Cervical cancer screening by cotesting method for Vietnamese women 25–55 years old: a cost-effectiveness analysis by Hien Thu Bui, Van Nu Hanh Pham, Thang Hong Vu

“…Background Cervical cancer (CC) is preventable through regular screening and vaccination against human papillomavirus (HPV). However, CC remains a significant public health issue in low-income and middle-income countries (LMICs) like Vietnam, where financial constraints hinder the widespread implementation of HPV vaccination and screening programmes. …”
Get full text

Prevalence and genotype distribution of cervical human papilomavirus infection in the pre-vaccination era: a population-based study in the Canary Islands by Silvia De Sanjosé, Vanesa Garcia, Octavio Arencibia, Virginia Benito, Amina Lubrano, Miguel Andujar, Esther Roura, Alejandra Torres, Begoña Vega, Marta Pavcovich, Miguel Angel Sanchez, Jose Luis Trujillo, Lucia Almeida, Milagros Santana, Rosaura Hurtado, Norberto Medina, Sonia Carballo, Maria del Carmen Camacho, Arancha Ruiz del Pozo, Alfoso Quesada, Eduardo Salido, Laia Bruni, Diana Alemán, Mónica Almeida, Ana María Arencibia, María Isabel Armas, Guillermina Batista, Victoria Bernal, Francisca Bernaldo de Quirós, Sili Bolaños, Dolores Casaña, Luisa Celedón, Isabel Cruz, Elisa Díaz, Inocencia Duarte, Felisa Expósito, Carmelo Felipe, Carlos Galván, María José García, María Isabel García, Virginia García, Elena Giménez, Teresa Godoy, Catalina Gómez, Lucia González, Luisa Gutiérrez, Mónica Hernández, Delia Herrera, Laura Herrera, Rosario Laseca, Carmen Marrero, Ofelia Marrero, Noa Mateos, Olivia Medina, Josefa Mendoza, Lucia Montesdeoca, Rosa Monzón, Cristina Morales, Mercedes Morales, M Dolores Navarro, María Ángeles Nieto, Noelia Pérez, Yurena Pérez, Antonio Ramos, Antonio Rico, Margarita Roldán, Esther Salamanca, Rosario Sánchez, Raquel Santana, Elvira Santos, Antonia Solanes, Elisabeth Soutto, Dulce Suarez, María Jesús Suárez, María Ángeles Tadeo, Virgen Valdés, Gabriela Valido, Iralla Vega, Maria del Pino Vega, María Angeles Afonso, Elisa Baena, María Pilar Baz, José de Armas, Alicia de la Puerta, Josefina García, María Asuncion González, Célida González, María Teresa Hernández, Josefa Limiñana, Carmen Rosa León, Fernando Marín, Emma Manrique, José Roberto Negrín, Rosa Olavarrieta, Verónica Perera, Concepción Sabater, Candelaria Sosvilla

“…Objective National Spanish studies show that prevalence of cervical human papillomavirus (HPV) infection in the female population is increasingly frequent, with an overall estimate of 14% in women aged 18–65 years. …”
Get full text

Role of Epstein-Barr Virus and Human Papilloma Virus in the Development of Oropharyngeal Cancer: A Literature Review by Michela Migliaro, Daniela Massuh, María Fernanda Infante, Ana María Brahm, María Trinidad San Martín, Duniel Ortuño

“…The aim of this review was to describe the association and related mechanisms between HPV, EBV, and the development of oral and oropharyngeal cancer. …”
Get full text

Human Papillomavirus, Human Immunodeficiency Virus, and Oral Microbiota Interplay in Nigerian Youth (HOMINY): A Prospective Cohort Study Protocol by Jia Liu, Esosa Osagie, Paul Akhigbe, Nosakhare Idemudia, Ozoemene Obuekwe, Ruxton Adebiyi, Nicolas Schlecht, Yana Bromberg, Fidelis E Eki-Udoko, Nosayaba Osazuwa-Peters, Modupe Oluseun Coker

“…Introduction Persistent oral infections with high-risk human papillomavirus (HR-HPV) are a potential cause of most oropharyngeal cancers (OPCs). …”
Get full text

Human Papilloma Virus Infection in Patients with Male Accessory Gland Infection: Usefulness of the Ultrasound Evaluation by Rosita A. Condorelli, Enzo Vicari, Laura M. Mongioi, Giorgio I. Russo, Giuseppe Morgia, Sandro La Vignera, Aldo E. Calogero

“…This study evaluated the ultrasound (US) features of 20 patients with MAGI and concomitant papilloma virus (HPV) infection compared to 20 patients with microbial (presence of Chlamydia trachomatis alone) MAGI and 20 patients with amicrobial (inflammatory) MAGI. …”
Get full text

Giant Squamous Cell Papilloma of the Eyelid—Diagnostic and Therapeutic Challenges by Attila Vass, Gábor Vass, Erika Gabriella Kis, Levente Kuthi, Judit Oláh, Tibor Hortobágyi, Edit Tóth-Molnár

