Comparison of effectiveness in smoking cessation using nicotine replacement therapy and electronic cigarettes by Adrianna Kopaczyńska, Katarzyna Szafrańska, Szymon Niemirka, Aleksandra Janiak, Kinga Dominiczak, Łukasz Grądalski, Filip Dębicki

“… Nicotine, a potent psychoactive alkaloid found in tobacco leaves, is recognized for its high addictive potential, contributing to over 8 million deaths annually according to the World Health Organization. This article explores the complexities of nicotine addiction, highlighting its dual nature as both a learned behavior and a physical dependence. …”
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Caution when using network partners for target identification in drug discovery by Dandan Tan, Yiheng Chen, Yann Ilboudo, Kevin Y.H. Liang, Guillaume Butler-Laporte, J. Brent Richards

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YTHDF2 in peritumoral hepatocytes mediates chemotherapy-induced antitumor immune responses through CX3CL1-mediated CD8+ T cell recruitment by Zhenyun Yang, Xin Wang, Yizhen Fu, Weijie Wu, Zili Hu, Qingyang Lin, Wei Peng, Yangxun Pan, Juncheng Wang, Jinbin Chen, Dandan Hu, Zhongguo Zhou, Li Xu, Yaojun Zhang, Jiajie Hou, Minshan Chen

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Pathological Microenvironment‐Remodeling Nanoparticles to Alleviate Liver Fibrosis: Reversing Hepatocytes‐Hepatic Stellate Cells Malignant Crosstalk by Ling‐Feng Zhang, Wen‐Qi Deng, Xing‐Huan Wang, Qing‐Wen Huang, Su‐Qing Liang, Ze‐Quan Ding, Liang Qi, Yi Wang, Tian‐Jiao Zhou, Lei Xing, Jai‐Woo Lee, Yu‐Kyoung Oh, Hu‐Lin Jiang

“…Abstract During the onset and malignant development of liver fibrosis, the pernicious interplay between damaged hepatocytes and activated hepatic stellate cells (HSCs) induce a self‐perpetuating vicious cycle, deteriorating fibrosis progression and posing a grave threat to public health. The secretions released by damaged hepatocytes and activated HSCs interact through autocrine or paracrine mechanisms, involving multiple signaling pathways. …”
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Anti-Inflammatory and Anti-Migratory Effects of Morin on Non-Small-Cell Lung Cancer Metastasis via Inhibition of NLRP3/MAPK Signaling Pathway by Punnida Arjsri, Kamonwan Srisawad, Sonthaya Umsumarng, Pilaiporn Thippraphan, Songyot Anuchapreeda, Pornngarm Dejkriengkraikul

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Uji Kualitas Mikrobiologis Minuman Teh Poci yang Dijual Pedagang Kaki Lima di Pasar Raya Padang by Genta Pradana, Roslaili Rasyid, Edison

“…The research occured from November 2011 until September 2012 using the Most Probable Number method, consists of two phases presumtive and confirmative.The result of the test showed that all thirteen<br />samples were positive which means all the samples did not fulfill the microbiological quality of drinks published by the Indonesian Health Ministry.<br />Keywords:  street sellers, Teh Poci, higiene<br /><br /><br /><br />…”
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Sacubitril/valsartan is associated with improvements in quality of life in adult congenital heart disease patients with systemic right ventricular failure by Philippine Kiès, Marieke Nederend, Ralph M.L. Neijenhuis, Anna E. van Groningen, Monique R.M. Jongbloed, Hubert W. Vliegen, J. Wouter Jukema, Anastasia D. Egorova

“…This study aimed to evaluate the medium-term QOL changes in sRV failure patients treated with sacubitril/valsartan.Methods In this single-centre, prospective cohort study, patients with symptomatic sRV failure completed the Netherlands Organisation for Applied Scientific Research/Academic Hospital Leiden Questionnaire for Adult’s Health-Related Quality of Life (TAAQOL) at baseline and after starting treatment with sacubitril/valsartan. …”
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Preservation of Bilateral Corticospinal Projections from Injured Hemisphere After Perinatal Stroke by Cameron P. Casey, Ellen N. Sutter, Alina Grimaldo, Kellie M. Collins, Jose Guerrero-Gonzalez, Ryan M. McAdams, Douglas C. Dean, Bernadette T. Gillick

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Human Leukocyte Antigen Class I and II Alleles and Overall Survival in Diffuse Large B-Cell Lymphoma and Follicular Lymphoma by Yani Lu, Amr M. Abdou, James R. Cerhan, Lindsay M. Morton, Richard K. Severson, Scott Davis, Wendy Cozen, Nathaniel Rothman, Leslie Bernstein, Stephen Chanock, Patricia Hartge, Sophia S. Wang

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Modulating Brain Connectivity by Simultaneous Dual-Mode Stimulation over Bilateral Primary Motor Cortices in Subacute Stroke Patients by Jungsoo Lee, Eunhee Park, Ahee Lee, Won Hyuk Chang, Dae-Shik Kim, Yong-Il Shin, Yun-Hee Kim

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Sodium butyrate attenuates oxidative stress, apoptosis, and excessive mitophagy in sodium fluoride-induced hepatotoxicity in rats by Jing Xia, Xiaolin Zhang, Leiyu Xu, Nan Yan, Zhenxiang Sun, Xiaoxu Duan, Lu Meng, Rong Qi, Fu Ren, Zhengdong Wang

