Phosphorylation of SIRT7 by ATM causes DNA mismatch repair downregulation and adaptive mutability during chemotherapy by Lianhui Sun, Guangjian Fan, Zhuqing Zhang, Dong Chang, Xiaoyu Zhang, Tongqing Zhang, Jichuan Geng, Xiaoxia Zhang, Menghan Lin, Chen Hu, Jiaqi Zhou, Mengxue Wang, Liu Cao, Mary Zhang, Baokun He, Shengping Zhang, Chuangui Wang

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HER-SAFE study design: an open-label, randomised controlled trial to investigate the safety of withdrawal of pharmacological treatment for recovered HER2-targeted therapy-related c... by Robin Chung, James C Moon, Alexander R Lyon, Charlotte H Manisty, Muhummad Sohaib Nazir, Malcolm Walker, Peter Kellman, Benjamin Dowsing, Daniel Chen, Jessica Artico, Mark Westwood, Hakim-Moulay Dehbi, Rebecca Roylance, Tom Crake, Peter Schmid, Arjun Ghosh, Maria Sol Andres, Joanna Pedra, Orla Worn

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Clinical characteristics and frailty status in heart failure with preserved vs. reduced ejection fraction by Tomoyuki Hamada, Toru Kubo, Kazuya Kawai, Yoko Nakaoka, Toshikazu Yabe, Takashi Furuno, Eisuke Yamada, Hiroaki Kitaoka, Kochi YOSACOI study

“…Physical frailty was diagnosed on the basis of the Japanese version of Cardiovascular Health (J‐CHS) Study criteria. Patients for whom left ventricular ejection fraction data were not available (n = 19), patients with heart failure with mildly reduced ejection fraction (n = 172), and patients who were not assessed by the J‐CHS criteria (n = 225) were excluded. …”
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PRACTICAL TRAINING OF OFFICERS OF THE STATE FIRE SERVICE THROUGH GAME-BASED LEARNING by V. V. Bulgakov, A. A. Lazarev, E. P. Konovalenko, T. A. Mochalova

“…It is common knowledge that lives and health of people as well as safe operation of various infrastructures depend on the high level of professionalism of the staff responsible for safety. …”
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Prediksi Produksi Biofarmaka Menggunakan Model Fuzzy Time Series dengan Pendekatan Percentage Change dan Frequency Based Partition by Dwi Ekasari Harmadji, Solikhin Solikhin, Uky Yudatama, Agus Purwanto

“…Consumers worldwide, especially in Indonesia, are gravitating towards healthier food and health goods. So the demand for medicinal plants as raw materials increases. …”
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PCR-detection rates of T. pallidum ssp. pallidum in swab samples from the Czech Republic (2004–2022): Combined RPR, IgM, and PCR tests efficiently detect active syphilis by Eliška Vrbová, Petra Pospíšilová, Eliška Dastychová, Martina Kojanová, Miluše Kreidlová, Daniela Vaňousová, Filip Rob, Přemysl Procházka, Alena Krchňáková, Vladimír Vašků, Radim Strnadel, Olga Faustmannová, Monika Dvořáková Heroldová, Ivana Kuklová, Hana Zákoucká, David Šmajs

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Iron Overload in Transfusion-Dependent Indonesian Thalassemic Patients by Pandji Irani Fianza, Anita Rahmawati, Sri Hudaya Widihastha, Shofura Afifah, Mohammad Ghozali, Andre Indrajaya, Dilli Marayuzan Akbar Pratama, Dimmy Prasetya, Teddy Arnold Sihite, Mas Rizky A. A. Syamsunarno, Djatnika Setiabudi, Suthat Fucharoen, Ramdan Panigoro

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Increased Chemokine Production is a Hallmark of Rhesus Macaque Natural Killer Cells Mediating Robust Anti-HIV Envelope-Specific Antibody-Dependent Cell-Mediated Cytotoxicity by Junsuke Nohara, Tyler Evangelous, Madison Berry, Whitney Beck, Sarah Mudrak, Shalini Jha, R. Keith Reeves, Kevin J. Wiehe, Justin Pollara, Georgia Tomaras, Todd Bradley, Guido Ferrari

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A Case of Undiagnosed HIV Infection in a 57-Year-Old Woman with Multiple Myeloma: Consequences on Chemotherapy Efficiency and Safety by I. Poizot-Martin, S. Brégigeon, C. Tamalet, R. Bouabdallah, O. Zaegel-Faucher, V. Obry-Roguet, A. Ivanova, C.E. Cano, C. Solas

“…Non-AIDS-defining cancers represent a rising health issue among HIV-infected patients. Nevertheless, HIV testing is not systematic during the initial cancer staging. …”
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Adequate Reporting Among Ventral Hernia Repair Operative Reports: A Cross-Sectional Study of Prevalence of Details and Association With Clinical Outcomes by Said Maldonado, BS, Nicole B. Lyons, MD, Jonathan S. Lall, BS, J. Scott Zimmerle, MBA, Brendan Rosamond, BS, Ashlynn Mills, BS, Yoolim Alex Seo, BS, Angelica Calderon Rodriguez, BS, Rainna Coelho, MD, Natalia Cavagnaro, MD, Zuhair Ali, MD, Mike K. Liang, MD