“…Squamous cell papilloma (SCP) is generally a human papillomavirus (HPV) induced exophytic or endophytic proliferation on the surface of the skin, oral cavity, larynx, esophagus, cervix, vagina, and anal canal. …”
Get full text

Biomarkers of pembrolizumab efficacy in advanced anal squamous cell carcinoma: analysis of a phase II clinical trial and a cohort of long-term responders by Jeffrey A Meyerhardt, Sunil Kumar, Jessica A Zerillo, Aparna Parikh, James M Cleary, Scott Rodig, Benjamin Schlechter, Kimmie Ng, Stephanie K Dougan, Nora Horick, Glenn J Hanna, Andrew L Coveler, Anuj K Patel, Nadine J McCleary, Douglas A Rubinson, Jeffrey W Clark, Kent Mouw, Kathleen Pfaff, Thomas A Abrams, Matthew B Yurgelun, Eliezer M Van Allen, S Jennifer Wang, Leah H Biller, Harshabad Singh, Emma L Welsh, Brandon M Huffman, Lestat R Ali, Megan T Hoffman, Katherine A Metayer, Shayla Murray, Alexandra Bird, Jennifer A Chan, Wolfram Goessling, Jeffrey S Wisch, Brendan Reardon, Robert J Mayer, Catherine Del Vecchio Fitz, Charlotte Kuperwasser

“…Patients who benefited from pembrolizumab had decreasing TTMV-HPV DNA scores and a complete responder’s TTMV-HPV DNA became undetectable. …”
Get full text

Knowledge, Attitude, And Practices of The Educated Women of North India Toward Cervical Cancer by Ishita Miglani, Urvashi Gandhi, Poonam Laul

“…Girls and women aged 15 years and more studying in educational institutions or those who have completed their graduation were asked to fill out the questionnaire if willing to do so anonymously. 824 respondents filled out the online survey. 75% of the respondents had good knowledge about pap smear and HPV vaccination. Only 80 respondents (9.7%) were vaccinated against HPV. 255 (30.9%) had been screened with a pap smear at least once in their lifetime. …”
Get full text

CINⅡ-Ⅲ级年轻患者宫颈组织p16,p21和Ki-67表达的改变

“…【目的】 探讨宫颈上皮内瘤变(CIN)Ⅱ-Ⅲ级 < 35岁患者宫颈组织中细胞周期素依赖激酶抑制蛋白p16p21和细胞增殖抗原Ki-67的表达特点【方法】选择2008年3月至2009年8月广东省人民医院妇科门诊因宫颈疾病就诊患者，第2代杂交捕获试验(HCⅡ)检测高危型人乳头瘤病毒(HPV) DNA负荷量，经活检或手术后病理诊断CINⅡ-Ⅲ级共109例，分为两组，< 35岁组48例，≥ 35岁组61例，并用宫颈组织病理切片进行p16p21和Ki-67免疫组化检测，比较两组高危型HPV DNA负荷量和p16p21和Ki-67蛋白表达差异【结果】 全部病例均检测到高危型HPV DNA,阳性率为100%，但两组HPV DNA负荷量差异无统计学意义[< 35岁组：(498 ± 848 pg/mL，≥ 35岁组:(548 ± 756) pg/mL，P > 0.05]；两组间p16阳性表达率无统计学差异(< 35岁组:100%，≥ 35岁组:96.72%，P > 0.05)，但 < 35岁组p21和Ki-67表达阳性率(p21:60.42%，Ki-67:91.67%)明显高于 ≥ 35岁组(p21:39.34%，Ki-67:75.41%，P < 0.05) 【结论】 CIN年轻患者宫颈组织p21和Ki-67表达率升高，可增加p21和Ki-67检测预测宫颈病变进展状态…”
Get full text

Alpha-linolenic acid-mediated epigenetic reprogramming of cervical cancer cell lines by Amrita Ulhe, Prerna Raina, Amol Chaudhary, Ruchika Kaul-Ghanekar

“…RT-PCR was utilized to assess the expression of tumor regulatory genes (hTERT, DAPK, RARβ, and CDH1) and their promoter methylation in HeLa (HPV18-positive), SiHa (HPV16-positive) and C33a (HPV-negative) cervical cancer cell lines. …”
Get full text

Costs and Resource Use Among Patients with Cervical Cancer, Cervical Intraepithelial Neoplasia, and Genital Warts in Algeria by Ali-Chakib Bennacef, Aomar Ammar Khodja, Fadl Allah Abou-Bekr, Tidiane Ndao, Ryan Holl, Goran Benčina

“…**Background:** Cervical cancer rates in North Africa have risen in the last 10 years, suggesting that this region might benefit from cervical cancer screening and HPV vaccination programs. To assess the potential benefits of cervical cancer screening and HPV vaccination in North African countries, country-specific data on the prevalence and burden of HPV-related conditions are needed. …”
Get full text