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Ultrahigh-Performance Radio Frequency System-on-Chip Implementation of a Kalman Filter-Based High-Precision Time and Frequency Synchronization for Networked Integrated Sensing and... by Roghayeh Ghasemi, Patrick Fenske, Tobias Koegel, Markus Hehn, Ingrid Ullmann, Martin Vossiek

“…The integration of radar sensing and imaging capabilities into future integrated sensing and communication (ISAC) networks enables advanced use cases, including autonomous vehicle navigation, real-time health monitoring, and smart city management. However, ultraprecise time and frequency synchronization is crucial for unlocking the full potential of such networked ISAC systems. …”
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Unmet Medical Needs in the Management of Ulcerative Colitis: Results of an Italian Delphi Consensus by Marco Daperno, Alessandro Armuzzi, Silvio Danese, Walter Fries, Giuseppina Liguori, Ambrogio Orlando, Claudio Papi, Mariabeatrice Principi, Fernando Rizzello, Angelo Viscido, Paolo Gionchetti

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Impact of Thrombocytopenia on In-Hospital Outcome in Patients Undergoing Percutaneous Coronary Intervention by Zhongxiu Chen, Zheng Liu, Nan Li, Ran Liu, Miye Wang, Duolao Wang, Chen Li, Kai Li, Fangbo Luo, Yong He

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Real-world satisfaction and experience with injection and autoinjector device for ofatumumab indicated for multiple sclerosis by Amy Perrin Ross, Jacqueline Nicholas, Ming-Hui Tai, Stephen Yeung, Nazneen Fatima Shaikh, Helen Chen, Mariana Fernandes, Aaron Cortright, Kevin Hawkins

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Avian influenza mRNA vaccine encoding hemagglutinin provides complete protection against divergent H5N1 viruses in specific-pathogen-free chickens by Zhaoyang Wang, Chongyu Tian, Jiahang Zhu, Shiqian Wang, Xiang Ao, Yanjuan He, Huixin Chen, Xiuying Liao, Deming Kong, Yongfei Zhou, Wanbo Tai, Ming Liao, Huiying Fan

“…Abstract Background The rapid mutation of avian influenza virus (AIV) poses a significant threat to both the poultry industry and public health. Herein, we have successfully developed an mRNA-LNPs candidate vaccine for H5 subtype highly pathogenic avian influenza and evaluated its immunogenicity and protective efficacy. …”
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Efficacy of Shenqi Pollen Capsules for High-Altitude Deacclimatization Syndrome via Suppression of the Reoxygenation Injury and Inflammatory Response by Binfeng He, Mingdong Hu, Zhihui Liang, Qianli Ma, Yunhai Zi, Zhiwei Dong, Qi Li, Yongjun Luo, Guisheng Qian, Liang Guo, Kexiong Lin, Zhenyu Liu, Guansong Wang

“…High-altitude deacclimatization syndrome (HADAS) is involved in hypoxia-reoxygenation injury and inflammatory response, induced a series of symptoms, and has emerged as a severe public health issue. Here, we investigated the mechanism as well as potential means to prevent HADAS using Shenqi pollen capsules (SPCs) in subjects with HADAS in a multicenter, double-blinded, randomized, placebo-controlled study. …”
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Preliminary ultrasonography study of the pancreas in the dromedary camel (Camelus dromedarius) by El Hassania Lakhel, Khalid El Allali, Mohamed Rachid Achaâban, Rahma Azrib

“…The pancreatic major duct was seen as an anechoic circle with a hyperechoic wall, with a maximum diameter of 1 cm, and the left lobe scanned beneath the cranial extremity of the spleen; its ultrasonographic pattern showed an irregular hypoechoic band with a mean thickness of 2.32 ± 0.32 cm (n = 14) in young camels and 3.08 ± 0.52 cm (n = 8) in the adults, including a small splenic vein.ConclusionUltrasonography combined with Doppler techniques provides valuable information on pancreatic health, blood flow, and tissue perfusion, aiding early detection of pancreatic diseases and, consequently, minimizing economic losses in camel husbandry.…”
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Tolerability and Effectiveness of Regorafenib Treatment in Patients with Unresectable Hepatocellular Carcinoma: Real-World Data from the United States by Finn RS, Iyer R, Kalman RS, Parikh ND, Cabrera R, Babajanyan S, Kaseb AO

“…Richard S Finn,1 Renuka Iyer,2 Richard S Kalman,3 Neehar D Parikh,4 Roniel Cabrera,5 Svetlana Babajanyan,6 Ahmed O Kaseb7 1Department of Medicine, University of California, Los Angeles, CA, USA; 2Department of Medicine, Roswell Park Cancer Institute, Buffalo, NY, USA; 3Department of Medicine, Einstein Medical Center, Philadelphia, PA, USA; 4Division of Gastroenterology and Hepatology, University of Michigan, Ann Arbor, MI, USA; 5Department of Medicine, University of Florida Health, Gainesville, FL, USA; 6US Medical Affairs, Oncology, Bayer Healthcare, Whippany, NJ, USA; 7Department of Gastrointestinal Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USACorrespondence: Richard S Finn, Department of Medicine, University of California, Los Angeles, CA, USA, Tel +1-310-586-2091, Email rfinn@mednet.ucla.eduIntroduction: While several systemic therapies are available for unresectable hepatocellular carcinoma (uHCC), there is a lack of granular real-world evidence to support the efficacy and safety of these therapies. …”
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Feasibility of remote robot empowered teleultrasound scanning for radioactive patients by Ying Liang, Lu Wang, Manuel Escobar Amoresa, Zirui Jiang, Bo Yu, Jiami Li, Man Lu

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