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Strong inhibitory effects of Desmodesmus sp. on Microcystis blooms: Potential as a biological control agent in aquaculture by Bo Yang, Yuhua Li, Zihan Wang, Zhiguang Yue, Junqi Wen, Xueqin Zhao, Hu Zhang, Xianfeng Wang, Xiufen Wang, Man Zhang

“…Microcystis blooms in aquaculture present a significant threat to economic interests and human health. The method of ‘algae suppression’ has shown potential in mitigating these blooms, with the inhibitory capabilities of the introduced algal species playing a crucial role. …”
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Adverse events of hepatic anti-fibrotic agents in phase 3 and above clinical trials: a descriptive analysis of the WHO-VigiAccess database by Yuwei Liu, Yuwei Liu, Xu Zhao, Xu Zhao, Xinrui Wang, Xinrui Wang, Qiang Zhou, Qiang Zhou

“…This study assessed ADRs associated with anti-fibrotic agents as reported in the World Health Organization (WHO) VigiAccess database and compared the adverse reaction characteristics of these agents for optimizing therapeutic strategies.MethodsA detailed search was conducted on ClinicalTrial.gov to identify phase 3 or 4 clinical trials involving hepatic anti-fibrotic agents. …”
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Evaluation of host immune responses to Mycobacteriophage Fionnbharth by route of delivery by Thomas Smytheman, Tiffany Pecor, Dana E. Miller, Debora Ferede, Suhavi Kaur, Matthew H. Harband, Hazem F. M. Abdelaal, Carlos A. Guerrero-Bustamante, Krista G. Freeman, Whitney E. Harrington, Lisa M. Frenkel, Graham F. Hatfull, Rhea N. Coler, Sasha E. Larsen

“…Focused intervention strategies to block transmission would significantly reduce the global health burden of TB. Mycobacteriophages (phages) are a sorely underutilized biologic therapy for the pathogen M.tb, and here we aimed to address outstanding questions about their utility for clinical applications. …”
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Carbohydrate ligand engagement with CD11b enhances differentiation of tumor-associated myeloid cells for immunotherapy of solid cancers by Mei Zhang, Veronique Roche, Victor Sandoval, Claire Wolford, Zachary Senders, Julian Anthony Kim, Susan Pereira Ribeiro, Alex Yicheng Huang, Rafick-Pierre Sekaly, Joshua Lyons

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Impaired peroxisomal beta-oxidation in microglia triggers oxidative stress and impacts neurons and oligodendrocytes by Ali Tawbeh, Catherine Gondcaille, Fatima-Ezzahra Saih, Quentin Raas, Damien Loichot, Yannick Hamon, Céline Keime, Alexandre Benani, Francesca Di Cara, Mustapha Cherkaoui-Malki, Pierre Andreoletti, Stéphane Savary

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From Anatase TiO₂ Nano-Cuboids to Nano-Bipyramids: Influence of Particle Shape on the TiO₂ Photocatalytic Degradation of Emerging Contaminants in Contrasted W... by Humaira Asghar, Daphne Hermosilla, Francesco Pellegrino, Virginia Muelas-Ramos, Christian de los Ríos, Antonio Gascó, Valter Maurino, Muhammad Ahsan Iqbal

“…Water pollution, resulting from industrial effluents, agricultural runoff, and pharmaceutical residues, poses serious threats to ecosystems and human health, highlighting the need for innovative approaches to effective remediation, particularly for non-biodegradable emerging pollutants. …”
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Increased methane production associated with community shifts towards Methanocella in paddy soils with the presence of nanoplastics by Zhibin He, Yarong Hou, Ying Li, Qicheng Bei, Xin Li, Yong-Guan Zhu, Werner Liesack, Matthias C. Rillig, Jingjing Peng

“…Abstract Background Planetary plastic pollution poses a major threat to ecosystems and human health in the Anthropocene, yet its impact on biogeochemical cycling remains poorly understood. …”
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RBD-displaying OMV nanovaccine boosts immunity against SARS-CoV-2 by Rang Feng, Ruo-Yi Xue, Chang Liu, Guo-Cheng Li, Yan Deng, Zhe Jin, Jing-Yi Liu, Shan-Shan Zhang, Hao Cheng, Man-Ying Guo, Quan-Ming Zou, Hai-Bo Li

“…Abstract Background Since the emergence of SARS-CoV-2, the causative agent of COVID-19, the global health landscape has confronted an unprecedented and formidable challenge. …”
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Mycochemistry, antioxidant, anticancer activity, and molecular docking of compounds of F12 of ethyl acetate extract of Astraeus asiaticus with BcL2 and Caspase 3 by Swapan Kumar Ghosh, Koushik Pandey, Madhuparna Ghosh, Pradip Kumar Sur

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A Novel Artificial Intelligence–Enhanced Digital Network for Prehospital Emergency Support: Community Intervention Study by Ji Hoon Kim, Min Joung Kim, Hyeon Chang Kim, Ha Yan Kim, Ji Min Sung, Hyuk-Jae Chang

“…While the system demonstrated improvements for certain patient groups facing transfer challenges, further research and modifications are necessary to fully realize its benefits in diverse health care contexts. Trial RegistrationClinicalTrials.gov NCT04829279; https://clinicaltrials.gov/study/NCT04829279…”
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