High prevalence of p16 staining in malignant tumors. by Noémi De Wispelaere, Sebastian Dwertmann Rico, Marcus Bauer, Andreas M Luebke, Martina Kluth, Franziska Büscheck, Claudia Hube-Magg, Doris Höflmayer, Natalia Gorbokon, Sören Weidemann, Katharina Möller, Christoph Fraune, Christian Bernreuther, Ronald Simon, Christian Kähler, Anne Menz, Andrea Hinsch, Frank Jacobsen, Patrick Lebok, Till Clauditz, Guido Sauter, Ria Uhlig, Waldemar Wilczak, Stefan Steurer, Eike Burandt, Rainer Krech, David Dum, Till Krech, Andreas Marx, Sarah Minner

“…Comparison of human papilloma virus (HPV) status and p16 in 497 squamous cell carcinomas of different organs revealed HPV in 80.4% of p16 positive and in 20.6% of p16 negative cancers (p<0.0001). …”
Get full text

Modeling optimal combination of breast and cervical cancer screening strategies in China by Xuewei Liu, Yanbo Wang, Bei Gao, Xinlin Lu, Yuan Wang, Wenli Lu

“…Conclusions From a social cost–benefit perspective, biennial BUS and MAM in parallel screening, and quinquennial HPV screening is the most efficient combination strategy with limited budget, while annual CBE, BUS and MAM in series screening and biennial TCT and HPV in series screening are the most efficient combination strategy with sufficient budget.…”
Get full text

Squamous Cell Papilloma of the Urinary Bladder Endoscopically Mimicking Cancer by Dimosthenis Miliaras, Ioannis Vakalopoulos, Eleftherios Anagnostou

“…The tumor cells were negative for HPV DNA. These lesions are extremely rare, and even though they are considered benign and non-HPV related, they should be followed, since recurrence has been reported.…”
Get full text

Survival outcomes of marijuana users in p16 positive oropharynx cancer patients by Han Zhang, Michael Xie, Marc Levin, Stuart D. Archibald, B. Stanley Jackson, J. E. M. Young, Michael K. Gupta

“…Abstract Background Oropharynx squamous cell carcinoma (OPSCC) has become the predominant subsite for head and neck mucosal cancers (HNC) due to the rise of human papillomavirus (HPV) related disease. Previous studies have suggested an association between marijuana use and HPV-related OPSCC. …”
Get full text

Methylation sites of human papillomavirus 16 as potential biomarkers for cervical cancer progression by Sha Ji, Nannan Ji

“…ObjectiveTo investigate the methylation levels at 13 specific sites of the human papillomavirus 16 (HPV16) L1 gene as potential biomarkers for the diagnosis of cervical cancer.MethodsSamples were collected from the gynecological outpatient and inpatient departments of the Xinjiang Uygur Autonomous Region People’s Hospital. …”
Get full text

二氧化碳激光打孔预处理联合5-氨基酮戊酸光动力治疗难治性巨大跖疣 by 戴海蓉, 李巧飞, 凌宏忠, 谢继璜, 李玉华, 曹光玲

“…HPV型别与难治性跖疣病情和治疗预后的相关性有待进一步深入研究。…”
Get full text

Electrochemical detection of human papillomavirus DNA based on an ultrasensitive electrochemical sensing platform using N-graphene paper by Jia Wang, Juelan Ye, Gang Li

“…Human papillomavirus (HPV) is the primary cause of cervical cancer, a major global health concern affecting women worldwide. …”
Get full text

Outcomes of Human Papilloma Virus Vaccination in a Private Women Health Clinic in Lebanon by Muhieddine Seoud, Iman Jaafar, Rayan Ghanem, Christiane Soubhieh, Abdallah Adra, Anwar Nassar, Ali Khalil

“…Methods. Opportunistic HPV vaccination is offered at the Women’s Health Center of the AUBMC. …”
Get full text

Detection of cervical precancerous lesions and cancer by small-scale RT-qPCR analysis of oppositely deregulated mRNAs pairs in cytological smears by Anastasia A. Artyukh, Mikhail K. Ivanov, Mikhail K. Ivanov, Sergei E. Titov, Sergei E. Titov, Victoria V. Dzyubenko, Sergey E. Krasilnikov, Sergey E. Krasilnikov, Anastasia O. Shumeikina, Anastasia O. Shumeikina, Anastasia O. Shumeikina, Nikita A. Afanasev, Anastasia V. Malek, Sergei A. Glushkov, Eduard F. Agletdinov

“…BackgroundCervical screening, aimed at detecting precancerous lesions and preventing cancer, is based on cytology and HPV testing. Both methods have limitations, the main ones being the variable diagnostic sensitivity of cytology and the moderate specificity of HPV testing. …”
Get full text