Integrative deep immune profiling of the elderly reveals systems-level signatures of aging, sex, smoking, and clinical traitsResearch in context by Lennart Riemann, Rodrigo Gutierrez, Ivan Odak, Joana Barros-Martins, Lennart M. Roesner, Ximena Leon Lara, Christine Falk, Thomas F. Schulz, Gesine Hansen, Thomas Werfel, Reinhold Förster, Berislav Bošnjak, Felix Jenniches, Norman Klopp, Till Robin Lesker, Martin Stangel

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Immune-checkpoint-inhibitor therapy directed against PD-L1 is tolerated in the heart without manifestation of cardiac inflammation in a preclinical reversible melanoma mouse model by Caroline Schoenherr, Caroline Schoenherr, Stefan Pietzsch, Stefan Pietzsch, Cristina Barca, Franziska E. Müller, Frauke S. Bahr, Martina Kasten, Andre Zeug, Sergej Erschow, Christine S. Falk, Evgeni Ponimaskin, James T. Thackeray, Denise Hilfiker-Kleiner, Denise Hilfiker-Kleiner, Melanie Ricke-Hoch

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Case Report of a Traumatic Atlantoaxial Rotatory Subluxation with Bilateral Locked Cervical Facets: Management, Treatment, and Outcome by Nael Hawi, Dirk Alfke, Emmanouil Liodakis, Mohamed Omar, Christian Krettek, Christian Walter Müller, Rupert Meller

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Ablation of the deubiquitinating enzyme cylindromatosis (CYLD) augments STAT1-mediated M1 macrophage polarization and fosters Staphylococcus aureus control by Christina Schmidt, Kunjan Harit, Stephan Traidl, Michael Naumann, Thomas Werfel, Thomas Werfel, Lennart M. Roesner, Lennart M. Roesner, Gopala Nishanth, Dirk Schlüter, Dirk Schlüter

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Functional and Structural Investigation of Myenteric Neurons in the Human Colon by Kristin Elfers, Alina Sophia Sehnert, Alexander Wagner, Ulrich Zwirner, Helena Linge, Ulf Kulik, Daniel Poehnert, Markus Winny, Benjamin Gundert, Heiko Aselmann, Gemma Mazzuoli-Weber

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Pre T-Cell Receptor Alpha (pTα) Expression Patterns and Functional Analysis in Human T-Cell Lymphoblastic Leukemia by Philipp Ivanyi, Michael Morgan, Wenji Piao, Sya N. Ukena, Klaus Steube, Arnold Ganser, Anke Franzke

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Integrating Knowledge Graphs with Symbolic AI: The Path to Interpretable Hybrid AI Systems in Medicine by Maria-Esther Vidal, Yashrajsinh Chudasama, Hao Huang, Disha Purohit, Maria Torrente

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Intestinal Organoids in Colitis Research: Focusing on Variability and Cryopreservation by Talke F. zur Bruegge, Andrea Liese, Sören Donath, Stefan Kalies, Maike Kosanke, Oliver Dittrich-Breiholz, Sandra Czech, Verena N. Bauer, André Bleich, Manuela Buettner

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Alpha-synuclein pathology enhances peripheral and CNS immune responses to bacterial endotoxins by Anna-Sophia Hartke, Cara S. Schreiber, Kristina Lau, Ivo Wiesweg, Inken Waltl, Ulrich Kalinke, Franziska Richter, Christopher Käufer

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Acquisition of innate B cell properties and generation of autoreactive IgA antibodies by follicular B cells during homeostatic proliferation by Laura Kampe, Laura Kampe, Christian Melcher, Christian Melcher, Katrin Westphal, Katrin Westphal, Korbinian Brand, Niko Föger, Niko Föger, Kyeong-Hee Lee, Kyeong-Hee Lee

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Point spread function estimation with computed wavefronts for deconvolution of hyperspectral imaging data by Miroslav Zabic, Michel Reifenrath, Charlie Wegner, Hans Bethge, Timm Landes, Sophia Rudorf, Dag Heinemann

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Intraoperative Conversion to ALPPS in a Case of Intrahepatic Cholangiocarcinoma by F. Oldhafer, K. I. Ringe, K. Timrott, M. Kleine, W. Ramackers, S. Cammann, M. D. Jäger, J. Klempnauer, H. Bektas, F. W. R. Vondran

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Quantized Inverse Design for Photonic Integrated Circuits by Frederik Schubert, Yannik Mahlau, Konrad Bethmann, Fabian Hartmann, Reinhard Caspary, Marco Munderloh, Jörn Ostermann, Bodo Rosenhahn

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Micromechanical behavior of the apple fruit cuticle investigated by Brillouin light scattering microscopy by Timm Landes, Bishnu P. Khanal, Hans Lukas Bethge, Tina Lehrich, Maximilian Seydi Kilic, Franz Renz, Miroslav Zabic, Moritz Knoche, Dag Heinemann

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Expression of CD24 in Human Bone Marrow-Derived Mesenchymal Stromal Cells Is Regulated by TGFβ3 and Induces a Myofibroblast-Like Genotype by Luisa Marilena Schäck, Manuela Buettner, Alexander Wirth, Claudia Neunaber, Christian Krettek, Andrea Hoffmann, Sandra Noack

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Risk Balancing of Cold Ischemic Time against Night Shift Surgery Possibly Reduces Rates of Reoperation and Perioperative Graft Loss by Nikos Emmanouilidis, Julius Boeckler, Bastian P. Ringe, Alexander Kaltenborn, Frank Lehner, Hans Friedrich Koch, Jürgen Klempnauer, Harald Schrem

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Acute Enterovirus Encephalitis as a Cause for Isolated Visual and Auditory Hallucinations in a 22-Year-Old Patient by M. Deest, C. Eberlein, S. Bleich, H. Frieling, T. Skripuletz, A. Neyazi

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Tailoring Bimetallic Pt/Pd Cryogels for Efficient Ethanol Electro‐Oxidation by Hadir Borg, Dániel Zámbó, Patrick Bessel, Daniel Kranz, Marina Rosebrock, Franziska Lübkemann‐Warwas, Nadja C. Bigall, Dirk Dorfs

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Simultaneous Bilateral Quadriceps Tendon Rupture following Long-Term Low-Dose Nasal Corticosteroid Application by Mohamed Omar, Philipp Haas, Max Ettinger, Christian Krettek, Maximilian Petri

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Remission Achieved in Refractory Advanced Takayasu Arteritis Using Rituximab by D. Ernst, M. Greer, M. Stoll, D. Meyer-Olson, R. E. Schmidt, T. Witte

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