhao, Nianlin Xie, Mingxiang Ye, Yong Zhang, Zhipei Zhang, Mengyang Li, Xiaofeng Lai, Jian Zhang, Zhongping Gu

Get full text

Ophiostomatoid fungi associated with pine bark beetles and infested pines in south-eastern Australia, including Graphilbum ipis-grandicollis sp. nov. by Conrad Trollip, Angus J. Carnegie, Quang Dinh, Jatinder Kaur, David Smith, Ross Mann, Brendan Rodoni, Jacqueline Edwards

“…To achieve this, we reviewed Australian plant pathogen reference collections, and analysed samples collected during forest health surveillance programs from the major pine growing regions in south-eastern Australia. …”
Get full text

The impact of emotional abuse on Internet addiction in Chinese children: the sequential mediation roles of emotional dysregulation and regulatory emotional self-efficacy by Wang Liu, Wang Liu, Jie Huang, Jie Huang, Yu-Ling Li, Yu-Ling Li, Xiang Gao, Xiang Gao, Zi-Yi Xu, Zi-Yi Xu, Yong-Hui Li, Yong-Hui Li

Get full text

Klebsiella pneumoniae employs a type VI secretion system to overcome microbiota-mediated colonization resistance by Andrew S. Bray, Christopher A. Broberg, Andrew W. Hudson, Weisheng Wu, Ravinder K. Nagpal, Maidul Islam, Juan D. Valencia-Bacca, Fawaz Shahid, Giovanna E. Hernandez, Noah A. Nutter, Kimberly A. Walker, Emma F. Bennett, Taylor M. Young, Andrew J. Barnes, David A. Ornelles, Virginia L. Miller, M. Ammar Zafar

Get full text

Effects of Compressive and Tensile Strain on Macrophages during Simulated Orthodontic Tooth Movement by Agnes Schröder, Paul Käppler, Ute Nazet, Jonathan Jantsch, Peter Proff, Fabian Cieplik, James Deschner, Christian Kirschneck

“…During orthodontic tooth movement (OTM) to therapeutically correct the position of misaligned teeth, thus improving oral health and quality of life, fibroblasts, macrophages, and other immune cells within the periodontal ligament (PDL), which connects a tooth to its surrounding bone, are exposed to compressive and tensile strain. …”
Get full text

Use of ascorbic acid (vitamin C) and alpha tocopherol (vitamin E) as adjuvants in the treatment of neuropathic pain by Fernando Antonio Silva de Azevedo-Filho, Yasmim Machado Chaves de Castro, Marcos Pinho Cerqueira, Thiago Arruda Rodrigues, Yussef Ali-Abdouni, Patrícia Maria de Moraes Barros Fucs

“…At the initial assessment, the patients answered the Quick Disabilities of the Arm, Shoulder and Hand (Quick-DASH) to assess upper limb functionality; quality of life was described using the World Health Organization Quality of Life-Bref (WHOQOL-bref) and pain assessment was measured using the visual analogue scale (VAS). …”
Get full text

Association between Serum Cystatin C and Diabetic Foot Ulceration in Patients with Type 2 Diabetes: A Cross-Sectional Study by Jie Zhao, Wuquan Deng, Yuping Zhang, Yanling Zheng, Lina Zhou, Johnson Boey, David G. Armstrong, Gangyi Yang, Ziwen Liang, Bing Chen

Get full text

Etiological, Clinical, and Epidemiological Characteristics of Acute Viral Gastroenteritis in an Adult Population in a Tertiary Level Hospital in Spain by Sara Herranz-Ulldemolins, Anna Sellarès-Crous, Miriam J. Álvarez-Martínez, M. Eugenia Valls, Marta Aldea Novo, Anna Vilella Morató, Laura Rodriguez, Mireia Navarro, Roser Vendrell, Josep Barrachina, Miguel J. Martínez, M. Ángeles Marcos

“…Abstract Introduction Acute gastroenteritis (AGE) represents a significant global health burden, with enteric viruses being a leading cause of gastroenteritis worldwide. …”
Get full text

Comparing the Coagulation Performance of Rice Husk, Cypress Leaves, and Eucalyptus Leaves Powders with That of Alum in Improving the Turbidity and pH of Some Local Water Sources in... by Cornelius Tsamo, Eric Fru Zama, Ngu Elton Yerima, Ajingne Nelson Mandela Fuh

“…Water with turbidity and pH values within the World Health Organization’s guideline value of < 5 NTU and 6.5–8.5, respectively, were obtained using studied low cost and locally available biocoagulants.…”
Get full text

An Effective Iterative Process Utilizing Transcendental Sine Functions for the Generation of Julia and Mandelbrot Sets by Khairul Habib Alam, Yumnam Rohen, Anita Tomar, Naeem Saleem, Maggie Aphane, Asima Razzaque

Get full text

Exosome-loaded tannic acid–thioctic acid hydrogel enhances wound healing in coagulation disorders by Yuesheng Tu, Weixin Zheng, Zichu Ding, Jie Xiang, Qinfeng Yang, Yuchen Liu, Jue Cao, Yuling Shen, Zinan Tang, Shen Lin, Lei Fan, Yaowen Xu, Bin Chen

Get full text

The occurrence and safety evaluation of phthalic acid esters in Oasis agricultural soils of Xinjiang, China by Hejiang Liu, Xiuting Liu, Kai Wang, Xingwang Ma, Haihe Gao, Xuejun Liu, Changrong Yan

“…Furthermore, the concentrations of all PAEs were below China's soil quality risk control standards, and the non-carcinogenic risks to both adults and children were below the current threshold, indicating relatively low risks to both the human health and the environment. These findings are crucial for understanding the presence and safety evaluation of PAEs in Xinjiang Oasis farmland, and they provide important reference data for managing and controlling PAE contamination in agricultural soils.…”
Get full text

SHASI-ML: a machine learning-based approach for immunogenicity prediction in Salmonella vaccine development by Ottavia Spiga, Ottavia Spiga, Ottavia Spiga, Anna Visibelli, Francesco Pettini, Bianca Roncaglia, Annalisa Santucci, Annalisa Santucci, Annalisa Santucci

“…IntroductionAccurate prediction of immunogenic proteins is crucial for vaccine development and understanding host-pathogen interactions in bacterial diseases, particularly for Salmonella infections which remain a significant global health challenge.MethodsWe developed SHASI-ML, a machine learning-based framework for predicting immunogenic proteins in Salmonella species. …”
Get full text

Reconstruction of built-up urban areas taking into account accessibility to limited mobility population groups: the case of Krasnodar by E. P. Shnurnikova, S. P. Gorzova, V. V. Kononenko

“…Uncomfortable housing conditions can hinder therapeutic and preventive care aimed at health improvement, and physical barriers in housing and yard spaces can hamper the socialization of disabled residents. …”
Get full text

Macrofilaricidal Activity in Wuchereria bancrofti after 2 Weeks Treatment with a Combination of Rifampicin plus Doxycycline by Alexander Yaw Debrah, Sabine Mand, Yeboah Marfo-Debrekyei, Linda Batsa, Anna Albers, Sabine Specht, Ute Klarmann, Kenneth Pfarr, Ohene Adjei, Achim Hoerauf

Get full text

Temporary spinal cord stimulation combined with lidocaine patch for postherpetic neuralgia in the elderly: a controlled study by Yun Li, Chunhui Hao, Shengtao Wang, Feng Qiu, Xuli Zhao, Tao Sun

Get full text